Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

Science

Volumn 303, Issue 5663, 2004, Pages 1514-1516

  Solforosi, Laura ^a   Criado, Jose R ^a   McGavern, Dorian B ^a   Wirz, Sebastian ^a   Sánchez Alavez, Manuel ^a   Sugama, Shuei ^a   DeGiorgio, Lorraine A ^b   Volpe, Bruce T ^b   Wiseman, Erika ^a   Abalos, Gil ^a   Masliah, Eliezer ^c   Gilden, Donald ^d   Oldstone, Michael B ^a   Conti, Bruno ^a   Williamson, R Anthony ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROSSLINKING; DISEASES; NEUROLOGY; PHYSIOLOGICAL MODELS;

APOPTOSIS; PRION DISEASES;

ANTIBODIES;

PRION PROTEIN;

CELLS AND CELL COMPONENTS; PRION DISEASE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CEREBELLUM; CROSS LINKING; HIPPOCAMPUS; IN VIVO STUDY; MOUSE; NERVE CELL; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL SURVIVAL; CEREBELLUM; COMPLEMENT ACTIVATION; DIMERIZATION; HIPPOCAMPUS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; IN SITU NICK-END LABELING; MICE; MICE, INBRED C57BL; NEURAL CELL ADHESION MOLECULES; NEURONS; PRPC PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 12144291519     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094273     Document Type: Article

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15. We thank E. Leclerc, A. Hessell, T. Bartfai, and D. Wills for their help. Supported by NIH grants HL63817, AG04342, and AI09484, an award from the Department of Defense National Prion Research Program 17-03-1-0511, NIH training grant AG00080 (D.M.), and the Clark Fellowship in Neurophysiology from the Brain Research and Treatment Center, Scripps Clinic (J.R.C.).