DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Nature

Volumn 434, Issue 7035, 2005, Pages 864-870

  Bartkova, Jirina ^a   Hořejší, Zuzana ^a,e   Koed, Karen ^b   Krämer, Alwin ^a   Tort, Frederic ^a   Zleger, Karsten ^b   Guldberg, Per ^a   Sehested, Maxwell ^c   Nesland, Jahn M ^d   Lukas, Claudia ^a   Orntoft, Torben ^b   Lukas, Jiri ^a   Bartek, Jiri ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c Mental Health Services CPH   (Denmark)

^d UNIVERSITY OF OSLO   (Norway)

^e INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELLS; DATA ACQUISITION; DISEASES; GROWTH KINETICS; HEALTH CARE; TISSUE; TUMORS;

ANTI-CANCER BARRIERS; CELL PROLIFERATION; DNA DAMAGE; GROWTH ARREST;

DNA;

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 2; DNA; GENOMIC DNA; HISTONE H2A; HISTONE H2AX; PROTEIN P53; UNCLASSIFIED DRUG; CDC25A PROTEIN; CELL CYCLE PROTEIN; CYCLIN E; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F;

ASTRONOMY;

ALLELE; APOPTOSIS; ARTICLE; BLADDER CANCER; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER STAGING; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; COLON CANCER; CONTROLLED STUDY; DEFENSE MECHANISM; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GENOME ANALYSIS; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CANCER; MALIGNANT TRANSFORMATION; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; ONCOGENE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STRESS; ALLELIC IMBALANCE; BLADDER TUMOR; CELL CYCLE; CELL TRANSFORMATION; ENZYMOLOGY; GENETICS; GENOMIC INSTABILITY; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

ALLELIC IMBALANCE; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN E; DNA DAMAGE; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; ENZYME ACTIVATION; GENES, P53; GENOMIC INSTABILITY; HUMANS; MUTATION; NEOPLASMS; ONCOGENES; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; URINARY BLADDER NEOPLASMS;

EID: 17244367849     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03482     Document Type: Article

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