Regulation of chromatin structure by site-specific histone H3 methyltransferases

Nature

Volumn 406, Issue 6796, 2000, Pages 593-599

  Rea, Stephen ^a   Eisenhaber, Frank ^a   O'Carroll, Dónal ^a   Strahl, Brian D ^b   Sun, Zu Wen ^b   Schmid, Manfred ^a   Opravil, Susanne ^a   Mechtier, Karl ^a   Ponting, Chris P ^c   Allis, C David ^b   Jenuwein, Thomas ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; HISTONE H3; LYSINE; METHYLTRANSFERASE; SERINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CHROMOSOME; CONTROLLED STUDY; DROSOPHILA; EMBRYO; ENZYME ACTIVITY; EVOLUTION; FETUS; FIBROBLAST; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; METHYLATION; MITOSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; CHROMATIN; DROSOPHILA; HELA CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; LYSINE; METHYLATION; METHYLTRANSFERASES; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SUBSTRATE SPECIFICITY;

EID: 0034632829     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35020506     Document Type: Article

References (49)

1. Strahl, B. D. & Allis, C. D. The language of covalent histone modifications. Nature 403, 41-45 (2000).
2. Grunstein, M. Yeast heterochromatin: regulation of its assembly and inheritance by histones. Cell 93, 325-328 (1998).
3. Turner, B. M. Histone acetylation as an epigenetic determinant of long-term transcriptional competence. Cell. Mol. Life Sci. 54, 21-31 (1998).
4. Karpen, G. & Allshire, R. C. The case for epigenetic effects on centromere identity and function. Trends Genet. 13, 489-496 (1997).
5. Wei, Y., Lanlan, Y., Bowen, J., Gorovsky, M. A. & Allis, C. D. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 97, 99-109 (1999).
6. Chen, D. et al. Regulation of transcription by a protein methyltransferase. Science 284, 2174-2177 (1999).
7. Strahl, B. D., Ohba, R., Cook, R. G. & Allis, C. D. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc. Natl Acad. Sci. USA 96, 14967-14972 (1999).
8. Sassone-Corsi, P. et al. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3. Science 285, 886-891 (1999).
9. Hsu, J.-Y. et al. Mitolic phosphorylation of histone H3 is governed by Ipll/aurora kinase and Glc7/ PP1 phosphatase in budding yeast and nematodes. Cell 102, 1-20 (2000).
10. Reuter, G. & Spierer, P. Position-effect variegation and chromatin proteins. BioEssays 14, 605-612 (1992).
11. Allshire, R. C., Nimmo, E. R., Ekwall, K., Javerzat, J. P. & Cranston, G. Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Genes Dev. 9, 218-233 (1995).
12. Wallrath, L. L. Unfolding the mysteries of heterochromatin. Curr. Opin. Genet. Dev. 8, 147-153 (1998).
13. De Rubertis, F. et al. The histone deacetylase RPD3 counteracts genomic silencing in Drosophila and yeast. Nature 384, 589-591 (1996).
14. Grewal, S. I., Bonaduce, M. J. & Klar, A. J. Histone deacetylase homologs regulate epigenetic inheritance of transcriptional silencing and chromosome segregation in fission yeast. Genetics 150, 563-576 (1999).
15. Baksa, K. et al. Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position effect variegation and mitosis in Drosophila melanogaster. Genetics 135, 117-125 (1993).
16. Larsson, J., Zhang, J. & Rasmuson-Lestander, Ȧ. Mutations in the Drosophila melanogaster gene encoding S-adenosyl methionine suppress position-effect variegation. Genetics 143, 887-896 (1996).
17. Eissenberg, J. C., Morris, G. D., Reuter, G. & Hartnett, T. The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation. Genetics 131, 345-352 (1992).
18. Cléard, F., Delattre, M. & Spierer, P. SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J. 16, 5280-5288 (1997).
19. Tschiersch, B. et al. The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J. 13, 3822-3831 (1994).
20. Schotta, G. & Reuter, G. Controlled expression of tagged proteins in Drosophila using a new modular P-element vector system. Mol. Gen. Genet. 262, 916-920 (2000).
21. Henikoff, S. in Epigenetic Mechanisms of Gene Regulation (eds Russo, V. A. E., Martienssen, R. A. & Riggs, A. D) 319-334 (CSHL, New York, 1996).
22. Ivanova, A. V., Bonaduce, M. J., Ivanov, S. V. & Klar, A. J. S. The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Nature Genet. 19, 192-195 (1998).
23. + disrupt the localisation of the chromo domain protein Swi6p and impair centromere function. J. Cell Sci. 109, 2637-2648 (1996).
24. Aagaard, L. et al. Functional mammalian homologues of the Drosophila PEV modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J. 18, 1923-1938 (1999).
25. Aasland, R. & Stewart, A. F. The chromo shadow domain, a second chromodomain in heterochromatin-binding protein 1, HP1. Nucleic Acids Res. 23, 3168-3173 (1995).
26. Koonin, E. V., Zhou, S. & Lucchesi, J. C. The chromo superfamily: new members, duplication of the chromo domain and possible role in delivering transcription regulators to chromatin. Nucleic Acids Res. 23, 4229-4232 (1995).
27. Jenuwein, T., Laible, G., Dorn, R. & Reuter, G. SET-domain proteins modulate chromatin domains in eu-and heterochromatin. Cell. Mol. Life Sci. 54, 80-93 (1998).
28. Ball, L. J. et al. Structure of the chromatin binding (chromo) domain from mouse modifier protein 1. EMBO J. 16, 2473-2481 (1997).
29. Platero, J. S., Harnett, T. & Eissenberg, J. C. Functional analysis of the chromo domain of HP-1. EMBO J. 14, 3977-3986 (1995).
30. Jones, R. S. & Gelbart, W. M. The Drosophila Polycomb-group gene Enhancer of zeste contains a region with sequence similarity to trithorax. Mol. Cell. Biol. 13, 6357-6366 (1993).
31. Stassen, M. J., Bailey, D., Nelson, S., Chinwalla, V. & Harte, P. J. The Drosophila trithorax protein contains a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Mech. Dev. 52, 209-223 (1995).
32. Schultz, J., Copley, R. R., Doerks, T., Ponting, C. P. & Bork, P. SMART: a web-based tool for the study of genetically mobile domains. Nucleic Acids Res. 28, 231-234 (2000).
33. Klein, R. R. & Houtz, R. L. Cloning and developmental expression of pea ribulose-1,5-biphosphate carboxylase/oxygenase large subunit N-methyltransferase. Plant Mol. Biol. 27, 249-261 (1995).
34. t-methyltransferase. Protein Exp. Purif. 14, 104-112 (1998).
35. Melcher, M. et al. Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation and mitotic progression. Mol. Cell. Biol. 29, 3728-3741 (2000).
36. Laible, G., et al. Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisae telomeres. EMBO J. 16, 3219-3232 (1997).
37. Tkachuk, D. C., Kohler, S. & Cleary, M. L. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 71, 691-700 (1992).
38. Sullivan, K. F., Hechenberger, M. & Masri, K. Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. J. Cell Biol. 127, 581-592 (1994).
39. Pehrson, J. R. & Fried, V. A. MacroH2A, a core histone containing a large nonhistone region. Science 257, 1398-1400 (1992).
40. Hendzel, M. J. et al. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106, 348-360 (1997).
41. Martzen, M. R. et al. A biochemical genomics approach for identifying genes by the activity of their products. Science 286, 1153-1155 (1999).
42. Cui, X. et al. Association of SET domain and myotubularin-related proteins modulates growth control. Nature Genet. 18, 331-337 (1998).
43. Firestein, R., Cui, X., Huie, P. & Cleary, M. L. SET domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9. Mol. Cell. Biol. 20, 4900-4909 (2000).
44. Murzina, N., Verrault, A., Laue, E. & Stillman, B. Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor1 and HP1 proteins. Mol. Cell 4, 529-540 (1999).
45. Birney, E., Thompson, J. D. & Gibson, T. J. PairWise and Search Wise: finding the optimal alignment in a simultaneous comparison of a protein profile against all DNA translation frames. Nucleic Acids Res. 24, 2730-2739 (1996).
46. Eddy, S. R. Profile hidden Markov models. Bioinformatics 14, 755-763 (1998).
47. Altschul, S. F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 17, 3389-33402 (1997).
48. Frishman, D. & Argos, P. Seventy-five percent accuracy in protein secondary structure prediction. Proteins Struct. Funct. Genet. 27, 329-335 (1997).
49. 2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol. Cell 3, 389-395 (1999).