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Volumn 19, Issue 3, 1999, Pages 2109-2117

Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN E; PROTEIN P16; PROTEIN P21; RETINOBLASTOMA PROTEIN;

EID: 0033013980     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.3.2109     Document Type: Article
Times cited : (654)

References (58)
  • 1
    • 0030477686 scopus 로고    scopus 로고
    • Involvement of the cyclin-dependent kinase inhibitor p16 (Ink4a) in replicative senescence of normal human fibroblasts
    • Alcorta, D. A., Y. Xiong, G. Hannon, D. Beach, and J. C. Barrett. 1996. Involvement of the cyclin-dependent kinase inhibitor p16 (Ink4a) in replicative senescence of normal human fibroblasts. Proc. Natl. Acad. Sci. USA 93:13742-13747.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 13742-13747
    • Alcorta, D.A.1    Xiong, Y.2    Hannon, G.3    Beach, D.4    Barrett, J.C.5
  • 3
    • 0029827323 scopus 로고    scopus 로고
    • Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle
    • Bresnahan, W. A., I. Boldogh, T. Ma, T. Albrecht, and E. A. Thompson. 1996. Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle. Cell Growth Differ. 7:1283-1290.
    • (1996) Cell Growth Differ. , vol.7 , pp. 1283-1290
    • Bresnahan, W.A.1    Boldogh, I.2    Ma, T.3    Albrecht, T.4    Thompson, E.A.5
  • 4
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21Cip1/Waf1 gene in normal diploid human fibroblasts
    • Brown, J. P., W. Wei, and J. M. Sedivy. 1997. Bypass of senescence after disruption of p21Cip1/Waf1 gene in normal diploid human fibroblasts. Science 277:831-834.
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 5
    • 0030964277 scopus 로고    scopus 로고
    • The biology of replicative senescence
    • Campisi, J. 1997. The biology of replicative senescence. Eur. J. Cancer 33:703-709.
    • (1997) Eur. J. Cancer , vol.33 , pp. 703-709
    • Campisi, J.1
  • 6
    • 0032556952 scopus 로고    scopus 로고
    • p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells
    • Cayrol, C., M. Kniebiehler, and B. Ducommun. 1998. p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene 16:311-320.
    • (1998) Oncogene , vol.16 , pp. 311-320
    • Cayrol, C.1    Kniebiehler, M.2    Ducommun, B.3
  • 7
    • 0025882841 scopus 로고
    • Senescent human fibroblasts have a post-transcriptional block in the expression of the proliferating cell nuclear antigen gene
    • Chang, C.-D., P. Phillips, K. E. Lipson, V. J. Cristofalo, and R. Baserga. 1991. Senescent human fibroblasts have a post-transcriptional block in the expression of the proliferating cell nuclear antigen gene. J. Biol. Chem. 266:8663-8666.
    • (1991) J. Biol. Chem. , vol.266 , pp. 8663-8666
    • Chang, C.-D.1    Phillips, P.2    Lipson, K.E.3    Cristofalo, V.J.4    Baserga, R.5
  • 10
    • 0031019197 scopus 로고    scopus 로고
    • Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
    • Connell-Crowley, L., J. W. Harper, and D. W. Goodrich. 1997. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol. Biol. Cell 8:287-301.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 287-301
    • Connell-Crowley, L.1    Harper, J.W.2    Goodrich, D.W.3
  • 12
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • DiLeonardo, A., S. P. Linke, K. Clarkin, and G. M. Wahl. 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8:2540-2551.
    • (1994) Genes Dev. , vol.8 , pp. 2540-2551
    • Dileonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 14
    • 0027332123 scopus 로고
    • Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes
    • Dulić, V., L. F. Drullinger, E. Lees, S. I. Reed, and G. H. Stein. 1993. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc. Natl. Acad. Sci. USA 90:11034-11038.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11034-11038
    • Dulić, V.1    Drullinger, L.F.2    Lees, E.3    Reed, S.I.4    Stein, G.H.5
  • 15
    • 0028220204 scopus 로고
    • p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • Dulić, V., W. K. Kaufmann, S. J. Wilson, T. D. Tisty, E. Lees, J. W. Harper, S. J. Elledge, and S. I. Reed. 1994. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013-1023.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulić, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tisty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 18
    • 0030924438 scopus 로고    scopus 로고
    • Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb
    • Ezhevsky, S. A., H. Nagahara, A. M. Vocero-Akbani, D. Gius, M. C. Wei, and S. F. Dowdy. 1997. Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. USA 94:10699-10704.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10699-10704
    • Ezhevsky, S.A.1    Nagahara, H.2    Vocero-Akbani, A.M.3    Gius, D.4    Wei, M.C.5    Dowdy, S.F.6
  • 19
    • 0023125009 scopus 로고
    • The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation
    • Fairweather, D. S., M. Fox, and G. P. Margison. 1987. The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation. Exp. Cell Res. 168:153-159.
    • (1987) Exp. Cell Res. , vol.168 , pp. 153-159
    • Fairweather, D.S.1    Fox, M.2    Margison, G.P.3
  • 20
    • 0025373259 scopus 로고
    • Oxidative damage to DNA during aging: 8-hydroxy-2′ -deoxyguanosine in rat organ DNA and urine
    • Fraga, C. G., M. K. Shigenaga, J. W. Park, P. Degan, and B. N. Ames. 1990. Oxidative damage to DNA during aging: 8-hydroxy-2′ -deoxyguanosine in rat organ DNA and urine. Proc. Natl. Acad. Sci. USA 87:4533-4537.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4533-4537
    • Fraga, C.G.1    Shigenaga, M.K.2    Park, J.W.3    Degan, P.4    Ames, B.N.5
  • 22
    • 0029917511 scopus 로고    scopus 로고
    • The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts
    • Hara, E., J. A. Uzman, G. P. Dimri, J. O. Nehlin, A. Testori, and J. Campisi. 1996. The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. Dev. Genet. 18:161-172.
    • (1996) Dev. Genet. , vol.18 , pp. 161-172
    • Hara, E.1    Uzman, J.A.2    Dimri, G.P.3    Nehlin, J.O.4    Testori, A.5    Campisi, J.6
  • 23
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., A. B. Futcher, and C. W. Greider. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 25
    • 0029915265 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H
    • Higashi, H., I. Suzuki-Takahashi, S. Saitoh, K. Segawa, Y. Taya, A. Okuyama, S. Nishimura, and M. Kitagawa. 1996. Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur. J. Biochem. 237: 460-467.
    • (1996) Eur. J. Biochem. , vol.237 , pp. 460-467
    • Higashi, H.1    Suzuki-Takahashi, I.2    Saitoh, S.3    Segawa, K.4    Taya, Y.5    Okuyama, A.6    Nishimura, S.7    Kitagawa, M.8
  • 26
    • 0028918388 scopus 로고
    • Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases Cdk4 and Cdk6
    • Hirai, H., M. F. Roussel, J. Y. Kato, R. A. Ashmun, and C. J. Sherr. 1995. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases Cdk4 and Cdk6. Mol. Cell. Biol. 15:2672-2681.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2672-2681
    • Hirai, H.1    Roussel, M.F.2    Kato, J.Y.3    Ashmun, R.A.4    Sherr, C.J.5
  • 27
    • 0029134016 scopus 로고
    • Role of the cyclin-dependent kinase inhibitors in the development of cancer
    • Hirama, T., and H. P. Koeffler. 1995. Role of the cyclin-dependent kinase inhibitors in the development of cancer. Blood 86:841-854.
    • (1995) Blood , vol.86 , pp. 841-854
    • Hirama, T.1    Koeffler, H.P.2
  • 31
    • 0025827242 scopus 로고
    • Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area
    • Kumazaki, T., R. S. Robetorye, S. C. Robetorye, and J. R. Smith. 1991. Fibronectin expression increases during in vitro cellular senescence: correlation with increased cell area. Exp. Cell Res. 195:13-19.
    • (1991) Exp. Cell Res. , vol.195 , pp. 13-19
    • Kumazaki, T.1    Robetorye, R.S.2    Robetorye, S.C.3    Smith, J.R.4
  • 33
    • 0028034775 scopus 로고
    • Transcríptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb
    • Li, Y., M. A. Nichols, J. W. Shay, and Y. Xiong. 1994. Transcríptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Cancer Res. 54:6078-6082.
    • (1994) Cancer Res. , vol.54 , pp. 6078-6082
    • Li, Y.1    Nichols, M.A.2    Shay, J.W.3    Xiong, Y.4
  • 34
    • 0029146558 scopus 로고
    • Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation
    • Lois, A. F., L. T. Cooper, Y. Geng, T. Nobori, and D. Carson. 1995. Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. Cancer Res. 55:4010-4013.
    • (1995) Cancer Res. , vol.55 , pp. 4010-4013
    • Lois, A.F.1    Cooper, L.T.2    Geng, Y.3    Nobori, T.4    Carson, D.5
  • 35
    • 0032510327 scopus 로고    scopus 로고
    • Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts
    • McConnell, B. B., M. Starborg, S. Brookes, and G. Peters. 1998. Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr. Biol. 8:351-354.
    • (1998) Curr. Biol. , vol.8 , pp. 351-354
    • McConnell, B.B.1    Starborg, M.2    Brookes, S.3    Peters, G.4
  • 36
    • 0032576632 scopus 로고    scopus 로고
    • waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA replication or stress-activated kinases
    • waf1 can block cells at two points in the cell cycle, but does not interfere with processive DNA replication or stress-activated kinases. Oncogene 16: 431-441.
    • (1998) Oncogene , vol.16 , pp. 431-441
    • Medema, R.H.1    Klompmaker, R.2    Smits, V.A.J.3    Rijksen, G.4
  • 37
    • 0026793281 scopus 로고
    • Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts
    • Millis, A. J. T., M. Hoyle, H. M. McCue, and H. Martini. 1992. Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp. Cell Res. 201:373-379.
    • (1992) Exp. Cell Res. , vol.201 , pp. 373-379
    • Millis, A.J.T.1    Hoyle, M.2    McCue, H.M.3    Martini, H.4
  • 38
    • 0017225329 scopus 로고
    • Relationship between cell replication and volume in senescent human diploid fibroblasts
    • Mitsui, Y., and E. L. Schneider. 1976. Relationship between cell replication and volume in senescent human diploid fibroblasts. Mech. Ageing Dev. 5:45-56.
    • (1976) Mech. Ageing Dev. , vol.5 , pp. 45-56
    • Mitsui, Y.1    Schneider, E.L.2
  • 39
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins, J. R. 1992. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 40
    • 0028342664 scopus 로고
    • Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
    • Noda, A., Y. Ning, S. F. Venable, O. M. Pereira-Smith, and J. R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211:90-98.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 42
    • 0028129498 scopus 로고
    • Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts
    • Pagano, M., A. M. Theodoras, S. W. Tam, and G. F. Draetta. 1994. Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 8:1627-1639.
    • (1994) Genes Dev. , vol.8 , pp. 1627-1639
    • Pagano, M.1    Theodoras, A.M.2    Tam, S.W.3    Draetta, G.F.4
  • 43
    • 0030927929 scopus 로고    scopus 로고
    • Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
    • Planas-Silva, M. D., and R. A. Weinberg. 1997. Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol. Cell. Biol. 17:4059-4069.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4059-4069
    • Planas-Silva, M.D.1    Weinberg, R.A.2
  • 45
    • 0024534983 scopus 로고
    • Selective enrichment and biochemical characterization of seven human skin fibroblast cell types in vitro
    • Rodemann, H. P., K. Bayreuther, P. I. Franz, K. Dittman, and M. Albiez. 1989. Selective enrichment and biochemical characterization of seven human skin fibroblast cell types in vitro. Exp. Cell Res. 180:84-93.
    • (1989) Exp. Cell Res. , vol.180 , pp. 84-93
    • Rodemann, H.P.1    Bayreuther, K.2    Franz, P.I.3    Dittman, K.4    Albiez, M.5
  • 47
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/Cdk4
    • Serrano, M., G. J. Hannon, and D. Beach. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/Cdk4. Nature 366: 704-707.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 50
    • 0028171292 scopus 로고
    • 1 phase progression: Cycling on cue
    • 1 phase progression: cycling on cue. Cell 79:551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 51
    • 0025150387 scopus 로고
    • Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts
    • Stein, G. H., M. Beeson, and L. Gordon. 1990. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249: 666-669.
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 52
    • 0029317383 scopus 로고
    • Origins of G1 arrest in senescent human fibroblasts
    • Stein, G. H., and V. Dulić. 1995. Origins of G1 arrest in senescent human fibroblasts. Bioessays 17:537-543.
    • (1995) Bioessays , vol.17 , pp. 537-543
    • Stein, G.H.1    Dulić, V.2
  • 53
    • 0020312319 scopus 로고
    • Carcinogen-transformed human cells are inhibited from entry into S phase by fusion to senescent cells but cells transformed by DNA tumor viruses overcome the inhibition
    • Stein, G. H., R. M. Yanishevsky, L. Gordon, and M. Beeson. 1982. Carcinogen-transformed human cells are inhibited from entry into S phase by fusion to senescent cells but cells transformed by DNA tumor viruses overcome the inhibition. Proc. Natl. Acad. Sci. USA 79:5287-5291.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 5287-5291
    • Stein, G.H.1    Yanishevsky, R.M.2    Gordon, L.3    Beeson, M.4
  • 54
    • 0028352434 scopus 로고
    • The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
    • Waga, S., G. J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369:574-578.
    • (1994) Nature , vol.369 , pp. 574-578
    • Waga, S.1    Hannon, G.J.2    Beach, D.3    Stillman, B.4
  • 55
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 56
    • 0024445960 scopus 로고
    • Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity
    • West, M. D., O. M. Pereira-Smith, and J. R. Smith. 1989. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp. Cell Res. 184:138-147.
    • (1989) Exp. Cell Res. , vol.184 , pp. 138-147
    • West, M.D.1    Pereira-Smith, O.M.2    Smith, J.R.3
  • 57
    • 0028169236 scopus 로고
    • p21-containing cyclin kinases exist in both active and inactive states
    • Zhang, H., G. J. Hannon, and D. Beach. 1994. p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8:1750-1758.
    • (1994) Genes Dev. , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 58
    • 0027440552 scopus 로고
    • Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
    • Zhang, H., Y. Xiong, and D. Beach. 1993. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Biol. Cell. 4:897-906.
    • (1993) Mol. Biol. Cell. , vol.4 , pp. 897-906
    • Zhang, H.1    Xiong, Y.2    Beach, D.3


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