-
1
-
-
0031929684
-
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein
-
Alcalay, M., Tomassoni, L., Colombo, E., Stoldt, S., Grignani, F., Fagioli, M., Szekely, L., Helin, K., and Pelicci, P.G. (1998). The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol. Cell. Biol. 18, 1084-1093.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 1084-1093
-
-
Alcalay, M.1
Tomassoni, L.2
Colombo, E.3
Stoldt, S.4
Grignani, F.5
Fagioli, M.6
Szekely, L.7
Helin, K.8
Pelicci, P.G.9
-
2
-
-
0032504783
-
p14ARF links the tumour suppressors RB and p53
-
Bates, S., Phillips, A.C., Clark, P.A., Stott, F., Peters, G., Ludwig, R.L., and Vousden, K.H. (1998). p14ARF links the tumour suppressors RB and p53. Nature 395, 124-125.
-
(1998)
Nature
, vol.395
, pp. 124-125
-
-
Bates, S.1
Phillips, A.C.2
Clark, P.A.3
Stott, F.4
Peters, G.5
Ludwig, R.L.6
Vousden, K.H.7
-
3
-
-
0029031349
-
Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes
-
Beijersbergen, R.L., Carlee, L., Kerkhoven, R.M., and Bernards, R. (1995). Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 9, 1340-1353.
-
(1995)
Genes Dev.
, vol.9
, pp. 1340-1353
-
-
Beijersbergen, R.L.1
Carlee, L.2
Kerkhoven, R.M.3
Bernards, R.4
-
4
-
-
0032128171
-
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
-
Botquin, V., Hess, H., Fuhrmann, G., Anastassiadis, C., Gross, M.K., Vriend, G., and Scholer, H.R. (1998). New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 12, 2073-2090.
-
(1998)
Genes Dev.
, vol.12
, pp. 2073-2090
-
-
Botquin, V.1
Hess, H.2
Fuhrmann, G.3
Anastassiadis, C.4
Gross, M.K.5
Vriend, G.6
Scholer, H.R.7
-
5
-
-
0033636905
-
Requirements for cell cycle arrest by p16INK4a
-
Bruce, J.L., Hurford, R.K., Jr., Classon, M., Koh, J., and Dyson, N. (2000). Requirements for cell cycle arrest by p16INK4a. Mol. Cell 6, 737-742.
-
(2000)
Mol. Cell
, vol.6
, pp. 737-742
-
-
Bruce, J.L.1
Hurford Jr., R.K.2
Classon, M.3
Koh, J.4
Dyson, N.5
-
6
-
-
0033622003
-
p16INK4A and p19ARF act in overlapping pathways in cellular immortalization
-
Carnero, A., Hudson, J.D., Price, C.M., and Beach, D.H. (2000). p16INK4A and p19ARF act in overlapping pathways in cellular immortalization. Nat. Cell Biol. 2, 148-155.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 148-155
-
-
Carnero, A.1
Hudson, J.D.2
Price, C.M.3
Beach, D.H.4
-
7
-
-
0032490832
-
E2F-6: A novel member of the E2F family is an inhibitor of E2F-dependent transcription
-
Cartwright, P., Muller, H., Wagener, C., Holm, K., and Helin, K. (1998). E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription. Oncogene 17, 611-623.
-
(1998)
Oncogene
, vol.17
, pp. 611-623
-
-
Cartwright, P.1
Muller, H.2
Wagener, C.3
Holm, K.4
Helin, K.5
-
8
-
-
0033635597
-
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions
-
Dannenberg, J.H., van Rossum, A., Schuijff, L., and te Riele, H. (2000). Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev. 14, 3051-3064.
-
(2000)
Genes Dev.
, vol.14
, pp. 3051-3064
-
-
Dannenberg, J.H.1
Van Rossum, A.2
Schuijff, L.3
Te Riele, H.4
-
9
-
-
0030738479
-
Distinct roles for E2F proteins in cell growth control and apoptosis
-
DeGregori, J., Leone, G., Miron, A., Jakoi, L., and Nevins, J.R. (1997). Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94, 7245-7250.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 7245-7250
-
-
DeGregori, J.1
Leone, G.2
Miron, A.3
Jakoi, L.4
Nevins, J.R.5
-
10
-
-
0028361374
-
Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
-
Dimri, G.P., Hara, E., and Campisi, J. (1994). Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269, 16180-16186.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16180-16186
-
-
Dimri, G.P.1
Hara, E.2
Campisi, J.3
-
11
-
-
0033989829
-
Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
-
Dimri, G.P., Itahana, K., Acosta, M., and Campisi, J. (2000). Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol. Cell. Biol. 20, 273-285.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 273-285
-
-
Dimri, G.P.1
Itahana, K.2
Acosta, M.3
Campisi, J.4
-
12
-
-
0034663873
-
PML is induced by oncogenic ras and promotes premature senescence
-
Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., and Lowe, S.W. (2000). PML is induced by oncogenic ras and promotes premature senescence. Genes Dev. 14, 2015-2027.
-
(2000)
Genes Dev.
, vol.14
, pp. 2015-2027
-
-
Ferbeyre, G.1
De Stanchina, E.2
Querido, E.3
Baptiste, N.4
Prives, C.5
Lowe, S.W.6
-
13
-
-
0032482981
-
Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6
-
Gaubatz, S., Wood, J.G., and Livingston, D.M. (1998). Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Proc. Natl. Acad. Sci. USA 95, 9190-9195.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9190-9195
-
-
Gaubatz, S.1
Wood, J.G.2
Livingston, D.M.3
-
14
-
-
0033634869
-
E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control
-
Gaubatz, S., Lindeman, G.J., Ishida, S., Jakoi, L., Nevins, J.R., Livingston, D.M., and Rempel, R.E. (2000). E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol. Cell 6, 729-735.
-
(2000)
Mol. Cell
, vol.6
, pp. 729-735
-
-
Gaubatz, S.1
Lindeman, G.J.2
Ishida, S.3
Jakoi, L.4
Nevins, J.R.5
Livingston, D.M.6
Rempel, R.E.7
-
15
-
-
0034282763
-
Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases
-
Groth, A., Weber, J.D., Willumsen, B.M., Sherr, C.J., and Roussel, M.F. (2000). Oncogenic Ras induces p19ARF and growth arrest in mouse embryo fibroblasts lacking p21Cip1 and p27Kip1 without activating cyclin D-dependent kinases. J. Biol. Chem. 275, 27473-27480.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27473-27480
-
-
Groth, A.1
Weber, J.D.2
Willumsen, B.M.3
Sherr, C.J.4
Roussel, M.F.5
-
16
-
-
0033572879
-
Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes
-
Haddad, M.M., Xu, W., Schwahn, D.J., Liao, F., and Medrano, E.E. (1999). Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes. Exp. Cell Res. 253, 561-572.
-
(1999)
Exp. Cell Res.
, vol.253
, pp. 561-572
-
-
Haddad, M.M.1
Xu, W.2
Schwahn, D.J.3
Liao, F.4
Medrano, E.E.5
-
17
-
-
0034306996
-
The Rb/E2F pathway: Expanding roles and emerging paradigms
-
Harbour, J.W., and Dean, D.C. (2000). The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 14, 2393-2409.
-
(2000)
Genes Dev.
, vol.14
, pp. 2393-2409
-
-
Harbour, J.W.1
Dean, D.C.2
-
18
-
-
0033578816
-
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
-
Harbour, J.W., Luo, R.X., Dei Santi, A., Postigo, A.A., and Dean, D.C. (1999). Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98, 859-869.
-
(1999)
Cell
, vol.98
, pp. 859-869
-
-
Harbour, J.W.1
Luo, R.X.2
Dei Santi, A.3
Postigo, A.A.4
Dean, D.C.5
-
19
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick, L. (1965). The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636.
-
(1965)
Exp. Cell Res.
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
20
-
-
0033988256
-
E2F is required to prevent inappropriate S-phase entry of mammalian cells
-
He, S., Cook, B.L., Deverman, B.E., Weihe, U., Zhang, F., Prachand, V., Zheng, J., and Weintraub, S.J. (2000). E2F is required to prevent inappropriate S-phase entry of mammalian cells. Mol. Cell. Biol. 20, 363-371.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 363-371
-
-
He, S.1
Cook, B.L.2
Deverman, B.E.3
Weihe, U.4
Zhang, F.5
Prachand, V.6
Zheng, J.7
Weintraub, S.J.8
-
21
-
-
0028338653
-
Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein
-
Helin, K., and Harlow, E. (1994). Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. J. Virol. 68, 5027-5035.
-
(1994)
J. Virol.
, vol.68
, pp. 5027-5035
-
-
Helin, K.1
Harlow, E.2
-
22
-
-
0026652346
-
A cDNA encoding a pRb-binding protein with properties of the transcription factor E2F
-
Helin, K., Lees, J.A., Vidal, M., Dyson, N., Harlow, E., and Fattaey, A. (1992). A cDNA encoding a pRb-binding protein with properties of the transcription factor E2F. Cell 70, 337-350.
-
(1992)
Cell
, vol.70
, pp. 337-350
-
-
Helin, K.1
Lees, J.A.2
Vidal, M.3
Dyson, N.4
Harlow, E.5
Fattaey, A.6
-
23
-
-
0027382336
-
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein
-
Helin, K., Harlow, E., and Fattaey, A. (1993). Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol. Cell. Biol. 13, 6501-6508.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 6501-6508
-
-
Helin, K.1
Harlow, E.2
Fattaey, A.3
-
24
-
-
0029863840
-
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts
-
Herrera, R.E., Sah, V.P., Williams, B.O., Makela, T.P., Weinberg, R.A., and Jacks, T. (1996). Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol. Cell. Biol. 16, 2402-2407.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 2402-2407
-
-
Herrera, R.E.1
Sah, V.P.2
Williams, B.O.3
Makela, T.P.4
Weinberg, R.A.5
Jacks, T.6
-
25
-
-
0028276864
-
Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter
-
Hsiao, K.M., McMahon, S.L., and Farnham, P.J. (1994). Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter. Genes Dev. 8, 1526-1537.
-
(1994)
Genes Dev.
, vol.8
, pp. 1526-1537
-
-
Hsiao, K.M.1
McMahon, S.L.2
Farnham, P.J.3
-
26
-
-
0030850752
-
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
-
Hsieh, J.K., Fredersdorf, S., Kouzarides, T., Martin, K., and Lu, X. (1997). E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 11, 1840-1852.
-
(1997)
Genes Dev.
, vol.11
, pp. 1840-1852
-
-
Hsieh, J.K.1
Fredersdorf, S.2
Kouzarides, T.3
Martin, K.4
Lu, X.5
-
27
-
-
0028791305
-
Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity
-
Johnson, D.G. (1995). Regulation of E2F-1 gene expression by p130 (Rb2) and D-type cyclin kinase activity. Oncogene 11, 1685-1692.
-
(1995)
Oncogene
, vol.11
, pp. 1685-1692
-
-
Johnson, D.G.1
-
28
-
-
0027491775
-
Expression of transcription factor E2F1 induces quiescent cells to enter S-phase
-
Johnson, D.G., Schwarz, J.K., Cress, W.D., and Nevins, J.R. (1993). Expression of transcription factor E2F1 induces quiescent cells to enter S-phase. Nature 365, 349-352.
-
(1993)
Nature
, vol.365
, pp. 349-352
-
-
Johnson, D.G.1
Schwarz, J.K.2
Cress, W.D.3
Nevins, J.R.4
-
29
-
-
0028364529
-
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression
-
Johnson, D.G., Ohtani, K., and Nevins, J.R. (1994). Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8, 1514-1525.
-
(1994)
Genes Dev.
, vol.8
, pp. 1514-1525
-
-
Johnson, D.G.1
Ohtani, K.2
Nevins, J.R.3
-
30
-
-
0026766083
-
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
-
Kaelin, W.G., Krek, W., Sellers, W.R., DeCaprio, J.A., Ajchenbaum, F., Fuchs, C.S., Chittenden, T., Li, Y., Farnham, P.J., Blanar, M.A., et al. (1992). Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70, 351-364.
-
(1992)
Cell
, vol.70
, pp. 351-364
-
-
Kaelin, W.G.1
Krek, W.2
Sellers, W.R.3
DeCaprio, J.A.4
Ajchenbaum, F.5
Fuchs, C.S.6
Chittenden, T.7
Li, Y.8
Farnham, P.J.9
Blanar, M.A.10
-
31
-
-
0030728468
-
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
-
Kamijo, T., Zindy, F., Roussel, M.F., Quelle, D.E., Downing, J.R., Ashmun, R.A., Grosveld, G., and Sherr, C.J. (1997). Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649-659.
-
(1997)
Cell
, vol.91
, pp. 649-659
-
-
Kamijo, T.1
Zindy, F.2
Roussel, M.F.3
Quelle, D.E.4
Downing, J.R.5
Ashmun, R.A.6
Grosveld, G.7
Sherr, C.J.8
-
32
-
-
0031307157
-
The role of cyclin e in cell proliferation, development and cancer
-
Keyomarsi, K., and Herliczek, T.W. (1997). The role of cyclin E in cell proliferation, development and cancer. Prog. Cell Cycle Res. 3, 171-191.
-
(1997)
Prog. Cell Cycle Res.
, vol.3
, pp. 171-191
-
-
Keyomarsi, K.1
Herliczek, T.W.2
-
33
-
-
0029052951
-
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
-
Koh, J., Enders, G.H., Dynlacht, B.D., and Harlow, E. (1995). Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature 375, 506-510.
-
(1995)
Nature
, vol.375
, pp. 506-510
-
-
Koh, J.1
Enders, G.H.2
Dynlacht, B.D.3
Harlow, E.4
-
34
-
-
0028960617
-
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
-
Kowalik, T.F., DeGregori, J., Schwarz, J.K., and Nevins, J.R. (1995). E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol. 69, 2491-2500.
-
(1995)
J. Virol.
, vol.69
, pp. 2491-2500
-
-
Kowalik, T.F.1
DeGregori, J.2
Schwarz, J.K.3
Nevins, J.R.4
-
35
-
-
0028362359
-
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
-
Krek, W., Ewen, M.E., Shirodkar, S., Arany, Z., Kaelin, W.J., and Livingston, D.M. (1994). Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78, 161-172.
-
(1994)
Cell
, vol.78
, pp. 161-172
-
-
Krek, W.1
Ewen, M.E.2
Shirodkar, S.3
Arany, Z.4
Kaelin, W.J.5
Livingston, D.M.6
-
36
-
-
0029559027
-
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
-
Krek, W., Xu, G., and Livingston, D.M. (1995). Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83, 1149-1158.
-
(1995)
Cell
, vol.83
, pp. 1149-1158
-
-
Krek, W.1
Xu, G.2
Livingston, D.M.3
-
37
-
-
0035817687
-
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
-
Krimpenfort, P., Quon, K.C., Mooi, W.J., Loonstra, A., and Berns, A. (2001). Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 413, 83-86.
-
(2001)
Nature
, vol.413
, pp. 83-86
-
-
Krimpenfort, P.1
Quon, K.C.2
Mooi, W.J.3
Loonstra, A.4
Berns, A.5
-
38
-
-
0029054399
-
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
-
Lukas, J., Parry, D., Aagaard, L., Mann, D.J., Bartkova, J., Strauss, M., Peters, G., and Bartek, J. (1995). Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature 375, 503-506.
-
(1995)
Nature
, vol.375
, pp. 503-506
-
-
Lukas, J.1
Parry, D.2
Aagaard, L.3
Mann, D.J.4
Bartkova, J.5
Strauss, M.6
Peters, G.7
Bartek, J.8
-
39
-
-
0035836772
-
p19ARF targets certain E2F species for degradation
-
Martelli, F., Hamilton, T., Silver, D.P., Sharpless, N.E., Bardeesy, N., Rokas, M., DePinho, R.A., Livingston, D.M., and Grossman, S.R. (2001). p19ARF targets certain E2F species for degradation. Proc. Natl. Acad. Sci. USA 98, 4455-4460.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4455-4460
-
-
Martelli, F.1
Hamilton, T.2
Silver, D.P.3
Sharpless, N.E.4
Bardeesy, N.5
Rokas, M.6
DePinho, R.A.7
Livingston, D.M.8
Grossman, S.R.9
-
40
-
-
0028983491
-
Growth suppression by p16ink4 requires functional retinoblastoma protein
-
Medema, R.H., Herrera, R.E., Lam, F., and Weinberg, R.A. (1995). Growth suppression by p16ink4 requires functional retinoblastoma protein. Proc. Natl. Acad. Sci. USA 92, 6289-6293.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 6289-6293
-
-
Medema, R.H.1
Herrera, R.E.2
Lam, F.3
Weinberg, R.A.4
-
41
-
-
0037998134
-
The E2F transcription factors: Key regulators of cell proliferation
-
Muller, H., and Helin, K. (2000). The E2F transcription factors: key regulators of cell proliferation. Biochim. Biophys. Acta 1470, M1-12.
-
(2000)
Biochim. Biophys. Acta
, vol.1470
-
-
Muller, H.1
Helin, K.2
-
42
-
-
0028136903
-
Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter
-
Neuman, E., Flemington, E.K., Sellers, W.R., and Kaelin, W.G., Jr. (1994). Transcription of the E2F-1 gene is rendered cell cycle dependent by E2F DNA-binding sites within its promoter. Mol. Cell. Biol. 14, 6607-6615.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6607-6615
-
-
Neuman, E.1
Flemington, E.K.2
Sellers, W.R.3
Kaelin Jr., W.G.4
-
43
-
-
0031080378
-
Analysis of chromatin structure by in vivo formaldehyde cross-linking
-
Orlando, V., Strutt, H., and Paro, R. (1997). Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11, 205-214.
-
(1997)
Methods
, vol.11
, pp. 205-214
-
-
Orlando, V.1
Strutt, H.2
Paro, R.3
-
44
-
-
0032504784
-
p19ARF links the tumour suppressor p53 to Ras
-
Palmero, I., Pantoja, C., and Serrano, M. (1998). p19ARF links the tumour suppressor p53 to Ras. Nature 395, 125-126.
-
(1998)
Nature
, vol.395
, pp. 125-126
-
-
Palmero, I.1
Pantoja, C.2
Serrano, M.3
-
45
-
-
0033517357
-
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras
-
Pantoja, C., and Serrano, M. (1999). Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene 18, 4974-4982.
-
(1999)
Oncogene
, vol.18
, pp. 4974-4982
-
-
Pantoja, C.1
Serrano, M.2
-
46
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
Pearson, M., Carbone, R., Sebastiani, C., Cioce, M., Fagioli, M., Saito, S., Higashimoto, Y., Appella, E., Minucci, S., Pandolfi, P.P., and Pelicci, P.G. (2000). PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-210.
-
(2000)
Nature
, vol.406
, pp. 207-210
-
-
Pearson, M.1
Carbone, R.2
Sebastiani, C.3
Cioce, M.4
Fagioli, M.5
Saito, S.6
Higashimoto, Y.7
Appella, E.8
Minucci, S.9
Pandolfi, P.P.10
Pelicci, P.G.11
-
47
-
-
0035156849
-
Escape from premature senescence is not sufficient for oncogenic transformation by Ras
-
Peeper, D.S., Dannenberg, J.H., Douma, S., te Riele, H., and Bernards, R. (2001). Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat. Cell Biol. 3, 198-203.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 198-203
-
-
Peeper, D.S.1
Dannenberg, J.H.2
Douma, S.3
Te Riele, H.4
Bernards, R.5
-
48
-
-
0036167650
-
A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence
-
Peeper, D.S., Shvarts, A., Brummelkamp, T., Douma, S., Koh, E.Y., Daley, G.Q., and Bernards, R. (2002). A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence. Nat. Cell Biol. 4, 148-153.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 148-153
-
-
Peeper, D.S.1
Shvarts, A.2
Brummelkamp, T.3
Douma, S.4
Koh, E.Y.5
Daley, G.Q.6
Bernards, R.7
-
49
-
-
33444465032
-
The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
-
Pomerantz, J., Schreiber, A.N., Liegeois, N.J., Silverman, A., Alland, L., Chin, L., Potes, J., Chen, K., Orlow, I., Lee, H.W., et al. (1998). The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Nature 392, 569-574.
-
(1998)
Nature
, vol.392
, pp. 569-574
-
-
Pomerantz, J.1
Schreiber, A.N.2
Liegeois, N.J.3
Silverman, A.4
Alland, L.5
Chin, L.6
Potes, J.7
Chen, K.8
Orlow, I.9
Lee, H.W.10
-
50
-
-
0027947383
-
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
-
Qin, X.Q., Livingston, D.M., Kaelin, W.G., Jr., and Adams, P.D. (1994). Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 91, 10918-10922.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 10918-10922
-
-
Qin, X.Q.1
Livingston, D.M.2
Kaelin Jr., W.G.3
Adams, P.D.4
-
51
-
-
0028983370
-
The transcription factor E2F-1 is a downstream target of RB action
-
Qin, X.Q., Livingston, D.M., Ewen, M., Sellers, W.R., Arany, Z., and Kaelin, W.J. (1995). The transcription factor E2F-1 is a downstream target of RB action. Mol. Cell. Biol. 15, 742-755.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 742-755
-
-
Qin, X.Q.1
Livingston, D.M.2
Ewen, M.3
Sellers, W.R.4
Arany, Z.5
Kaelin, W.J.6
-
52
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle, D.E., Zindy, F., Ashmun, R.A., and Sherr, C.J. (1995). Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83, 993-1000.
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
Sherr, C.J.4
-
53
-
-
0033637086
-
Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization
-
Sage, J., Mulligan, G.J., Attardi, L.D., Miller, A., Chen, S., Williams, B., Theodorou, E., and Jacks, T. (2000). Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization. Genes Dev. 14, 3037-3050.
-
(2000)
Genes Dev.
, vol.14
, pp. 3037-3050
-
-
Sage, J.1
Mulligan, G.J.2
Attardi, L.D.3
Miller, A.4
Chen, S.5
Williams, B.6
Theodorou, E.7
Jacks, T.8
-
54
-
-
0029612231
-
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
-
Sellers, W.R., Rodgers, J.W., and Kaelin, W.G., Jr. (1995). A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc. Natl. Acad. Sci. USA 92, 11544-11548.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 11544-11548
-
-
Sellers, W.R.1
Rodgers, J.W.2
Kaelin Jr., W.G.3
-
55
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano, M., Lin, A.W., McCurrach, M.E., Beach, D., and Lowe, S.W. (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602.
-
(1997)
Cell
, vol.88
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
56
-
-
0028144410
-
The transcription factor E2F-1 mediates the autoregulation of Rb gene expression
-
Shan, B., Chang, C.Y., Jones, D., and Lee, W.H. (1994). The transcription factor E2F-1 mediates the autoregulation of Rb gene expression. Mol. Cell. Biol. 14, 299-309.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 299-309
-
-
Shan, B.1
Chang, C.Y.2
Jones, D.3
Lee, W.H.4
-
57
-
-
0030069682
-
Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis
-
Shan, B., Durfee, T., and Lee, W.H. (1996). Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis. Proc. Natl. Acad. Sci. USA 93, 679-684.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 679-684
-
-
Shan, B.1
Durfee, T.2
Lee, W.H.3
-
58
-
-
0035817688
-
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
-
Sharpless, N.E., Bardeesy, N., Lee, K.H., Carrasco, D., Castrillon, D.H., Aguirre, A.J., Wu, E.A., Horner, J.W., and DePinho, R.A. (2001). Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413, 86-91.
-
(2001)
Nature
, vol.413
, pp. 86-91
-
-
Sharpless, N.E.1
Bardeesy, N.2
Lee, K.H.3
Carrasco, D.4
Castrillon, D.H.5
Aguirre, A.J.6
Wu, E.A.7
Horner, J.W.8
DePinho, R.A.9
-
59
-
-
0032191393
-
Tumor surveillance via the ARF-p53 pathway
-
Sherr, C.J. (1998). Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991.
-
(1998)
Genes Dev.
, vol.12
, pp. 2984-2991
-
-
Sherr, C.J.1
-
60
-
-
0034682721
-
Cellular senescence: Mitotic clock or culture shock?
-
Sherr, C.J., and DePinho, R.A. (2000). Cellular senescence: mitotic clock or culture shock? Cell 102, 407-410.
-
(2000)
Cell
, vol.102
, pp. 407-410
-
-
Sherr, C.J.1
DePinho, R.A.2
-
61
-
-
0025150387
-
Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
-
Stein, G.H., Beeson, M., and Gordon, L. (1990). Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249, 666-669.
-
(1990)
Science
, vol.249
, pp. 666-669
-
-
Stein, G.H.1
Beeson, M.2
Gordon, L.3
-
62
-
-
0028276685
-
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1
-
Tanaka, N., Ishihara, M., Kitagawa, M., Harada, H., Kimura, T., Matsuyama, T., Lamphier, M.S., Aizawa, S., Mak, T.W., and Taniguchi, T. (1994). Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell 77, 829-839.
-
(1994)
Cell
, vol.77
, pp. 829-839
-
-
Tanaka, N.1
Ishihara, M.2
Kitagawa, M.3
Harada, H.4
Kimura, T.5
Matsuyama, T.6
Lamphier, M.S.7
Aizawa, S.8
Mak, T.W.9
Taniguchi, T.10
-
63
-
-
0032539797
-
E2F-6, a member of the E2F family that can behave as a transcriptional repressor
-
Trimarchi, J.M., Fairchild, B., Verona, R., Moberg, K., Andon, N., and Lees, J.A. (1998). E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Proc. Natl. Acad. Sci. USA 95, 2850-2855.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2850-2855
-
-
Trimarchi, J.M.1
Fairchild, B.2
Verona, R.3
Moberg, K.4
Andon, N.5
Lees, J.A.6
-
64
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein, B., Lane, D., and Levine, A.J. (2000). Surfing the p53 network. Nature 408, 307-310.
-
(2000)
Nature
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
65
-
-
0034703742
-
p53: Death star
-
Vousden, K.H. (2000). p53: death star. Cell 103, 691-694.
-
(2000)
Cell
, vol.103
, pp. 691-694
-
-
Vousden, K.H.1
-
66
-
-
0032417694
-
Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts
-
Wang, Z.M., Yang, H., and Livingston, D.M. (1998). Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts. Proc. Natl. Acad. Sci. USA 95, 15583-15586.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15583-15586
-
-
Wang, Z.M.1
Yang, H.2
Livingston, D.M.3
-
67
-
-
0033130010
-
Nucleolar Art sequesters Mdm2 and activates p53
-
Weber, J.D., Taylor, L.J., Roussel, M.F., Sherr, C.J., and Bar-Sagi, D. (1999). Nucleolar Art sequesters Mdm2 and activates p53. Nat. Cell Biol. 1, 20-26.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 20-26
-
-
Weber, J.D.1
Taylor, L.J.2
Roussel, M.F.3
Sherr, C.J.4
Bar-Sagi, D.5
-
68
-
-
0034665749
-
p53-independent functions of the p19(ARF) tumor suppressor
-
Weber, J.D., Jeffers, J.R., Rehg, J.E., Randle, D.H., Lozano, G., Roussel, M.F., Sherr, C.J., and Zambetti, G.P. (2000). p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev. 14, 2358-2365.
-
(2000)
Genes Dev.
, vol.14
, pp. 2358-2365
-
-
Weber, J.D.1
Jeffers, J.R.2
Rehg, J.E.3
Randle, D.H.4
Lozano, G.5
Roussel, M.F.6
Sherr, C.J.7
Zambetti, G.P.8
-
69
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg, R.A. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
70
-
-
0027429964
-
A c-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-abl tyrosine kinase in the cell cycle
-
Welch, P.J., and Wang, J.Y.J. (1993). A c-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-abl tyrosine kinase in the cell cycle. Cell 75, 779-790.
-
(1993)
Cell
, vol.75
, pp. 779-790
-
-
Welch, P.J.1
Wang, J.Y.J.2
-
71
-
-
0028222124
-
p53 and E2F-1 cooperate to mediate apoptosis
-
Wu, X., and Levine, A.J. (1994). p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91, 3602-3606.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 3602-3606
-
-
Wu, X.1
Levine, A.J.2
-
72
-
-
0035936113
-
The E2F1-3 transcription factors are essential for cellular proliferation
-
Wu, L., Timmers, C., Maiti, B., Saavedra, H.I., Sang, L., Chong, G.T., Nuckolls, F., Giangrande, P., Wright, F.A., Field, S.J., et al. (2001). The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414, 457-462.
-
(2001)
Nature
, vol.414
, pp. 457-462
-
-
Wu, L.1
Timmers, C.2
Maiti, B.3
Saavedra, H.I.4
Sang, L.5
Chong, G.T.6
Nuckolls, F.7
Giangrande, P.8
Wright, F.A.9
Field, S.J.10
-
73
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao, Z.X., Chen, J., Levine, A.J., Modjtahedi, N., Xing, J., Sellers, W.R., and Livingston, D.M. (1995). Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375, 694-698.
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.X.1
Chen, J.2
Levine, A.J.3
Modjtahedi, N.4
Xing, J.5
Sellers, W.R.6
Livingston, D.M.7
-
74
-
-
0033000482
-
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
-
Zhang, Y., and Xiong, Y. (1999). Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Mol. Cell 3, 579-591.
-
(1999)
Mol. Cell
, vol.3
, pp. 579-591
-
-
Zhang, Y.1
Xiong, Y.2
-
75
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang, Y., Xiong, Y., and Yarbrough, W.G. (1998). ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 92, 725-734.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
76
-
-
0033515424
-
Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition
-
Zhang, H.S., Postigo, A.A., and Dean, D.C. (1999). Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibition. Cell 97, 53-61.
-
(1999)
Cell
, vol.97
, pp. 53-61
-
-
Zhang, H.S.1
Postigo, A.A.2
Dean, D.C.3
-
77
-
-
0034737290
-
Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
-
Zhang, H.S., Gavin, M., Dahiya, A., Postigo, A.A., Ma, D., Luo, R.X., Harbour, J.W., and Dean, D.C. (2000). Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101, 79-89.
-
(2000)
Cell
, vol.101
, pp. 79-89
-
-
Zhang, H.S.1
Gavin, M.2
Dahiya, A.3
Postigo, A.A.4
Ma, D.5
Luo, R.X.6
Harbour, J.W.7
Dean, D.C.8
|