Coupling endoplasmic reticulum stress to the cell-death program: A novel HSP90-independent role for the small chaperone protein p23

Cell Death and Differentiation

Volumn 13, Issue 3, 2006, Pages 415-425

  Rao, R V ^a   Niazi, K ^a   Mollahan, P ^a   Mao, X ^a   Crippen, D ^a   Poksay, K S ^a   Chen, S ^a   Bredesen, D E ^a,b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Caspase; Endoplasmic reticulum; ER stress; HSP90; p23

Indexed keywords

BH3 PROTEIN; CALCIUM; CASPASE 3; CASPASE 7; CASPASE 8; CHAPERONE; HEAT SHOCK PROTEIN 90; PROTEIN P23; PROTEIN P53 UPREGULATED MODULATOR OF APOPTOSIS; SMALL INTERFERING RNA; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CALCIUM HOMEOSTASIS; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL ORGANELLE; CELL PROTECTION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN SYNTHESIS; STEROIDOGENESIS; STRESS; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; BCL-2-ASSOCIATED X PROTEIN; CASPASES; ENDOPLASMIC RETICULUM; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MICE; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS; RNA INTERFERENCE;

ANIMALIA;

EID: 33645141178     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401761     Document Type: Article

References (39)

1. Rutkowski DT and Kaufman RJ (2004) A trip to the ER: Coping with stress. Trends Cell Biol. 14: 20-28
2. Ron D (2002) Translational control in the endoplasmic reticulum stress response. J. Clin. Invest. 110: 1383-1388
3. Kaufman RJ (1999) Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls. Genes Dev. 13: 1211-1233
4. Rao RV, Ellerby HM and Bredesen DE (2004) Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 111: 372-380
5. Rao RV and Bredesen DE (2004) Misfolded proteins, endoplasmic reticulum stress and neurodegeneration. Curr. Opin. Cell Biol. 16: 653-662
6. Ward MW, Kogel D and Prehn JH (2004) Neuronal apoptosis: BH3-only proteins the real killers? J. Bioenerg. Biomembr. 36: 295-298
7. Rao RV, Poksay KS, Castro-Obregon S, Schilling B, Row RH, Del Rio G, Gibson BW, Ellerby HM and Bredesen DE (2004) Molecular components of a cell death pathway activated by endoplasmic reticulum stress. J. Biol. Chem. 279: 177-187
8. Rao RV, Hermel E, Castro-Obregon S, del Rio G, Ellerby LM, Ellerby HM and Bredesen DE (2001) Coupling endoplasmic reticulum stress to the cell death program. Mechanism of caspase activation. J. Biol. Chem. 276: 33869-33874
9. Felts SJ and Toft DO (2003) p23, a simple protein with complex activities. Cell Stress Chaperones 8: 108-113
10. Weaver AJ, Sullivan WP, Felts SJ, Owen BA and Toft DO (2000) Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone. J. Biol. Chem. 275: 23045-23052
11. Gazit G, Lu J and Lee AS (1999) De-regulation of GRP stress protein expression in human breast cancer cell lines. Breast Cancer Res. Treat 54: 135-146
12. Rao RV, Castro-Obregon S, Frankowski H, Schuler M, Stoka V, Del Rio G, Bredesen DE and Ellerby HM (2002) Coupling Endoplasmic Reticulum Stress to the Cell Death Program. AN Apaf-1-independent intrinsic pathway. J. Biol. Chem. 277: 21836-21842
13. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D and Yuan J (2005) A selective inhibitor of elF2alpha dephosphorylation protects cells from ER stress. Science 307: 935-939
14. Bourdon JC, Renzing J, Robertson PL, Fernandes KN and Lane DP (2002) Scotin, a novel p53-inducible proapoptotic protein located in the ER and the nuclear membrane. J. Cell Biol. 158: 235-246
15. Reimertz C, Kogel D, Rami A, Chittenden T and Prehn JH (2003) Gene expression during ER stress-induced apoptosis in neurons: Induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. J. Cell Biol. 162: 587-597
16. Weiki T, Abelmann K and Buchner J (1999) An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function. J. Mol. Biol. 293: 685-691
17. Oxelmark E, Knoblauch R, Amal S, Su LF, Schapira M and Garabedian MJ (2003) Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling. J. Biol. Chem. 278: 36547-36555
18. Liu FT, Newland AC and Jia L (2003) Bax conformational change is a crucial step for PUMA-mediated apoptosis in human leukemia. Biochem. Biophys. Res. Commun. 310: 956-962
19. Cartron PF, Gallenne T, Bougras G, Gautier F, Manero F, Vusio P, Meflah K, Vallette FM and Juin P (2004) The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA. Mol. Cell. 16: 807-818
20. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB and Korsmeyer SJ (2001) Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730
21. Chae HJ, Kim HR, Xu C, Bailly-Maitre B, Krajewska M, Krajewski S, Banares S, Cui J, Digicaylioglu M, Ke N, Kitada S, Monosov E, Thomas M, Kress CL, Babendure JR, Tsien RY, Lipton SA and Reed JC (2004) BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol. Cell 15: 355-366
22. Yamaguchi H and Wang HG (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J. Biol. Chem. 279: 45495-45502
23. Nakagawa T and Yuan J (2000) Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 150: 887-894
24. Rao RV, Peel A, Logvinova A, del Rio G, Hermel E, Yokota T, Goldsmith PC, Ellerby LM, Ellerby HM and Bredesen DE (2002) Coupling endoplasmic reticulum stress to the cell death program: Role of the ER chaperone GRP78. FEBS Lett. 514: 122-128
25. Zhu S and Tytgat J (2004) Evolutionary epitopes of Hsp90 and p23: implications for their interaction. FASEB. J. 18: 940-947
26. Bose S, Weikl T, Bugl H and Buchner J (1996) Chaperone function of Hsp90-associated proteins. Science 274: 1715-1717
27. Gausdal G, Gjertsen BT, Fladmark KE, Demol H, Vandekerckhove J and Doskeland SO (2004) Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. Leukemia 18: 1989-1996
28. Cheng EH, Kirsch DG, Clem RJ, Ravi R, Kasten MB, Bedi A, Ueno K and Hardwick JM (1997) Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278: 1966-1968
29. Li H, Zhu H, Xu CJ and Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501
30. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL and Zambetti GP (2003) Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4: 321-328
31. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L and Chittenden T (2001) Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc. Natl. Acad. Sci. USA 98: 11318-11323
32. Nakano K and Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7: 683-694
33. Yu J, Wang Z, Kinzler KW, Vogelstein B and Zhang L (2003) PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc. Natl. Acad. Sci. USA 100: 1931-1936
34. Danial NN and Korsmeyer SJ (2004) Cell death: Critical control points. Cell 116: 205-219
35. Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM and Huang DC (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol. Cell 17: 393-403
36. Freeman BC, Toft DO and Morimoto RI (1996) Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science 274: 1718-1720
37. Garcia-Ranea JA, Mirey G, Camonis J and Valencia A (2002) p23 and HSP20/ alpha-crystallin proteins define a conserved sequence domain present in other eukaryotic protein families. FEBS Lett. 529: 162-167
38. Morishima N, Nakanishi K, Takenouchi H, Shibata T and Yasuhiko Y (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J. Biol. Chem. 277: 34287-34294
39. Buckley CD, Pilling D, Henriquez NV, Parsonage G, Threlfall K, Scheel-Toellner D, Simmons DL, Akbar AN, Lord JM and Salmon M (1999) ROD peptides induce apoptosis by direct caspase-3 activation. Nature 397: 534-539