-
1
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T., Morrison S.J., Clarke M.F., and Weissman I.L. Stem cells, cancer, and cancer stem cells. Nature 414 (2001) 105-111
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
2
-
-
0031028973
-
Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity
-
Haan de G., Nijhof W., and Zant van G. Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: correlation between lifespan and cycling activity. Blood 89 (1997) 1543-1550
-
(1997)
Blood
, vol.89
, pp. 1543-1550
-
-
Haan de, G.1
Nijhof, W.2
Zant van, G.3
-
3
-
-
0032920969
-
Development and aging of primitive hematopoietic stem cells in BALB/cBy mice
-
Chen J., Astle C.M., and Harrison D.E. Development and aging of primitive hematopoietic stem cells in BALB/cBy mice. Exp Hematol 27 (1999) 928-935
-
(1999)
Exp Hematol
, vol.27
, pp. 928-935
-
-
Chen, J.1
Astle, C.M.2
Harrison, D.E.3
-
4
-
-
0032856214
-
Evidence for a continuous decline in hematopoietic cell function from birth: application to evaluating bone marrow failure in children
-
Marley S.B., Lewis J.L., Davidson R.J., et al. Evidence for a continuous decline in hematopoietic cell function from birth: application to evaluating bone marrow failure in children. Br J Haematol 106 (1999) 162-166
-
(1999)
Br J Haematol
, vol.106
, pp. 162-166
-
-
Marley, S.B.1
Lewis, J.L.2
Davidson, R.J.3
-
5
-
-
0041666387
-
The role of stem cells in aging
-
Zant van G., and Liang Y. The role of stem cells in aging. Exp Hematol 31 (2003) 659-672
-
(2003)
Exp Hematol
, vol.31
, pp. 659-672
-
-
Zant van, G.1
Liang, Y.2
-
6
-
-
23744439044
-
Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells
-
Liang Y., Zant van G., and Szilvassy S.J. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 106 (2005) 1479-1487
-
(2005)
Blood
, vol.106
, pp. 1479-1487
-
-
Liang, Y.1
Zant van, G.2
Szilvassy, S.J.3
-
7
-
-
33749365721
-
Increased hematopoietic stem cell mobilization in aged mice
-
Xing Z., Ryan M.A., Daria D., et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 108 (2006) 2190-2197
-
(2006)
Blood
, vol.108
, pp. 2190-2197
-
-
Xing, Z.1
Ryan, M.A.2
Daria, D.3
-
8
-
-
33845738849
-
Stem cell continuum: directed differentiation hotspots
-
Colvin G.A., Dooner M.S., Dooner G.J., et al. Stem cell continuum: directed differentiation hotspots. Exp Hematol 35 (2007) 96-107
-
(2007)
Exp Hematol
, vol.35
, pp. 96-107
-
-
Colvin, G.A.1
Dooner, M.S.2
Dooner, G.J.3
-
9
-
-
0036733675
-
Chromatin modification and epigenetic reprogramming in mammalian development
-
Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 3 (2002) 662-673
-
(2002)
Nat Rev Genet
, vol.3
, pp. 662-673
-
-
Li, E.1
-
10
-
-
1842527031
-
Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm
-
Prindull G., and Zipori D. Environmental guidance of normal and tumor cell plasticity: epithelial mesenchymal transitions as a paradigm. Blood 103 (2004) 2892-2899
-
(2004)
Blood
, vol.103
, pp. 2892-2899
-
-
Prindull, G.1
Zipori, D.2
-
11
-
-
0037084392
-
Biological roles and mechanistic actions of co-repressor complexes
-
Jepsen K., and Rosenfeld M.G. Biological roles and mechanistic actions of co-repressor complexes. J Cell Sci 115 (2002) 689-698
-
(2002)
J Cell Sci
, vol.115
, pp. 689-698
-
-
Jepsen, K.1
Rosenfeld, M.G.2
-
12
-
-
0042889127
-
Composition-sensitive analysis of the human genome for regulatory signals
-
Kel-Margoulis O.V., Tschekmenev D., Kel A.E., et al. Composition-sensitive analysis of the human genome for regulatory signals. In Silico Biol 3 (2003) 145-171
-
(2003)
In Silico Biol
, vol.3
, pp. 145-171
-
-
Kel-Margoulis, O.V.1
Tschekmenev, D.2
Kel, A.E.3
-
13
-
-
20144386500
-
Large-scale collection and characterization of promotors of human and mouse genes
-
Suzuki Y., Yamashita R., Shirota M., et al. Large-scale collection and characterization of promotors of human and mouse genes. In Silico Biol 4 (2004) 429-444
-
(2004)
In Silico Biol
, vol.4
, pp. 429-444
-
-
Suzuki, Y.1
Yamashita, R.2
Shirota, M.3
-
14
-
-
0030041298
-
Cell cycle co-ordination in embryo cloning by nuclear transfer
-
Campbell K.H.S., Loi P., Otaegui P.J., and Wilmut I. Cell cycle co-ordination in embryo cloning by nuclear transfer. Rev Reprod 1 (1996) 40-46
-
(1996)
Rev Reprod
, vol.1
, pp. 40-46
-
-
Campbell, K.H.S.1
Loi, P.2
Otaegui, P.J.3
Wilmut, I.4
-
15
-
-
0035816538
-
Epigenetic instability in ES cells and cloned mice
-
Humpherys D., Eggan K., Akutsu H., et al. Epigenetic instability in ES cells and cloned mice. Science 293 (2001) 95-97
-
(2001)
Science
, vol.293
, pp. 95-97
-
-
Humpherys, D.1
Eggan, K.2
Akutsu, H.3
-
17
-
-
3242771311
-
Nuclear reprogramming in mammalian somatic cell nuclear cloning
-
Tamada H., and Kikyo N. Nuclear reprogramming in mammalian somatic cell nuclear cloning. Cytogenet Genome Res 105 (2004) 285-291
-
(2004)
Cytogenet Genome Res
, vol.105
, pp. 285-291
-
-
Tamada, H.1
Kikyo, N.2
-
18
-
-
0037324703
-
Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer
-
Dean W., Santos F., and Reik W. Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. Semin Cell Develop Biol 14 (2003) 93-100
-
(2003)
Semin Cell Develop Biol
, vol.14
, pp. 93-100
-
-
Dean, W.1
Santos, F.2
Reik, W.3
-
19
-
-
39449128840
-
Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning
-
Niemann H., Tian X.C., King W.A., and Lee R.S.F. Epigenetic reprogramming in embryonic and foetal development upon somatic cell nuclear transfer cloning. Reproduction 135 (2008) 151-163
-
(2008)
Reproduction
, vol.135
, pp. 151-163
-
-
Niemann, H.1
Tian, X.C.2
King, W.A.3
Lee, R.S.F.4
-
20
-
-
0345059767
-
Applying the principles of stem-cell biology to cancer
-
Pardal R., Clarke M.F., and Morrison S.J. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 3 (2003) 895-902
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 895-902
-
-
Pardal, R.1
Clarke, M.F.2
Morrison, S.J.3
-
21
-
-
33847065486
-
The epigenomics of cancer
-
Jones P.A., and Baylin S.B. The epigenomics of cancer. Cell 128 (2007) 683-692
-
(2007)
Cell
, vol.128
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
22
-
-
38349183668
-
Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
-
Hong D., Gupta R., Ancliff P., et al. Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia. Science 319 5861 (2008) 336-339
-
(2008)
Science
, vol.319
, Issue.5861
, pp. 336-339
-
-
Hong, D.1
Gupta, R.2
Ancliff, P.3
-
23
-
-
20444469539
-
Hypothesis: cell plasticity, linking embryonal stem cells to adult stem cell reservoirs and metastatic cancer cells?
-
Prindull G. Hypothesis: cell plasticity, linking embryonal stem cells to adult stem cell reservoirs and metastatic cancer cells?. Exp Hematol 33 (2005) 738-746
-
(2005)
Exp Hematol
, vol.33
, pp. 738-746
-
-
Prindull, G.1
-
25
-
-
29244469466
-
The epigenetic progenitor origin of human cancer
-
Feinberg A.P., Ohlsson R., and Henikoff S. The epigenetic progenitor origin of human cancer. Nat Rev Genet 7 (2006) 21-33
-
(2006)
Nat Rev Genet
, vol.7
, pp. 21-33
-
-
Feinberg, A.P.1
Ohlsson, R.2
Henikoff, S.3
-
26
-
-
0032542364
-
Genetic instabilities in human cancers
-
Lengauer C., Kinzler K.W., and Vogelstein B. Genetic instabilities in human cancers. Nature 396 (1998) 643-649
-
(1998)
Nature
, vol.396
, pp. 643-649
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
27
-
-
34748866686
-
Signaling pathways in cancer and embryonic stem cells
-
Dreesen O., and Brivanlou A.H. Signaling pathways in cancer and embryonic stem cells. Stem Cell Rev 3 (2007) 7-17
-
(2007)
Stem Cell Rev
, vol.3
, pp. 7-17
-
-
Dreesen, O.1
Brivanlou, A.H.2
-
28
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
Egger G., Liang G., Aparicio A., and Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 429 (2004) 457-463
-
(2004)
Nature
, vol.429
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
29
-
-
40149091137
-
Modeling cancer progression via pathway dependencies
-
Edelman E.J., Guinney J., Chi J.T., Febbo P.G., and Mukherjee S. Modeling cancer progression via pathway dependencies. PloS Comput Biol 4 2 (2008) e28
-
(2008)
PloS Comput Biol
, vol.4
, Issue.2
-
-
Edelman, E.J.1
Guinney, J.2
Chi, J.T.3
Febbo, P.G.4
Mukherjee, S.5
-
30
-
-
21544467270
-
Cell intrinsic alterations underlie hematopoietic stem cell aging
-
Rossi D.J., Bryder D., Zahn J.M., et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A 102 (2005) 9194-9199
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 9194-9199
-
-
Rossi, D.J.1
Bryder, D.2
Zahn, J.M.3
-
31
-
-
0034065926
-
Hematopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hematopoietic growth factors and remodeling of cytokine network
-
Bagnara G.P., Bonsi L., Strippoli P., et al. Hematopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hematopoietic growth factors and remodeling of cytokine network. J Gerontol Biol Sci 55A (2000) B61-B70
-
(2000)
J Gerontol Biol Sci
, vol.55 A
-
-
Bagnara, G.P.1
Bonsi, L.2
Strippoli, P.3
-
32
-
-
0033377979
-
Control of the cell cycle and apoptosis
-
Lundberg A.S., and Weinberg R.A. Control of the cell cycle and apoptosis. Eur J Cancer 35 (1999) 531-539
-
(1999)
Eur J Cancer
, vol.35
, pp. 531-539
-
-
Lundberg, A.S.1
Weinberg, R.A.2
-
33
-
-
9244224723
-
Intrinsic tumor suppression
-
Lowe S.W., Cepero E., and Evan G. Intrinsic tumor suppression. Nature 432 (2004) 307-315
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
34
-
-
14644410453
-
The signals and pathways activating cellular senescence
-
Ben-Porath I., and Weinberg R.A. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37 (2005) 961-976
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 961-976
-
-
Ben-Porath, I.1
Weinberg, R.A.2
-
35
-
-
33847737716
-
DNA damage checkpoints: from initiation to recovery or adaptation
-
Bartek J., and Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 19 (2007) 238-245
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 238-245
-
-
Bartek, J.1
Lukas, J.2
-
36
-
-
0037365789
-
ATM and related protein kinases: safegurading genome integrity
-
Shiloh Y. ATM and related protein kinases: safegurading genome integrity. Nat Rev Cancer 3 (2003) 155-168
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
37
-
-
33744976344
-
Applying whole-genome studies of epigenetic regulation to study human disease
-
Lieb J.D., Beck S., Bulyk M.L., et al. Applying whole-genome studies of epigenetic regulation to study human disease. Cytogenet Genome Res 114 (2006) 1-15
-
(2006)
Cytogenet Genome Res
, vol.114
, pp. 1-15
-
-
Lieb, J.D.1
Beck, S.2
Bulyk, M.L.3
-
38
-
-
0037372003
-
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
-
Jaenisch R., and Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature Genet Suppl 33 (2003) 245-254
-
(2003)
Nature Genet Suppl
, vol.33
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
39
-
-
34247465595
-
Could epigenetics play a role in the developmental origins of health and disease?
-
Cutfield W.S., Hofman P.L., Mitchell M., and Morison I.M. Could epigenetics play a role in the developmental origins of health and disease?. Pediatr Res 61 (2007) 68R-75R
-
(2007)
Pediatr Res
, vol.61
-
-
Cutfield, W.S.1
Hofman, P.L.2
Mitchell, M.3
Morison, I.M.4
-
40
-
-
0035839126
-
Epigenetic reprogramming in mammalian development
-
Reik W., Dean W., and Walter J. Epigenetic reprogramming in mammalian development. Science 293 (2001) 1089-1093
-
(2001)
Science
, vol.293
, pp. 1089-1093
-
-
Reik, W.1
Dean, W.2
Walter, J.3
-
41
-
-
0037470542
-
Aging and genome maintenance: lessons from the mouse?
-
Hasty P., Campisi J., Hoeijmakers J., Steeg van H., and Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 299 (2003) 1355-1359
-
(2003)
Science
, vol.299
, pp. 1355-1359
-
-
Hasty, P.1
Campisi, J.2
Hoeijmakers, J.3
Steeg van, H.4
Vijg, J.5
-
42
-
-
0025081078
-
The fetal and infant origins of adult disease
-
Barker D.J. The fetal and infant origins of adult disease. BMJ 301 (1990) 1111
-
(1990)
BMJ
, vol.301
, pp. 1111
-
-
Barker, D.J.1
-
43
-
-
33646793302
-
Epigenetics, evolution, endocrine disruption, health, and disease
-
Crews D., and McLachlan J.A. Epigenetics, evolution, endocrine disruption, health, and disease. Endocrinology 147 Suppl (2006) S4-S10
-
(2006)
Endocrinology
, vol.147
, Issue.SUPPL
-
-
Crews, D.1
McLachlan, J.A.2
-
44
-
-
34247528878
-
Maternal stress during pregnancy predisposes for iron deficiency in infant monkeys impacting innate immunity
-
Coe C.L., Lubach G.R., and Shirtcliff E.A. Maternal stress during pregnancy predisposes for iron deficiency in infant monkeys impacting innate immunity. Pediatr Res 61 (2007) 520-524
-
(2007)
Pediatr Res
, vol.61
, pp. 520-524
-
-
Coe, C.L.1
Lubach, G.R.2
Shirtcliff, E.A.3
-
45
-
-
34247557054
-
The function of the epigenome in cell reprogramming
-
Lanzuolo C., and Orlando V. The function of the epigenome in cell reprogramming. Cell Mol Life Sci 64 (2007) 1043-1062
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 1043-1062
-
-
Lanzuolo, C.1
Orlando, V.2
-
46
-
-
0042396926
-
Consequences of manipulating gametes and embryos of ruminant species
-
McEvoy T.G., Ashworth C.J., Rooke J.A., and Sinclair K.D. Consequences of manipulating gametes and embryos of ruminant species. Reprod Suppl 61 (2003) 167-182
-
(2003)
Reprod Suppl
, vol.61
, pp. 167-182
-
-
McEvoy, T.G.1
Ashworth, C.J.2
Rooke, J.A.3
Sinclair, K.D.4
-
47
-
-
3242775383
-
Maternal and environmental factors in early cloned embryo development
-
Gao S., and Latham K.E. Maternal and environmental factors in early cloned embryo development. Cytogenet Genome Res 105 (2004) 279-284
-
(2004)
Cytogenet Genome Res
, vol.105
, pp. 279-284
-
-
Gao, S.1
Latham, K.E.2
-
48
-
-
23044514669
-
Epigenetic differences arise during the lifetime of monozygotic twins
-
Fraga M.F., Ballestar E., Paz M.F., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102 (2005) 10604-10609
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 10604-10609
-
-
Fraga, M.F.1
Ballestar, E.2
Paz, M.F.3
-
49
-
-
17444403604
-
Phenotypic differences in genetically identical organisms: the epigenetic perspective
-
Wong A.H.C., Gottesman I.L., and Petronis A. Phenotypic differences in genetically identical organisms: the epigenetic perspective. Human Mol Genet 14 (2005) R11-R18
-
(2005)
Human Mol Genet
, vol.14
-
-
Wong, A.H.C.1
Gottesman, I.L.2
Petronis, A.3
-
50
-
-
33745752370
-
Epigenetics and twins: three variations on the theme
-
Petronis A. Epigenetics and twins: three variations on the theme. Trends Genet 22 (2006) 347-350
-
(2006)
Trends Genet
, vol.22
, pp. 347-350
-
-
Petronis, A.1
-
51
-
-
0035990297
-
DNA damage and its processing. Relation to human disease
-
Bohr V.A. DNA damage and its processing. Relation to human disease. J Inherit Metab Dis 25 (2002) 215-222
-
(2002)
J Inherit Metab Dis
, vol.25
, pp. 215-222
-
-
Bohr, V.A.1
-
52
-
-
4644221953
-
Functional links between transcription, DNA repair and apoptosis
-
Berardi P., Russell M., El-Osta A., and Riabowol K. Functional links between transcription, DNA repair and apoptosis. Cell Mol Life Sci 61 (2004) 2173-2180
-
(2004)
Cell Mol Life Sci
, vol.61
, pp. 2173-2180
-
-
Berardi, P.1
Russell, M.2
El-Osta, A.3
Riabowol, K.4
-
53
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
Boer de J., Andressoo J.O., Wit de J., et al. Premature aging in mice deficient in DNA repair and transcription. Science 296 (2002) 1276-1279
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
Boer de, J.1
Andressoo, J.O.2
Wit de, J.3
-
54
-
-
33751301357
-
Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polio-like kinase 1 kinases
-
Syljuasen R.G., Jensen S., Bartek J., and Lukas J. Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polio-like kinase 1 kinases. Cancer Res 66 (2006) 10253-10257
-
(2006)
Cancer Res
, vol.66
, pp. 10253-10257
-
-
Syljuasen, R.G.1
Jensen, S.2
Bartek, J.3
Lukas, J.4
-
55
-
-
31944436267
-
Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantel cell lymphoma
-
Hutter G., Scheubner M., Zimmermann Y., et al. Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantel cell lymphoma. Genes Chromosomes Cancer 45 (2006) 203-210
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 203-210
-
-
Hutter, G.1
Scheubner, M.2
Zimmermann, Y.3
-
56
-
-
33847613305
-
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors
-
Herceg Z. Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors. Mutagenesis 22 (2007) 91-103
-
(2007)
Mutagenesis
, vol.22
, pp. 91-103
-
-
Herceg, Z.1
-
57
-
-
33644846509
-
Epigenetic gene silencing in cancer-a mechanism for early pathway addiction
-
Baylin S.B., and Ohm J.E. Epigenetic gene silencing in cancer-a mechanism for early pathway addiction. Nature Rev Cancer 6 (2006) 107-116
-
(2006)
Nature Rev Cancer
, vol.6
, pp. 107-116
-
-
Baylin, S.B.1
Ohm, J.E.2
-
58
-
-
21844446596
-
Overview of cancer epigenetics
-
Jones P.A. Overview of cancer epigenetics. Semin Hematol 42 Suppl (2005) S3-S8
-
(2005)
Semin Hematol
, vol.42
, Issue.SUPPL
-
-
Jones, P.A.1
-
59
-
-
33846576622
-
Epigenetic stem cell signature in cancer
-
Widschwendter M., Fiegl H., Egle D., et al. Epigenetic stem cell signature in cancer. Nat Genet 39 (2007) 157-158
-
(2007)
Nat Genet
, vol.39
, pp. 157-158
-
-
Widschwendter, M.1
Fiegl, H.2
Egle, D.3
-
60
-
-
8844265508
-
Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins
-
Ringrose L., and Paro R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet 38 (2004) 413-443
-
(2004)
Annu Rev Genet
, vol.38
, pp. 413-443
-
-
Ringrose, L.1
Paro, R.2
-
61
-
-
33646865180
-
Control of developmental regulators by polycomb in human embryonic stem cells
-
Lee T.I., Jenner R.G., Boyer L.A., et al. Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125 (2006) 301-313
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
Jenner, R.G.2
Boyer, L.A.3
-
62
-
-
33646870495
-
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
-
Bracken A.P., Dietrich N., Pasini D., Hansen K.H., and Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 20 (2006) 1123-1136
-
(2006)
Genes Dev
, vol.20
, pp. 1123-1136
-
-
Bracken, A.P.1
Dietrich, N.2
Pasini, D.3
Hansen, K.H.4
Helin, K.5
-
64
-
-
0036709213
-
Signalling, cell cycle and pluripotency in embryonal stem cells
-
Burdon T., Smith A., and Savatier P. Signalling, cell cycle and pluripotency in embryonal stem cells. Trends Cell Biol 12 (2002) 432-438
-
(2002)
Trends Cell Biol
, vol.12
, pp. 432-438
-
-
Burdon, T.1
Smith, A.2
Savatier, P.3
-
65
-
-
0024389675
-
The human blastocyst: cell number, death and allocation during late preimplantation development in vitro
-
Hardy K., Handyside A.H., and Winston R.M.L. The human blastocyst: cell number, death and allocation during late preimplantation development in vitro. Development 107 (1989) 597-604
-
(1989)
Development
, vol.107
, pp. 597-604
-
-
Hardy, K.1
Handyside, A.H.2
Winston, R.M.L.3
-
66
-
-
0031930570
-
Effect of maternal age and conditions of fertilization on programmed cell death during murine preimplantation embryo development
-
Jurisicova A., Rogers I., Fasciani A., Casper R.F., and Varmuza S. Effect of maternal age and conditions of fertilization on programmed cell death during murine preimplantation embryo development. Mol Hum Reprod 4 (1998) 139-145
-
(1998)
Mol Hum Reprod
, vol.4
, pp. 139-145
-
-
Jurisicova, A.1
Rogers, I.2
Fasciani, A.3
Casper, R.F.4
Varmuza, S.5
-
67
-
-
4544233730
-
Culture and characterization of human embryonic stem cells
-
Draper J.S., Moore H.D., Ruban L.N., Gokhale P.J., and Andrews P.W. Culture and characterization of human embryonic stem cells. Stem Cells Dev 13 (2004) 325-336
-
(2004)
Stem Cells Dev
, vol.13
, pp. 325-336
-
-
Draper, J.S.1
Moore, H.D.2
Ruban, L.N.3
Gokhale, P.J.4
Andrews, P.W.5
-
68
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee I., Bachman K.E., Park B.H., et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416 (2002) 552-556
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
Bachman, K.E.2
Park, B.H.3
-
69
-
-
0037436509
-
Loss of IGF2 imprinting: a potential marker of colorectal cancer risk
-
Cui H., Cruz-Correa M., Giardiello F.M., et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science 299 (2003) 1753-1755
-
(2003)
Science
, vol.299
, pp. 1753-1755
-
-
Cui, H.1
Cruz-Correa, M.2
Giardiello, F.M.3
-
70
-
-
34248347084
-
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotypic instability
-
Mantel C., Guo Y., Lee M.R., et al. Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotypic instability. Blood 109 (2007) 4518-4527
-
(2007)
Blood
, vol.109
, pp. 4518-4527
-
-
Mantel, C.1
Guo, Y.2
Lee, M.R.3
-
71
-
-
0036902234
-
Regulation of APC-Cdc20 by the spindle checkpoint
-
Yu H. Regulation of APC-Cdc20 by the spindle checkpoint. Curr Opin Cell Biol 14 (2002) 706-714
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 706-714
-
-
Yu, H.1
-
72
-
-
1842486792
-
The spindle checkpoint, aneuploidy, and cancer
-
Bharadwaj R., and Yu H. The spindle checkpoint, aneuploidy, and cancer. Oncogene 23 (2004) 2016-2927
-
(2004)
Oncogene
, vol.23
, pp. 2016-2927
-
-
Bharadwaj, R.1
Yu, H.2
-
73
-
-
2942567685
-
Lethality to human cancer cells through masssive chromosome loss by inhibition of the mitotic checkpoint
-
Kops G.J.P.L., Foltz D.R., and Cleveland D.W. Lethality to human cancer cells through masssive chromosome loss by inhibition of the mitotic checkpoint. Proc Natl Acad Sci U S A 101 (2004) 8699-8704
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8699-8704
-
-
Kops, G.J.P.L.1
Foltz, D.R.2
Cleveland, D.W.3
-
74
-
-
34247378186
-
A leukemic fusion protein attenuates the spindle checkpoint and promotes aneuploidy
-
Boyapati A., Yan M., Peterson L.F., Biggs J.R., LeBeau M.M., and Zhang D.E. A leukemic fusion protein attenuates the spindle checkpoint and promotes aneuploidy. Blood 109 (2007) 3963-3971
-
(2007)
Blood
, vol.109
, pp. 3963-3971
-
-
Boyapati, A.1
Yan, M.2
Peterson, L.F.3
Biggs, J.R.4
LeBeau, M.M.5
Zhang, D.E.6
-
75
-
-
0037092955
-
In utero origin of t(8;21) AML1-Eto translocations in childhood acute myeloid leukemia
-
Wiemels J.L., Xiao Z., Buffler P.A., et al. In utero origin of t(8;21) AML1-Eto translocations in childhood acute myeloid leukemia. Blood 99 (2002) 3801-3805
-
(2002)
Blood
, vol.99
, pp. 3801-3805
-
-
Wiemels, J.L.1
Xiao, Z.2
Buffler, P.A.3
-
76
-
-
0141482011
-
Leukemia in twins: lessons in natural history
-
Greaves M.F., Maia A.T., Wiemels J.L., and Ford A.M. Leukemia in twins: lessons in natural history. Blood 102 (2003) 2321-2333
-
(2003)
Blood
, vol.102
, pp. 2321-2333
-
-
Greaves, M.F.1
Maia, A.T.2
Wiemels, J.L.3
Ford, A.M.4
-
77
-
-
34547222536
-
Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma
-
Scintu M., Vitale R., Prencipe M., et al. Genomic instability and increased expression of BUB1B and MAD2L1 genes in ductal breast carcinoma. Cancer Lett 254 (2007) 298-307
-
(2007)
Cancer Lett
, vol.254
, pp. 298-307
-
-
Scintu, M.1
Vitale, R.2
Prencipe, M.3
-
78
-
-
0036144048
-
DNA methylation patterns and epigenetic memory
-
Bird A. DNA methylation patterns and epigenetic memory. Genes Dev 16 (2002) 6-21
-
(2002)
Genes Dev
, vol.16
, pp. 6-21
-
-
Bird, A.1
-
79
-
-
33845265660
-
discrete stem cells: subsets or a continuum? [letter]
-
Kirkland M.A., Quesenberry P.J., and Roeder I. discrete stem cells: subsets or a continuum? [letter]. Blood 108 (2006) 3949
-
(2006)
Blood
, vol.108
, pp. 3949
-
-
Kirkland, M.A.1
Quesenberry, P.J.2
Roeder, I.3
-
80
-
-
0029130085
-
Propagating memory of transcriptional states
-
Paro R. Propagating memory of transcriptional states. Trends Genet 11 (1995) 295-297
-
(1995)
Trends Genet
, vol.11
, pp. 295-297
-
-
Paro, R.1
-
81
-
-
0142185046
-
Age-related epigenetic changes and the immune system
-
Issa J.P. Age-related epigenetic changes and the immune system. Clin Immunol 109 (2003) 103-108
-
(2003)
Clin Immunol
, vol.109
, pp. 103-108
-
-
Issa, J.P.1
-
82
-
-
0037414839
-
Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates
-
Shen X., Xiao H., Ranallo R., Wu W.H., and Wu C. Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Science 299 (2003) 112-114
-
(2003)
Science
, vol.299
, pp. 112-114
-
-
Shen, X.1
Xiao, H.2
Ranallo, R.3
Wu, W.H.4
Wu, C.5
-
83
-
-
34247473070
-
Epigenetics of long-range chromatin interactions
-
Ling J.Q., and Hoffman A.R. Epigenetics of long-range chromatin interactions. Pediatr Res 61 (2007) 11R-16R
-
(2007)
Pediatr Res
, vol.61
-
-
Ling, J.Q.1
Hoffman, A.R.2
-
84
-
-
0035499457
-
Reprogramming of genome function through epigenetic inheritance
-
Surani M.A. Reprogramming of genome function through epigenetic inheritance. Nature 414 (2001) 122-128
-
(2001)
Nature
, vol.414
, pp. 122-128
-
-
Surani, M.A.1
-
85
-
-
25144525014
-
Core transcriptional regulatory circuitry in human embryonic stem cells
-
Boyer L.A., Lee T.I., Cole M.F., et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 (2005) 947-956
-
(2005)
Cell
, vol.122
, pp. 947-956
-
-
Boyer, L.A.1
Lee, T.I.2
Cole, M.F.3
-
86
-
-
0036591876
-
Chromatin as a eukaryotic template of genetic information
-
Cavalli G. Chromatin as a eukaryotic template of genetic information. Curr Opin Cell Biol 14 (2002) 269-278
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 269-278
-
-
Cavalli, G.1
-
87
-
-
0036532114
-
Programming off and on states in chromatin: mechanisms of polycomb and thrithorax group complexes
-
Simon J.A., and Tamkun J.W. Programming off and on states in chromatin: mechanisms of polycomb and thrithorax group complexes. Curr Opin Genet Dev 12 (2002) 210-218
-
(2002)
Curr Opin Genet Dev
, vol.12
, pp. 210-218
-
-
Simon, J.A.1
Tamkun, J.W.2
-
88
-
-
0033926403
-
Review: chromatin structural features and targets that regulate transcription
-
Wolffe A.P., and Guschin D. Review: chromatin structural features and targets that regulate transcription. J Struct Biol 129 (2000) 102-122
-
(2000)
J Struct Biol
, vol.129
, pp. 102-122
-
-
Wolffe, A.P.1
Guschin, D.2
-
89
-
-
2342475666
-
Polycomb complexes and silencing mechanisms
-
Lund A.H., and Lohuizen van M. Polycomb complexes and silencing mechanisms. Curr Opin Cell Biol 16 (2004) 239-246
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 239-246
-
-
Lund, A.H.1
Lohuizen van, M.2
-
90
-
-
0043135127
-
Polycomb-group proteins are involved in silencing processes caused by a transgenic element from the murine imprinted H19/Igf2 region in Drosophila
-
Erhardt S., Lyko F., Ainscough J.F.X., Surani M.A., and Paro R. Polycomb-group proteins are involved in silencing processes caused by a transgenic element from the murine imprinted H19/Igf2 region in Drosophila. Dev Genes Evol 213 (2003) 336-344
-
(2003)
Dev Genes Evol
, vol.213
, pp. 336-344
-
-
Erhardt, S.1
Lyko, F.2
Ainscough, J.F.X.3
Surani, M.A.4
Paro, R.5
-
92
-
-
0035252592
-
E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis
-
Müller H., Bracken A.P., Vernell R., et al. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev 15 (2001) 267-285
-
(2001)
Genes Dev
, vol.15
, pp. 267-285
-
-
Müller, H.1
Bracken, A.P.2
Vernell, R.3
-
93
-
-
27144544622
-
Assembly of variant histones into chromatin
-
Henikoff S., and Ahmad K. Assembly of variant histones into chromatin. Ann Rev Cell Dev Biol 21 (2005) 133-153
-
(2005)
Ann Rev Cell Dev Biol
, vol.21
, pp. 133-153
-
-
Henikoff, S.1
Ahmad, K.2
-
94
-
-
0037062951
-
RNA interference
-
Hannon G.J. RNA interference. Nature 418 (2002) 244-251
-
(2002)
Nature
, vol.418
, pp. 244-251
-
-
Hannon, G.J.1
-
96
-
-
33344469959
-
The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
-
Kamminga L.M., Bystrykh L.V., Boer de A., et al. The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. Blood 107 (2006) 2170-2179
-
(2006)
Blood
, vol.107
, pp. 2170-2179
-
-
Kamminga, L.M.1
Bystrykh, L.V.2
Boer de, A.3
-
97
-
-
33747732171
-
INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells
-
INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells. J Biol Chem 281 (2006) 24790-24802
-
(2006)
J Biol Chem
, vol.281
, pp. 24790-24802
-
-
Reynolds, P.A.1
Sigaroudinia, M.2
Zardo, G.3
-
98
-
-
4143054651
-
Activated p53 suppresses the histone methyltransferase EZH2 gene
-
Tang X., Milyavsky M., Shats I., Erez N., Goldfinger N., and Rotter V. Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene 23 (2004) 5759-5769
-
(2004)
Oncogene
, vol.23
, pp. 5759-5769
-
-
Tang, X.1
Milyavsky, M.2
Shats, I.3
Erez, N.4
Goldfinger, N.5
Rotter, V.6
-
99
-
-
0029100039
-
Chromatin complexes regulating gene expression in Drosophila
-
Pirrotta V. Chromatin complexes regulating gene expression in Drosophila. Curr Opin Genet Dev 5 (1995) 466-472
-
(1995)
Curr Opin Genet Dev
, vol.5
, pp. 466-472
-
-
Pirrotta, V.1
-
100
-
-
32844459336
-
The Polycomb group protein EZH2 directly controls DNA methylation
-
Viré E., Brenner C., Deplus R., et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439 (2006) 871-874
-
(2006)
Nature
, vol.439
, pp. 871-874
-
-
Viré, E.1
Brenner, C.2
Deplus, R.3
-
101
-
-
0033398254
-
Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status
-
Voncken J.W., Schweizer D., Aagaard L., Sattler L., Jantsch M.F., and Lohuizen van M. Chromatin-association of the Polycomb group protein BMI1 is cell cycle-regulated and correlates with its phosphorylation status. J Cell Sci 112 (1999) 4627-4639
-
(1999)
J Cell Sci
, vol.112
, pp. 4627-4639
-
-
Voncken, J.W.1
Schweizer, D.2
Aagaard, L.3
Sattler, L.4
Jantsch, M.F.5
Lohuizen van, M.6
-
102
-
-
0033399122
-
Cell memory and cancer-the story of the trithorax and polycomb group genes
-
Caldas C., and Aparicio S. Cell memory and cancer-the story of the trithorax and polycomb group genes. Cancer Metastasis Rev 18 (1999) 313-329
-
(1999)
Cancer Metastasis Rev
, vol.18
, pp. 313-329
-
-
Caldas, C.1
Aparicio, S.2
-
104
-
-
33746498580
-
Transformation from committed progenitor to leukemia stem cell initiated by MLL-AF9
-
Krivtsov A.V., Twomey D., Feng Z., et al. Transformation from committed progenitor to leukemia stem cell initiated by MLL-AF9. Nature 442 (2006) 818-822
-
(2006)
Nature
, vol.442
, pp. 818-822
-
-
Krivtsov, A.V.1
Twomey, D.2
Feng, Z.3
-
107
-
-
0026460896
-
Telomere length predicts replicative capacity of human fibroblasts
-
Allsopp R.C., Vaziri H., Patterson C., et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A 89 (1992) 10114-10118
-
(1992)
Proc Natl Acad Sci U S A
, vol.89
, pp. 10114-10118
-
-
Allsopp, R.C.1
Vaziri, H.2
Patterson, C.3
-
108
-
-
34247225987
-
Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomere-deficient mouse
-
Khoo C.M., Carrasco D.R., Bodenberg M.W., Paik J.H., and DePinho R.A. Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomere-deficient mouse. Proc Natl Acad Sci U S A 104 (2007) 3931-3936
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3931-3936
-
-
Khoo, C.M.1
Carrasco, D.R.2
Bodenberg, M.W.3
Paik, J.H.4
DePinho, R.A.5
-
109
-
-
0034774859
-
Cellular senescence, cancer and aging: the telomere connection
-
Campisi J., Kim S., Lim C.S., and Rubio M. Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol 36 (2001) 1619-1637
-
(2001)
Exp Gerontol
, vol.36
, pp. 1619-1637
-
-
Campisi, J.1
Kim, S.2
Lim, C.S.3
Rubio, M.4
-
110
-
-
33746211311
-
Telomere length homeostasis
-
Hug N., and Linger J. Telomere length homeostasis. Chromosoma 115 (2006) 413-425
-
(2006)
Chromosoma
, vol.115
, pp. 413-425
-
-
Hug, N.1
Linger, J.2
-
111
-
-
33847243648
-
Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint
-
Jacob N.K., Lescasse R.L., Linger B.R., and Price C.M. Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint. Mol Cell Biol 27 (2007) 1592-1601
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1592-1601
-
-
Jacob, N.K.1
Lescasse, R.L.2
Linger, B.R.3
Price, C.M.4
-
112
-
-
33847372924
-
Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest
-
Glover L., Alsford S., Beattie C., and Horn D. Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest. Nucl Acids Res 35 (2007) 872-880
-
(2007)
Nucl Acids Res
, vol.35
, pp. 872-880
-
-
Glover, L.1
Alsford, S.2
Beattie, C.3
Horn, D.4
-
113
-
-
1842789989
-
Mechanisms of cellular senescence in human and mouse cells
-
Itahana K., Campisi J., and Dimri G. Mechanisms of cellular senescence in human and mouse cells. Biogerontology 5 (2004) 1-10
-
(2004)
Biogerontology
, vol.5
, pp. 1-10
-
-
Itahana, K.1
Campisi, J.2
Dimri, G.3
-
115
-
-
34047178427
-
WRN at telomeres: implications for aging and cancer
-
Multani A.S., and Chang S. WRN at telomeres: implications for aging and cancer. J Cell Sci 120 (2007) 713-721
-
(2007)
J Cell Sci
, vol.120
, pp. 713-721
-
-
Multani, A.S.1
Chang, S.2
-
116
-
-
0033529563
-
For better or worse? Telomerase inhibition and cancer
-
Lange de T., and Jacks T. For better or worse? Telomerase inhibition and cancer. Cell 98 (1999) 273-275
-
(1999)
Cell
, vol.98
, pp. 273-275
-
-
Lange de, T.1
Jacks, T.2
-
117
-
-
53749098455
-
MLL modulates telomere length in mammalian cells
-
626a, Abstract 2209
-
Caslini C., and Hess J.L. MLL modulates telomere length in mammalian cells. Blood 108 11, part 1 (2006) 626a, Abstract 2209
-
(2006)
Blood
, vol.108
, Issue.11 PART 1
-
-
Caslini, C.1
Hess, J.L.2
-
118
-
-
0032080191
-
Telomerase activity in candidate stem cells from fetal liver and adult bone marrow
-
Yui J., Chiu C.P., and Lansdorp P.M. Telomerase activity in candidate stem cells from fetal liver and adult bone marrow. Blood 91 (1998) 3255-3262
-
(1998)
Blood
, vol.91
, pp. 3255-3262
-
-
Yui, J.1
Chiu, C.P.2
Lansdorp, P.M.3
-
119
-
-
33749018683
-
Telomerase promotor reprogramming and interaction with general transcription factors in the human mesenchymal stem cell
-
Serakinci N., Hoare S.F., Kassem M., Atkinson S.P., and Keith W.N. Telomerase promotor reprogramming and interaction with general transcription factors in the human mesenchymal stem cell. Regen Med 1 (2006) 125-131
-
(2006)
Regen Med
, vol.1
, pp. 125-131
-
-
Serakinci, N.1
Hoare, S.F.2
Kassem, M.3
Atkinson, S.P.4
Keith, W.N.5
-
120
-
-
34248336270
-
p53-dependent integration of telomere and growth factor deprivation signals
-
Beliveau A., Bassett E., Lo A.T., et al. p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A 104 (2007) 4431-4436
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4431-4436
-
-
Beliveau, A.1
Bassett, E.2
Lo, A.T.3
-
121
-
-
0041966056
-
Reversal of human cellular senescence: roles of the p53 and p16 pathways
-
Beauséjour C.M., Krtolica A., Galimi F., et al. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J 22 (2003) 4212-4222
-
(2003)
EMBO J
, vol.22
, pp. 4212-4222
-
-
Beauséjour, C.M.1
Krtolica, A.2
Galimi, F.3
-
122
-
-
0032781973
-
Resistance to apoptosis in human cells conferred by telomerase function and telomere stability
-
Holt S.E., Glinsky V.V., Ivanova A.B., and Glinsky G.V. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol Carcinog 25 (1999) 241-248
-
(1999)
Mol Carcinog
, vol.25
, pp. 241-248
-
-
Holt, S.E.1
Glinsky, V.V.2
Ivanova, A.B.3
Glinsky, G.V.4
-
123
-
-
33947223187
-
DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse
-
Maser R.S., Wong K.K., Sahin E., et al. DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cel Biol 27 (2007) 2253-2265
-
(2007)
Mol Cel Biol
, vol.27
, pp. 2253-2265
-
-
Maser, R.S.1
Wong, K.K.2
Sahin, E.3
-
124
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomerase loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin L., Artandi S.E., Shen Q., et al. p53 deficiency rescues the adverse effects of telomerase loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97 (1999) 527-538
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
-
125
-
-
0033553577
-
Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity
-
Nguyen D.C., and Crowe D.L. Intact functional domains of the retinoblastoma gene product (pRb) are required for downregulation of telomerase activity. Biochim Biophys Acta 1445 (1999) 207-215
-
(1999)
Biochim Biophys Acta
, vol.1445
, pp. 207-215
-
-
Nguyen, D.C.1
Crowe, D.L.2
-
126
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 (2003) 194-198
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
-
127
-
-
0034012226
-
The role of senescence and immortalization in carcinogenesis
-
Reddel R.R. The role of senescence and immortalization in carcinogenesis. Carcinogenesis 21 (2000) 477-484
-
(2000)
Carcinogenesis
, vol.21
, pp. 477-484
-
-
Reddel, R.R.1
-
128
-
-
0034978564
-
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans
-
Rudolph K.L., Millard M., Bosenberg M.W., and DePinho R.A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 28 (2001) 155-159
-
(2001)
Nat Genet
, vol.28
, pp. 155-159
-
-
Rudolph, K.L.1
Millard, M.2
Bosenberg, M.W.3
DePinho, R.A.4
-
129
-
-
85047689866
-
Telomeres, stem cells, senescence, and cancer
-
Sharpless N.E., and DePinho R.A. Telomeres, stem cells, senescence, and cancer. J Clin Invest 113 (2004) 160-168
-
(2004)
J Clin Invest
, vol.113
, pp. 160-168
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
130
-
-
0343228751
-
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
-
González-Suárez E., Samper E., Flores J.M., and Blasco M.A. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet 26 (2000) 114-117
-
(2000)
Nat Genet
, vol.26
, pp. 114-117
-
-
González-Suárez, E.1
Samper, E.2
Flores, J.M.3
Blasco, M.A.4
-
131
-
-
26644464602
-
Cyclic induction of senescence with intermittent AZT treatment accelerates both apoptosis and telomere loss
-
Ji H.J., Rha S.Y., Jeung H.C., Yang S.H., An S.W., and Chung H.C. Cyclic induction of senescence with intermittent AZT treatment accelerates both apoptosis and telomere loss. Breast Cancer Res Treat 93 (2005) 227-236
-
(2005)
Breast Cancer Res Treat
, vol.93
, pp. 227-236
-
-
Ji, H.J.1
Rha, S.Y.2
Jeung, H.C.3
Yang, S.H.4
An, S.W.5
Chung, H.C.6
-
132
-
-
20244369733
-
Targeting human telomerase for cancer therapeutics
-
Guittat L., Alberti P., Gomez D., et al. Targeting human telomerase for cancer therapeutics. Cytotechnology 45 (2004) 75-90
-
(2004)
Cytotechnology
, vol.45
, pp. 75-90
-
-
Guittat, L.1
Alberti, P.2
Gomez, D.3
-
133
-
-
16544387068
-
Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells
-
Thelen P., Wuttke W., Jarry H., Grzmil M., and Ringert R.H. Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells. J Urol 171 (2004) 1934-1938
-
(2004)
J Urol
, vol.171
, pp. 1934-1938
-
-
Thelen, P.1
Wuttke, W.2
Jarry, H.3
Grzmil, M.4
Ringert, R.H.5
-
134
-
-
33746589840
-
Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence
-
Datta A., Bellon M., Sinha-Datta U., et al. Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. Blood 108 (2006) 1021-1029
-
(2006)
Blood
, vol.108
, pp. 1021-1029
-
-
Datta, A.1
Bellon, M.2
Sinha-Datta, U.3
-
135
-
-
0036683055
-
Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases
-
Kim G.D., Ni J., Kelesoglu N., Roberts R.J., and Pradhan S. Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J 21 (2002) 4183-4195
-
(2002)
EMBO J
, vol.21
, pp. 4183-4195
-
-
Kim, G.D.1
Ni, J.2
Kelesoglu, N.3
Roberts, R.J.4
Pradhan, S.5
-
136
-
-
0035839057
-
The role of DNA methylation in mammalian epigenetics
-
Jones P.A., and Takai D. The role of DNA methylation in mammalian epigenetics. Science 293 (2001) 1068-1070
-
(2001)
Science
, vol.293
, pp. 1068-1070
-
-
Jones, P.A.1
Takai, D.2
-
137
-
-
0032146274
-
The regulation of E2F by pRB-family proteins
-
Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 12 (1998) 2245-2262
-
(1998)
Genes Dev
, vol.12
, pp. 2245-2262
-
-
Dyson, N.1
-
139
-
-
0035813188
-
Order from destruction
-
Bartek J., and Lukas J. Order from destruction. Science 294 (2001) 66-67
-
(2001)
Science
, vol.294
, pp. 66-67
-
-
Bartek, J.1
Lukas, J.2
-
140
-
-
34247497759
-
Epigenetics-a science of heritable biological adaptation
-
Devaskar S.U., and Raychaudhuri S. Epigenetics-a science of heritable biological adaptation. Pediatr Res 61 (2007) 1R-4R
-
(2007)
Pediatr Res
, vol.61
-
-
Devaskar, S.U.1
Raychaudhuri, S.2
-
142
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl B.D., and Allis C.D. The language of covalent histone modifications. Nature 403 (2000) 41-45
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
143
-
-
0035839136
-
Translating the histone code
-
Jenuwein T., and Allis C.D. Translating the histone code. Science 293 (2001) 1074-1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
144
-
-
0344407016
-
Histone deacetylases: unique players in shaping the epigenetic histone code
-
Thiagalingam S., Cheng K.H., Lee H.J., Mineva N., Thiagalingam A., and Ponte F.J. Histone deacetylases: unique players in shaping the epigenetic histone code. Ann NY Acad Sci U S A 983 (2003) 84-100
-
(2003)
Ann NY Acad Sci U S A
, vol.983
, pp. 84-100
-
-
Thiagalingam, S.1
Cheng, K.H.2
Lee, H.J.3
Mineva, N.4
Thiagalingam, A.5
Ponte, F.J.6
-
145
-
-
6044256118
-
Histones and histone modifications
-
Peterson C.L., and Laniel M.A. Histones and histone modifications. Curr Biol 14 (2004) R546-R551
-
(2004)
Curr Biol
, vol.14
-
-
Peterson, C.L.1
Laniel, M.A.2
-
147
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova J., Horejsi Z., Koed K., et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434 (2005) 864-870
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
-
148
-
-
0033564697
-
CDK inhibitors: positive and negative regulators of G1-phase progression
-
Sherr C.J., and Roberts J.M. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13 (1999) 1501-1512
-
(1999)
Genes Dev
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
149
-
-
0034255298
-
The Swi/Snf family: nucleosome-remodeling complexes and transcriptional control
-
Sudarsanam P., and Winston F. The Swi/Snf family: nucleosome-remodeling complexes and transcriptional control. Trends Genet 16 (2000) 345-351
-
(2000)
Trends Genet
, vol.16
, pp. 345-351
-
-
Sudarsanam, P.1
Winston, F.2
-
150
-
-
0037961635
-
The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling
-
Angelov D., Molla A., Perche P.Y., et al. The histone variant macroH2A interferes with transcription factor binding and SWI/SNF nucleosome remodeling. Mol Cell 11 (2003) 1033-1041
-
(2003)
Mol Cell
, vol.11
, pp. 1033-1041
-
-
Angelov, D.1
Molla, A.2
Perche, P.Y.3
-
151
-
-
0034826968
-
The eukaryotic gene transcription machinery
-
Kornberg R.D. The eukaryotic gene transcription machinery. Biol Chem 382 (2001) 1103-1107
-
(2001)
Biol Chem
, vol.382
, pp. 1103-1107
-
-
Kornberg, R.D.1
-
152
-
-
21244467166
-
Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies
-
Bhalla K.N. Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. J Clin Oncol 23 (2005) 3971-3993
-
(2005)
J Clin Oncol
, vol.23
, pp. 3971-3993
-
-
Bhalla, K.N.1
-
153
-
-
33748314757
-
Breaking barriers to transcription elongation
-
Saunders A., Core L.J., and Lis J.T. Breaking barriers to transcription elongation. Mol Cell Biol 7 (2006) 557-567
-
(2006)
Mol Cell Biol
, vol.7
, pp. 557-567
-
-
Saunders, A.1
Core, L.J.2
Lis, J.T.3
-
155
-
-
45549088264
-
Cyclin E and SV40 Small t Antigen cooperates to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts
-
Sotillo E., Garriga J., Kurimchak A., and Grana X. Cyclin E and SV40 Small t Antigen cooperates to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts. J Biol Chem 283 (2008) 11280-11292
-
(2008)
J Biol Chem
, vol.283
, pp. 11280-11292
-
-
Sotillo, E.1
Garriga, J.2
Kurimchak, A.3
Grana, X.4
-
156
-
-
0037309326
-
Tumor suppression by Ink4a-Arf: progress and puzzles
-
Lowe S.W., and Sherr C.J. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev 13 (2003) 77-83
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 77-83
-
-
Lowe, S.W.1
Sherr, C.J.2
-
157
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein G.H., Drullinger L.F., Soulard A., and Dulic V. Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 19 (1999) 2109-2117
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
158
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta D.A., Xiong Y., Phelps D., Hannon G., Beach D., and Barrett J.C. Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A 93 (1996) 13742-13747
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
159
-
-
0035487104
-
The INK4a/ARF network in tumour suppression
-
Sherr C.J. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2 (2001) 731-737
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 731-737
-
-
Sherr, C.J.1
-
160
-
-
0032504783
-
p14ARF links the tumour suppressors RB and p53
-
Bates S., Phillips A.C., Clark P.A., et al. p14ARF links the tumour suppressors RB and p53. Nature 395 (1998) 124-125
-
(1998)
Nature
, vol.395
, pp. 124-125
-
-
Bates, S.1
Phillips, A.C.2
Clark, P.A.3
-
161
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle D.E., Zindy F., Ashmun R.A., and Sherr C.J. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83 (1995) 993-1000
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
164
-
-
33846852215
-
Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications
-
Gonzalez-Paz N., Chng W.J., McClure R.F., et al. Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications. Blood 109 (2007) 1228-1232
-
(2007)
Blood
, vol.109
, pp. 1228-1232
-
-
Gonzalez-Paz, N.1
Chng, W.J.2
McClure, R.F.3
-
165
-
-
33846878522
-
Methylation and expression of the p16INK4A tumor suppressor gene in multiple myeloma
-
Dib A., Barlogie B., Shaughnessy Jr. J.D., and Kuehl W.M. Methylation and expression of the p16INK4A tumor suppressor gene in multiple myeloma. Blood 109 (2007) 1337-1338
-
(2007)
Blood
, vol.109
, pp. 1337-1338
-
-
Dib, A.1
Barlogie, B.2
Shaughnessy Jr., J.D.3
Kuehl, W.M.4
-
167
-
-
34147167052
-
Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases
-
Golubnitschaja O. Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases. Amino Acids 32 (2007) 359-371
-
(2007)
Amino Acids
, vol.32
, pp. 359-371
-
-
Golubnitschaja, O.1
-
168
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis V.G., Vassiliou L.V., Karakaidos P., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434 (2005) 907-913
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
-
169
-
-
0029849620
-
Cancer cell cycles
-
Sherr C.J. Cancer cell cycles. Science 274 (1996) 1672-1677
-
(1996)
Science
, vol.274
, pp. 1672-1677
-
-
Sherr, C.J.1
-
170
-
-
17844387825
-
Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas
-
Azechi H., Nishida N., Fukuda Y., et al. Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. Oncology 60 (2001) 346-354
-
(2001)
Oncology
, vol.60
, pp. 346-354
-
-
Azechi, H.1
Nishida, N.2
Fukuda, Y.3
-
171
-
-
33947603650
-
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors
-
Chen S., Chen L., Le N.T., et al. Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors. Bioorgan Med Chem Lett 17 (2007) 2134-2138
-
(2007)
Bioorgan Med Chem Lett
, vol.17
, pp. 2134-2138
-
-
Chen, S.1
Chen, L.2
Le, N.T.3
-
172
-
-
33645278944
-
Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression
-
Grillo M., Bott M.J., Khandke N., et al. Validation of cyclin D1/CDK4 as an anticancer drug target in MCF-7 breast cancer cells: effect of regulated overexpression of cyclin D1 and siRNA-mediated inhibition of endogenous cyclin D1 and CDK4 expression. Breast Cancer Res Treat 95 (2006) 185-194
-
(2006)
Breast Cancer Res Treat
, vol.95
, pp. 185-194
-
-
Grillo, M.1
Bott, M.J.2
Khandke, N.3
-
173
-
-
34147127727
-
In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00
-
Joshi K.S., Rathos M.J., Joshi R.D., et al. In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00. Mol Cancer Ther 6 (2007) 918-925
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 918-925
-
-
Joshi, K.S.1
Rathos, M.J.2
Joshi, R.D.3
-
174
-
-
1842579570
-
Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro
-
Tagoh H., Melnik S., Lefevre P., Chong S., Riggs A.D., and Bonifer C. Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro. Blood 103 (2004) 2950-2955
-
(2004)
Blood
, vol.103
, pp. 2950-2955
-
-
Tagoh, H.1
Melnik, S.2
Lefevre, P.3
Chong, S.4
Riggs, A.D.5
Bonifer, C.6
-
175
-
-
0030924438
-
Hypo-phosphorylation of the retinoblastoma protein (pRB) by cyclin D:Cdk4/6 complexes results in active pRb
-
Ezhevsky S.A., Nagahara H., Vocero-Akbani A.M., Gius D.R., Wei M.C., and Dowdy S.F. Hypo-phosphorylation of the retinoblastoma protein (pRB) by cyclin D:Cdk4/6 complexes results in active pRb. Proc Natl Acad Sci U S A 94 (1997) 10699-10704
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 10699-10704
-
-
Ezhevsky, S.A.1
Nagahara, H.2
Vocero-Akbani, A.M.3
Gius, D.R.4
Wei, M.C.5
Dowdy, S.F.6
-
176
-
-
0033575960
-
The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death
-
Knudsen K.E., Weber E., Arden K.C., Cavenee W.K., Feramisco J.R., and Knudsen E.S. The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death. Oncogene 18 (1999) 5239-5245
-
(1999)
Oncogene
, vol.18
, pp. 5239-5245
-
-
Knudsen, K.E.1
Weber, E.2
Arden, K.C.3
Cavenee, W.K.4
Feramisco, J.R.5
Knudsen, E.S.6
-
177
-
-
33645766155
-
/BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule
-
/BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule. J Cancer Res Clin Oncol 132 (2006) 417-426
-
(2006)
J Cancer Res Clin Oncol
, vol.132
, pp. 417-426
-
-
Lim, I.K.1
-
178
-
-
34547137412
-
Skp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas
-
Skp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas. Blood 110 (2007) 1631-1638
-
(2007)
Blood
, vol.110
, pp. 1631-1638
-
-
Lwin, T.1
Hazlehurst, L.A.2
Dessureault, S.3
-
179
-
-
0027769876
-
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
-
Serrano M., Hannon G.J., and Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366 (1993) 704-707
-
(1993)
Nature
, vol.366
, pp. 704-707
-
-
Serrano, M.1
Hannon, G.J.2
Beach, D.3
-
180
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita M., Nunez S., Heard E., et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113 (2003) 703-716
-
(2003)
Cell
, vol.113
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
-
181
-
-
3042728747
-
Overexpression of E2F1 associated with LOH at RB locus and hyperphosphorylation of RB in non-small cell lung carcinoma
-
Imai M.A., Oda Y., Oda M., Nakanishi I., and Kawahara E. Overexpression of E2F1 associated with LOH at RB locus and hyperphosphorylation of RB in non-small cell lung carcinoma. J Cancer Res Clin Oncol 130 (2004) 320-326
-
(2004)
J Cancer Res Clin Oncol
, vol.130
, pp. 320-326
-
-
Imai, M.A.1
Oda, Y.2
Oda, M.3
Nakanishi, I.4
Kawahara, E.5
-
182
-
-
0034703742
-
p53: death star
-
Vousden K.H. p53: death star. Cell 103 (2000) 691-694
-
(2000)
Cell
, vol.103
, pp. 691-694
-
-
Vousden, K.H.1
-
183
-
-
3342982324
-
Cip/Waf1 translocation correlate with caspase-3 activation in TGF-β1-induced apoptosis of HuH-7 cells
-
Cip/Waf1 translocation correlate with caspase-3 activation in TGF-β1-induced apoptosis of HuH-7 cells. Apoptosis 9 (2004) 211-221
-
(2004)
Apoptosis
, vol.9
, pp. 211-221
-
-
Fan, G.1
Ma, X.2
Wong, P.Y.3
Rodrigues, C.M.P.4
Steer, C.J.5
-
184
-
-
0034724446
-
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
-
Khan S.H., Moritsugu J., and Wahl G.M. Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion. Proc Natl Acad Sci U S A 97 (2000) 3266-3271
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3266-3271
-
-
Khan, S.H.1
Moritsugu, J.2
Wahl, G.M.3
-
185
-
-
25644440744
-
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
-
Varela I., Cadinanos J., Pendás A.M., et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437 (2005) 564-568
-
(2005)
Nature
, vol.437
, pp. 564-568
-
-
Varela, I.1
Cadinanos, J.2
Pendás, A.M.3
-
187
-
-
33846921755
-
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
-
Dumble M., Moore L., Chambers S.M., et al. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109 (2007) 1736-1742
-
(2007)
Blood
, vol.109
, pp. 1736-1742
-
-
Dumble, M.1
Moore, L.2
Chambers, S.M.3
-
188
-
-
0142250909
-
p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding
-
Peterson E.J., Bögler O., and Taylor S.M. p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding. Cancer Res 63 (2003) 6579-6582
-
(2003)
Cancer Res
, vol.63
, pp. 6579-6582
-
-
Peterson, E.J.1
Bögler, O.2
Taylor, S.M.3
-
190
-
-
0037089689
-
E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
-
Rayman J.B., Takahashi Y., Indjeian V.B., et al. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev 16 (2002) 933-947
-
(2002)
Genes Dev
, vol.16
, pp. 933-947
-
-
Rayman, J.B.1
Takahashi, Y.2
Indjeian, V.B.3
-
191
-
-
0037089150
-
Gene expression changes in response to E2F1 activation
-
Stanelle J., Stiewe T., Theseling C.C., Peter M., and Pützer B.M. Gene expression changes in response to E2F1 activation. Nucleic Acid Res 30 (2002) 1859-1867
-
(2002)
Nucleic Acid Res
, vol.30
, pp. 1859-1867
-
-
Stanelle, J.1
Stiewe, T.2
Theseling, C.C.3
Peter, M.4
Pützer, B.M.5
-
193
-
-
33749187810
-
INK4a induces an age-dependent decline in islet regenerative potential
-
INK4a induces an age-dependent decline in islet regenerative potential. Nature 443 (2006) 453-457
-
(2006)
Nature
, vol.443
, pp. 453-457
-
-
Krishnamurthy, J.1
Ramsey, M.R.2
Ligon, K.L.3
-
194
-
-
33749171885
-
INK4a expression decreases forebrain progenitors and neurogenesis during aging
-
INK4a expression decreases forebrain progenitors and neurogenesis during aging. Nature 443 (2006) 448-452
-
(2006)
Nature
, vol.443
, pp. 448-452
-
-
Molofsky, A.V.1
Slutsky, S.G.2
Joseph, N.M.3
-
195
-
-
2942722811
-
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
-
Frolov M.V., and Dyson N.J. Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci 117 (2004) 2173-2181
-
(2004)
J Cell Sci
, vol.117
, pp. 2173-2181
-
-
Frolov, M.V.1
Dyson, N.J.2
-
196
-
-
0037188911
-
Histone methylation: dynamic or static?
-
Bannister A.J., Schneider R., and Kouzarides T. Histone methylation: dynamic or static?. Cell 109 (2002) 801-806
-
(2002)
Cell
, vol.109
, pp. 801-806
-
-
Bannister, A.J.1
Schneider, R.2
Kouzarides, T.3
-
197
-
-
0034632829
-
Regulation of chromatin structure by site-specific histone H3 methyltransferases
-
Rea S., Eisenhaber F., O'Carroll D., et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406 (2000) 593-599
-
(2000)
Nature
, vol.406
, pp. 593-599
-
-
Rea, S.1
Eisenhaber, F.2
O'Carroll, D.3
-
198
-
-
0038576158
-
The power and the promise of DNA methylation markers
-
Laird P.W. The power and the promise of DNA methylation markers. Nat Rev Cancer 3 (2003) 253-266
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 253-266
-
-
Laird, P.W.1
-
199
-
-
0036591878
-
The many faces of histone lysine methylation
-
Lachner M., and Jenuwein T. The many faces of histone lysine methylation. Curr Opin Cell Biol 14 (2002) 286-298
-
(2002)
Curr Opin Cell Biol
, vol.14
, pp. 286-298
-
-
Lachner, M.1
Jenuwein, T.2
-
200
-
-
0036532235
-
Heterochromatin: new possibilities for the inheritance of structure
-
Grewal S.I.S., and Elgin S.C.R. Heterochromatin: new possibilities for the inheritance of structure. Curr Opin Genet Dev 12 (2002) 178-187
-
(2002)
Curr Opin Genet Dev
, vol.12
, pp. 178-187
-
-
Grewal, S.I.S.1
Elgin, S.C.R.2
-
201
-
-
0037924433
-
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
-
Bachman K.E., Park B.H., Rhee I., et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell 3 (2003) 89-95
-
(2003)
Cancer Cell
, vol.3
, pp. 89-95
-
-
Bachman, K.E.1
Park, B.H.2
Rhee, I.3
-
202
-
-
0030828073
-
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentrometric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
-
Hendzel M.J., Wei Y., Mancini M.A., et al. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentrometric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106 (1997) 348-360
-
(1997)
Chromosoma
, vol.106
, pp. 348-360
-
-
Hendzel, M.J.1
Wei, Y.2
Mancini, M.A.3
-
203
-
-
1642358490
-
Linking the epigenetic "language" of covalent histone modifications to cancer
-
Hake S.B., Xiao A., and Allis C.D. Linking the epigenetic "language" of covalent histone modifications to cancer. Br J Cancer 90 (2004) 761-769
-
(2004)
Br J Cancer
, vol.90
, pp. 761-769
-
-
Hake, S.B.1
Xiao, A.2
Allis, C.D.3
-
204
-
-
33645802169
-
Cyclin-dependent kinase pathways as targets for cancer treatment
-
Shapiro G.I. Cyclin-dependent kinase pathways as targets for cancer treatment. J Clin Oncol 24 (2006) 1770-1783
-
(2006)
J Clin Oncol
, vol.24
, pp. 1770-1783
-
-
Shapiro, G.I.1
-
205
-
-
34347339526
-
Role for histone deacetylase 1 in human tumor proliferation
-
Senese S., Zaragoza K., Minardi S., et al. Role for histone deacetylase 1 in human tumor proliferation. Mol Cell Biol 27 (2007) 4784-4795
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4784-4795
-
-
Senese, S.1
Zaragoza, K.2
Minardi, S.3
-
207
-
-
0036532202
-
Histone methylation in transcriptional control
-
Kouzarides T. Histone methylation in transcriptional control. Curr Opin Genet Dev 12 (2002) 198-209
-
(2002)
Curr Opin Genet Dev
, vol.12
, pp. 198-209
-
-
Kouzarides, T.1
-
208
-
-
1042302747
-
Histone deacetylase activity is required for embryonic stem cell differentiation
-
Lee J.H., Hart S.R.L., and Skalnik D.G. Histone deacetylase activity is required for embryonic stem cell differentiation. Genesis 38 (2004) 32-38
-
(2004)
Genesis
, vol.38
, pp. 32-38
-
-
Lee, J.H.1
Hart, S.R.L.2
Skalnik, D.G.3
-
209
-
-
0036599352
-
Regulation of lifespan by histone deacetylase
-
Chang K.T., and Min K.T. Regulation of lifespan by histone deacetylase. Ageing Res Rev 1 (2002) 313-326
-
(2002)
Ageing Res Rev
, vol.1
, pp. 313-326
-
-
Chang, K.T.1
Min, K.T.2
-
210
-
-
30544442161
-
Histone acetylation increases chromatin accessibility
-
Görisch S.M., Wachsmuth M., Tóth K.F., Lichter P., and Rippe K. Histone acetylation increases chromatin accessibility. J Cell Sci 118 (2005) 5825-5834
-
(2005)
J Cell Sci
, vol.118
, pp. 5825-5834
-
-
Görisch, S.M.1
Wachsmuth, M.2
Tóth, K.F.3
Lichter, P.4
Rippe, K.5
-
211
-
-
33846496172
-
Regulation of telomere movement by telomere chromatin structure
-
Pandita T.K., Hunt C.R., Sharma G.G., and Yang Q. Regulation of telomere movement by telomere chromatin structure. Cell Mol Life Sci 64 (2007) 131-138
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 131-138
-
-
Pandita, T.K.1
Hunt, C.R.2
Sharma, G.G.3
Yang, Q.4
-
212
-
-
34247508639
-
Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
-
Godfrey K.M., Lillycrop K.A., Burdge G.C., Gluckman P.D., and Hanson M.A. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res 61 (2007) 5R-10R
-
(2007)
Pediatr Res
, vol.61
-
-
Godfrey, K.M.1
Lillycrop, K.A.2
Burdge, G.C.3
Gluckman, P.D.4
Hanson, M.A.5
-
213
-
-
20144388146
-
Loss of acetylation at Lys 16 and trimethylation at Lys 20 of histone H4 is a common hallmark of human cancer
-
Fraga M.F., Ballestar E., Villar-Garea A., et al. Loss of acetylation at Lys 16 and trimethylation at Lys 20 of histone H4 is a common hallmark of human cancer. Nat Genet 37 (2005) 391-400
-
(2005)
Nat Genet
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
-
214
-
-
33645768490
-
Inhibition of SIRT1 reactivates cancer silenced genes without loss of promotor DNA hypermethylation
-
Pruitt K., Zinn R.L., Ohm J.E., et al. Inhibition of SIRT1 reactivates cancer silenced genes without loss of promotor DNA hypermethylation. PLoS Genet 2 (2006) e40
-
(2006)
PLoS Genet
, vol.2
-
-
Pruitt, K.1
Zinn, R.L.2
Ohm, J.E.3
-
215
-
-
5144222440
-
WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promotor in human cervical cancer cells
-
WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promotor in human cervical cancer cells. Biochem Biophys Res Com 324 (2004) 860-867
-
(2004)
Biochem Biophys Res Com
, vol.324
, pp. 860-867
-
-
Li, H.1
Wu, X.2
-
216
-
-
34548814434
-
Mitotic drug targets and the development of novel anti-mitotic anticancer drugs
-
Schmidt M., and Bastians H. Mitotic drug targets and the development of novel anti-mitotic anticancer drugs. Drug Resist Updat 10 (2007) 162-181
-
(2007)
Drug Resist Updat
, vol.10
, pp. 162-181
-
-
Schmidt, M.1
Bastians, H.2
-
217
-
-
10444282190
-
Histone-deacetylase inhibitors for the treatment of cancer
-
Lindemann R.K., Gabrielli B., and Johnstone R.W. Histone-deacetylase inhibitors for the treatment of cancer. Cell Cycle 3 (2004) 779-788
-
(2004)
Cell Cycle
, vol.3
, pp. 779-788
-
-
Lindemann, R.K.1
Gabrielli, B.2
Johnstone, R.W.3
-
218
-
-
33947581039
-
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias
-
Gojo I., Jiemjit A., Trepel J.B., et al. Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias. Blood 109 (2007) 2781-2790
-
(2007)
Blood
, vol.109
, pp. 2781-2790
-
-
Gojo, I.1
Jiemjit, A.2
Trepel, J.B.3
-
219
-
-
33846918136
-
Histone deacetylase inhibitors suppress IFNα-induced up-regulation of promyelocytic leukemia protein
-
Vlasáková J., Nováková Z., Rossmeislová L., Kahle M., Hozák P., and Hodný Z. Histone deacetylase inhibitors suppress IFNα-induced up-regulation of promyelocytic leukemia protein. Blood 109 (2007) 1373-1380
-
(2007)
Blood
, vol.109
, pp. 1373-1380
-
-
Vlasáková, J.1
Nováková, Z.2
Rossmeislová, L.3
Kahle, M.4
Hozák, P.5
Hodný, Z.6
-
220
-
-
3042711192
-
Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival
-
Florenes V.A., Skrede M., Jorgensen K., and Nesland J.M. Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. Melanoma Res 14 (2004) 173-181
-
(2004)
Melanoma Res
, vol.14
, pp. 173-181
-
-
Florenes, V.A.1
Skrede, M.2
Jorgensen, K.3
Nesland, J.M.4
-
221
-
-
13444274622
-
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
-
Insinga A., Monestiroli S., Ronzoni S., et al. Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nat Med 11 (2005) 71-76
-
(2005)
Nat Med
, vol.11
, pp. 71-76
-
-
Insinga, A.1
Monestiroli, S.2
Ronzoni, S.3
-
222
-
-
0036652176
-
Histone acetylation and deacetylation: identification of acetylation and methylation sites of hela histone H4 by mass spectrometry
-
Zhang K., Williams K.E., Huang L., et al. Histone acetylation and deacetylation: identification of acetylation and methylation sites of hela histone H4 by mass spectrometry. Mol Cell Proteomics 1 (2002) 500-508
-
(2002)
Mol Cell Proteomics
, vol.1
, pp. 500-508
-
-
Zhang, K.1
Williams, K.E.2
Huang, L.3
-
223
-
-
33644626412
-
Heterochromatin assembly: a new twist on an old model
-
Horn P.J., and Peterson C.L. Heterochromatin assembly: a new twist on an old model. Chromosome Res 14 (2006) 83-94
-
(2006)
Chromosome Res
, vol.14
, pp. 83-94
-
-
Horn, P.J.1
Peterson, C.L.2
-
224
-
-
2342599619
-
The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
-
Yang X.J. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res 32 (2004) 959-976
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 959-976
-
-
Yang, X.J.1
-
225
-
-
0035142070
-
Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation
-
Kitabayashi I., Aikawa Y., Yokoyama A., et al. Fusion of MOZ and p300 histone acetyltransferases in acute monocytic leukemia with a t(8;22)(p11;q13) chromosome translocation. Leukemia 15 (2001) 89-94
-
(2001)
Leukemia
, vol.15
, pp. 89-94
-
-
Kitabayashi, I.1
Aikawa, Y.2
Yokoyama, A.3
-
226
-
-
0035883954
-
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails
-
Zhang Y., and Reinberg D. Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 15 (2001) 2343-2360
-
(2001)
Genes Dev
, vol.15
, pp. 2343-2360
-
-
Zhang, Y.1
Reinberg, D.2
-
227
-
-
0043127085
-
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
-
Fischle W., Wang Y., Jacobs S.A., Kim Y., Allis C.D., and Khorasanizadeh S. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev 17 (2003) 1870-1881
-
(2003)
Genes Dev
, vol.17
, pp. 1870-1881
-
-
Fischle, W.1
Wang, Y.2
Jacobs, S.A.3
Kim, Y.4
Allis, C.D.5
Khorasanizadeh, S.6
-
228
-
-
38149079435
-
MLL core components give the green light to histone methylation
-
Crawford B.D., and Hess J.L. MLL core components give the green light to histone methylation. ACS Chem Biol 1 (2006) 495-498
-
(2006)
ACS Chem Biol
, vol.1
, pp. 495-498
-
-
Crawford, B.D.1
Hess, J.L.2
-
229
-
-
2942715029
-
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
-
Yokoyama A., Wang Z., Wysocka J., et al. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol 24 (2004) 5639-5649
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5639-5649
-
-
Yokoyama, A.1
Wang, Z.2
Wysocka, J.3
-
230
-
-
29244438472
-
CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set 1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex
-
Lee J.H., and Skalnik D.G. CpG-binding protein (CXXC finger protein 1) is a component of the mammalian Set 1 histone H3-Lys4 methyltransferase complex, the analogue of the yeast Set1/COMPASS complex. J Biol Chem 280 (2005) 41725-41731
-
(2005)
J Biol Chem
, vol.280
, pp. 41725-41731
-
-
Lee, J.H.1
Skalnik, D.G.2
-
231
-
-
20444397430
-
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
-
Dou Y., Milne T.A., Tackett A.J., et al. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121 (2005) 873-885
-
(2005)
Cell
, vol.121
, pp. 873-885
-
-
Dou, Y.1
Milne, T.A.2
Tackett, A.J.3
-
232
-
-
20044380143
-
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors
-
Milne T.A., Hughes C.M., Lloyd R., Yang Z., Rozenblatt-Rosen O., Dou Y., Schnepp R.W., Krankel C., LiVolsi V.A., Gibbs D., Hua X., Roeder R.G., Meyerson M., and Hess J.L. Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A 102 (2005) 749-754
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 749-754
-
-
Milne, T.A.1
Hughes, C.M.2
Lloyd, R.3
Yang, Z.4
Rozenblatt-Rosen, O.5
Dou, Y.6
Schnepp, R.W.7
Krankel, C.8
LiVolsi, V.A.9
Gibbs, D.10
Hua, X.11
Roeder, R.G.12
Meyerson, M.13
Hess, J.L.14
-
233
-
-
0037133565
-
Comprehensive analysis of CpG islands in human chromosomes 21 and 22
-
Takai D., and Jones P.A. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A 99 (2002) 3740-3745
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 3740-3745
-
-
Takai, D.1
Jones, P.A.2
-
235
-
-
39449088247
-
Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression
-
Ansari K.I., Mishra B.P., and Mandal S.S. Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression. Biochim Biophys Acta 1779 (2008) 66-73
-
(2008)
Biochim Biophys Acta
, vol.1779
, pp. 66-73
-
-
Ansari, K.I.1
Mishra, B.P.2
Mandal, S.S.3
-
236
-
-
34547644459
-
Interaction of MLL amino terminal sequences with menin is required for transformation
-
Caslini C., Yang Z., El-Osta M., Milne T.A., Slany R.K., and Hess J.L. Interaction of MLL amino terminal sequences with menin is required for transformation. Cancer Res 67 (2007) 7275-7283
-
(2007)
Cancer Res
, vol.67
, pp. 7275-7283
-
-
Caslini, C.1
Yang, Z.2
El-Osta, M.3
Milne, T.A.4
Slany, R.K.5
Hess, J.L.6
-
237
-
-
2442591839
-
Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis
-
Daser A., and Rabbitts T.H. Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. Genes Dev 18 (2004) 965-974
-
(2004)
Genes Dev
, vol.18
, pp. 965-974
-
-
Daser, A.1
Rabbitts, T.H.2
-
238
-
-
0033919595
-
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promotors
-
Robertson K.D., Ait-Si-Ali S., Yokochi T., Wade P.A., Jones P.L., and Wolffe A.P. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promotors. Nat Genet 25 (2000) 338-342
-
(2000)
Nat Genet
, vol.25
, pp. 338-342
-
-
Robertson, K.D.1
Ait-Si-Ali, S.2
Yokochi, T.3
Wade, P.A.4
Jones, P.L.5
Wolffe, A.P.6
-
239
-
-
0035943709
-
Dnmt3a and Dnmt3b are transcription repressors that exhibit unique locatization properties to heterochromatin
-
Bachman K.E., Rountree M.R., and Baylin S.B. Dnmt3a and Dnmt3b are transcription repressors that exhibit unique locatization properties to heterochromatin. J Biol Chem 276 (2001) 32282-32287
-
(2001)
J Biol Chem
, vol.276
, pp. 32282-32287
-
-
Bachman, K.E.1
Rountree, M.R.2
Baylin, S.B.3
-
240
-
-
33846649587
-
Polycomb-mediated methylation of Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
-
Schlesinger Y., Straussman R., Keshet I., et al. Polycomb-mediated methylation of Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 39 (2007) 232-236
-
(2007)
Nat Genet
, vol.39
, pp. 232-236
-
-
Schlesinger, Y.1
Straussman, R.2
Keshet, I.3
-
241
-
-
3042701155
-
Epigenomics: beyond CpG islands
-
Fazzari M.J., and Greally J.M. Epigenomics: beyond CpG islands. Nat Rev Genet 5 (2004) 446-455
-
(2004)
Nat Rev Genet
, vol.5
, pp. 446-455
-
-
Fazzari, M.J.1
Greally, J.M.2
-
242
-
-
0034625064
-
Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a
-
Ramsahoye B.H., Biniszkiewicz D., Lyko F., Clark V., Bird A.P., and Jaenisch R. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a. Proc Natl Acad Sci U S A 97 (2000) 5237-5242
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 5237-5242
-
-
Ramsahoye, B.H.1
Biniszkiewicz, D.2
Lyko, F.3
Clark, V.4
Bird, A.P.5
Jaenisch, R.6
-
243
-
-
0036145156
-
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
-
Esteller M., and Herman J.G. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol 196 (2002) 1-7
-
(2002)
J Pathol
, vol.196
, pp. 1-7
-
-
Esteller, M.1
Herman, J.G.2
-
244
-
-
0035873225
-
Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
-
Fuks F., Burgers W.A., Godin N., Kasai M., and Kouzarides T. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J 20 (2001) 2536-2544
-
(2001)
EMBO J
, vol.20
, pp. 2536-2544
-
-
Fuks, F.1
Burgers, W.A.2
Godin, N.3
Kasai, M.4
Kouzarides, T.5
-
245
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
Eden A., Gaudet F., Waghmare A., and Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300 (2003) 455
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
246
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
Gaudet F., Hodgson J.G., Eden A., et al. Induction of tumors in mice by genomic hypomethylation. Science 300 (2003) 489-492
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
Hodgson, J.G.2
Eden, A.3
-
247
-
-
0344321897
-
Impact of aging on DNA methylation
-
Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2 (2003) 245-261
-
(2003)
Ageing Res Rev
, vol.2
, pp. 245-261
-
-
Richardson, B.1
-
249
-
-
0345357773
-
Gene silencing in cancer in association with promotor hypermethylation
-
Herman J.G., and Baylin S.B. Gene silencing in cancer in association with promotor hypermethylation. N Engl J Med 349 (2003) 2042-2054
-
(2003)
N Engl J Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
250
-
-
33344478730
-
Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2
-
Kitajima K., Tanaka M., Zheng J., et al. Redirecting differentiation of hematopoietic progenitors by a transcription factor, GATA-2. Blood 107 (2006) 1857-1863
-
(2006)
Blood
, vol.107
, pp. 1857-1863
-
-
Kitajima, K.1
Tanaka, M.2
Zheng, J.3
-
251
-
-
33646157746
-
Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b
-
Suzuki M., Yamada T., Kihara-Negishi F., et al. Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. Oncogene 25 (2005) 2477-2488
-
(2005)
Oncogene
, vol.25
, pp. 2477-2488
-
-
Suzuki, M.1
Yamada, T.2
Kihara-Negishi, F.3
-
253
-
-
0242551379
-
DNMT cooperativity-the developing links between methylation, chromatin structure and cancer
-
EL-Osta A. DNMT cooperativity-the developing links between methylation, chromatin structure and cancer. Bioessays 25 (2003) 1071-1084
-
(2003)
Bioessays
, vol.25
, pp. 1071-1084
-
-
EL-Osta, A.1
-
254
-
-
34247348182
-
The C/EBPδ tumor suppressor is silenced by hypermethylation in acute myeloid leukemia
-
3985-3905
-
Agrawal S., Hofmann W.K., Tidow N., et al. The C/EBPδ tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Blood 109 (2007) 3985-3905
-
(2007)
Blood
, vol.109
-
-
Agrawal, S.1
Hofmann, W.K.2
Tidow, N.3
-
255
-
-
0343621494
-
Aberrant CpG-island methylation has non-random and tumor-type-specific patterns
-
Costello J.F., Frühwald M.C., Smiraglia D.J., et al. Aberrant CpG-island methylation has non-random and tumor-type-specific patterns. Nat Genet 24 (2000) 132-138
-
(2000)
Nat Genet
, vol.24
, pp. 132-138
-
-
Costello, J.F.1
Frühwald, M.C.2
Smiraglia, D.J.3
-
256
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander E.S., Linton L.M., Birren B., et al. Initial sequencing and analysis of the human genome. Nature 409 (2001) 860-921
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
Linton, L.M.2
Birren, B.3
-
257
-
-
3342927934
-
Role of transposable elements in heterochromatin and epigenetic control
-
Lippman Z., Gendrel A.V., Black M., et al. Role of transposable elements in heterochromatin and epigenetic control. Nature 430 (2004) 471-476
-
(2004)
Nature
, vol.430
, pp. 471-476
-
-
Lippman, Z.1
Gendrel, A.V.2
Black, M.3
-
258
-
-
1542513556
-
Mobile elements: driver of genome evolution
-
Kazazian Jr. H.H. Mobile elements: driver of genome evolution. Science 303 (2004) 1626-1632
-
(2004)
Science
, vol.303
, pp. 1626-1632
-
-
Kazazian Jr., H.H.1
-
259
-
-
0033800838
-
Stress and transposable elements: co-evolution or useful parasites?
-
Capy P., Gasperi G., Biémont C., and Bazin C. Stress and transposable elements: co-evolution or useful parasites?. Heredity 85 (2000) 101-106
-
(2000)
Heredity
, vol.85
, pp. 101-106
-
-
Capy, P.1
Gasperi, G.2
Biémont, C.3
Bazin, C.4
-
260
-
-
0347364634
-
Activation of a LTR-retrotransposon by telomere erosion
-
Scholes D.T., Kenny A.E., Gamache E.R., Mou Z., and Curcio M.J. Activation of a LTR-retrotransposon by telomere erosion. Proc Natl Acad Sci U S A 100 (2003) 15736-15741
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15736-15741
-
-
Scholes, D.T.1
Kenny, A.E.2
Gamache, E.R.3
Mou, Z.4
Curcio, M.J.5
-
261
-
-
2442667886
-
Transcriptional disruption by L1 retrotransposon and implications for mammalian transcriptomes
-
Han J.S., Szak S.T., and Boeke J.D. Transcriptional disruption by L1 retrotransposon and implications for mammalian transcriptomes. Nature 429 (2004) 268-274
-
(2004)
Nature
, vol.429
, pp. 268-274
-
-
Han, J.S.1
Szak, S.T.2
Boeke, J.D.3
-
262
-
-
33748323138
-
Epigenetic regulation of the rice retrotransposon Tos17
-
Cheng C., Daigen M., and Hirochika H. Epigenetic regulation of the rice retrotransposon Tos17. Mol Gen Genomics 276 (2006) 378-390
-
(2006)
Mol Gen Genomics
, vol.276
, pp. 378-390
-
-
Cheng, C.1
Daigen, M.2
Hirochika, H.3
-
263
-
-
3142718393
-
Activation of a rice endogenous retrotransposon Tos17 in tissue culture is accompanied by cytosine demethylation and causes heritable alteration in methylation pattern of flanking genomic regions
-
Liu Z.L., Han F.P., Tan M., et al. Activation of a rice endogenous retrotransposon Tos17 in tissue culture is accompanied by cytosine demethylation and causes heritable alteration in methylation pattern of flanking genomic regions. Theor Appl Genet 109 (2004) 200-209
-
(2004)
Theor Appl Genet
, vol.109
, pp. 200-209
-
-
Liu, Z.L.1
Han, F.P.2
Tan, M.3
-
264
-
-
34249819684
-
Physical and functional interactions of human endogenous retrovirus proteins Np9 and Rec with the promyelocytic leukemia zinc finger protein
-
Denne M., Sauter M., Armbruester V., Licht J.D., Roemer K., and Mueller-Lantzsch N. Physical and functional interactions of human endogenous retrovirus proteins Np9 and Rec with the promyelocytic leukemia zinc finger protein. J Virol 81 (2007) 5607-5616
-
(2007)
J Virol
, vol.81
, pp. 5607-5616
-
-
Denne, M.1
Sauter, M.2
Armbruester, V.3
Licht, J.D.4
Roemer, K.5
Mueller-Lantzsch, N.6
-
265
-
-
23844558503
-
Human endogenous retroviruses: from infectious elements to human genes
-
Parseval de N., and Heidmann T. Human endogenous retroviruses: from infectious elements to human genes. Cytogenet Genome Res 110 (2005) 318-332
-
(2005)
Cytogenet Genome Res
, vol.110
, pp. 318-332
-
-
Parseval de, N.1
Heidmann, T.2
-
266
-
-
33845456646
-
Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer
-
Wang-Johanning F., Liu J., Rycaj K., et al. Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer. Int J Cancer 120 (2006) 81-90
-
(2006)
Int J Cancer
, vol.120
, pp. 81-90
-
-
Wang-Johanning, F.1
Liu, J.2
Rycaj, K.3
-
267
-
-
36148960428
-
Reprogramming somatic cells towards pluripotency by defined factors
-
Lewitzky M., and Yamanaka S. Reprogramming somatic cells towards pluripotency by defined factors. Curr Opin Biotechnol 18 (2007) 467-473
-
(2007)
Curr Opin Biotechnol
, vol.18
, pp. 467-473
-
-
Lewitzky, M.1
Yamanaka, S.2
-
269
-
-
20144381235
-
Expression of human endogenous retrovirus K in melanomas and melanoma cell lines
-
Büscher K., Trefzer U., Hofmann M., Sterry W., Kurth R., and Denner J. Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. Cancer Res 65 (2005) 4172-4180
-
(2005)
Cancer Res
, vol.65
, pp. 4172-4180
-
-
Büscher, K.1
Trefzer, U.2
Hofmann, M.3
Sterry, W.4
Kurth, R.5
Denner, J.6
-
270
-
-
0034917315
-
Endogenous retroviruses in the human genome sequence
-
reviews
-
Griffiths D.J. Endogenous retroviruses in the human genome sequence. Genome Biol 2 (2001) 1017.1-1017.5 reviews
-
(2001)
Genome Biol
, vol.2
-
-
Griffiths, D.J.1
-
271
-
-
34250813062
-
Insertional polymorphisms: a new lease of life for endogenous retroviruses in human disease
-
Moyes D., Griffiths D.J., and Venables P.J. Insertional polymorphisms: a new lease of life for endogenous retroviruses in human disease. Trends Genet 23 (2007) 326-333
-
(2007)
Trends Genet
, vol.23
, pp. 326-333
-
-
Moyes, D.1
Griffiths, D.J.2
Venables, P.J.3
-
272
-
-
5144227841
-
Retroelements and the human genome: new perspectives on an old relation
-
Bannert N., and Kurth R. Retroelements and the human genome: new perspectives on an old relation. Proc Natl Acad Sci U S A 101 Suppl 2 (2004) 14572-14579
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.SUPPL. 2
, pp. 14572-14579
-
-
Bannert, N.1
Kurth, R.2
-
273
-
-
0042371625
-
The evolution, distribution and diversity of endogenous retroviruses
-
Gifford R., and Tristem M. The evolution, distribution and diversity of endogenous retroviruses. Virus Genes 26 (2003) 3,291-3,315
-
(2003)
Virus Genes
, vol.26
-
-
Gifford, R.1
Tristem, M.2
-
274
-
-
34247126552
-
Are postnatal hemangioblasts generated by dedifferentiation from committed hematopoietic stem cells?
-
Prindull G.A., and Fibach E. Are postnatal hemangioblasts generated by dedifferentiation from committed hematopoietic stem cells?. Exp Hematol 35 (2007) 691-701
-
(2007)
Exp Hematol
, vol.35
, pp. 691-701
-
-
Prindull, G.A.1
Fibach, E.2
-
275
-
-
0036830524
-
Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in metazoans
-
Perez-Pomares J.M., and Munoz-Chapuli E. Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in metazoans. Anat Rec 268 (2002) 343-351
-
(2002)
Anat Rec
, vol.268
, pp. 343-351
-
-
Perez-Pomares, J.M.1
Munoz-Chapuli, E.2
-
276
-
-
0033769681
-
Primary cells suppress oncogene-dependent apoptosis
-
Duelli D.M., and Lazebnik Y.A. Primary cells suppress oncogene-dependent apoptosis. Nat Cell Biol 2 (2000) 859-862
-
(2000)
Nat Cell Biol
, vol.2
, pp. 859-862
-
-
Duelli, D.M.1
Lazebnik, Y.A.2
-
278
-
-
0036392034
-
Epigenetics wins over genetics: induction of differentiation in tumor cells
-
Lotem J., and Sachs L. Epigenetics wins over genetics: induction of differentiation in tumor cells. Semin Cancer Biol 12 (2002) 339-346
-
(2002)
Semin Cancer Biol
, vol.12
, pp. 339-346
-
-
Lotem, J.1
Sachs, L.2
-
279
-
-
34147175640
-
Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulation potential
-
Araki H., Yoshinaga K., Boccuni P., Zhao Y., Hoffman R., and Mahmud N. Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulation potential. Blood 109 (2007) 3570-3578
-
(2007)
Blood
, vol.109
, pp. 3570-3578
-
-
Araki, H.1
Yoshinaga, K.2
Boccuni, P.3
Zhao, Y.4
Hoffman, R.5
Mahmud, N.6
-
280
-
-
33644915538
-
Effect of 5-ara-2′-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the ε{lunate}-, γ-, and β-globin promoters in Papio anubis
-
Lavelle D., Vaitkus K., Hankewych M., Singh M., and DeSimone J. Effect of 5-ara-2′-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the ε{lunate}-, γ-, and β-globin promoters in Papio anubis. Exp Hematol 34 (2006) 339-347
-
(2006)
Exp Hematol
, vol.34
, pp. 339-347
-
-
Lavelle, D.1
Vaitkus, K.2
Hankewych, M.3
Singh, M.4
DeSimone, J.5
-
281
-
-
33847220784
-
Mechanisms of disease: epigenesis
-
Waggoner D. Mechanisms of disease: epigenesis. Semin Pediatr Neurol 14 (2007) 7-14
-
(2007)
Semin Pediatr Neurol
, vol.14
, pp. 7-14
-
-
Waggoner, D.1
-
282
-
-
21744462604
-
Summing up cancer stem cells
-
Huntly B.J.P., and Gilliland D.G. Summing up cancer stem cells. Nature 435 (2005) 1169-1170
-
(2005)
Nature
, vol.435
, pp. 1169-1170
-
-
Huntly, B.J.P.1
Gilliland, D.G.2
-
284
-
-
30444446406
-
The paradox of response and survival in cancer therapeutics
-
Huff C.A., Matsui W., Smith B.D., and Jones R.J. The paradox of response and survival in cancer therapeutics. Blood 107 (2006) 431-434
-
(2006)
Blood
, vol.107
, pp. 431-434
-
-
Huff, C.A.1
Matsui, W.2
Smith, B.D.3
Jones, R.J.4
|