DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

Nature

Volumn 416, Issue 6880, 2002, Pages 552-556

  Rhee, Ina ^a,b   Bachman, Kurtis E ^b   Park, Ben Ho ^a,b   Jair, Kam Wing ^b   Yen, Ray Whay Chiu ^b   Schuebel, Kornel E ^b   Cui, Hengmi ^a   Feinberg, Andrew P ^a   Lengauer, Christoph ^b   Kinzler, Kenneth W ^a,b   Baylin, Stephen B ^a,b   Vogelstein, Bert ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; ENZYMES; INSULIN; MUTAGENESIS; TUMORS;

EPIGENETIC SILENCING; OPTIMAL NEOPLASTIC PROLIFERATION;

GENES;

DNA METHYLTRANSFERASE; PROTEIN DNMT1; PROTEIN DNMT3B; PROTEIN P16; SOMATOMEDIN B; SOMATOMEDIN C; UNCLASSIFIED DRUG;

CANCER;

ARTICLE; CANCER CELL; CELL PROLIFERATION; COLORECTAL CANCER; DEMETHYLATION; DNA METHYLATION; DNMT3B GENE; GENE DELETION; GENE INACTIVATION; GENE LOCUS; GENE SILENCING; GENETIC ASSOCIATION; GENOME IMPRINTING; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENE TARGETING; GENES, TUMOR SUPPRESSOR; HUMANS; INSULIN-LIKE GROWTH FACTOR II; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROMOTER REGIONS (GENETICS); TISSUE INHIBITOR OF METALLOPROTEINASE-3; TUMOR CELLS, CULTURED;

EID: 18344390653     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/416552a     Document Type: Article

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