The low-affinity nerve growth factor receptor p75(NGFR) mediates death of PC12 cells after nerve growth factor withdrawal

Journal of Neuroscience Research

Volumn 45, Issue 2, 1996, Pages 117-128

  Barrett, Graham L ^a   Georgiou, A ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

antisense inhibition of gene expression; apoptosis; neurotrophins; p75(NGFR); PC12 cells; trk proteins

Indexed keywords

NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; GENE REPRESSION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION;

ANIMALS; CELL DEATH; CELL DIFFERENTIATION; CELL SURVIVAL; DOWN-REGULATION; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; PC12 CELLS; RATS; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, NERVE GROWTH FACTOR; RNA, MESSENGER;

EID: 0030017892     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960715)45:2<117::AID-JNR4>3.0.CO;2-D     Document Type: Article

References (31)

1. NGFR nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development. Proc Natl Acad Sci USA 91: 6501-6505.
2. Benedetti M, Levi A, Chao MV (1993): Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc Natl Acad Sci USA 90: 7859-7863.
3. Bothwell M (1991): Tissue localisation of nerve growth factor and nerve growth factor receptors. Curr Top Microbiol Immunol 165:55-70.
4. Carroll SL, Silos-Santiago I, Frese SE, Ruit KG, Milbrandt J, Snider WD (1992): Dorsal root ganglion neurons expressing trk are selectively sensitive to NGF deprivation in utero. Neuron 9:779-788.
5. Davies AM, Lee KF, Jaenisch R (1993): p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11:565-574.
6. Dechant G, Rodriguez-Tebar A, Barde YA (1994): Neurotrophin receptors. Prog Neurobiol 42:347-352.
7. Dobrowsky RT, Werner M, Castellino AM, Chao MV, Hannun YA (1994): Activation of the sphingomyelin cycle through the low-affinity NGF receptor. Science 265:1596-1599.
8. Greene LA (1978): Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. Cell Biol 78:747-755.
9. Hantzopoulos PA, Suri C, Glass DJ, Goldfarb MP, Yancopoulos GD (1994): The low affinity NGF receptor, p75, can collaborate with each of the trks to potentiate functional responses to the neurotrophins. Neuron 13:187-201.
10. Hempstead BL, Rabin SJ, Kaplan L, Reid S, Parada LF, Kaplan DR (1992): Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron 9:883-896.
11. Ibanez CF, Ebendal T, Barbany G, Murray-Rust J, Blundell TL, Persson H (1992): Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product. Cell 69:329-341.
12. Jing S, Tapley P, Barbacid M (1992): Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron 9:1067-1079.
13. Johnson E Jr, Yip HK (1985): Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival. Nature 314:751-752.
14. Johnson E Jr, Taniuchi M, Clark HB, Springer JE, Koh S, Tayrien MW, Loy R (1987): Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system. J Neurosci 7:923-929.
15. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF (1991): The trk proto-oncogene product: A signal transducing receptor for nerve growth factor. Science 252:554-558.
16. Kiss J, Shooter EM, Patel AJ (1993): A low-affinity nerve growth factor receptor antibody is internalized and retrogradely transported selectively into cholinergic neurons of the rat basal forebrain. Neuroscience 57:297-305.
17. Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M (1991): The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189-197.
18. Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R (1992): Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69:737-749.
19. Lee KF, Davies AM, Jaenisch R (1994): p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. Development 120:1027-1033.
20. Loeb DM, Greene LA (1993): Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants. J Neurosci 13:2919-2929.
21. Loeb DM, Maragos J, Martin-Zanca D, Chao MV, Parada LF, Greene LA (1991): The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines. Cell 66: 961-966.
22. Mahadeo D, Kaplan L, Chao MV, Hempstead BL (1994): High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors. J Biol Chem 269:6884-6891.
23. McMahon SB, Armanini MP, Ling LH, Phillips HS (1994): Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron 12:1161-1171.
24. Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE (1993): Induction of apoptosis by the low-affinity NGF receptor. Science 261:345-348.
25. Rabizadeh S, Bitler CM, Butcher LL, Bredesen DE (1994): Expression of the low-affinity nerve growth factor receptor enhances β-amyloid peptide toxicity. Proc Natl Acad Sci USA 91: 10703-10706.
26. Rothe M, Wong SC, Henzel WJ, Goeddel DV (1994): A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78:681-692.
27. Tybulewicz VL, Crawford CE, Jackson PK, Bronson RT, Mulligan RC (1991): Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65: 1153-1163.
28. Verdi JM, Birren SJ, Ibanez CF, Persson H, Kaplan DR, Benedetti M, Chao MV, Anderson DJ (1994): p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron 12:733-745.
29. Verge VM, Merlio JP, Grondin J, Ernfors P, Persson H, Riopelle RJ, Hokfelt T, Richardson PM (1992): Colocalization of NGF binding sites, trk mRNA, and low-affinity NGF receptor mRNA in primary sensory neurons: Responses to injury and infusion of NGF. J Neurosci 12:4011-4022.
30. Vickland H, Westrum LE, Kott JN, Patterson SL, Bothwell MA (1991): Nerve growth factor receptor expression in the young and adult rat olfactory system. Brain Res 565:269-279.
31. Van Q, Johnson E Jr (1987): A quantitative study of the developmental expression of nerve growth factor (NGF) receptor in rats. Dev Biol 121:139-148.