β-Amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: Suppression by omega-3 fatty acids and curcumin

Journal of Neuroscience

Volumn 29, Issue 28, 2009, Pages 9078-9089

  Ma, Qiu Lan ^a,c   Yang, Fusheng ^a,c   Rosario, Emily R ^a,c   Ubeda, Oliver J ^a,c   Beech, Walter ^a,c   Gant, Dana J ^a,c   Ping, Ping Chen ^a,c   Hudspeth, Beverly ^a,c   Chen, Cory ^a,c   Zhao, Yongle ^a,c   Vinters, Harry V ^b   Frautschy, Sally A ^a,b,c   Cole, Greg M ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CURCUMIN; DOCOSAHEXAENOIC ACID; FISH OIL; INSULIN RECEPTOR SUBSTRATE 1; STRESS ACTIVATED PROTEIN KINASE; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES MELLITUS; FETUS; HIPPOCAMPUS; HUMAN; INSULIN RESISTANCE; LIPID DIET; MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RAT; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; CELLS, CULTURED; CURCUMIN; DISEASE MODELS, ANIMAL; EMBRYO, MAMMALIAN; ENZYME INHIBITORS; FATTY ACIDS, OMEGA-3; HIPPOCAMPUS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICE, TRANSGENIC; MIDDLE AGED; NEURONS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; POSTMORTEM CHANGES; PRESENILIN-1; RATS; RATS, SPRAGUE-DAWLEY; SERINE; SIGNAL TRANSDUCTION; TAU PROTEINS;

EID: 67650729973     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1071-09.2009     Document Type: Article

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