Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 8, 2007, Pages 2134-2138

  Chen, Shaoqing ^a   Chen, Li ^a   Le, Nam T ^a   Zhao, Chunlin ^a   Sidduri, Achyutharao ^a   Lou, Jian Ping ^a   Michoud, Christophe ^a   Portland, Louis ^a   Jackson, Nicole ^a   Liu, Jin Jun ^a   Konzelmann, Fred ^a   Chi, Feng ^a   Tovar, Christian ^a   Xiang, Qing ^a   Chen, Yingsi ^a   Wen, Yang ^a   Vassilev, Lyubomir T ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Anticancer; CDK1 inhibitor; Cyclin dependent kinase

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR; QUINOLINYL METHYLENE THIAZOLINONE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE PROGRESSION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL;

ANTINEOPLASTIC AGENTS; CDC2 PROTEIN KINASE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 33947603650     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.081     Document Type: Article

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