Reprogramming somatic cells towards pluripotency by defined factors

Current Opinion in Biotechnology

Volumn 18, Issue 5, 2007, Pages 467-473

  Lewitzky, Marc ^a   Yamanaka, Shinya ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG THERAPY; GENETIC ENGINEERING; RATS; TRANSCRIPTION;

CELL THERAPY; NUCLEAR TRANSFER; PLURIPOTENCY; SOMATIC CELLS;

CELL CULTURE;

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX2;

CELL DIFFERENTIATION; CELL NUCLEUS TRANSPLANTATION; CHIMERA; EMBRYONIC STEM CELL; EPIGENETICS; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SOMATIC CELL; SOMATIC CELL THERAPY; STEM CELL TRANSPLANTATION;

CELL DIFFERENTIATION; GENETIC ENGINEERING; HUMANS; HYBRID CELLS; STEM CELLS; TRANSCRIPTION FACTORS;

MAMMALIA; MUS;

EID: 36148960428     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2007.09.007     Document Type: Review

References (59)

1. Fujimori T., Kurotaki Y., Miyazaki J., and Nabeshima Y. Analysis of cell lineage in two- and four-cell mouse embryos. Development 130 (2003) 5113-5122
2. Niwa H. How is pluripotency determined and maintained?. Development 134 (2007) 635-646
3. Boyer L.A., Mathur D., and Jaenisch R. Molecular control of pluripotency. Curr Opin Genet Dev 16 (2006) 455-462
4. Spivakov M., and Fisher A.G. Epigenetic signatures of stem cell identity. Nat Rev Genet 8 (2007) 263-271
5. Surani M.A., Hayashi K., and Hajkova P. Genetic and epigenetic regulators of pluripotency. Cell 128 (2007) 747-762
6. Wakayama T., Hayashi Y., and Ogura A. Participation of the female pronucleus derived from the second polar body in full embryonic development of mice. J Reprod Fertil 110 (1997) 263-266
7. Wilmut I., Schnieke A.E., McWhir J., Kind A.J., and Campbell K.H. Viable offspring derived from fetal and adult mammalian cells. Nature 385 (1997) 810-813
8. Hochedlinger K., and Jaenisch R. Nuclear reprogramming and pluripotency. Nature 441 (2006) 1061-1067
9. Egli D., Rosains J., Birkhoff G., and Eggan K. Developmental reprogramming after chromosome transfer into mitotic mouse zygotes. Nature 447 (2007) 679-685. First demonstration of successful SCNT into mouse zygote, not unfertilized eggs.
10. Takahashi K., and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006) 663-676. The first paper describing the generation of pluripotent cells from somatic cells by defined factors.
11. Alberio R., Campbell K.H., and Johnson A.D. Reprogramming somatic cells into stem cells. Reproduction 132 (2006) 709-720
12. Cowan C.A., Atienza J., Melton D.A., and Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 309 (2005) 1369-1373
13. Do J.T., and Scholer H.R. Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 22 (2004) 941-949
14. Matsumura H., Tada M., Otsuji T., Yasuchika K., Nakatsuji N., Surani A., and Tada T. Targeted chromosome elimination from ES-somatic hybrid cells. Nat Methods 4 (2007) 23-25
15. Hansis C., Barreto G., Maltry N., and Niehrs C. Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1. Curr Biol 14 (2004) 1475-1480
16. Freberg C.T., Dahl J.A., Timoskainen S., and Collas P. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell 18 (2007) 1543-1553
17. Taranger C.K., Noer A., Sorensen A.L., Hakelien A.M., Boquest A.C., and Collas P. Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. Mol Biol Cell 16 (2005) 5719-5735
18. Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1 (2007) 39-49
19. Tokuzawa Y., Kaiho E., Maruyama M., Takahashi K., Mitsui K., Maeda M., Niwa H., and Yamanaka S. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol 23 (2003) 2699-2708
20. •].
21. •].
22. Wernig M., Meissner A., Foreman R., Brambrink T., Ku M., Hochedlinger K., Bernstein B.E., and Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448 (2007) 318-324. These papers describe an improvement of iPS cell pluripotency by using Nanog- or Oct3/4-expression as a marker for selection of re-programmed cells.
23. Bernstein B.E., Mikkelsen T.S., Xie X., Kamal M., Huebert D.J., Cuff J., Fry B., Meissner A., Wernig M., Plath K., et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125 (2006) 315-326
24. Niwa H., Miyazaki J., and Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24 (2000) 372-376
25. Boyer L.A., Lee T.I., Cole M.F., Johnstone S.E., Levine S.S., Zucker J.P., Guenther M.G., Kumar R.M., Murray H.L., Jenner R.G., et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122 (2005) 947-956
26. Loh Y.H., Wu Q., Chew J.L., Vega V.B., Zhang W., Chen X., Bourque G., George J., Leong B., Liu J., et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet 38 (2006) 431-440
27. Chew J.L., Loh Y.H., Zhang W., Chen X., Tam W.L., Yeap L.S., Li P., Ang Y.S., Lim B., Robson P., et al. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25 (2005) 6031-6046
28. Kuroda T., Tada M., Kubota H., Kimura H., Hatano S.Y., Suemori H., Nakatsuji N., and Tada T. Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression. Mol Cell Biol 25 (2005) 2475-2485
29. Rodda D.J., Chew J.L., Lim L.H., Loh Y.H., Wang B., Ng H.H., and Robson P. Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem 280 (2005) 24731-24737
30. Gu P., Goodwin B., Chung A.C., Xu X., Wheeler D.A., Price R.R., Galardi C., Peng L., Latour A.M., Koller B.H., et al. Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. Mol Cell Biol 25 (2005) 3492-3505
31. Ben-Shushan E., Sharir H., Pikarsky E., and Bergman Y. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol 15 (1995) 1034-1048
32. Sylvester I., and Scholer H.R. Regulation of the Oct-4 gene by nuclear receptors. Nucleic Acids Res 22 (1994) 901-911
33. Barnea E., and Bergman Y. Synergy of SF1 and RAR in activation of Oct-3/4 promoter. J Biol Chem 275 (2000) 6608-6619
34. Niwa H., Toyooka Y., Shimosato D., Strumpf D., Takahashi K., Yagi R., and Rossant J. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123 (2005) 917-929
35. Fuhrmann G., Chung A.C., Jackson K.J., Hummelke G., Baniahmad A., Sutter J., Sylvester I., Scholer H.R., and Cooney A.J. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell 1 (2001) 377-387
36. Sato N., Kondo M., and Arai K. The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. Biochem Biophys Res Commun 344 (2006) 845-851
37. Avilion A.A., Nicolis S.K., Pevny L.H., Perez L., Vivian N., and Lovell-Badge R. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17 (2003) 126-140
38. Ivanova N., Dobrin R., Lu R., Kotenko I., Levorse J., DeCoste C., Schafer X., Lun Y., and Lemischka I.R. Dissecting self-renewal in stem cells with RNA interference. Nature 442 (2006) 533-538
39. Yuan H., Corbi N., Basilico C., and Dailey L. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9 (1995) 2635-2645
40. Nishimoto M., Fukushima A., Okuda A., and Muramatsu M. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol Cell Biol 19 (1999) 5453-5465
41. Wang Z.X., Teh C.H., Kueh J.L., Lufkin T., Robson P., and Stanton L.W. Oct4 and sox2 directly regulate expression of another pluripotency transcription factor, zfp206, in embryonic stem cells. J Biol Chem 282 (2007) 12822-12830
42. Shi W., Wang H., Pan G., Geng Y., Guo Y., and Pei D. Regulation of the pluripotency marker Rex-1 by Nanog and Sox2. J Biol Chem 281 (2006) 23319-23325
43. Selvakumaran M., Liebermann D.A., and Hoffman-Liebermann B. Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factor-induced myeloid differentiation before c-myc: role in leukemogenesis. Mol Cell Biol 12 (1992) 2493-2500
44. Knoepfler P.S., Cheng P.F., and Eisenman R.N. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 16 (2002) 2699-2712
45. Waikel R.L., Kawachi Y., Waikel P.A., Wang X.J., and Roop D.R. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 28 (2001) 165-168
46. Satoh Y., Matsumura I., Tanaka H., Ezoe S., Sugahara H., Mizuki M., Shibayama H., Ishiko E., Ishiko J., Nakajima K., et al. Roles for c-Myc in self-renewal of hematopoietic stem cells. J Biol Chem 279 (2004) 24986-24993
47. Cartwright P., McLean C., Sheppard A., Rivett D., Jones K., and Dalton S. LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development 132 (2005) 885-896
48. Humphrey R.K., Beattie G.M., Lopez A.D., Bucay N., King C.C., Firpo M.T., Rose-John S., and Hayek A. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells 22 (2004) 522-530
49. Matsuda T., Nakamura T., Nakao K., Arai T., Katsuki M., Heike T., and Yokota T. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 18 (1999) 4261-4269
50. Sato N., Meijer L., Skaltsounis L., Greengard P., and Brivanlou A.H. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10 (2004) 55-63
51. Sears R., Nuckolls F., Haura E., Taya Y., Tamai K., and Nevins J.R. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 14 (2000) 2501-2514
52. Paling N.R., Wheadon H., Bone H.K., and Welham M.J. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J Biol Chem 279 (2004) 48063-48070
53. Hao J., Li T.G., Qi X., Zhao D.F., and Zhao G.Q. WNT/beta-catenin pathway upregulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol 290 (2006) 81-91
54. Seoane J., Le H.V., and Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419 (2002) 729-734
55. Adhikary S., and Eilers M. Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol 6 (2005) 635-645
56. Li Y., McClintick J., Zhong L., Edenberg H.J., Yoder M.C., and Chan R.J. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood 105 (2005) 635-637
57. Nakatake Y., Fukui N., Iwamatsu Y., Masui S., Takahashi K., Yagi R., Yagi K., Miyazaki J., Matoba R., Ko M.S., et al. Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol Cell Biol 26 (2006) 7772-7782
58. Rowland B.D., Bernards R., and Peeper D.S. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 7 (2005) 1074-1082
59. Lin T., Chao C., Saito S., Mazur S.J., Murphy M.E., Appella E., and Xu Y. p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression. Nat Cell Biol 7 (2005) 165-171