Lethal recessive myelin toxicity of prion protein lacking its central domain

EMBO Journal

Volumn 26, Issue 2, 2007, Pages 538-547

  Baumann, Frank ^a   Tolnay, Markus ^a   Brabeck, Christine ^b,f   Pahnke, Jens ^a,g   Kloz, Ulrich ^c   Niemann, Hartmut H ^d   Heikenwalder, Mathias ^a   Rülicke, Thomas ^e   Bürkle, Alexander ^b   Aguzzi, Adriano ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^f Klinikum Brandenburg   (Germany)

^g UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Functional domain mapping; Neurotoxicity; Physiological function; Prion

Indexed keywords

MYELIN; PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE INHERITANCE; CONTROLLED STUDY; DELETION MUTANT; INDUCED MUTATION; LETHALITY; MOUSE; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN VARIANT; TRANSGENIC MOUSE;

ANIMALS; GENE DELETION; GENES, LETHAL; GENES, RECESSIVE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MUTANT PROTEINS; MYELIN SHEATH; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; SURVIVAL ANALYSIS;

MUS;

EID: 33846498655     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601510     Document Type: Article

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