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Volumn 20, Issue 10, 2001, Pages 2536-2544

Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription

Author keywords

Dnmt3a; Histone deacetylation; Methylation; Transcriptional repression

Indexed keywords

ACYLTRANSFERASE; DEACETYLASE DERIVATIVE; DNA; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; METHYLTRANSFERASE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 0035873225     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.10.2536     Document Type: Article
Times cited : (480)

References (50)
  • 1
    • 18744427037 scopus 로고    scopus 로고
    • Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family
    • Aapola, U. et al. (2000) Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family. Genomics, 65, 293-298.
    • (2000) Genomics , vol.65 , pp. 293-298
    • Aapola, U.1
  • 2
    • 0028861418 scopus 로고
    • The PHD finger: Implications for chromatin-mediated transcriptional regulation
    • Aasland, R., Gibson, T.J. and Stewart, A.F. (1995) The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem. Sci., 20, 56-59.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 56-59
    • Aasland, R.1    Gibson, T.J.2    Stewart, A.F.3
  • 3
    • 0032500590 scopus 로고    scopus 로고
    • RP58 associates with condensed chromatin and mediates a sequence- specific transcriptional repression
    • Aoki, K., Meng, G., Suzuki, K., Takashi, T., Kameoka, Y., Nakahara., K., Ishida, R. and Kasai, M. (1998) RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression. J. Biol. Chem., 273, 26698-26704.
    • (1998) J. Biol. Chem. , vol.273 , pp. 26698-26704
    • Aoki, K.1    Meng, G.2    Suzuki, K.3    Takashi, T.4    Kameoka, Y.5    Nakahara, K.6    Ishida, R.7    Kasai, M.8
  • 4
    • 0029165110 scopus 로고
    • CBP-mduced stimulation of c-Fos activity is abrogated by E1A
    • Bannister, A.J. and Kouzarides, T. (1995) CBP-mduced stimulation of c-Fos activity is abrogated by E1A. EMBO J., 14, 4758-4762.
    • (1995) EMBO J. , vol.14 , pp. 4758-4762
    • Bannister, A.J.1    Kouzarides, T.2
  • 5
    • 0030480969 scopus 로고    scopus 로고
    • The CBP co-activator is a histone acetyltransferase
    • Bannister, A.J. and Kouzarides, T. (1996) The CBP co-activator is a histone acetyltransferase. Nature, 384, 641-643.
    • (1996) Nature , vol.384 , pp. 641-643
    • Bannister, A.J.1    Kouzarides, T.2
  • 6
    • 0028040875 scopus 로고
    • The POZ domain: A conserved protein-protein interaction motif
    • Bardwell, V.J. and Treisman, R. (1994) The POZ domain: a conserved protein-protein interaction motif. Genes Dev., 8, 1664-1677.
    • (1994) Genes Dev. , vol.8 , pp. 1664-1677
    • Bardwell, V.J.1    Treisman, R.2
  • 7
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor, T.H. (2000) The DNA methyltransferases of mammals. Hum. Mol. Genet., 9, 2395-2402.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 8
    • 0023701018 scopus 로고
    • Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases
    • Bestor, T., Laudano, A., Mattaliano, R. and Ingram, V. (1988) Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J. Mol. Biol., 203, 971-983.
    • (1988) J. Mol. Biol. , vol.203 , pp. 971-983
    • Bestor, T.1    Laudano, A.2    Mattaliano, R.3    Ingram, V.4
  • 9
    • 0032484989 scopus 로고    scopus 로고
    • Retinoblastoma protein recruits histone deacetylase to repress transcription
    • Brehm, A., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J. and Kouzarides, T. (1998) Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature, 391, 597-601.
    • (1998) Nature , vol.391 , pp. 597-601
    • Brehm, A.1    Miska, E.A.2    McCance, D.J.3    Reid, J.L.4    Bannister, A.J.5    Kouzarides, T.6
  • 10
    • 0033522479 scopus 로고    scopus 로고
    • The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth
    • Brehm, A., Nielsen, S.J., Miska, E.A., McCance, D.J., Reid, J.L., Bannister, A.J. and Kouzarides, T. (1999) The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth. EMBO J., 18, 2449-2458.
    • (1999) EMBO J. , vol.18 , pp. 2449-2458
    • Brehm, A.1    Nielsen, S.J.2    Miska, E.A.3    McCance, D.J.4    Reid, J.L.5    Bannister, A.J.6    Kouzarides, T.7
  • 11
    • 0030977310 scopus 로고    scopus 로고
    • A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins
    • Cross, S.H., Meehan, R.R., Nan, X. and Bird, A. (1997) A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins. Nature Genet., 16, 256-259.
    • (1997) Nature Genet. , vol.16 , pp. 256-259
    • Cross, S.H.1    Meehan, R.R.2    Nan, X.3    Bird, A.4
  • 12
  • 13
    • 0031255159 scopus 로고    scopus 로고
    • Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain
    • Gibbons, R.J. et al (1997) Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain. Nature Genet., 17, 146-148.
    • (1997) Nature Genet. , vol.17 , pp. 146-148
    • Gibbons, R.J.1
  • 14
    • 0027520469 scopus 로고
    • The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro
    • Hagemeier, C., Cook, A. and Kouzarides, T. (1993) The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res., 21, 4998-5004.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 4998-5004
    • Hagemeier, C.1    Cook, A.2    Kouzarides, T.3
  • 15
    • 0033499867 scopus 로고    scopus 로고
    • In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b
    • Hsieh, C.L. ( 1999) In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol. Cell. Biol., 19, 8211-8218.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8211-8218
    • Hsieh, C.L.1
  • 16
    • 0030743612 scopus 로고    scopus 로고
    • DNA methylation and imprinting: Why bother?
    • Jaenisch, R. (1997) DNA methylation and imprinting: why bother? Trends Genet., 13, 323-329.
    • (1997) Trends Genet. , vol.13 , pp. 323-329
    • Jaenisch, R.1
  • 18
  • 19
    • 0033000990 scopus 로고    scopus 로고
    • Histone acetylases and deacetylases in cell proliferation
    • Kouzarides, T. (1999) Histone acetylases and deacetylases in cell proliferation. Curr. Opin. Genet. Dev., 9, 40-48.
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 40-48
    • Kouzarides, T.1
  • 20
    • 0024582758 scopus 로고
    • Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains
    • Lauster, R., Trautner, T.A. and Noyer-Weidner, M. (1989) Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains. J. Mol. Biol., 206, 305-312.
    • (1989) J. Mol. Biol. , vol.206 , pp. 305-312
    • Lauster, R.1    Trautner, T.A.2    Noyer-Weidner, M.3
  • 21
    • 0030833656 scopus 로고    scopus 로고
    • The HMG-box transcription factor HBPI is targeted by the pocket proteins and E1A
    • Lavender, P., Vandel, L., Bannister, A.J. and Kouzarides, T. (1997) The HMG-box transcription factor HBPI is targeted by the pocket proteins and E1A. Oncogene, 14, 2721-2728.
    • (1997) Oncogene , vol.14 , pp. 2721-2728
    • Lavender, P.1    Vandel, L.2    Bannister, A.J.3    Kouzarides, T.4
  • 22
    • 0029803192 scopus 로고    scopus 로고
    • De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
    • Lei, H., Oh, S.P., Okano, M., Juttermann, R., Goss, K.A., Jaenisch, R. and Li, E. (1996) De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development, 122, 3195-3205.
    • (1996) Development , vol.122 , pp. 3195-3205
    • Lei, H.1    Oh, S.P.2    Okano, M.3    Juttermann, R.4    Goss, K.A.5    Jaenisch, R.6    Li, E.7
  • 23
    • 0026439115 scopus 로고
    • A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
    • Leonhardt, H., Page, A.W., Weier, H.U. and Bestor, T.H. (1992) A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell, 71, 865-873.
    • (1992) Cell , vol.71 , pp. 865-873
    • Leonhardt, H.1    Page, A.W.2    Weier, H.U.3    Bestor, T.H.4
  • 24
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E., Bestor, T.H. and Jaenisch, R. (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell, 69, 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 25
    • 0032519312 scopus 로고    scopus 로고
    • Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci
    • Liu, Y., Oakeley, E.J., Sun, L. and Jost, J.P. (1998) Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci. Nucleic Acids Res., 26, 1038-1045.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1038-1045
    • Liu, Y.1    Oakeley, E.J.2    Sun, L.3    Jost, J.P.4
  • 27
    • 0027225233 scopus 로고
    • Analysis of the murine All-1 gene reveals conserved domains with human All-1 and identifies a motif shared with DNA methyltransferases
    • Ma, Q. et al. (1993) Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases. Proc. Natl Acad. Sci. USA, 90, 6350-6354.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6350-6354
    • Ma, Q.1
  • 29
    • 0023119242 scopus 로고
    • Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
    • Monk, M., Boubelik, M. and Lehnert, S. (1987) Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. Development. 99, 371-382.
    • (1987) Development , vol.99 , pp. 371-382
    • Monk, M.1    Boubelik, M.2    Lehnert, S.3
  • 31
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan, X., Ng, H.H., Johnson, C.A., Laherty, C.D., Turner, B.M., Eisenman, R.N. and Bird, A. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature, 393, 386-389.
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 32
    • 0033119780 scopus 로고    scopus 로고
    • DNA methylation and chromatin modification
    • Ng, H.-H. and Bird, A. (1999) DNA methylation and chromatin modification. Curr. Opin. Genet. Dev., 9, 158-163.
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 158-163
    • Ng, H.-H.1    Bird, A.2
  • 34
    • 0033973587 scopus 로고    scopus 로고
    • Active repression of methylated genes by the chromosomal protein MBD1
    • Ng, H.H., Jeppesen, P. and Bird, A. (2000) Active repression of methylated genes by the chromosomal protein MBD1. Mol. Cell. Biol., 20, 1394-1406.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1394-1406
    • Ng, H.H.1    Jeppesen, P.2    Bird, A.3
  • 35
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • Okano, M., Xie, S. and Li, E. (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nature Genet., 19, 219-220.
    • (1998) Nature Genet. , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 36
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M., Bell, D.W., Haber, D.A. and Li, E. (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell, 99, 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 37
    • 0031025621 scopus 로고    scopus 로고
    • Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide
    • Ramchandani, S., MacLeod, A.R., Pinard, M., von Hofe, E. and Szyf, M. (1997) Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc. Natl Acad. Sci. USA, 94, 684-689.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 684-689
    • Ramchandani, S.1    MacLeod, A.R.2    Pinard, M.3    Von Hofe, E.4    Szyf, M.5
  • 38
    • 0032168678 scopus 로고    scopus 로고
    • CpG methylation, chromatin structure and gene silencing - A three-way connection
    • Razin, A. (1998) CpG methylation, chromatin structure and gene silencing - a three-way connection. EMBO J., 17, 4905-4908.
    • (1998) EMBO J. , vol.17 , pp. 4905-4908
    • Razin, A.1
  • 39
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • Robertson, K.D., Ait-Si-Ali, S., Yokochi, T., Wade, P.A., Jones, P.L. and Wolffe, A.P. (2000) DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nature Genet., 25, 338-342.
    • (2000) Nature Genet. , vol.25 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 40
    • 0033945861 scopus 로고    scopus 로고
    • DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
    • Rountree, M.R., Bachman, K.E. and Baylin, S.B. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nature Genet., 25, 269-277.
    • (2000) Nature Genet. , vol.25 , pp. 269-277
    • Rountree, M.R.1    Bachman, K.E.2    Baylin, S.B.3
  • 41
    • 0023503627 scopus 로고
    • Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse
    • Sanford, J.P., Clark, H.J., Chapman, V.M. and Rossant, J. (1987) Differences in DNA methylation during oogenesis and spermatogenesis and their persistence during early embryogenesis in the mouse. Genes Dev., 1, 1039-1046.
    • (1987) Genes Dev. , vol.1 , pp. 1039-1046
    • Sanford, J.P.1    Clark, H.J.2    Chapman, V.M.3    Rossant, J.4
  • 42
    • 0032076565 scopus 로고    scopus 로고
    • Imprinting and the initiation of gene silencing in the germ line
    • Surani, M.A. (1998) Imprinting and the initiation of gene silencing in the germ line. Cell, 93, 309-312.
    • (1998) Cell , vol.93 , pp. 309-312
    • Surani, M.A.1
  • 43
    • 0029932598 scopus 로고    scopus 로고
    • A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p
    • Taunton, J., Hassig, C.A. and Schreiber, S.L. (1996) A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science, 272, 408-411.
    • (1996) Science , vol.272 , pp. 408-411
    • Taunton, J.1    Hassig, C.A.2    Schreiber, S.L.3
  • 44
    • 0029973718 scopus 로고    scopus 로고
    • De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5)-methyltransferase
    • Vertino, P.M., Yen, R.W., Gao, J. and Baylin, S.B. (1996) De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5)-methyltransferase. Mol. Cell. Biol., 16, 4555-4565.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4555-4565
    • Vertino, P.M.1    Yen, R.W.2    Gao, J.3    Baylin, S.B.4
  • 45
    • 0032845039 scopus 로고    scopus 로고
    • Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
    • Wade, P.A., Gegonne, A., Jones, P.L., Ballestar, E., Aubry, F. and Wolffe, A.P. (1999) Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation. Nature Genet., 23, 62-66.
    • (1999) Nature Genet. , vol.23 , pp. 62-66
    • Wade, P.A.1    Gegonne, A.2    Jones, P.L.3    Ballestar, E.4    Aubry, F.5    Wolffe, A.P.6
  • 46
    • 0033547330 scopus 로고    scopus 로고
    • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
    • Xu, G.L. et al. (1999) Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature, 402, 187-191.
    • (1999) Nature , vol.402 , pp. 187-191
    • Xu, G.L.1
  • 47
    • 0031577334 scopus 로고    scopus 로고
    • DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe
    • Yoder, J.A., Soman, N.S., Verdine, G.L. and Bestor, T.H. (1997) DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe. J. Mol. Biol., 270, 385-395.
    • (1997) J. Mol. Biol. , vol.270 , pp. 385-395
    • Yoder, J.A.1    Soman, N.S.2    Verdine, G.L.3    Bestor, T.H.4
  • 48
    • 0029294663 scopus 로고
    • Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function
    • Yoshida, M., Horinouchi, S. and Beppu, T. (1995) Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. BioEssays, 17, 423-430.
    • (1995) Bioessays , vol.17 , pp. 423-430
    • Yoshida, M.1    Horinouchi, S.2    Beppu, T.3
  • 49
    • 0032538293 scopus 로고    scopus 로고
    • The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
    • Zhang, Y., LeRoy, G., Seelig, H.P., Lane, W.S. and Reinberg, D. (1998) The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Cell, 95, 279-289.
    • (1998) Cell , vol.95 , pp. 279-289
    • Zhang, Y.1    Leroy, G.2    Seelig, H.P.3    Lane, W.S.4    Reinberg, D.5
  • 50
    • 0033180082 scopus 로고    scopus 로고
    • Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
    • Zhang, Y., Ng, H.H., Erdjument-Bromage, H., Tempst, P., Bird, A. and Reinberg, D. (1999) Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev., 13, 1924-1935.
    • (1999) Genes Dev. , vol.13 , pp. 1924-1935
    • Zhang, Y.1    Ng, H.H.2    Erdjument-Bromage, H.3    Tempst, P.4    Bird, A.5    Reinberg, D.6


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