Evaluation of quinacrine treatment for prion diseases

Journal of Virology

Volumn 77, Issue 15, 2003, Pages 8462-8469

  Barret, A ^a   Tagliavini, F ^c   Forloni, G ^d   Bate, C ^e   Salmona, M ^d   Colombo, L ^d   De Luigi, A ^d   Limido, L ^c   Suardi, S ^c   Rossi, G ^c   Auvre F ^a   Adjou, K T ^b   Sales N ^a   Williams, A ^e   Lasmezas C ^a   Deslys, J P ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b ECOLE NATIONALE VÉTÉRINAIRE D ALFORT   (France)

^c DEPARTMENT OF NEUROSURGERY   (Italy)

^d MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^e UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; CHLORPROMAZINE; MEPACRINE; MS 1191; MS 8209; PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN HOMOGENATE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CHLORPROMAZINE; CRICETINAE; DRUG RESISTANCE; ENDOPEPTIDASE K; HUMANS; MELATONIN; MICE; MICE, INBRED C57BL; PEPTIDES; PRION DISEASES; PRIONS; PRPC PROTEINS; PRPSC PROTEINS; QUINACRINE; TUMOR CELLS, CULTURED;

EID: 0038447100     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.15.8462-8469.2003     Document Type: Article

References (36)

1. Adjou, K. T., N. Privat, S. Demart, J. P. Deslys, M. Seman, J. J. Hauw, and D. Dormont. 2000. MS-8209, an amphotericin B analogue, delays the appearance of spongiosis, astrogliosis and PrPres accumulation in the brain of scrapie-infected hamsters. J. Comp. Pathol. 122:3-8.
2. Bate, C., S. Reid, and A. Williams. 2001. Killing of prion-damaged neurones by microglia. Neuroreport 12:2589-2594.
3. Beringue, V., F. Lamoury, K. T. Adjou, T. Maignien, M. Demoy, P. Couvreur, and D. Dormont. 2000. Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice. Arch. Virol. Suppl. 16:39-56.
4. Bolton, D. C., M. P. McKinley, and S. B. Prusiner. 1982. Identification of a protein that purifies with the scrapie prion. Science 218:1309-1311.
5. Caughey, B., D. Ernst, and R. E. Race. 1993. Congo red inhibition of scrapie agent replication. J. Virol. 67:6270-6272.
6. Caughey, B., G. J. Raymond, D. A. Kocisko, and P. T. Lansbury, Jr. 1997. Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies. J. Virol. 71:4107-4110.
7. Caughey, W. S., L. D. Raymond, M. Horiuchi, and B. Caughey. 1998. Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines. Proc. Natl. Acad. Sci. USA 95:12117-12122.
8. Collins, S. J., V. Lewis, M. Brazier, A. F. Hill, A. Fletcher, and C. L. Masters. 2002. Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model. Ann. Neurol. 52:503-506.
9. Demaimay, R., J. Harper, H. Gordon, D. Weaver, B. Chesebro, and B. Caughey. 1998. Structural aspects of Congo red as an inhibitor of protease-resistant prion protein formation. J. Neurochem. 71:2534-2541.
10. Demart, S., J. G. Fournier, C. Creminon, Y. Frobert, F. Lamoury, D. Marce, C. Lasmezas, D. Dormont, J. Grassi, and J. P. Deslys. 1999. New insight into abnormal prion protein using monoclonal antibodies. Biochem. Biophys. Res. Commun. 265:652-657.
11. Deslys, J. P., E. Comoy, S. Hawkins, S. Simon, H. Schimmel, G. Wells, J. Grassi, and J. Moynagh. 2001. Screening slaughtered cattle for BSE. Nature 409:476-478.
12. Doh-Ura, K., T. Iwaki, and B. Caughey. 2000. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J. Virol. 74:4894-4897.
13. Farquhar, C. F., and A. G. Dickinson. 1986. Prolongation of scrapie incubation period by an injection of dextran sulphate 500 within the month before or after infection. J. Gen. Virol. 67:463-473.
14. Forloni, G., N. Angeretti, R. Chiesa, E. Monzani, M. Salmona, O. Bugiani, and F. Tagliavini. 1993. Neurotoxicity of a prion protein fragment. Nature 362:543-546.
15. Forloni, G., S. Iussich, T. Awan, L. Colombo, N. Angeretti, L. Girola, I. Bertani, G. Poli, M. Caramelli, M. G. Bruzzone, L. Farina, L. Limido, G. Rossi, G. Giaccone, J. W. Ironside, O. Bugiani, M. Salmona, and F. Tagliavini. 2002. Tetracyclines affect prion infectivity. Proc. Natl. Acad. Sci. USA 99:10849-10854.
16. Grassi, J., C. Creminon, Y. Frobert, P. Fretier, I. Turbica, H. Rezaei, G. Hunsmann, E. Comoy, and J. P. Deslys. 2000. Specific determination of the proteinase K-resistant form of the prion protein using two-site immunometric assays. Application to the post-mortem diagnosis of BSE. Arch. Virol. Suppl. 16:197-205.
17. Kimberlin, R. H., and C. A. Walker. 1986. Suppression of scrapie infection in mice by heteropolyanion 23, dextran sulfate, and some other polyanions. Antimicrob. Agents Chemother. 30:409-413.
18. Korth, C., B. C. May, F. E. Cohen, and S. B. Prusiner. 2001. Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease. Proc. Natl. Acad. Sci. USA 98:9836-9841.
19. Ladogana, A., P. Casaccia, L. Ingrosso, M. Cibati, M. Salvatore, Y. G. Xi, C. Masullo, and M. Pocchiari. 1992. Sulphate polyanions prolong the incubation period of scrapie-infected hamsters. J. Gen. Virol. 73:661-665.
20. Love, R. 2001. Old drugs to treat new variant Creutzfeldt-Jakob disease. Lancet 358:563.
21. Lullmann-Rauch, R., R. Pods, and B. von Witzendorff. 1996. The antimalarials quinacrine and chloroquine induce weak lysosomal storage of sulphated glycosaminoglycans in cell culture and in vivo. Toxicology 110:27-37.
22. Milhavet, O., A. Mange, D. Casanova, and S. Lehmann. 2000. Effect of Congo red on wild-type and mutated prion proteins in cultured cells. J. Neurochem. 74:222-230.
23. Nishida, N., D. A. Harris, D. Vilette, H. Laude, Y. Frobert, J. Grassi, D. Casanova, O. Milhavet, and S. Lehmann. 2000. Successful transmission of three mouse-adapted scrapie strains to murine neuroblastoma cell lines overexpressing wild-type mouse prion protein. J. Virol. 74:320-325.
24. Piccardo, P., J. P. Langeveld, A. F. Hill, S. R. Dlouhy, K. Young, G. Giaccone, G. Rossi, M. Bugiani, O. Bugiani, R. H. Meloen, J. Collinge, F. Tagliavini, and B. Ghetti. 1998. An antibody raised against a conserved sequence of the prion protein recognizes pathological isoforms in human and animal prion diseases, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. Am. J. Pathol. 152:1415-1420.
25. Pocchiari, M., S. Schmittinger, and C. Masullo. 1987. Amphotericin B delays the incubation period of scrapie in intracerebrally inoculated hamsters. J. Gen. Virol. 68:219-223.
26. Priola, S. A., A. Raines, and W. S. Caughey. 2000. Porphyrin and phthalocyanine antiscrapie compounds. Science 287:1503-1506.
27. Prusiner, S. B. 1991. Molecular biology of prion diseases. Science 252:1515-1522.
28. Prusiner, S. B., M. P. McKinley, K. A. Bowman, D. C. Bolton, P. E. Bendheim, D. F. Groth, and G. G. Glenner. 1983. Scrapie prions aggregate to form amyloid-like birefringent rods. Cell 35:349-358.
29. Rodolfo, K., R. Hassig, K. L. Moya, Y. Frobert, J. Grassi, and L. Di Giamberardino. 1999. A novel cellular prion protein isoform present in rapid anterograde axonal transport. Neuroreport 10:3639-3644.
30. Saborio, G. P., B. Permanne, and C. Soto. 2001. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature 411:810-813.
31. Soto, C., R. J. Kascsak, G. P. Saborio, P. Aucouturier, T. Wisniewski, F. Prelli, R. Kascsak, E. Mendez, D. A. Harris, J. Ironside, F. Tagliavini, R. I. Carp, and B. Frangione. 2000. Reversion of prion protein conformational changes by synthetic beta-sheet breaker peptides. Lancet 355:192-197.
32. Supattapone, S., H. O. Nguyen, F. E. Cohen, S. B. Prusiner, and M. R. Scott. 1999. Elimination of prions by branched polyamines and implications for therapeutics. Proc. Natl. Acad. Sci. USA 96:14529-14534.
33. Supattapone, S., H. Wille, L. Uyechi, J. Safar, P. Tremblay, F. C. Szoka, F. E. Cohen, S. B. Prusiner, and M. R. Scott. 2001. Branched polyamines cure prion-infected neuroblastoma cells. J. Virol. 75:3453-3461.
34. Tagliavini, F., G. Forloni, L. Colombo, G. Rossi, L. Girola, B. Canciani, N. Angeretti, L. Giampaolo, E. Peressini, T. Awan, L. De Gioia, E. Ragg, O. Bugiani, and M. Salmona. 2000. Tetracycline affects abnormal properties of synthetic PrP peptides and PrP(Sc) in vitro. J. Mol. Biol. 300:1309-1322.
35. Tagliavini, F., R. A. McArthur, B. Canciani, G. Giaccone, M. Porro, M. Bugiani, P. M. Lievens, O. Bugiani, E. Peri, P. Dall'Ara, M. Rocchi, G. Poli, G. Forloni, T. Bandiera, M. Varasi, A. Suarato, P. Cassutti, M. A. Cervini, J. Lansen, M. Salmona, and C. Post. 1997. Effectiveness of anthracycline against experimental prion disease in Syrian hamsters. Science 276:1119-1122.
36. Tagliavini, F., F. Prelli, L. Verga, G. Giaccone, R. Sarma, P. Gorevic, B. Ghetti, F. Passerini, E. Ghibaudi, G. Forloni, et al. 1993. Synthetic peptides homologous to prion protein residues 106-147 form amyloid-like fibrils in vitro. Proc. Natl. Acad. Sci. USA 90:9678-9682.