Programmed cell death mechanisms in neurological disease

Current Molecular Medicine

Volumn 8, Issue 3, 2008, Pages 173-186

  Bredesen, Dale E ^a,b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Autophagy; Caspase; Dependence receptors; Neurodegeneration; Paraptosis; Programmed cell death

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; AMYLOID PRECURSOR PROTEIN; ANDROGEN RECEPTOR; APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; ATAXIN 1; ATAXIN 3; ATM PROTEIN; BECLIN 1; BH3 PROTEIN; CASPASE; CASPASE 12; CASPASE 3; CASPASE 7; DNA DEPENDENT PROTEIN KINASE; FAS ASSOCIATED DEATH DOMAIN PROTEIN; GLUCOSE REGULATED PROTEIN 78; HEAT SHOCK PROTEIN 90; HUNTINGTIN; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR RECEPTOR NUR77; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; PROTEIN IRE1; PROTEIN NOXA; PROTEIN P53; PUMA PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; AUTOPHAGY; CELL DAMAGE; CELL DEATH; CELL MEDIATED CYTOTOXICITY; CELL SURVIVAL; CELL SWELLING; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; EXCITOTOXICITY; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; HUMAN; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; METABOLISM;

ANIMALS; APOPTOSIS; AUTOPHAGY; CASPASES; HUMANS; MODELS, BIOLOGICAL; NERVOUS SYSTEM DISEASES; PROTEIN FOLDING;

EID: 45549098179     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652408784221315     Document Type: Review

References (166)

1. Graham, R.K., Deng, Y., Slow, E.J., Haigh, B., Bissada, N., Lu, G., Pearson, J., Shehadeh, J., Bertram, L., Murphy, Z., Warby, S.C., Doty, C.N., Roy, S., Wellington, C.L., Leavitt, B.R., Raymond, L.A., Nicholson, D.W. and Hayden, M.R. (2006) Cell, 125, 1179-1191.
2. Studnicka, F.K. (1905) Die Parietalorgane: Lehrbuch der vergleichende mikroskopischen Anatomie der Wirbeltiere, Oppel, A., eds., S.G. Fischer Verlag, Jena.
3. Levi-Montalcini, R. (1966) Harvey Lect., 60, 217-259.
4. Lockshin, R.A. and Williams, C.M. (1964) J. Insect. Physiol., 10, 643-649.
5. Kerr, J.F., Wyllie, A.H. and Currie, A.R. (1972) Br. J. Cancer, 26, 239-257.
6. Clarke, P.G. (1990) Anat. Embryol., 181, 195-213.
7. Cunningham, T.J. (1982) Int. Rev. Cytol., 74, 163-186.
8. Dal Canto, M.C. and Gurney, M.E. (1994) Am. J. Pathol., 145, 1271-1279.
9. Majno. G. and Jorls, I. (1995) Am. J. Pathol., 146, 3-15.
10. Oppenhelm, R.W. (1985) Trends Neurosci., 17, 487-493.
11. Oppenhelm, R.W. (1991) Annu. Rev. Neurosci., 14, 453-501.
12. Pilar, G. and Landmesser, L. (1976) J. Cell Biol., 68, 339-356.
13. Schwartz, L.M. (1991) Bioessays, 13, 389-395.
14. Schweichel, J.U. (1972) Z Anat. Entwicklungsgesch, 136, 192-203.
15. Schweichel, J.U. and Marker, H.J. (1973) Teratology, 7, 253-266.
16. Sperandio, S., de Belle, I. and Bredesen, D.E. (2000) Proc. Natl. Acad. Sci. U S A, 97, 14376-14381.
17. Turmaine, M., Raza, A., Mahal, A., Mangiarini, L., Bates, G.P. and Davies, S.W. (2000) Proc. Natl. Acad. Sci. U S A, 97, 8093-8097.
18. Vande Velde, C., Cizeau, J., Dubik, D., Alimonti, J., Brown, T., Israels, S., Hakem, R. and Greenberg, A.H. (2000) Mol. Cell Biol., 20, 5454-5468.
19. Niquet, J., Liu, H. and Wasterlain, C.G. (2005) Epilepsia, 46 Suppl 5, 43-48.
20. Zong, W.X. and Thompson, C.B. (2006) Genes Dev., 20, 1-15.
21. Fadok, V.A., Voelker, D.R., Campbell, P.A., Cohen, J.J., Bratton, D.L. and Henson, P.M. (1992) J. Immunol., 148, 2207-2216.
22. Thomberry, N.A. and Lazebnik, Y. (1998) Science, 281, 1312-1316.
23. Yuan, J., Shaham, S., Ledoux, S., Ellis, H.M. and Horvitz, H.R. (1993) Cell, 75, 641-652.
24. Salvesen, G.S. and Dixit, V. M. (1997) Cell, 91, 443-446.
25. Morishima, N., Nakanishi, K., Takenouchl, H., Shibata, T. and Yasuhiko. Y. (2002) J. Biol. Chem., 277, 34287-34294.
26. Rao, R.V., Castro-Obregon, S., Frankowski, H., Schuler, M., Stoke, V., Del Rio, G., Bradesen, D.E. and Ellerby, H.M. (2002) J. Biol. Chem., 277. 21836-21842.
27. Rao, R.V., Hermel, E., Castro-Obregon, S., del Rio, G., Ellerby, L.M., Ellerby, H.M. and Bredesen, D.E. (2001) J. Biol. Chem., 276, 33869-33874.
28. Rao, R.V., Peal, A., Logvinova, A., del Rio, G., Hermel, E., Yokota, T., Goldsmith, P.C., Ellerby, L.M., Ellerby, H.M. and Bredesen, D.E. (2002) FEBS Lett., 514, 122-128.
29. Yuan, J. and Yankner, B.A. (1999) Nat Cell Biol., 1, E44-45.
30. Green, D.R. and Kroemer, G. (2005) J. Clin. Invest., 115, 2610-2617.
31. Murray-Zmijewski, F., Lane, D.P. and Bourdon, J.C. (2006) Cell Death Differ.,
32. Kuwana, T., Bouchler-Heyes, L, Chipuk, J.E., Bonzon, C., Sullivan, B.A., Green, D.R. and Newmeyer, D.D. (2005) Mol. Cell, 17, 525-535.
33. Kuwana, T., Mackey. M.R., Perkins, G., Ellisman, M.H., Latterich, M., Schneiter, R., Green, D.R. and Newmeyer, D.D. (2002) Cell, 111, 331-342.
34. Stoka, V., Turk, B., Schendel, S.L., Kim, T.H., Cirman, T., Snipas, S.J., Ellerby, L.M., Bredesen, D., Freeze, H., Abrahamson, M., Bromme, D., Krajewski, S., Reed, J.C., Yin, X.M., Turk, V. and Salvesen, G.S. (2001) J. Biol. Chem., 276, 3149-3157.
35. Guo, B., Zhai, D., Cabezas, E., Welsh, K, Nouraini, S., Satterthwait, A.C. and Reed, J.C. (2003) Nature, 423, 456-461.
36. Zhai, D., Luciano, F., Zhu, X., Guo, B., Satterthwait, A.C. and Reed, J.C. (2005) J. Biol. Chem., 280, 15815-15824.
37. Luciano, F., Zhai, D., Zhu, X., Bailly-Maitre, B., Ricci, J.E., Satterthwait, A.C. and Reed, J.C. (2005) J. Biol. Chem., 280, 15825-15835.
38. Chipuk, J.E., Kuwana, T., Bouchier-Hayes, L., Droin, N.M., Newmayer, D.D., Schuler, M. and Green, D.R. (2004) Science, 303, 1010-1014.
39. Schuler, M., Bossy-Wetzel, E., Goldstein, J.C., Fitzgerald. P. and Green, D.R. (2000) J. Biol. Chem., 275, 7337-7342.
40. Chipuk, J.E., Bouchier-Hayes, L., Kuwana, T., Newmeyer, D.D. and Green, D.R. (2005) Science, 309, 1732-1735.
41. Li, H., Kolluri, S.K., Gu, J., Dawson, M.I., Cao, X. Hobbs, P.D., Lin, B., Chen, G., Lu, J., Lin, F., Xie, Z., Fontana, J.A., Reed, J.C. and Zhang, X. (2000) Science, 289, 1159-1164.
42. Lin, B., Kolluri, S.K., Lin, F., Liu, W., Han, Y.H., Cao, X., Dawson, M.I., Reed, J.C. and Zhang, X.K. (2004) Cell, 116, 527-540.
43. Bossy-Wetzel, E., Barsoum, M.J., Godzik, A., Schwarzenbacher, R. and Lipton, S.A. (2003) Curr. Opin. Cell Biol., 15, 706-716.
44. Germain, M., Mathai, J.P., McBride, H.M. and Shore, G.C. (2005) EMBO J., 24, 1546-1556.
45. Lee, Y.J., Jeong, S.Y., Karbowski, M., Smith, C.L. and Youle, R.J. (2004) Mol. Biol. Cell, 15, 5001-5011.
46. Alexander, C., Votruba, M., Pesch, U.E., Thiselton, D.L., Mayer, S., Moore, A., Rodriguez, M., Kellner, U., Leo-Kottler, B., Auburger, G., Bhattacharya, S.S. and Wissinger, B. (2000) Nat. Genet., 26, 211-215.
47. Boatright, K.M., Renatus, M., Scott, F.L., Sperandio, S., Shin, H., Pedersen, I.M., Ricci, J.E., Edris, W.A., Sutherlin, D.P., Green, D.R. and Salvesen, G.S. (2003) Mol. Cell, 11, 529-541.
48. Deveraux, Q.L., Takahashi, R., Salvesen, G.S. and Reed, J.C. (1997) Nature, 388, 300-304.
49. Holley, C.L., Olson, M.R., Colon-Ramos, D.A. and Kornbluth, S. (2002) Nat Cell Biol., 4, 439-444.
50. Du, C., Fang, M., Li, Y., Li, L. and Wang, X. (2000) Cell, 102, 33-42.
51. Verhagen, A.M., Ekert, P.G., Pakusch, M., Silke, J., Connolly, L.M., Reid, G.E., Moritz, R.L., Simpson, R.J. and Vaux, D.L. (2000) Cell, 102, 43-53.
52. Martins, L.M., Iaccarino, I., Tenev, T., Gschmeissner, S., Totty, N.F., Lemoine, N.R., Savopoulos, J., Gray, C.W., Creasy, C.L., Dingwall, C. and Downward, J. (2002) J. Biol. Chem., 277, 439-444.
53. Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K. and Takahashi, R. (2001) Mol. Cell, 8, 613-621.
54. Chan, F.K., Chun, H.J., Zheng, L., Siegel, R.M., Bui, K.L. and Lenardo, M.J. (2000) Science, 288, 2351-2354.
55. Siegel, R.M., Frederiksen, J.K., Zacharias, D.A., Chan, F.K., Johnson, M., Lynch, D., Tsien, R.Y. and Lenardo, M.J. (2000) Science, 288, 2354-2357.
56. Muzio, M., Chinnaiyan, A.M., Kischkel, F.C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J.D., Zhang, M., Gentz, R., Mann, M., Krammer, P.H., Peter, M.E. and Dixit, V.M. (1996) Cell, 85, 817-827.
57. Boatright, K.M., Deis, C., Denault, J.B., Sutherlin, D.P. and Salvesen, G.S. (2004) Biochem. J., 382, 651-657.
58. Fuentes-Prior, P. and Salvesen, G.S. (2004) Biochem. J., 384, 201-232.
59. Friedlander, R.M., Gagliardini, V., Hara, H., Fink, K.B., Li, W., MacDonald, G., Fishman, M.C., Greenberg, A.H., Moskowitz, M.A. and Yuan, J. (1997) J. Exp. Med., 185, 933-940.
60. Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B.A. and Yuan, A. (2000) Nature, 403, 98-103.
61. Fischer, H., Koenig, U., Eckhart, L. and Tschachler, E. (2002) Biochem. Biophys. Res. Commun., 293, 722-726.
62. Saleh, M., Vaillancourt, J.P., Graham, R.K., Huyck, M., Srinivasula, S.M., Alnemri, E.S., Steinberg, M.H., Nolan, V., Baldwin, C.T., Hotchkiss, R.S., Buchman, T.G., Zehnbauer, B.A., Hayden, M.R., Farrer, L.A., Roy, S. and Nicholson, D.W. (2004) Nature, 429, 75-79.
63. Bredesen, D.E., Ye, X., Tasinato, A., Sperandio, S., Wang, J.J., Assa-Munt, N. and Rabizadeh, S. (1998) Cell Death Differ., 5, 365-371.
64. Yao, R. and Cooper, G.M. (1995) Science, 267, 2003-2006.
65. Ellerby, L.M., Hackam, A.S., Propp, S.S., Ellerby, H.M., Rabizadeh, S., Cashman, N.R., Trifiro, M.A., Pinsky, L., Wellington, C.L., Salvesen, G.S., Hayden, M.R. and Bredesen, D.E. (1999) J. Neurochem., 72, 185-195.
66. Barrett, G.L. and Bartlett, P.F. (1994) Proc. Natl. Acad. Sci. USA, 91, 6501-6505.
67. Barrett, G.L. and Georgiou, A. (1996) J. Neurosci. Res., 45, 117-128.
68. Bordeaux, M.C., Forcet, C., Granger, L., Corset, V., Bidaud, C., Billaud, M., Bredesen, D.E., Edery, P. and Mehlen, P. (2000) EMBO J., 19, 4056-4063.
69. Bredesen, D.E. and Rabizadeh, S. (1997) Trends Neurosci., 20, 287-290.
70. Forcet, C., Ye, X., Granger, L., Corset, V., Shin, H., Bredesen, D.E. and Mehlen, P. (2001) Proc. Natl. Acad. Sci. USA, 98, 3416-3421.
71. Llambi, F., Causeret, F., Bloch-Gallego, E. and Mehlen, P. (2001) EMBO J., 20, 2715-2722.
72. Mehlen, P., Rabizadeh, S., Snipas, S.J., Assa-Munt, N., Salvesen, G.S. and Bredesen, D.E. (1998) Nature, 395, 801-804.
73. Rabizadeh, S. and Bredesen, D.E. (1994) Dev. Neurosci., 16, 207-211.
74. Rabizadeh, S., Oh, J., Zhong, L.T., Yang, J., Bitler, C.M., Butcher, L.L. and Bredesen, D.E. (1993) Science, 261, 345-348.
75. Stupack, D.G., Puente, X.S., Boutsaboualoy, S., Storgard, C.M. and Cheresh, D.A. (2001) J. Cell Biol., 155, 459-470.
76. Bredesen, D.E., Mehlen, P. and Rabizadeh, S. (2004) Physiol. Rev., 84, 411-430.
77. Thibert, C., Teillet, M.A., Lapointe, F., Mazelin, L., Le Douarin, N.M. and Mehlen, P. (2003) Science, 301, 843-846.
78. Mah, S.P., Zhong, L.T., Liu, Y., Roghani, A., Edwards, R.H. and Bredesen, D.E. (1993) J Neurochem., 60, 1183-1186.
79. Bredesen, D.E. (1996) Keeping neurons alive: the molecular control of apoptosis (part I): The Neuroscientist, eds., pp. 181-190.
80. Gervais, F.G., Xu, D., Robertson, G.S. Vaillancourt, J.P., Zhu, Y., Huang, J., LeBlanc, A., Smith, D., Rigby, M., Shearman, M.S., Clarke, E.E., Zheng, H., Van Der Ploeg, L.H., Ruffolo, S.C., Thornberry, N.A., Xanthoudakis, S., Zamboni, R.J., Roy, S. and Nicholson, D.W. (1999) Cell, 97, 395-406.
81. Lu, D.C., Rabizadeh, S., Chandra, S., Shayya, R.F., Ellerby, L.M., Ye, X., Salvesen, G.S., Koo, E.H. and Bredesen, D.E. (2000) Nat Med., 6, 397-404.
82. Lu, D.C., Shaked, G.M., Masilah, E., Bredesen, D.E. and Koo, E.H. (2003) Ann. Neurol., 54, 781-789.
83. Lu, D.C., Soriano, S., Bredesen, D.E. and Koo, E.H. (2003) J. Neurochem., 87, 733-741.
84. Ho, A. and Sudhof, T.C. (2004) Proc. Natl. Acad. Sci. U S A, 101, 2548-2553.
85. Shaked, G.M., Kummer, M.P., Lu, D.C., Galvan, V., Bredesen, D.E. and Koo, E.H. (2006) FASEB J., 20, 1254-1256.
86. Galvan, V., Gorostiza, O.F., Banwait, S., Ataie, M., Logvinova, A.V. Sitaraman, S., Carlson, E., Sagi, S.A., Chevallier, N., Jin, K., Greenberg, D.A. and Bredesen, D.E. (2006) Proc. Natl. Acad. Sci. U S A, 103, 7130-7135.
87. Banwait, S., Galvan, V., Zhang, J., Gorostiza, O.F., Ataie, M., Huang, W., Crippen, D., Koo, E. and Bredesen, D.E. J. Alzheimers. Dis., (in press).
88. Nguyen, T.V., Galvan, V., Huang, W., Banwait, S., Tang, H., Zhang, J. and Bredesen, D.E. (2007) J. Neurochem., 104(4), 1065-1080.
89. Shaked, G.M., Kummer, M.P., Lu, D.C., Galvan, V., Bredesen, D.E. and Koo, E.H. (2006) FASEB J., 20, 1254-1256.
90. Nishimoto, I. (1998) Neurobiol. Aging, 19, S33-38.
91. Ellerby, L.M., Andrusiak, R.L., Wellington, C.L., Hackam, A.S., Propp, S.S., Wood, J.D., Sharp, A.H., Margolis, R.L., Ross, C.A., Salvesen, G.S., Hayden, M.R. and Bredesen, D.E. (1999) J. Biol. Chem., 274, 8730-8736.
92. Hermel, E., Gafni, J., Propp, S.S., Leavitt, B.R., Wellington, C.L., Young, J.E., Hackam, A.S. Logvinova, A.V., Peel, A.L., Chen, S.F., Hook, V., Singaraja, R., Krajewski, S., Goldsmith, P.C., Ellerby, H.M., Hayden, M.R., Bredesen, D.E. and Ellerby, L.M. (2004) Cell Death Differ., 11, 424-438.
93. Wellington, C.L., Singaraja, R., Ellerby, L., Savill, J., Roy, S., Leavitt, B., Cattaneo, E., Hackam, A., Sharp, A., Thornberry, N., Nicholson, D.W., Bredesen, D.E. and Hayden, M.R. (2000) J. Biol. Chem., 275, 19831-19838.
94. Goldberg, Y.P., Nicholson. D.W., Rasper, D.M., Kalchman, M.A., Koide, H.B., Graham, R.K., Bromm, M., Kazemi-Esfarjani, P., Thornberry, N.A., Vaillancourt, J.P. and Hayden, M.R. (1996) Nat. Genet., 13, 442-449.
95. Baker, M., Mackenzie, I.R., Pickering-Brown, S.M., Gass, J., Rademakers, R., Lindholm, C., Snowden, J., Adamson, J., Sadovnick, A.D., Rollinson, S., Cannon, A., Dwosh, E., Neary, D., Melquist, S., Richardson, A., Dickson, D., Berger, Z., Eriksen, J., Robinson, T., Zehr, C., Dickey, C.A., Crook, R., McGowan, E., Mann, D., Boeve, B., Feldman, H. and Hutton, M. (2006) Nature, 442, 916-919.
96. Mackenzie, I.R. (2007) Acta Neuropathol., 114, 49-54.
97. Zhang, Y.J., Xu, Y.F., Dickey, C.A., Buratti, E., Baralle, F., Bailey, R., Pickering-Brown, S., Dickson, D. and Petrucelli, L. (2007) J. Neurosci., 27, 10530-10534.
98. Rao, R.V. and Bredesen, D.E. (2004) Curr. Opin. Cell Biol., 16, 653-662.
99. Kopito, R.R. and Ron, D. (2000) Nat. Cell Biol., 2, E207-209.
100. Taylor, J.P., Hardy, J. and Fischbeck, K.H. (2002) Science, 296, 1991-1995.
101. Dobson, C.M. (2003) Nature, 426, 884-890.
102. Kopito, R.R. (2000) Trends Cell Biol., 10, 524-530.
103. Kaufman, R.J. (1999) Genes Dev., 13, 1211-1233.
104. Dobson, C.M. and Ellis, R.J. (1998) EMBO J., 17, 5251-5254.
105. Selkoe, D.J. (2003) Nature, 426, 900-904.
106. Goldberg, A.L. (2003) Nature, 426, 895-899.
107. Sitia, R. and Braakman, I. (2003) Nature, 426, 891-894.
108. Sherman, M.Y. and Goldberg, A.L. (2001) Neuron, 29, 15-32.
109. Klein, W.L. (2002) Neurochem. Int., 41, 345-352.
110. Mucke, L., Masllah, E., Yu, G.Q., Mallory, M., Rockenstein, E.M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K. and McConlogue, L. (2000) J. Neurosci., 20, 4050-4058.
111. Scorrano, L., Oakes, S.A., Opferman, J.T., Cheng, E.H., Sorcinelli, M.D., Pozzan, T. and Korsmeyer, S.J. (2003) Science, 300, 135-139.
112. Ruiz-Vela, A., Opferman, J.T., Cheng, E.H. and Korsmeyer, S.J. (2005) EMBO Rep., 6, 379-385.
113. Mathai, J.P., Germain, M. and Shore, G.C. (2005) J. Biol. Chem., 280, 23829-23836.
114. Chae, H.J., Kim, H.R., Xu, C., Bailly-Maitre, B., Krajewska, M., Krajewski, S., Banares, S., Cui, J., Digicaylioglu, M., Ke, N., Kitada, S., Monosov, E., Thomas, M., Kress, C.L., Babendure, J.R., Tsien, R.Y., Lipton, S.A. and Reed, J.C. (2004) Mol. Cell, 15, 355-366.
115. Rao, R.V., Niazi, K., Mollahan, P., Mao, X., Crippen, D., Poksay, K.S., Chen, S. and Bredesen, D.E. (2006) Cell Death Differ., 13, 415-425.
116. Li, J., Lee, B. and Lee, A.S. (2006) J. Biol. Chem., 281, 7260-7270.
117. Reddy, R.K., Mao, C., Baumeister, P., Austin, R.C., Kaufman, R.J. and Lee, A.S. (2003) J. Biol. Chem., 278, 20915-20924.
118. Urano, F., Wang, X., Bertolotti, A., Zhang, Y., Chung, P., Harding, H.P. and Ron, D. (2000) Science, 287, 664-666.
119. Ng, F.W., Nguyen, M., Kwan, T., Branton, P.E., Nicholson, D.W., Cromlish, J.A. and Shore, G.C. (1997) J. Cell Biol., 139, 327-338.
120. Breckenridge. D.G., Stojanovic, M., Marcellus, R.C. and Shore, G.C. (2003) J. Cell Biol., 160, 1115-1127.
121. Roth, W., Kermer, P., Krajewska, M., Welsh, K., Davis, S., Krajewski, S. and Reed, J.C. (2003) Cell Death Differ., 10, 1178-1187.
122. Zhang, H., Xu, Q., Krajewski, S., Krajewska, M., Xie, Z., Fuess, S., Kitada, S., Pawlowski, K., Godzik, A. and Reed, J.C. (2000) Proc. Natl. Acad. Sci. U S A, 97, 2597-2602.
123. Hirabayashi, M., Inoue, K., Tanaka, K., Nakadate, K., Ohsawa, Y., Kamei, Y., Popiel, A.H., Sinohara, A., Iwamatsu, A., Kimura, Y., Uchiyama, Y., Hori, S. and Kakizuka, A. (2001) Cell Death Differ., 8, 977-984.
124. Kobayashi, T., Tanaka, K., Inoue, K. and Kakizuka, A. (2002) J. Biol. Chem., 277, 47358-47365.
125. Rao, R.V., Poksay, K.S., Castro-Obregon, S., Schilling, B., Row, R.H., Del Rio, G., Gibson, B.W., Ellerby, H.M. and Bredesen, D.E. (2004) J. Biol. Chem., 279, 177-187.
126. Watts, G.D., Wymer, J., Kovach, M.J., Mehta, S.G., Mumm, S., Darvish, D., Pestronk, A., Whyte, M.P. and Kimonis, V.E. (2004) Nat. Genet., 36, 377-381.
127. Mahul-Mellier, A.L., Hemming, F.J., Blot B., Fraboulet, S. and Sadoul, R. (2066) J. Neurosci., 26, 542-549.
128. Hegde, R.S., Mastrianni, J.A., Scott M.R., DeFea, K.A., Tremblay, P., Torchia, M., DeArmond, S.J., Prusiner, S.B. and Lingappa, V.R. (1998) Science, 279, 827-834.
129. Levine, B. and Yuan, J. (2005) J. Clin. Invest., 115, 2679-2688.
130. Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi. Y., Uchiyama, Y., Kominami, E., Tanaka, K. and Chiba, T. (2005) J. Cell Biol., 169, 425-434.
131. Yue, Z., Jin, S., Yang, C., Levine, A.J. and Heintz, N. (2003) Proc. Natl. Acad. Sci. U S A, 100, 15077-15082.
132. Shimizu, S., Kanaseki, T., Mizushima, N., Mizuta, T., Arakawa-Kobayashi, S., Thompson, C.B. and Tsujimoto, Y. (2004) Nat. Cell Biol., 6, 1221-1228.
133. Lum, J.J., Bauer, D.E., Kong, M., Harris, M.H., Li, C., Lindsten, T. and Thompson, C.B. (2005) Cell, 120, 237-248.
134. Yu, L., Alva, A., Su, H., Dutt, P., Freundt, E., Welsh, S., Baehrecke, E.H. and Lenardo, M.J. (2004) Science, 304, 1500-1502.
135. Yu, L., Wan, F., Dutta, S., Welsh, S., Liu, Z., Freundt, E., Baehrecke, E.H. and Lenardo, M. (2006) Proc. Natl. Acad. Sci. U S A, 103, 4952-4957.
136. Gomez-Santos, C., Ferrer, I., Santidrian, A.F., Barrachina, M., Gil, J. and Ambrosio, S. (2003) J. Neurosci. Res., 73, 341-350.
137. Borsello, T., Croquelols, K., Hornung, J.P. and Clarke, P.G. (2003) Eur. J. Neurosci., 18, 473-485.
138. Zhu, J.H., Horbinski, C. Guo, F., Watkins, S., Uchiyama, Y. and Chu, C.T. (2007) Am. J. Pathol., 170, 75-86.
139. Sperandio, S., Poksay, K., de Belle, I., Lafuente, M.J., Liu, B., Nasir, J. and Bredesen, D.E. (2004) Cell Death Differ., 11, 1066-1075.
140. Koh, J.Y., Gwag, B.J., Lobner, D. and Choi, D.W. (1995) Science, 268, 573-575.
141. Formigli, L., Papucci, L., Tani, A., Schiavone, N., Tempestini, A., Orlandini, G.E., Capaccioli, S. and Orlandini, S.Z. (2000) J. Cell Physiol., 182, 41-49.
142. Syntichaki, P., Xu, K., Driscoll, M. and Tavernarakis, N. (2002) Nature, 419, 939-944.
143. Bianchi, L., Gerstbrein, B., Frokjaer-Jensen, C., Royal, D.C., Mukherjee, G., Royal, M.A. Xue, J., Schafer, W.R. and Driscoll, M. (2004) Nat. Neurosci., 7, 1337-1344.
144. Yu, S.W., Wang, H., Poitras, M.F., Coombs, C., Bowers, W.J., Federoff, H.J., Poirier, G.G., Dawson, T.M. and Dawson, V.L. (2002) Science, 297, 259-263.
145. Liu, X., Van Vleet, T. and Schnellmann, R.G. (2004) Annu. Rev. Pharmacol. Toxicol., 44, 349-370.
146. Gilloteaux, J., Jamison, J.M., Arnold, D., Ervin, E., Eckroat, L., Docherty, J.J., Neal, D. and Summers, J.L. (1998) Scanning, 20, 564-575.
147. Novgorodov, S.A. and Gudz, T.I. (1996) J. Bioenerg. Biomembr., 28, 139-146.
148. Brenner, C., Cadiou, H., Vielra, H.L., Zamzami, N., Marzo, I., Xie, Z., Leber, B., Andrews, D., Duclohier, H., Reed, J.C. and Kroemer, G. (2000) Oncogene, 19, 329-336.
149. Adachi, M., Higuchi, H., Miura, S., Azuma, T., Inokuchi, S., Saito, H., Kato, S. and Ishii, H. (2004) Am. J. Physiol. Gastrointest. Liver Physiol., 287, G695-705.
150. Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D.R. Aebersold, R., Siderovski, D.P., Penninger, J.M. and Kroemer, G. (1999) Nature, 397, 441-446.
151. Polster, B.M., Basanez, G., Etxebarria, A., Hardwick, J.M. and Nicholls, D.G. (2005) J. Biol. Chem., 280, 6447-6454.
152. Egger, L., Schneider, J., Rheme, C., Tapernoux, M., Hacki, J. and Bomer, C. (2003) Cell Death Differ., 10, 1188-1203.
153. Perfettini, J.L., Reed, J.C., Israel, N., Martinou, J.C., Dautry-Varsat, A. and Ojcius, D.M. (2002) Infect. Immun., 70, 55-61.
154. Kane, D.J., Ord, T., Anton, R. and Bredesen, D.E. (1995) J. Neurosci. Res., 40, 269-275.
155. Chua, B.T., Guo, K. and Li, P. (2000) J. Biol. Chem., 275, 5131-5135.
156. Lankiewicz, S., Marc Luetjens, C., Truc Bui, N., Krohn, A.J., Poppe, M., Cole, G.M., Saido, T.C. and Prehn, J.H. (2000) J. Biol. Chem., 275, 17064-17071.
157. Yang, F., Sun, X., Beech, W., Teter, B., Wu, S., Sigel, J., Vinters, H.V., Frautschy, S.A. and Cole, G.M. (1998) Am. J. Pathol., 152, 379-389.
158. Tanaka, Y., Igarashi, S., Nakamura, M., Gafni, J., Torcassi, C., Schilling, G., Crippen, D., Wood, J.D., Sawa, A., Jenkins, N.A., Copeland, N.G., Borchelt, D.R., Ross, C.A. and Ellerby, L.M. (2006) Neurobiol. Dis., 21, 381-391.
159. Friedlander, R.M., Brown, R.H., Gagliardini, V., Wang, J. and Yuan, J. (1997) Nature, 388, 31.
160. Ona, V.O., Li, M., Vonsattel, J.P.G., Andrews, L.J., Khan, S.Q., Chung, W.M., Frey, A.S., Menon, A.S., Li, X-J., Stieg, P.E., Yuan, J., Penney, J.B., Young, A.B., Cho, J.-H.J. and Friedlander, R.M. (1999) Nature, 399, 263-267.
161. Butterfield, D.A. and Bush, A.I. (2004) Neurobiol. Aging, 25, 563-568.
162. Bredesen, D.E., Rao, R.V. and Mehlon. P. (2006) Nature, 443, 796-802.
163. Bursch, W., Hochegger, K., Torok, L., Marian, B., Ellinger, A. and Hermann, R.S. (2000) J. Cell Sci., 113 (Pt 7), 1189-1198.
164. Hall, I.H., Elkins, A.L., Karthikeyan, S. and Spielvogel, B.F. (1997) Anticancer Res., 17, 1195-1198.
165. Susin, S.A., Daugas, E., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M., Costantini, P., Ferri, K.F., Irinopoulou, T., Prevost, M.C., Brothers, G., Mak, T.W., Penninger, J., Earnshaw, W.C. and Kroemer, G. (2000) J. Exp. Med., 192, 571-580.
166. Ohno, M., Takemura, G., Ohno, A., Misao, J., Hayakawa, Y., Minatoguchi, S., Fujiwara, T. and Fujiwara, H. (1998) Circulation, 98, 1422-1430.