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Volumn 18, Issue 3, 2003, Pages 473-485

N-methyl-D-aspartate-triggered neuronal death in organotypic hippocampal cultures is endocytic, autophagic and mediated by the c-Jun N-terminal kinase pathway

Author keywords

Autophagic cell death; Excitotoxicity; Neuroprotection; Peptide inhibitor; Rat

Indexed keywords

ACID PHOSPHATASE; HORSERADISH PEROXIDASE; N METHYL DEXTRO ASPARTIC ACID; PEROXIDASE; PHOSPHOTRANSFERASE; PROTEIN C FOS; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR ELK 1; UNCLASSIFIED DRUG;

EID: 0042380209     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02757.x     Document Type: Article
Times cited : (157)

References (53)
  • 2
    • 0033636313 scopus 로고    scopus 로고
    • The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration
    • Alloway, P.G., Howard, L. & Dolph, P.J. (2000) The formation of stable rhodopsin-arrestin complexes induces apoptosis and photoreceptor cell degeneration. Neuron, 28, 129-138.
    • (2000) Neuron , vol.28 , pp. 129-138
    • Alloway, P.G.1    Howard, L.2    Dolph, P.J.3
  • 4
    • 0032979438 scopus 로고    scopus 로고
    • Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation
    • Behrens, A., Sibilia, M. & Wagner, E.F. (1999) Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nature Genet., 21, 326-329.
    • (1999) Nature Genet. , vol.21 , pp. 326-329
    • Behrens, A.1    Sibilia, M.2    Wagner, E.F.3
  • 5
    • 0035152487 scopus 로고    scopus 로고
    • Cell-permeable peptide inhibitors of JNK novel blockers of β-cell death
    • Bonny, C., Oberson, A., Negri, S., Sauser, C. & Schorderet, D.F. (2001) Cell-permeable peptide inhibitors of JNK novel blockers of β-cell death. Diabetes, 50, 77-82.
    • (2001) Diabetes , vol.50 , pp. 77-82
    • Bonny, C.1    Oberson, A.2    Negri, S.3    Sauser, C.4    Schorderet, D.F.5
  • 7
    • 0005033355 scopus 로고    scopus 로고
    • Cell-permeable peptides inhibit JNK action, and completely protect neurons from NMDA-induced necrotic death
    • Borsello, T., Bonny, C., Riederer, B.M. & Clarke, P.G.H. (2001) Cell-permeable peptides inhibit JNK action, and completely protect neurons from NMDA-induced necrotic death. Soc. Neurosci. Abstr., 27, 267-215.
    • (2001) Soc. Neurosci. Abstr. , vol.27 , pp. 267-215
    • Borsello, T.1    Bonny, C.2    Riederer, B.M.3    Clarke, P.G.H.4
  • 8
    • 0030757986 scopus 로고    scopus 로고
    • Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts
    • Brunk, U.T., Dalen, H., Roberg, K. & Hellquist, H.B. (1997) Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. Free Radic. Biol. Med., 23, 616-626.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 616-626
    • Brunk, U.T.1    Dalen, H.2    Roberg, K.3    Hellquist, H.B.4
  • 9
    • 0029741890 scopus 로고    scopus 로고
    • Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
    • Bursch, W., Ellinger, A., Kienzl, H., Török, L., Pandey, S., Sikorska, M., Walker, R. & Hermann, R.S. (1996) Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy. Carcinogenesis, 17, 1595-1607.
    • (1996) Carcinogenesis , vol.17 , pp. 1595-1607
    • Bursch, W.1    Ellinger, A.2    Kienzl, H.3    Török, L.4    Pandey, S.5    Sikorska, M.6    Walker, R.7    Hermann, R.S.8
  • 10
    • 0028793798 scopus 로고
    • Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation
    • Cavigelli, M., Dolfi, F., Claret, F.X. & Karin, M. (1995) Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO J., 14, 5957-5964.
    • (1995) EMBO J. , vol.14 , pp. 5957-5964
    • Cavigelli, M.1    Dolfi, F.2    Claret, F.X.3    Karin, M.4
  • 12
    • 0019968818 scopus 로고
    • Labelling of dying neurones by peroxidase injected intravascularly in chick embryos
    • Clarke, P.G.H. (1982) Labelling of dying neurones by peroxidase injected intravascularly in chick embryos. Neurosci. Lett., 30, 223-228.
    • (1982) Neurosci. Lett. , vol.30 , pp. 223-228
    • Clarke, P.G.H.1
  • 13
    • 0021133597 scopus 로고
    • Identical populations of phagocytes and dying neurons revealed by intravascularly injected horseradish peroxidase, and by endogenous glutaraldehyde-resistant acid phosphatase, in the brains of chick embryos
    • Clarke, P.G.H. (1984) Identical populations of phagocytes and dying neurons revealed by intravascularly injected horseradish peroxidase, and by endogenous glutaraldehyde-resistant acid phosphatase, in the brains of chick embryos. Histochem. J., 16, 955-969.
    • (1984) Histochem. J. , vol.16 , pp. 955-969
    • Clarke, P.G.H.1
  • 14
    • 0025283961 scopus 로고
    • Developmental cell death: Morphological diversity and multiple mechanisms
    • Clarke, P.G.H. (1990) Developmental cell death: morphological diversity and multiple mechanisms. Anat. Embryol. (Berlin), 181, 195-213.
    • (1990) Anat. Embryol. (Berlin) , vol.181 , pp. 195-213
    • Clarke, P.G.H.1
  • 15
    • 0002023977 scopus 로고    scopus 로고
    • Apoptosis versus necrosis. How valid a dichotomy for neurons?
    • Kaliotsos, V.E. & Ratan, R.R. (Eds). Humana Press, Totowa, NJ
    • Clarke, P.G.H. (1999) Apoptosis versus necrosis. How valid a dichotomy for neurons? In Kaliotsos, V.E. & Ratan, R.R. (Eds), Cell Death and Diseases of the Nervous System. Humana Press, Totowa, NJ, pp. 3-28.
    • (1999) Cell Death and Diseases of the Nervous System , pp. 3-28
    • Clarke, P.G.H.1
  • 16
    • 17644432163 scopus 로고
    • Effects of de-efferentation on chick spinal motoneurons: Peroxidase-uptake, and activities of acid phosphatase and N-acetyl-B-glucosaminidase
    • Clarke, P.G.H. & Martin, A.H. (1985) Effects of de-efferentation on chick spinal motoneurons: peroxidase-uptake, and activities of acid phosphatase and N-acetyl-B-glucosaminidase. Cell Biol. Int. Report, 9, 676-676.
    • (1985) Cell Biol. Int. Report , vol.9 , pp. 676
    • Clarke, P.G.H.1    Martin, A.H.2
  • 17
    • 0042815467 scopus 로고    scopus 로고
    • Endocytosis in excitotoxicity and its potential for specific targeting of neuroprotectants
    • Paris
    • Clarke, P.G.H., Bressoud, R., Croquelois, K., Hornung, J.P. & Borsello, T. (2002) Endocytosis in excitotoxicity and its potential for specific targeting of neuroprotectants. FENS Forum 2002, Paris, 149.8.
    • (2002) FENS Forum 2002 , vol.149 , pp. 8
    • Clarke, P.G.H.1    Bressoud, R.2    Croquelois, K.3    Hornung, J.P.4    Borsello, T.5
  • 18
    • 0030702877 scopus 로고    scopus 로고
    • Cleavage of rabaptin-5 blocks endosome fusion during apoptosis
    • Cosulich, S.C., Horiuchi, H., Zerial, M., Clarke, P.R. & Woodman, P.G. (1997) Cleavage of rabaptin-5 blocks endosome fusion during apoptosis. EMBO J., 16, 6182-6191.
    • (1997) EMBO J. , vol.16 , pp. 6182-6191
    • Cosulich, S.C.1    Horiuchi, H.2    Zerial, M.3    Clarke, P.R.4    Woodman, P.G.5
  • 19
    • 0028222874 scopus 로고
    • Autophagy and related mechanisms of lysosome-mediated protein degradation
    • Dunn, W.A. Jr (1994) Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol., 4, 139-143.
    • (1994) Trends Cell Biol. , vol.4 , pp. 139-143
    • Dunn W.A., Jr.1
  • 20
    • 0014913803 scopus 로고
    • A heme-peptide as an ultrastructural tracer
    • Feder, N. (1970) A heme-peptide as an ultrastructural tracer. J. Histochem. Cytochem., 18, 911-913.
    • (1970) J. Histochem. Cytochem. , vol.18 , pp. 911-913
    • Feder, N.1
  • 21
    • 0031694881 scopus 로고    scopus 로고
    • Endocytosis by the corneal endothelium. I. Regulation of binding and transport of hemeproteins and peroxidase-conjugated lectins across the tissue
    • Gordon, S.R., Czerwinski-Mowers, D., Marchand, J. & Shuffett, R. (1998) Endocytosis by the corneal endothelium. I. Regulation of binding and transport of hemeproteins and peroxidase-conjugated lectins across the tissue. Histochem. Cell Biol., 110, 251-262.
    • (1998) Histochem. Cell Biol. , vol.110 , pp. 251-262
    • Gordon, S.R.1    Czerwinski-Mowers, D.2    Marchand, J.3    Shuffett, R.4
  • 22
    • 0024370374 scopus 로고
    • Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos
    • Hornung, J.P., Koppel, H. & Clarke, P.G.H. (1989) Endocytosis and autophagy in dying neurons: an ultrastructural study in chick embryos. J. Comp. Neurol., 283, 425-437.
    • (1989) J. Comp. Neurol. , vol.283 , pp. 425-437
    • Hornung, J.P.1    Koppel, H.2    Clarke, P.G.H.3
  • 24
    • 0030741894 scopus 로고    scopus 로고
    • Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells
    • Kawasaki, H., Morooka, T., Shimohama, S., Kimura, J., Hirano, T., Gotoh, Y. & Nishida, E. (1997) Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem., 272, 18 518-18 521.
    • (1997) J. Biol. Chem. , vol.272 , pp. 18518-18521
    • Kawasaki, H.1    Morooka, T.2    Shimohama, S.3    Kimura, J.4    Hirano, T.5    Gotoh, Y.6    Nishida, E.7
  • 25
    • 0034307476 scopus 로고    scopus 로고
    • Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
    • Kegel, K.B., Kim, M., Sapp, E., McIntyre, C., Castaño, J.G., Aronin, N. & DiFiglia, M. (2000) Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J. Neurosci., 20, 7268-7278.
    • (2000) J. Neurosci. , vol.20 , pp. 7268-7278
    • Kegel, K.B.1    Kim, M.2    Sapp, E.3    McIntyre, C.4    Castaño, J.G.5    Aronin, N.6    DiFiglia, M.7
  • 26
    • 0033898887 scopus 로고    scopus 로고
    • Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
    • Kim, H.S., Park, C.H., Cha, S.H., Lee, J.H., Lee, S., Kim, Y., Rah, J.C., Jeong, S.J. & Suh, Y.H. (2000) Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. FASEB J., 14, 1508-1517.
    • (2000) FASEB J. , vol.14 , pp. 1508-1517
    • Kim, H.S.1    Park, C.H.2    Cha, S.H.3    Lee, J.H.4    Lee, S.5    Kim, Y.6    Rah, J.C.7    Jeong, S.J.8    Suh, Y.H.9
  • 27
    • 0033638395 scopus 로고    scopus 로고
    • A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila
    • Kiselev, A., Socolich, M., Vinos, J., Hardy, R.W., Zuker, C.S. & Ranganathan, R. (2000) A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila. Neuron, 28, 139-152.
    • (2000) Neuron , vol.28 , pp. 139-152
    • Kiselev, A.1    Socolich, M.2    Vinos, J.3    Hardy, R.W.4    Zuker, C.S.5    Ranganathan, R.6
  • 28
    • 0032184854 scopus 로고    scopus 로고
    • Ca2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures
    • Ko, H.W., Park, K.Y., Kim, H., Han, P.L., Kim, Y.U., Gwag, B.J. & Choi, E.J. (1998) Ca2+-mediated activation of c-Jun N-terminal kinase and nuclear factor kappa B by NMDA in cortical cell cultures. J. Neurochem., 71, 1390-1395.
    • (1998) J. Neurochem. , vol.71 , pp. 1390-1395
    • Ko, H.W.1    Park, K.Y.2    Kim, H.3    Han, P.L.4    Kim, Y.U.5    Gwag, B.J.6    Choi, E.J.7
  • 29
    • 0035955372 scopus 로고    scopus 로고
    • Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures
    • Kristensen, B.W., Noraberg, J. & Zimmer, J. (2001) Comparison of excitotoxic profiles of ATPA, AMPA, KA and NMDA in organotypic hippocampal slice cultures. Brain Res., 917, 21-44.
    • (2001) Brain Res. , vol.917 , pp. 21-44
    • Kristensen, B.W.1    Noraberg, J.2    Zimmer, J.3
  • 30
    • 0031942369 scopus 로고    scopus 로고
    • Calcium, free radicals and excitotoxins in neuronal apoptosis
    • Lipton, S.A. & Nicotera, P. (1998) Calcium, free radicals and excitotoxins in neuronal apoptosis. Cell Calcium, 23, 165-171.
    • (1998) Cell Calcium , vol.23 , pp. 165-171
    • Lipton, S.A.1    Nicotera, P.2
  • 32
    • 0034304390 scopus 로고    scopus 로고
    • The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review
    • Nixon, R.A., Cataldo, A.M. & Mathews, P.M. (2000) The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review. Neurochem. Res., 25, 1161-1172.
    • (2000) Neurochem. Res. , vol.25 , pp. 1161-1172
    • Nixon, R.A.1    Cataldo, A.M.2    Mathews, P.M.3
  • 33
    • 0036569331 scopus 로고    scopus 로고
    • Yeast autophagosomes: De novo formation of a membrane structure
    • Noda, T., Suzuki, K. & Ohsumi, Y. (2002) Yeast autophagosomes: de novo formation of a membrane structure. Trends Cell Biol., 12, 231-235.
    • (2002) Trends Cell Biol. , vol.12 , pp. 231-235
    • Noda, T.1    Suzuki, K.2    Ohsumi, Y.3
  • 34
    • 0002161368 scopus 로고    scopus 로고
    • Excitotoxic cell death
    • Koliatsos, V.E. & Ratan, R.R. (Eds). Humana Press, Totowa, NJ
    • Olney, J.W. & Ishimaru, M.J. (1999) Excitotoxic cell death. In Koliatsos, V.E. & Ratan, R.R. (Eds), Cell Death and Diseases of the Nervous System. Humana Press, Totowa, NJ, pp. 197-219.
    • (1999) Cell Death and Diseases of the Nervous System , pp. 197-219
    • Olney, J.W.1    Ishimaru, M.J.2
  • 35
    • 0020426353 scopus 로고
    • Mechanisms of chemical toxicity - A unifying hypothesis
    • Parke, D.V. (1982) Mechanisms of chemical toxicity - a unifying hypothesis. Regul. Toxicol. Pharmacol., 2, 267-286.
    • (1982) Regul. Toxicol. Pharmacol. , vol.2 , pp. 267-286
    • Parke, D.V.1
  • 37
    • 0031029859 scopus 로고    scopus 로고
    • Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum
    • Portera-Cailliau, C., Price, D.L. & Martin, L.J. (1997) Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J. Comp. Neurol., 378, 70-87.
    • (1997) J. Comp. Neurol. , vol.378 , pp. 70-87
    • Portera-Cailliau, C.1    Price, D.L.2    Martin, L.J.3
  • 38
    • 0026683322 scopus 로고
    • Toxin-induced cell lysis: Protection by 3-methyladenine and cycloheximide
    • Sandvig, K. & van Deurs, B. (1992) Toxin-induced cell lysis: protection by 3-methyladenine and cycloheximide. Exp. Cell Res., 200, 253-262.
    • (1992) Exp. Cell Res. , vol.200 , pp. 253-262
    • Sandvig, K.1    Van Deurs, B.2
  • 39
    • 0035815679 scopus 로고    scopus 로고
    • Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95
    • Savinainen, A., Garcia, E.P., Dorow, D., Marshall, J. & Liu, Y.F. (2001) Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95. J. Biol. Chem., 276, 11 382-11 386.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11382-11386
    • Savinainen, A.1    Garcia, E.P.2    Dorow, D.3    Marshall, J.4    Liu, Y.F.5
  • 40
    • 0034711544 scopus 로고    scopus 로고
    • Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background
    • Schauwecker, P.E. (2000) Seizure-induced neuronal death is associated with induction of c-Jun N-terminal kinase and is dependent on genetic background. Brain Res., 884, 116-128.
    • (2000) Brain Res. , vol.884 , pp. 116-128
    • Schauwecker, P.E.1
  • 41
    • 0030957325 scopus 로고    scopus 로고
    • Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons
    • Schwarzschild, M.A., Cole, R.L. & Hyman, S.E. (1997) Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons. J. Neurosci., 17, 3455-3466.
    • (1997) J. Neurosci. , vol.17 , pp. 3455-3466
    • Schwarzschild, M.A.1    Cole, R.L.2    Hyman, S.E.3
  • 42
    • 0036098552 scopus 로고    scopus 로고
    • AP-1 as a regulator of cell life and death
    • Shaulian, E. & Karin, M. (2002) AP-1 as a regulator of cell life and death. Nature Cell Biol., 4, E131-E136.
    • (2002) Nature Cell Biol. , vol.4
    • Shaulian, E.1    Karin, M.2
  • 43
    • 0021919140 scopus 로고
    • Dexamethasone increases expression of mannose receptors and decreases extracellular lysosomal enzyme accumulation in macrophages
    • Shepherd, V.L., Konish, M.G. & Stahl, P. (1985) Dexamethasone increases expression of mannose receptors and decreases extracellular lysosomal enzyme accumulation in macrophages. J. Biol. Chem., 260, 160-164.
    • (1985) J. Biol. Chem. , vol.260 , pp. 160-164
    • Shepherd, V.L.1    Konish, M.G.2    Stahl, P.3
  • 44
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini, L., Buchs, P.A. & Muller, D. (1991) A simple method for organotypic cultures of nervous tissue. J. Neurosci. Meth, 37, 173-182.
    • (1991) J. Neurosci. Meth , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 45
    • 0033621450 scopus 로고    scopus 로고
    • Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis
    • Swanton, E., Bishop, N. & Woodman, P. (1999) Human rabaptin-5 is selectively cleaved by caspase-3 during apoptosis. J. Biol. Chem., 274, 37 583-37 590.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37583-37590
    • Swanton, E.1    Bishop, N.2    Woodman, P.3
  • 46
    • 0032145886 scopus 로고    scopus 로고
    • Glutamate transporters are oxidant-vulnerable: A molecular link between oxidative and excitotoxic neurodegeneration?
    • Trotti, D., Danbolt, N.C. & Volterra, A. (1998) Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration? Trends Pharmacol. Sci., 19, 328-334.
    • (1998) Trends Pharmacol. Sci. , vol.19 , pp. 328-334
    • Trotti, D.1    Danbolt, N.C.2    Volterra, A.3
  • 47
    • 0031021357 scopus 로고    scopus 로고
    • An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus
    • Tsirka, S.E., Rogove, A.D., Bugge, T.H., Degen, J.L. & Strickland, S. (1997) An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J. Neurosci., 17, 543-552.
    • (1997) J. Neurosci. , vol.17 , pp. 543-552
    • Tsirka, S.E.1    Rogove, A.D.2    Bugge, T.H.3    Degen, J.L.4    Strickland, S.5
  • 48
    • 0026047370 scopus 로고
    • Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures
    • Vornov, J.J., Tasker, R.C. & Coyle, J.T. (1991) Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Exp. Neurol., 114, 11-22.
    • (1991) Exp. Neurol. , vol.114 , pp. 11-22
    • Vornov, J.J.1    Tasker, R.C.2    Coyle, J.T.3
  • 49
    • 0032870475 scopus 로고    scopus 로고
    • Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
    • Xue, L.Z., Fletcher, G.C. & Tolkovsky, A.M. (1999) Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution. Mol. Cell. Neurosci., 14, 180-198.
    • (1999) Mol. Cell. Neurosci. , vol.14 , pp. 180-198
    • Xue, L.Z.1    Fletcher, G.C.2    Tolkovsky, A.M.3
  • 51
    • 0037194894 scopus 로고    scopus 로고
    • A novel protein complex linking the d2 glutamate receptor and autophagy: Implications for neurodegeneration in Lurcher mice
    • Yue, Z.Y., Horton, A., Bravin, M., DeJager, P.L., Selimi, F. & Heintz, N. (2002) A novel protein complex linking the d2 glutamate receptor and autophagy: Implications for neurodegeneration in Lurcher mice. Neuron, 35, 921-933.
    • (2002) Neuron , vol.35 , pp. 921-933
    • Yue, Z.Y.1    Horton, A.2    Bravin, M.3    DeJager, P.L.4    Selimi, F.5    Heintz, N.6
  • 52
    • 0035142804 scopus 로고    scopus 로고
    • Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease
    • Zhu, X., Raina, A.K., Rottkamp, C.A., Aliev, G., Perry, G., Boux, H. & Smith, M.A. (2001) Activation and redistribution of c-Jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J. Neurochem., 76, 435-441.
    • (2001) J. Neurochem. , vol.76 , pp. 435-441
    • Zhu, X.1    Raina, A.K.2    Rottkamp, C.A.3    Aliev, G.4    Perry, G.5    Boux, H.6    Smith, M.A.7
  • 53
    • 0033782480 scopus 로고    scopus 로고
    • Neuronal apoptosis after CNS injury: The roles of glutamate and calcium
    • Zipfel, G.J., Babcock, D.J., Lee, J.M. & Choi, D.W. (2000) Neuronal apoptosis after CNS injury: The roles of glutamate and calcium. J. Neurotrauma, 17, 857-869.
    • (2000) J. Neurotrauma , vol.17 , pp. 857-869
    • Zipfel, G.J.1    Babcock, D.J.2    Lee, J.M.3    Choi, D.W.4


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