A new paradigm for neurotoxicity by FAD mutants of βAPP: A signaling abnormality

Neurobiology of Aging

Volumn 19, Issue SUPPL. 1, 1998, Pages

  Nishimoto, I ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

APp; Alzheimer's disease; Apoptosis; Autoactivation; Familial; G ; G(o) protein; Signal transduction; Transmembrane configuration

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN;

ALZHEIMER DISEASE; APOPTOSIS; CELL DEATH; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NEUROTOXICITY; POINT MUTATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; GTP-BINDING PROTEINS; HUMANS; MEMBRANE PROTEINS; MUTATION; NERVE DEGENERATION; PRESENILIN-1; SIGNAL TRANSDUCTION;

EID: 0031967942     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(98)00040-2     Document Type: Conference Paper

References (73)

1. Alcedo J., Ayzenzon M., Von Ohlen T., Noll M., Hooper J. E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell. 86:1996;221-232.
2. Asano T., Morishita R., Matsuda T., Fukada Y., Yoshizawa T., Kato K. Purification of four forms of the βγ subunit complex of G proteins containing different γ subunits. J. Biol. Chem. 268:1993;20512-20519.
3. o in neuronal membranes. Abstract of Society for Neuroscience. 21:Part1:207; 1995.
4. Bourne H. R., Sanders D. A., McCormick F. The GTPase superfamily Conserved structure and molecular mechanism . Nature. 349:1991;117-127.
5. Bourne H. R., Sanders D. A., McCormick F. The GTPase superfamily A conserved switch for diverse cell functions . Nature. 348:1990;125-132.
6. Camps M., Carozzi A., Schnabel P., Scheer A., Parker P. J., Gierschik P. Isoenzyme-selective stimulation of phospholipase C-β2 by G protein βγ-subunits. Nature. 360:1992;684-686.
7. Carracedo J., Ramirez R., Marchetti P., Pintado O. C., Baixeras E., Martinez C., Kroemer G. Pertussis toxin-sensitive GTP-binding proteins regulate activation-induced apoptotic cell death of human natural killer cells. Eur. J. Immunol. 25:1995;3094-3099.
8. Chartier-Harlin M.-C., Crawford F., Houlden H., Warren A., Hughes D., Fidani L., Goate A., Rossor M., Roques P., Hardy J. Mullan, M. Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene. Nature. 353:1991;844-846.
9. Chow N., Korenberg J. R., Chen X. N., Neve R. L. APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein. J. Biol. Chem. 271:1996;11339-11346.
10. Clapham D. E., Neer E. J. New roles for G-protein βγ-dimers in transmembrane signalling. Nature. 365:1993;403-406.
11. iα Nature. 363:1993;274-276.
12. Coso O. A., Teramoto H., Simonds W. F., Gutkind J. S. Signaling from G protein-coupled receptors to c-Jun kinase involves βγ subunits of heterotrimeric G proteins acting on a Ras and Rac1-dependent pathway. J. Biol. Chem. 271:1996;3963-3966.
13. Crespo P., Xu N., Simonds W. F., Gutkind J. S. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature. 369:1994;418-420.
14. Dittman A. H., Weber J. P., Hinds T. J., Choi E. J., Migeon J. C., Nathanson N. M., Storm D. R. A novel mechanism for coupling of m4 muscarinic acetylcholine receptors to calmodulin-sensitive adenylyl cyclases Crossover from G protein-coupled inhibition to stimulation . Biochemistry. 33:1994;943-951.
15. 2+ channels. Cell. 67:1991;21-33.
16. Dyrks T., Weidemann A., Multhaup G., Salbaum J. M., Lemaire H.-G., Kang J., Müller-Hill B., Masters C. L., Beyreuther K. Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease. EMBO J. 7:1988;949-957.
17. Fiore F., Zambrano N., Minopoli G., Donini V., Duilio A., Russo T. The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J. Biol. Chem. 270:1995;30853-30856.
18. Giambarella U., Yamatsuji T., Okamoto T., Matsui T., Ikezu T., Murayama Y., Levine M. A., Katz A., Gautam N., Nishimoto I. G protein βγ complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. EMBO J. 16:1997;4897-4907.
19. Goate A., Chartier-Harlin M.-C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., Mant R., Newton P., Rooke K., Roques P., Talbot C., Pericak-Vance M., Roses A., Williamson R., Rossor M., Owen M., Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
20. Goh J. W., Pennefather P. S. A pertussis toxin-sensitive G protein in hippocampal long-term potentiation. Science. 244:1989;980-983.
21. Gong X., Dubois D. H., Miller D. J., Shur B. D. Activation of a G protein complex by aggregation of β-1,4-galactosyltransferase on the surface of sperm. Science. 269:1995;1718-1721.
22. Gonzalo J. A., Gonzalez-Garcia A., Baixeras E., Zamzami N., Tarazona R., Rappuoli R., Marinez C., Kroemer G., Terezone R. J. Pertussis toxin interferes with superantigen-induced deletion of peripheral T cells without affecting T cell activation in vivo. Inhibition of deletion and associated programmed cell death depends on ADP-ribosyltransferase activity. J. Immunol. 152:1994;4291-4299.
23. Hardy J. Framing β-amyloid. Nature Genetics. 1:1992;233-234.
24. Hart A. C., Kramer H., Zipursky S. L. Extracellular domain of the boss transmembrane ligand acts as an antagonist of the sev receptor. Nature. 361:1993;732-736.
25. Ikezu T., Okamoto T., Komatsuzaki K., Matsui T., Martyn J. A. J., Nishimoto I. Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP. EMBO J. 15:1996;2468-2475.
26. 2-adrenergic receptor and have a Phe substitute in the G protein-activator sequence motif. FEBS Lett. 311:1992;29-32.
27. Inglese J., Koch W. J., Caron M. G., Lefkowitz R. J. Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. Nature. 359:1992;147-150.
28. Iñiguez-Lluhi J. A., Simon M. I., Robishaw J. D., Gilman A. G. G protein βγ subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of γ J. Biol. Chem. 267:1992;23409-23417.
29. Ito I., Okada D., Sugiyama H. Pertussis toxin suppresses long-term potentiation of hippocampal mossy fiber synapses. Neurosci. Lett. 90:1988;181-185.
30. Kang J., Lemaire H.-G., Unterback A, Salbaum J. M., Masters C. L., Grezeschik K. H., Multhaup G., Beyreuther K., Mer-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature. 325:1987;733-736.
31. Karlinsky H., Vaula G., Haines J. L., Ridgley J., Bergeron C., Mortilla M., Tupler R. G., Percy M. E., Robitaille Y., Noldy N. E., Yip T. C. K., Tanzi R. E., Gusella J. F., Becker R., Berg J. M., McLachlan D. R. C., St. George-Hyslop P. H. Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β-amyloid precursor protein gene. Neurology. 42:1992;1445-1453.
32. Katz A., Wu D., Simon M. I. Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C. Nature. 360:1992;686-689.
33. Kitaguchi N., Takahashi Y., Tokushima Y., Shiojiri S., Ito H. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature. 331:1988;530-532.
34. Komatsuzaki K., Murayama Y., Giambarella U., Ogata E., Seino S., Nishimoto I. A novel system that reports the G proteins linked to a given receptor a study of type 3 somatostatin receptor . FEBS Lett. 406:1997;165-170.
35. Krasnoperov V. G., Bittner M. A., Beavis R., Kuang Y., Salnikow K. V., Chepurny O. G., Little A. R., Plotnikov A. N., Wu D., Holz R. W., Petrenko A. G. α-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor. Neuron. 18:1997;925-937.
36. Lang J., Nishimoto I., Okamoto T., Sadoul K., Regazzi R., Kiraly K., Weller U., Wollheim C. B. Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active Gα subunits. EMBO J. 14:1995;3635-3644.
37. Lelianova V. G., Davletov B. A., Sterling A., Rahman M. A., Grishin E. V., Totty N. F., Ushkaryov Y. A. α-Latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors. J. Biol. Chem. 272:1997;21504-21508.
38. i and Gs. Requirement for multiple cytoplasmic domains in the coupling process. J. Biol. Chem. 266:1991;4816-4821.
39. Murayama Y., Takeda S., Yonezawa K., Ogata E., Nishimoto I. Cell surface receptor function of Alzheimer amyloid precursor protein activating Ser/Thr kinases. Gerontology. 42:1996;2-11.
40. Murrell J., Farlow M., Ghetti B., Benson M. D. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science. 254:1991;97-99.
41. Naruse S., Igarashi S., Kobayashi H., Aoki K., Inuzuka T., Kaneko K., Shimizu S., Iihara K., Kojima T., Miyatake T., Tsuji S. Mis-sense mutation Vallt→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease. Lancet. 337:1991;978-979.
42. Nishimoto I., Okamoto T., Matsuura Y., Okamoto T., Murayama Y., Ogata E. Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o). Nature. 362:1993;75-79.
43. Okamoto T., Takeda S., Giambarella U., Matsuura Y., Katada T., Nishimoto I. Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease. EMBO J. 15:1996;3769-3777.
44. Okamoto T., Takeda S., Murayama Y., Ogata E., Nishimoto I. Ligand-dependent G protein coupling function of amyloid transmembrane precursor. J. Biol. Chem. 270:1995;4205-4208.
45. 2-adrenergic receptors based upon characteristics in primary structure. J. Biol. Chem. 267:1992;8342-8346.
46. Okamoto T., Murayama Y., Hayashi Y., Inagaki M., Ogata E., Nishimoto I. Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation. Cell. 67:1991;723-730.
47. Okamoto T., Katada T., Murayama Y., Ui M., Ogata E., Nishimoto I. A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor. Cell. 62:1990;709-717.
48. Ponte P., Gonzalez-DeWhitt P., Schilling J., Miller J., Hsu D., Greenberg B., Davis K., Wallace W., Lieberburg I., Fuller F., Cordell B. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature. 311:1988;525-527.
49. Ramirez R., Carracedo J., Zamzami N., Castedo M., Kroemer G. Pertussis toxin inhibits activation-induced cell death of human thymocytes, pre-B leukemia cells and monocytes. J. Exp. Med. 180:1994;1147-1152.
50. Reuveny E., Slesinger P. A., Inglese J., Morales J. M., Iñiguez-Lluhi J. A., Lefkowitz R. J., Bourne H. R., Jan Y. N., Jan L. Y. Activation of the cloned muscarinic potassium channel by G protein βγ subunits. Nature. 370:1994;143-146.
51. Rogaev E. I., Sherrington R., Rogaeva E. A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., Mar L., Sorbi S., Nacmias B., Piacentini S., Amaducci L., Chumakov I., Cohen D., Lannfelt L., Fraser P. E., Rommens J. M., St. George-Hyslop P. H. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature. 376:1995;775-778.
52. Schuch U., Lohse M. J., Schachner M. Neural cell adhesion molecules influence second messenger systems. Neuron. 3:1989;13-20.
53. Selkoe D. J. Cell biology of the amyloid β-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell. Biol. 10:1994;373-403.
54. Shayeghi M., Doe C. L., Tavassoli M., Watts F. Z. Characterization of Schizosaccharomyces pombe rad31, a UBA-related gene required for DNA damage tolerance. Nucleic Acids Res. 25:1997;1162-1169.
55. Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J.-F., Bruni A. C., Montesi M. P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D., Brookes A., Sanseau P., Polinsky R. J., Wasco W., Da Silva H. A. R., Haines J. L., Pericak-Vance M. A., Tanzi R. E., Roses A. D., Fraser P. E., Rommens J. M., St. George-Hyslop P. H. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
56. Stephens L., Smrcka A., Cooke F. T., Jackson T. R., Sternweis P. C., Hawkins P. T. A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell. 77:1994;83-93.
57. o promote an increased number of neurites per cell. J. Neurosci. 14:1994;2327-2338.
58. Sun H., Seyer J. M., Patel T. B. A region in the cytosolic domain of the epidermal growth factor receptor antithetically regulates the stimulatory and inhibitory guanine nucleotide-binding regulatory proteins of adenylyl cyclase. Proc. Natl. Acad. Sci. USA. 92:1995;2229-2233.
59. 717) mutants. Science. 264:1994;1336-1340.
60. Tang W. J., Gilman A. G. Adenylyl cyclases. Cell. 70:1992;869-872.
61. Tanzi R. E., McClatchey A. I., Lamperti E. D., Villa-Komaroff L., Gusella J. F., Neve R. L. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. 331:1988;528-530.
62. Thomason P. A., James S. R., Casey P. J., Downes C. P. A G-protein βγ-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol. J. Biol. Chem. 269:1994;16525-16528.
63. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3 . Science. 271:1996;521-525.
64. Wolozin B., Iwasaki K., Vito P., Ganjei J. K., Lacaná E., Sunderland T., Zhao B., Kusiak J. W., Wasco W., D'Adamio L. Participation of presenilin 2 in apoptosis Enhanced basal activity conferred by an Alzheimer mutation . Science. 274:1996;1710-1713.
65. Woolkalis M. J., Manning D. R. Structural characteristics of the 35- and 36-kDa forms of the β subunit common to GTP-binding regulatory proteins. Mol. Pharmacol. 32:1987;1-6.
66. Xia W., Zhang J., Perez R., Koo E. H., Selkoe D. J. Interaction between amyloid precursor protein and presenilins in mammalian cells implications for the pathogenesis of Alzheimer disease . Proc. Natl. Acad. Sci. USA. 94:1997;8208-8213.
67. Yamatsuji T., Okamoto T., Takeda S., Murayama Y., Tanaka N., Nishimoto I. Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait-linked phenotype. EMBO J. 15:1996;498-509.
68. Yamatsuji T., Okamoto T., Takeda S., Fukumoto H., Iwatsubo T., Suzuki N., Asami-Odaka A., Ireland S., Kinane T. B., Nishimoto I. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science. 272:1996;1349-1352.
69. Yan G.-M., Lin S.-Z., Irwin R. P., Paul S. M. Activation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons. J. Neurochem. 65:1995;2425-2431.
70. Yan K., Kalyanaraman V., Gautam N. Differential ability to form the G protein βγ complex among members of the β and γ subunit families. J. Biol. Chem. 271:1996;7141-7146.
71. 717Vallt→Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups. Biochem. Biophys. Res. Commun. 178:1991;1141-1146.
72. Zambrano N., Buxbaum J. D., Minopoli G., Fiore F., De Candia P., De Renzis S., Faraonio R., Sabo S., Cheetham J., Sudol M., Russo T. Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's β-amyloid precursor proteins. J. Biol. Chem. 272:1997;6399-6405.
73. Zhao B., Chrest F. J., Horton W. E. Jr, Sisodia S. S., Kusiak J. W. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells. J. Neurosci. Res. 47:1997;253-263.