Induction of tumors in mice by genomic hypomethylation

Science

Volumn 300, Issue 5618, 2003, Pages 489-492

  Gaudet, François ^a,b,c   Hodgson, J Graeme ^d   Eden, Amir ^a   Jackson Grusby, Laurie ^a   Dausman, Jessica ^a   Gray, Joe W ^d   Leonhardt, Heinrich ^b,c   Jaenisch, Rudolf ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYMES; GENES; TISSUE;

GENOMIC HYPOMETHYLATION;

TUMORS;

COMPLEMENTARY DNA; DNA; DNA METHYLTRANSFERASE; RNA;

CANCER; DNA; GENOME;

ALLELE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CHROMOSOME; CONTROLLED STUDY; DNA METHYLATION; FIBROBLAST; GENE MUTATION; GENOME; LYMPHOMA; MOLONEY LEUKEMIA ONCOVIRUS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTO ONCOGENE; RETROVIRUS; T CELL LYMPHOMA; THYMOMA;

ALLELES; ANIMALS; BIRTH WEIGHT; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOME ABERRATIONS; CHROMOSOMES, MAMMALIAN; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENDOGENOUS RETROVIRUSES; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REARRANGEMENT; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, MYC; HETEROZYGOTE; LOSS OF HETEROZYGOSITY; LYMPHOMA, T-CELL; MICE; MICE, TRANSGENIC; MOLONEY MURINE LEUKEMIA VIRUS; TRISOMY; VIRUS ACTIVATION;

ANIMALIA; MOLONEY MURINE LEUKEMIA VIRUS; ONCOVIRINAE; UNIDENTIFIED RETROVIRUS;

EID: 0242584449     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083558     Document Type: Article

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