Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

Nature

Volumn 399, Issue 6733, 1999, Pages 263-267

  Ona, Victor O ^a   Li, Mingwel ^a   Vonsattel, Jean Paul G ^b   John Andrews, L ^a   Khan, Sohall Q ^a   Chung, Woosik M ^b   Frey, Ariel S ^b   Menon, Anil S ^b   Li, Xiao Jiang ^c   Stieg, Philip E ^a   Yuan, Junying ^d   Penney, John B ^b   Young, Anne B ^b   Cha, Jang Ho J ^b   Friedlander, Robert M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; HUNTINGTIN; INTERLEUKIN 1BETA CONVERTING ENZYME; NEUROTRANSMITTER RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CORPUS STRIATUM; DISEASE COURSE; ENZYME ACTIVATION; HUNTINGTON CHOREA; MALE; MOLECULAR WEIGHT; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; TRANSGENIC MOUSE;

ANIMALS; BRAIN; CASPASE 1; DISEASE PROGRESSION; ENZYME ACTIVATION; ENZYME INHIBITORS; FEMALE; HUNTINGTON DISEASE; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-1; MALE; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; WEIGHT LOSS;

ANIMALIA; MUS MUSCULUS;

EID: 0033587128     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/20446     Document Type: Article

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