Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Nature

Volumn 443, Issue 7110, 2006, Pages 448-452

  Molofsky, Anna V ^a   Slutsky, Shalom G ^a   Joseph, Nancy M ^a   He, Shenghui ^a   Pardal, Ricardo ^a,c   Krishnamurthy, Janakiraman ^b   Sharpless, Norman E ^b   Morrison, Sean J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; ENZYME INHIBITION; GENES; GENETIC ENGINEERING;

FOREBRAINS; NERVOUS SYSTEMS; NEUROGENESIS; STEM CELLS;

NEUROLOGY;

CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P16INK4A; CDKN2A PROTEIN, MOUSE; UNCLASSIFIED DRUG;

AGING; CELL ORGANELLE; ENZYME ACTIVITY; GENE EXPRESSION; NEUROLOGY; REGENERATION; SENESCENCE;

AGED; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; BRAIN VENTRICLE; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; DENTATE GYRUS; FOREBRAIN; GENE EXPRESSION; GENETIC CODE; INTESTINE INNERVATION; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; SENESCENCE; ANIMAL; BIOSYNTHESIS; CYTOLOGY; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; REGENERATION; STEM CELL;

MAMMALIA;

AGING; ANIMALS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; MICE; NEURONS; OLFACTORY BULB; PROSENCEPHALON; REGENERATION; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; STEM CELLS;

EID: 33749171885     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05091     Document Type: Article

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