Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 287, Issue 3 50-3, 2004, Pages

  Adachi, Masayuki ^a   Higuchi, Hajime ^a   Miura, Soichiro ^b   Azuma, Toshifumi ^a   Inokuchi, Sayaka ^a   Saito, Hidetsugu ^a   Kato, Shinzo ^a   Ishii, Hiromasa ^a,c  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Alcoholic liver disease; Cytochrome c; Mitochondria; Oxidative stress

Indexed keywords

ALCOHOL; ANION CHANNEL; ANTIBODY; CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2;

ALCOHOL LIVER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; LIVER CELL; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL MEMBRANE PERMEABILITY; CROSS-LINKING REAGENTS; CYCLOSPORINE; CYTOCHROMES C; ELECTROPHYSIOLOGY; ETHANOL; HEPATOCYTES; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; ION CHANNEL GATING; ION CHANNELS; MALE; MICROINJECTIONS; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

EID: 4143093663     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00415.2003     Document Type: Article

References (42)

1. Antonsson B, Montessuit S, Sanchez B, and Martinou JC. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem 276: 11615-11623, 2001.
2. Benedetti A, BruneLLi E, Risicato R, Cilluffo T, Jezequel AM, and Orlandi F. Subcellular changes and apoptosis induced by ethanol in rat Liver. J Hepatol 6: 137-143, 1988.
3. Bernardi P. The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death. Biochim Biophys Acta 1275: 5-9, 1996.
4. Beutner G, Ruck A, Riede B, and Brdiczka D. Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases. Biochim Biophys Acta 1368: 7-18, 1998.
5. Cathcart R, Schwiers E, and Ames BN. Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem 134: 111-116, 1983.
6. Drochmans P, Wanson JC, and Mosselmans R. Isolation and subfractionation on ficoll gradients of adult rat hepatocytes. Size, morphology, and biochemical characteristics of cell fractions. J Cell Biol 66: 1-22, 1975.
7. Eskes R, Desagher S, Antonsson B, and Martinou JC. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane. Mol Cell Biol 20: 929-935, 2000.
8. Finucane DM, Bossy-Wetzel E, Waterhouse NJ, Cotter TG, and Green DR. Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL. J Biol Chem 274: 2225-2233, 1999.
9. Goldin RD, Hunt NC, Clark J, and Wickramasinghe SN. Apoptotic bodies in a murine model of alcoholic liver disease: reversibility of ethanol-induced changes. J Pathol 171: 73-76, 1993.
10. Green DR and Reed JC. Mitochondria and apoptosis. Science 281: 1309-1312, 1998.
11. Handler JA and Thurman RG. Redox interactions between catalase and alcohol dehydrogenase pathways of ethanol metabolism in the perfused rat liver. J Biol Chem 265: 1510-1515, 1990.
12. Higuchi H, Adachi M, Miura S, Gores GJ, and Ishii H. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. Hepatology 34: 320-328, 2001.
13. Hsu YT, Wolter KG, and Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci USA 94: 3668-3672, 1997.
14. Huser J, Rechenmacher CE, and Blatter LA. Imaging the permeability pore transition in single mitochondria. Biophys J 74: 2129-2137, 1998.
15. Ishii H, Kurose I, and Kato S. Pathogenesis of alcoholic liver disease with particular emphasis on oxidative stress. J Gastroenterol Hepatol 12: S272-S282, 1997.
16. Jones B, Roberts PJ, Faubion WA, Kominami E, and Gores GJ. Cystatin A expression reduces bile salt-induced apoptosis in a rat hepatoma cell line. Am J Physiol Gastrointest Liver Physiol 275: G723-G730, 1998.
17. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, and Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95: 4997-5002, 1998.
18. Kaplowitz N and Tsukamoto H. Oxidative stress and liver disease. Prog Liver Dis 14: 131-159, 1996.
19. Kawahara H, Matsuda Y, and Takase S. Is apoptosis involved in alcoholic hepatitis? Alcohol Alcohol 29, Suppl 1: 113-118, 1994.
20. Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, and Schlesinger PH. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ 7: 1166-1173, 2000.
21. Kurose I, Higuchi H, Kato S, Miura S, Watanabe N, Kamegaya Y, Tomita K, Takaishi M, Horie Y, Fukuda M, Mizukami K, and Ishii H. Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Gastroenterology 112: 1331-1343, 1997.
22. Kurose I, Higuchi H, Miura S, Saito H, Watanabe N, Hokari R, Hirokawa M, Takaishi M, Zeki S, Nakamura T, Ebinuma H, Kato S, and Ishii H. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication. Hepatology 25: 368-378, 1997.
23. Kurose I, Miura S, Fukumura D, Yonei Y, Saito H, Tada S, Suematsu M, and Tsuchiya M. Nitric oxide mediates Kupffer cell-induced reduction of mitochondrial energization in hepatoma cells: a comparison with oxidative burst. Cancer Res 53: 2676-2682, 1993.
24. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA, Brenner DA, and Herman B. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Biophys Acta 1366: 177-196, 1998.
25. Marzo I, Brenner C, Zamzami N, Jurgensmeier JM, Susin SA, Vieira HL, Prevost MC, Xie Z, Matsuyama S, Reed JC, and Kroemer G. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 281: 2027-2031, 1998.
26. Masini A, Ceccarelli D, Gallesi D, Giovannini F, and Trenti T. Lipid hydroperoxide induced mitochondrial dysfunction following acute ethanol intoxication in rats. The critical role for mitochondrial reduced glutathione. Biochem Pharmacol 47: 217-224, 1994.
27. Murphy KM, Streips UN, and Lock RB. Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2. Oncogene 18: 5991-5999, 1999.
28. Nanji AA. Apoptosis and alcoholic liver disease. Semin Liver Dis 18: 187-190, 1998.
29. Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H, and Tsujimoto Y. Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci USA 95: 14681-14686, 1998.
30. Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, and Gores GJ. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 34: 248-253, 2001.
31. Petit PX, Goubern M, Diolez P, Susin SA, Zamzami N, and Kroemer G. Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: the impact of irreversible permeability transition. FEBS Lett 426: 111-116, 1998.
32. Petronilli V, Miotto G, Canton M, Brini M, Colonna R, Bernardi P, and Di Lisa F. Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 76: 725-734, 1999.
33. Saito M, Korsmeyer SJ, and Schlesinger PH. BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol 2: 553-555, 2000.
34. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9: 459-470, 2002.
35. Shimizu S, Ide T, Yanagida T, and Tsujimoto Y. Electrophysiological study of a novel large pore formed by Bax and the voltage-dependent anion channel that is permeable to cytochrome c. J Biol Chem 275: 12321-12325, 2000.
36. Shimizu S, Matsuoka Y, Shinohara Y, Yoneda Y, and Tsujimoto Y. Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol 152: 237-250, 2001.
37. Shimizu S, Narita M, and Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483-487, 1999.
38. Susin SA, Zamzami N, and Kroemer G. Mitochondria as regulators of apoptosis: doubt no more. Biochim Biophys Acta 1366: 151-165, 1998.
39. Thornberry NA and Lazebnik Y Caspases: enemies within. Science 281: 1312-1316, 1998.
40. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, and Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139: 1281-1292, 1997.
41. Yerushalmi B, Dahl R, Devereaux MW, Gumpricht E, and Sokol RJ. Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition. Hepatology 33: 616-626, 2001.
42. Zoratti M and Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta 1241: 139-176, 1995.