p53-Mediated Repression of DNA Methyltransferase 1 Expression by Specific DNA Binding

Cancer Research

Volumn 63, Issue 20, 2003, Pages 6579-6582

  Peterson, Erica J ^a   Bögler, Oliver ^c   Taylor, Shirley M ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c HENRY FORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DNA; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA CYTOSINE METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; ETOPOSIDE; GENOMIC DNA; MESSENGER RNA; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; CARCINOGENESIS; CHROMATIN; COLON CARCINOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; CPG ISLAND; DNA BINDING; EXON; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE LOSS; GENE REPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GENOME; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IONIZING RADIATION; METHYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STABILITY; TUMOR SUPPRESSOR GENE;

ANIMALS; BINDING SITES; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA, NEOPLASM; EXONS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; MICE; PROTEIN BINDING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0142250909     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Bird, A. P. The relationship of DNA methylation to cancer. Cancer Surv., 28: 87-101, 1996.
2. Baylin, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., and Issa, J. P. Alteration in DNA methylation is a fundamental aspect of neoplasia. Adv. Cancer Res., 72: 141-196, 1998.
3. Jones, P. A., and Laird, P. W. Cancer-epigenetics comes of age. Nat. Genet., 21: 163-167, 1999.
4. Robert, M-F., Morin, S., Beaulieu, N., Gaithier, F., Chute, I. C., Barsalou, A., and MacLoad, A. R. Dnmt1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Nat. Genet., 33: 61-65, 2002.
5. Vogelstein, B., Lane, D., and Levine, A. J. Surfing the p53 network. Nature (Lond.), 408: 307-310, 2000.
6. Ko, L. J., and Prives, C. p53: puzzle and paradigm. Genes Dev., 10: 1054-1072, 1996.
7. El-Diery, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., and Vogelstein, B. Definition of a consensus binding site for p53. Nat. Genet., 1: 45-49, 1992.
8. McLure, K. G., and Lee, P. W. K. How p53 binds as a tetramer. EMBO J., 17: 3342-3350, 1998.
9. Bogler, O., Su Huang, H-J., and Cavanee, W. K. Loss of wild-type p53 bestows a growth advantage on primary cortical astrocytes and facilitates their in vitro transformation. Cancer. Res., 55: 2746-2751, 1995.
10. Orlando, V., Strutt, H., and Paro, R. Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods, 11: 205-214, 1997.
11. Bogler, O., Huang, H. J., Kleihues, P., and Cavenee, W. K. The p53 gene and its role in human brain tumors. Glia, 15: 308-327, 1995.
12. Costello, J. F., Fruhwald, M. C., Smiraglia, D. J., Rush, L. J., Robertson, G. P., Gao, X., Wright, F. A., Feramiseo, J. D., Peltomaki, P., Lang, J. C., Schuller, D. E., Yu, L., Bloomfield, C. D., Caligiuri, M. A., Yates, A., Nishikawa, R., Su, H. H., Petrelli, N. J., Zhang, X., O'Dorisio, M. S., Held, W. A., Cavenee, W. K., and Plass, C. Aberrant CpG-island methylation has non-random and tumor-type-specific patterns. Nat. Genet., 24:132-138, 2000.
13. Waf1/Cip1 gene. Exp. Cell Res., 246: 280-289, 1999.
14. Kanaya, T., Kyo, S., Hamada, K., Takkura, M., Kitagawa, Y., Harada, H., and Inoue, M. Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription. Clin. Cancer Res., 6: 1239-1247, 2000.
15. Yun, J., Chae, H. D., Choy, H. E., Chung, J., Yoo, H. S., Han, M. H., and Shin, D. Y. p53 negatively regulates Cdc2 transcription via the CCAAT-binding NF-κB trancription factor. J. Biol. Chem., 274: 29677-29682, 1999.
16. Kubicka, S., Kuhnel, F., Zender, L., Rudolph, K. L., Plumpe, J., Manns, M., and Tautwein, C. p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. J. Biol. Chem., 274: 32137-32144, 1999.
17. Budhrum-Mahadeo, V., Morris, P. J., Smith, M. D., Midgley, C. A., Boxer, L. M., and Latchman, D. S. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J. Biol. Chem., 274: 15237-15244, 1999.
18. Lee, K. C., Crowe, A. J., and Bardon, M. C. p53-mediated repression of α-fetoprotein gene expression by specific DNA binding. Mol. Cell. Biol., 19: 1279-1288, 1999.
19. Farmer, G., Colgan, J., Nakatani, Y., Manley, J. L., and Prives, C. Functional interaction between p53, the TATA-binding protein (TBP), and TBP-associated factors in vivo. Mol. Cell. Biol., 16: 4295-4304, 1996.
20. Espinosa, J. M., and Emerson, B. M. Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment. Mol. Cell, 8: 57-69, 2001.
21. Kaeser, M. D., and Iggo, R. D. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding in vivo. Proc. Natl. Acad. Sci. USA, 99: 95-100, 2002.