Biological roles and mechanistic actions of corepressor complexes

Journal of Cell Science

Volumn 115, Issue 4, 2002, Pages 689-698

  Jepsen, Kristen ^a   Rosenfeld, Michael G ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Co repressor; HDAC; N CoR; SMRT

Indexed keywords

CELL NUCLEUS RECEPTOR; DNA BINDING PROTEIN; HISTONE DEACETYLASE; NUCLEAR RECEPTOR COREPRESSOR; REPRESSOR PROTEIN; SILENCING MEDIATOR OF RETINOIC AND THYROID HORMONE RECEPTOR; THYROID HORMONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; ENZYME ACTIVITY; GENE REPRESSION; GENE TARGETING; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; THYROID HORMONE RESISTANCE;

ANIMALS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASES; HUMANS; LEUKEMIA; MACROMOLECULAR SUBSTANCES; MUTATION; NUCLEAR PROTEINS; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; THYROID HORMONE RESISTANCE SYNDROME; TRANSCRIPTION FACTORS;

EID: 0037084392     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (138)

1. The SANT domain: A putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB
2. CoREST: A functional co-repressor required for regulation of neural-specific gene expression
3. Pbx-Hox heterodimers recruit coactivator-co-repressor complexes in an isoform-specific manner
4. The nuclear receptor co-repressor N-CoR regulates differentiation: N-CoR directly interacts with MyoD
5. A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor
6. X-linked late-onset sensorineural deafness caused by a deletion involving OA1 and a novel gene containing WD-40 repeats
7. The thyroid hormone receptor functions as a ligand-operated developmental switch between proliferation and differentiation of erythroid progenitors
8. Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin
9. Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae
10. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
11. Silencing subdomains of v-ErbA interact cooperatively with co-repressors: Involvement of helices 5/6
12. The leukemia-associated gene TEL encodes a transcription repressor which associates with SMRT and mSin3A
13. Groucho/TLE family proteins and transcriptional repression
14. A transcriptional co-repressor that interacts with nuclear hormone receptors
15. Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo
16. The nuclear co-repressors recognize distinct nuclear receptor complexes
17. The specificity of interactions between nuclear hormone receptors and co-repressors is mediated by distinct amino acid sequences within the interacting domains
18. Nuclear receptor DAX-1 recruits nuclear receptor co-repressor N-CoR to steroidogenic factor 1
19. Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
20. Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis
21. Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR
22. Histone acetylation at promoters is differentially affected by specific activators and repressors
23. The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression
24. Emerging connections between DNA methylation and histone acetylation
25. ebi regulates epidermal growth factor receptor signaling pathways in Drosophila
26. Identification of nuclear receptor co-repressor as a peroxisome proliferator-activated receptor alpha interacting protein
27. Transgenic targeting of a dominant negative co-repressor to liver blocks basal repression by thyroid hormone receptor and increases cell proliferation
28. Aberrant recruitment of the nuclear receptor co-repressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
29. Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation
30. Gene silencing: Two faces of SIR2
31. Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid cell transformation
32. The human histone deacetylase family
33. Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization
34. Histone function in transcription
35. A core SMRT co-repressor complex containing HDAC3 and TBL1, a WD40- repeat protein linked to deafness
36. The smrt and n-cor co-repressors are activating cofactors for histone deacetylase 3
37. Distinct interactions of PML-RARalpha and PLZF-RARalpha with co- repressors determine differential responses to RA in APL
38. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
39. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
40. SMRT co-repressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia
41. The SMRT co-repressor is regulated by a MEK-1 kinase pathway: Inhibition of co-repressor function is associated with SMRT phosphorylation and nuclear export
42. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
43. Characterization of human homologs of the Drosophila seven in absentia (sina) gene
44. The CoRNR motif controls the recruitment of co-repressors by nuclear hormone receptors
45. Determinants of CoRNR-dependent repression complex assembly on nuclear hormone receptors
46. Nuclear receptor co-repressors partner with class II histone deacetylases in a Sin3-independent repression pathway
47. Biochemical analysis of transcriptional repression by Drosophila histone deacetylase 1
48. Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1
49. The BCL-6 POZ domain and other POZ domains interact with the co- repressors N-CoR and SMRT
50. Transcriptional silencing and longevity protein Sir2 is an NAD- dependent histone deacetylase
51. Herp, a novel heterodimer partner of hes/e(spl) in notch signaling
52. The partial agonist activity of antagonist-occupied steroid receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the co-repressors N-CoR or SMRT
53. 2+/calmodulin-dependent protein kinase IV stimulates nuclear factor- kappa B transactivation via phosphorylation of the p65 subunit
54. Combinatorial roles of the nuclear receptor co-repressor in transcription and development
55. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
56. Multiple N-CoR complexes contain distinct histone deacetylases
57. Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor
58. A histone deacetylase co-repressor complex regulates the Notch signal transduction pathway
59. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
60. Sin meets NuRD and other tails of repression
61. Active repression of RAR signaling is required for head formation
62. The Ski Protein Family Is Required for MeCP2-mediated Transcriptional Repression
63. Syndrome of resistance to thyroid hormone: Insights into thyroid hormone action
64. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
65. Diverse signaling pathways modulate nuclear receptor recruitment of N- CoR and SMRT complexes
66. Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional co-repressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor
67. Characterization of receptor interaction and transcriptional repression by the co-repressor SMRT
68. Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack
69. Both co-repressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3
70. Molecular genetics of acute promyelocytic leukemia
71. Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
72. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
73. Negative control of p53 by Sir2 promotes cell survival under stress
74. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 co-repressors
75. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
76. The centromere and promoter factor, 1, CPF1, of Saccharomyces cerevisiae modulates gene activity through a family of factors including SPT21, RPD1 (SIN3), hdac and and CCR4
77. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
78. Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3- 3 to histone deacetylase 5
79. Smad regulation in TGF-β signal transduction
80. Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein
81. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
82. Mechanism of co-repressor binding and release from nuclear hormone receptors
83. Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: Implications in negative regulation of STAT5-dependent transcription
84. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
85. The regulation of yeast mating-type chromatin structure by SIR: An action at a distance affecting both transcription and transposition
86. Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast
87. Interaction of short-range repressors with Drosophila CtBP in the embryo
88. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
89. Unique forms of human and mouse nuclear receptor co-repressor SMRT
90. SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor co-repressor
91. Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins
92. Molecular determinants of nuclear receptor-co-repressor interaction
93. Drosophila CtBP: A Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression
94. A suppressor of mating-type locus mutations in Saccharomyces cerevisiae: Evidence for and identification of cryptic mating-type loci
95. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription
96. Defective release of co-repressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone
97. The c-erb-A protein is a high-affinity receptor for thyroid hormone
98. Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif
99. Two receptor interacting domains in the nuclear hormone receptor co-repressor RIP13/N-CoR
100. Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription
101. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins
102. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
103. Gene silencing by chicken ovalbumin upstream promoter-transcription factor I (COUP-TFI) is mediated by transcriptional co-repressors, nuclear receptor-co-repressor (N-CoR) and silencing mediator for retinoic acid hormone receptor (SMRT)
104. Coactivator and co-repressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
105. A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family
106. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila
107. Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein
108. PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism
109. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
110. CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase biosynthesis in Salmonella typhimurium LT2
111. Decoding the nucleosome
112. The CtBP family: Enigmatic and enzymatic transcriptional co-repressors
113. A novel nuclear receptor co-repressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the co-repressor KAP-1
114. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
115. Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae
116. SIRT1 Functions as an NAD-Dependent p53 Deacetylase
117. RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae
118. RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes
119. TEL contacts multiple co-repressors and specifically associates with histone deacetylase-3
120. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDACl complex
121. Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells
122. The histone deacetylase-3 complex contains nuclear receptor co-repressors
123. Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection
124. Components of the SMRT co-repressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6
125. SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains
126. The extreme C terminus of progesterone receptor contains a transcriptional repressor domain that functions through a putative co-repressor
127. Signal-specific co-activator domain requirements for Pit-1 activation
128. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
129. Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional co-repressors
130. CoREST is an integral component of the CoREST- human histone deacetylase complex
131. A nuclear hormone receptor co-repressor mediates transcriptional silencing by receptors with distinct repression domains
132. Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
133. Proteasomal regulation of nuclear receptor co-repressor-mediated repression
134. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities
135. SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex
136. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
137. Nuclear localization of cbf1 is regulated by interactions with the smrt co-repressor complex
138. The SMRT co-repressor is a target of phosphorylation by protein kinase CK2 (casein kinase II)