Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease

American Journal of Pathology

Volumn 152, Issue 2, 1998, Pages 379-389

  Yang, Fusheng ^a   Sun, Xiaoyan ^a   Beech, Walter ^a   Teter, Bruce ^a   Wu, Sherry ^a   Sigel, Jason ^a   Vinters, Harry V ^a   Frautschy, Sally A ^a   Cole, Greg M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ANTIBODY; ASPARTIC ACID; CYSTEINE PROTEINASE; DNA; INTERLEUKIN 1BETA CONVERTING ENZYME;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MICROGLIA; NEUROBLASTOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ACTINS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIBODIES; APOPTOSIS; BRAIN; CASPASE 1; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; IMMUNOHISTOCHEMISTRY; MICROGLIA; MIDDLE AGED; NEUROBLASTOMA; NEURONS; PEPTIDE FRAGMENTS; SENILE PLAQUES; TUMOR CELLS, CULTURED;

EID: 0031930313     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Miller DK: The role of the Caspase family of cysteine proteases in apoptosis. Semin Immunol 1997, 9:35-39
2. Steller H: Mechanisms and genes of cellular suicide. Science 1995, 267:1445-1449
3. Schlegel J, Peters I, Orreniur S, Miller DK, Thornberry NA, Yamin TT, Nicholson DW: CPP32/apopain is a key interleukin 1β converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem 1996, 271:1841-1844
4. Nicholson DW, Ali A, Thornberry NA, Valllancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin T-T, Yu VL, Miller DK: Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995, 376:37-43
5. Mashima T, Naito M, Fujita N, Noguchi K, Tsuruo T: Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis. Biochem Biophys Res Commun 1995, 217:1185-1192
6. Lazebnik YA, Takahashi A, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC: Studies of the lamin protease reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci USA 1995, 92:9042-9046
7. Enari M, Talanian RV, Wong WW, Nagata S: Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 1996, 380:723-726
8. Kayalar C, Örd T, Testa MP, Zhong L-T, Bredesen D: Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition. Proc Natl Acad Sci USA 1996, 93:2234-2238
9. Song Q, Wei T, Les-Miller S, Alnemri E, Watters D, Lavin MF: Resistance of actin to cleavage during apoptosis. Proc Natl Acad Sci USA 1997, 94:157-162
10. Lassman H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM: Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ. Acta Neuropathol 1995, 89:35-41
11. Smale G, Nichols NR, Brady DR, Finch CE, Horton WE Jr: Evidence for apoptotic cell death in Alzheimer's disease. Exp Neurol 1995, 133:225-230
12. Su JH, Anderson AJ, Cummings BJ, Cotman CW: Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 1994, 5:2529-2533
13. Cotman CW, Anderson AJ: A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol Neurobiol 1995, 10:19-45
14. Mak K, Yang F, Vinters HV, Frautschy SA, Cole GM: Polyclonals to β-amyloid (1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum. Brain Res 1994, 667:138-142
15. Yang F, Mak K, Vinters HV, Frautschy SA, Cole GM: Monoclonal antibody to the C-terminus of β-amyloid. NeuroReport 1994, 15:2117-2120
16. Cole GM, Wu K, Timiras PS: A culture model for age-related human neurofibrillary pathology. Int J Dev Neurosci 1985, 3:23-32
17. Nakagawa-Yagi Y: Induction of apoptotic cell death in differentiating neuroblastoma SH-SY5Y cells by colchicine. Biochem Biophys Res Commun 1994, 199:807-817
18. Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM Jr: Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J Cell Biol 1994, 127:1717-1727
19. Wyllie AH, Kerr JFR, Currie AR: Cell death: the significance of apoptosis. Int Rev Cytol 1980, 68:251-306
20. Columbano A: Cell death: current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo. J Cell Biochem 1995, 58:181-190
21. Charriaut-Marlangue C, Ben-Ari Y: A cautionary note on the use of the TUNEL stain to determine apoptosis. NeuroReport 1995, 7:61-64
22. Mundle SD, Raza A: The two in situ techniques do not differentiate between apoptosis and necrosis but rather reveal distinct patterns of DNA fragmentation in apoptosis. Lab Invest 1995, 72:611-613
23. Nakajima H, Golstein P, Henkart PA: The target cell nucleus is not required for cell-mediated granzyme - or Fas-based cytotoxicity. J Exp Med 1995, 181:1905-1909
24. Schulze-Osthoff K, Walczak H, Droge W, Krammer PH: Cell nucleus and DNA fragmentation are not required for apoptosis. J Cell Biol 1994, 127:15-20
25. Cotter TG, Lennon SV, Glynn JM, Green DR: Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Res 1992, 52:997-1005
26. Endresen PC, Fandrem J, Eide TJ, Aarbakke J: Morphological modifications of apoptosis in HL-60 cells: effects of homocysteine and cytochalasins on apoptosis by 3-deazaadenosine. Virchows Arch B Cell Pathol 1995, 426:257-266
27. Kuida K, Zheng TS, Na S, Kuan C-Y, Yang D, Karasuyama H, Rakic P, Flavell RA: Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996, 384:368-371
28. Posmantur R, McGinnis K, Nadimpalli R, Gilbertsen RB, Wang KKW: Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells. J Neurochem 1997, 68: 2328-2337
29. Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grunberg J, Haass C, Jacobsen H: Presenilins are processed by caspase-type proteases. J Biol Chem 1997, 272:20655-20659
30. Melino G, Thiele CJ, Knight RA, Piacentini M: Retinoids and the control of growth/death decisions in human neuroblastoma cell lines. J Neurooncol 1997, 31:65-83
31. Lasorella A, Iavaorne A, Israel MA: Differentiation of neuroblastoma enhances Bcl-2 expression and induces alteration of apoptosis and drug resistance. Cancer Res 1995, 55:4711-4716
32. Miossec C, Dutilleul V, Fassy F, Diu-Hercend A: Evidence for CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J Biol Chem 1997, 272:13459-13462
33. Leavitt J: Discovery and characterization of two novel human cancer-related proteins using two-dimensional gel electrophoresis. Electrophoresis 1994, 15:345-357
34. Portera-Cailliau C, Price DL: Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J Comp Neurol 1997, 378:70-78
35. Vito P, Wolozin B, Ganjei JK, Iwasaki K, Lacana E, D'Adamio L: Requirement of the familial Alzheimer's disease gene PS2 for apoptosis: opposing effect of ALG-3. J Biol Chem 1996, 271:31025-31028
36. Wolozin B, Iwasaki K, Vito P, Ganjei JK, Lacana E, Sunderland T, Zhao B, Kusiak JW, Wasco W, D'Adamio L: Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science 1996, 274:1710-1713
37. Bhat RV, DiRocco R, Marcy VR, Flood DG, Zhu Y, Dobrzanski P, Siman R, Scott R, Contreras PC, Miller M: Increased expression of IL-1β converting enzyme in hippocampus after ischemia: selective localization in microglia. J Neurosci 1996, 16:4146-4154
38. McGeer PL, McGeer EG: The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res Rev 1995, 21:195-218
39. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei F-Y, Wong W, Kamen R, Seshadri T: Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 1995, 80:401-411
40. Gehrmann J, Banati RB: Microglial turnover in the injured CNS: activated microglia undergo delayed DNA fragmentation following peripheral nerve injury. J Neuropathol Exp Neurol 1995, 54:680-685
41. Paresce DM, Ghosh RN, Maxfield FR: Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor. Neuron 1996, 17:553-565
42. Iyer R, Hamilton R, Li L, Holian A: Silica-induced apoptosis mediated via scavenger receptor in human alveolar macrophages. Toxicol Appl Pharmacol 1996, 141:84-92
43. Korotzer AR, Pike CJ, Cotman CW: β-amyloid peptides induce degeneration of cultured rat microglia. Brain Res 1993, 624:121-125
44. Vanderklish P, Saido TC, Gall C, Arai A, Lynch G: Proteolysis of spectrin by calpain accompanies theta-burst stimulation in cultured hippocampal slices. Mol Brain Res 1995, 32:25-35