-
1
-
-
0344622606
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick, L. & Moorhead, P. S. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 25, 585-621 (1961).
-
(1961)
Exp. Cell Res.
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.S.2
-
2
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar, A. G. et al. Extension of life-span by introduction of telomerase into normal human cells, Science 279, 349-352 (1998).
-
(1998)
Science
, vol.279
, pp. 349-352
-
-
Bodnar, A.G.1
-
3
-
-
0037365789
-
ATM related protein kinases: Safeguarding genome integrity
-
Shiloh, Y. ATM and related protein kinases: safeguarding genome integrity. Nature Rev. Cancer 3, 155-168 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
4
-
-
0036948433
-
Toward maintaining the genome: DNA damage and replication checkpoints
-
Nyberg, K. A., Michelson, R. J., Putnam, C. W. & Weinert, T. A. Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36, 617-656 (2002).
-
(2002)
Annu. Rev. Genet.
, vol.36
, pp. 617-656
-
-
Nyberg, K.A.1
Michelson, R.J.2
Putnam, C.W.3
Weinert, T.A.4
-
5
-
-
0037468232
-
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
-
Lou, Z., Minter-Dykhouse, K., Wu, X. & Chen, J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421, 957-961 (2003).
-
(2003)
Nature
, vol.421
, pp. 957-961
-
-
Lou, Z.1
Minter-Dykhouse, K.2
Wu, X.3
Chen, J.4
-
6
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
Stewart, G. S., Wang, B., Bignell, C. R., Taylor, A. M. R. & Elledge, S. J. MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature 421, 961-966 (2003).
-
(2003)
Nature
, vol.421
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.R.4
Elledge, S.J.5
-
7
-
-
0037468169
-
MDC1 is required for the intra-S-phase DNA damage checkpoint
-
Goldberg, M. et al. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421, 952-956 (2003).
-
(2003)
Nature
, vol.421
, pp. 952-956
-
-
Goldberg, M.1
-
8
-
-
0034114544
-
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
-
Webley, K. et al. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol. Cell. Biol. 20, 2803-2808 (2000).
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 2803-2808
-
-
Webley, K.1
-
9
-
-
0037148277
-
Protection of mammalian telomeres
-
de Lange, T. Protection of mammalian telomeres. Oncogene 21, 532-540 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 532-540
-
-
De Lange, T.1
-
10
-
-
0033605145
-
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder, J., Broccoli, D., Dai, Y., Hardy, S. & de Lange, T. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325 (1999).
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
De Lange, T.5
-
11
-
-
0037102234
-
Different telomere damage signaling pathways in human and mouse cells
-
Smogorzewska, A. & De Lange, T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21, 4338-4348 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 4338-4348
-
-
Smogorzewska, A.1
De Lange, T.2
-
12
-
-
0031984598
-
Short telomeres on human chromosome 17p
-
Martens, U. M. et al. Short telomeres on human chromosome 17p. Nature Genet. 18, 76-80 (1998).
-
(1998)
Nature Genet.
, vol.18
, pp. 76-80
-
-
Martens, U.M.1
-
13
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
van Steensel, B., Smogorzewska, A. & de Lange, T. TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413 (1998).
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
-
14
-
-
0032529169
-
+ and Saccharomyces cerevisiae RAD17: Linkage to checkpoint control and mammalian meiosis
-
+ and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes Dev. 12, 2560-2573 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 2560-2573
-
-
Freire, R.1
-
15
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas, C., Falck, J., Bartkova, J., Bartek, J. & Lukas, J. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nature Cell Biol. 5, 255-260 (2003).
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
16
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman, C. E. et al. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281, 1677-1679 (1998).
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
-
17
-
-
0032472330
-
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
-
Cliby, W. A. et al. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17, 159-169 (1998).
-
(1998)
EMBO J.
, vol.17
, pp. 159-169
-
-
Cliby, W.A.1
-
18
-
-
0036892831
-
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
-
Heffernan, T. P. et al. An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol. Cell. Biol. 22, 8552-8561 (2002).
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 8552-8561
-
-
Heffernan, T.P.1
-
19
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab, N. H., Malikzay, A., Appel, M. & Halazonetis, T. D. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev. 14, 278-288 (2000).
-
(2000)
Genes Dev.
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
20
-
-
0034949629
-
DNA replication licensing and human cell proliferation
-
Stoeber, K. et al. DNA replication licensing and human cell proliferation. J. Cell Sci. 114, 2027-2041 (2001).
-
(2001)
J. Cell Sci.
, vol.114
, pp. 2027-2041
-
-
Stoeber, K.1
-
21
-
-
0038013875
-
Senescence, apoptosis and therapy-cutting the lifelines of cancer
-
Schmitt, C. A. Senescence, apoptosis and therapy-cutting the lifelines of cancer. Nature Rev. Cancer 3, 286-295 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 286-295
-
-
Schmitt, C.A.1
-
22
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello, S. et al. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nature Cell Biol. 5, 741-747 (2003).
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 741-747
-
-
Parrinello, S.1
-
23
-
-
0033822365
-
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
-
Wong, K. K. et al. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genet. 26, 85-88 (2000).
-
(2000)
Nature Genet.
, vol.26
, pp. 85-88
-
-
Wong, K.K.1
-
24
-
-
0034606226
-
Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals
-
Goytisolo, F. A. et al. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J. Exp. Med. 192, 1625-1636 (2000).
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1625-1636
-
-
Goytisolo, F.A.1
-
25
-
-
0035500487
-
Cellular senescence as a tumor-suppressor mechanism
-
Campisi, J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 11, S27-S31 (2001).
-
(2001)
Trends Cell Biol.
, vol.11
-
-
Campisi, J.1
-
26
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
Hoeijmakers, J. H. Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374 (2001).
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
27
-
-
0035822641
-
Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
-
d'Adda di Fagagna, F. et al. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curr. Biol. 11, 1192-1196 (2001).
-
(2001)
Curr. Biol.
, vol.11
, pp. 1192-1196
-
-
D'Adda Di Fagagna, F.1
-
28
-
-
0037376804
-
DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones
-
Fiegler, H. et al. DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones. Genes Chromosom. Cancer 36, 361-374 (2003).
-
(2003)
Genes Chromosom. Cancer
, vol.36
, pp. 361-374
-
-
Fiegler, H.1
-
29
-
-
0037069326
-
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
-
Zhao, H., Watkins, J. L. & Piwnica-Worms, H. Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints. Proc. Natl Acad. Sci. USA 99, 14795-14800 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 14795-14800
-
-
Zhao, H.1
Watkins, J.L.2
Piwnica-Worms, H.3
-
30
-
-
0012966157
-
Chk1 regulares the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc 25A
-
Sorensen, C. S. et al. Chk1 regulares the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell 3, 247-258 (2003).
-
(2003)
Cancer Cell
, vol.3
, pp. 247-258
-
-
Sorensen, C.S.1
|