Library design, synthesis, and screening: Pyridine dicarbonitriles as potential prion disease therapeutics

Journal of Medicinal Chemistry

Volumn 49, Issue 2, 2006, Pages 607-615

  Reddy, Tummala R K ^a   Mutter, Roger ^a   Heal, William ^a   Guo, Kai ^a   Gillet, Valerie J ^a   Pratt, Steven ^a   Chen, Beining ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 BENZYLSULFANYL 4 THIOPHEN 2 YLPYRIDINE 3,5 DICARBONITRILE; PYRIDINE DERIVATIVE; PYRIDINE DICARBONITRILE DERIVATIVE; UNCLASSIFIED DRUG;

AROMATIZATION; ARTICLE; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; PRION DISEASE; SCORING SYSTEM; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE;

COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; DATABASES, FACTUAL; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NITRILES; PRION DISEASES; PRPC PROTEINS; PYRIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 31544475731     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050610f     Document Type: Article

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