-
1
-
-
0043236283
-
Protein folding and misfolding: A paradigm of self-assembly and regulation in complex biogical systems
-
Vendruscolo, M., Zurdo, J., MacPhee, C. E. & Dobson, C. M. Protein folding and misfolding: a paradigm of self-assembly and regulation in complex biogical systems. Phil. Trans. R. Soc. Lond. 361, 1205-1222 (2003).
-
(2003)
Phil. Trans. R. Soc. Lond.
, vol.361
, pp. 1205-1222
-
-
Vendruscolo, M.1
Zurdo, J.2
MacPhee, C.E.3
Dobson, C.M.4
-
2
-
-
0033617266
-
From computer simulations to human disease: Emerging themes in protein folding
-
Radford, S. E. & Dobson, C. M. From computer simulations to human disease: emerging themes in protein folding. Cell 97, 291-298 (1999).
-
(1999)
Cell
, vol.97
, pp. 291-298
-
-
Radford, S.E.1
Dobson, C.M.2
-
3
-
-
0344301982
-
Protein folding: A perspective from theory and experiment
-
Dobson, C. M., Sali, A. & Karplus, M. Protein folding: a perspective from theory and experiment. Angew. Chem. Int. Ed. Eng. 37, 868-893 (1998).
-
(1998)
Angew. Chem. Int. Ed. Eng.
, vol.37
, pp. 868-893
-
-
Dobson, C.M.1
Sali, A.2
Karplus, M.3
-
4
-
-
0028924552
-
Navigating the folding routes
-
Wolynes, P. G., Onuchic, J. N. & Thirumalai, D. Navigating the folding routes. Science 267, 1619-1620 (1995).
-
(1995)
Science
, vol.267
, pp. 1619-1620
-
-
Wolynes, P.G.1
Onuchic, J.N.2
Thirumalai, D.3
-
5
-
-
1842298212
-
From Levinthal to pathways to funnels
-
Dill, K. A. & Chan, H. S. From Levinthal to pathways to funnels. Nature Struct. Biol. 4, 10-19 (1997).
-
(1997)
Nature Struct. Biol.
, vol.4
, pp. 10-19
-
-
Dill, K.A.1
Chan, H.S.2
-
6
-
-
0009586942
-
Understanding protein folding via free energy surfaces from theory and experiment
-
Dinner, A. R., Sali, A., Smith, L. J., Dobson, C. M. & Karplus, M. Understanding protein folding via free energy surfaces from theory and experiment. Trends Biochem. Sci. 25, 331-339 (2000).
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 331-339
-
-
Dinner, A.R.1
Sali, A.2
Smith, L.J.3
Dobson, C.M.4
Karplus, M.5
-
7
-
-
0028776642
-
Protein folding: Matching speed and stability
-
Baldwin, R. L. Protein folding: matching speed and stability. Nature 369, 183-184 (1994).
-
(1994)
Nature
, vol.369
, pp. 183-184
-
-
Baldwin, R.L.1
-
8
-
-
0542397796
-
Kinetics and dynamics of loops, α-helices, β-hairpins, and fast-folding proteins
-
Eaton, W. A., Munoz, V., Thompson, P. A., Henry, E. R. & Hofrichter, J. Kinetics and dynamics of loops, α-helices, β-hairpins, and fast-folding proteins. Acc. Chem. Res. 31, 745-753 (1998).
-
(1998)
Acc. Chem. Res.
, vol.31
, pp. 745-753
-
-
Eaton, W.A.1
Munoz, V.2
Thompson, P.A.3
Henry, E.R.4
Hofrichter, J.5
-
9
-
-
0037038372
-
Absolute comparison of simulated and experimental protein-folding dynamics
-
Snow, C. D., Nguyen, H., Pande, V. S. & Gruebele, M. Absolute comparison of simulated and experimental protein-folding dynamics. Nature 420, 102-106 (2002).
-
(2002)
Nature
, vol.420
, pp. 102-106
-
-
Snow, C.D.1
Nguyen, H.2
Pande, V.S.3
Gruebele, M.4
-
10
-
-
0038329308
-
Folding at the speed limit
-
Yang, W. Y. & Gruebele, M. Folding at the speed limit. Nature 423, 193-197 (2003).
-
(2003)
Nature
, vol.423
, pp. 193-197
-
-
Yang, W.Y.1
Gruebele, M.2
-
11
-
-
0037456298
-
The complete folding pathway of a protein from nanoseconds to microseconds
-
Mayor, U. et al. The complete folding pathway of a protein from nanoseconds to microseconds. Nature 421, 863-867 (2003).
-
(2003)
Nature
, vol.421
, pp. 863-867
-
-
Mayor, U.1
-
12
-
-
0032502839
-
Contact order, transition state placement and the refolding rates of single domain proteins
-
Plaxco, K. W., Simons, K. T. & Baker, D. Contact order, transition state placement and the refolding rates of single domain proteins. J. Mol. Biol. 277, 985-994 (1998).
-
(1998)
J. Mol. Biol.
, vol.277
, pp. 985-994
-
-
Plaxco, K.W.1
Simons, K.T.2
Baker, D.3
-
13
-
-
0037126290
-
Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy
-
Schuler, B., Lipman, E. A. & Eaton, W. A. Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy. Nature 419, 743-747 (2002).
-
(2002)
Nature
, vol.419
, pp. 743-747
-
-
Schuler, B.1
Lipman, E.A.2
Eaton, W.A.3
-
15
-
-
0034652206
-
Transition-state structure as a unifying basis in protein-folding mechanisms: Contact order, chain topology, stability, and the extended nucleus mechanism
-
Fersht, A. R. Transition-state structure as a unifying basis in protein-folding mechanisms: contact order, chain topology, stability, and the extended nucleus mechanism. Proc. Natl Acad. Sci. USA 97, 1525-1529 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1525-1529
-
-
Fersht, A.R.1
-
16
-
-
0034743155
-
From folding surfaces to folding proteins: A review and assessment of simulation studies of protein folding and unfolding
-
Shea, J. E. & Brooks, C. L. From folding surfaces to folding proteins: a review and assessment of simulation studies of protein folding and unfolding. Annu. Rev. Phys. Chem. 52, 499-535 (2001).
-
(2001)
Annu. Rev. Phys. Chem.
, vol.52
, pp. 499-535
-
-
Shea, J.E.1
Brooks, C.L.2
-
17
-
-
0037154980
-
Protein folding and unfolding at atomic resolution
-
Fersht, A. R. & Daggett, V. Protein folding and unfolding at atomic resolution. Cell 108, 573-582 (2002).
-
(2002)
Cell
, vol.108
, pp. 573-582
-
-
Fersht, A.R.1
Daggett, V.2
-
18
-
-
0035252350
-
Three key residues form a critical contact network in a transition state for protein folding
-
Vendruscolo, M., Paci, E., Dobson, C. M. & Karplus, M. Three key residues form a critical contact network in a transition state for protein folding. Nature 409, 641-646 (2001).
-
(2001)
Nature
, vol.409
, pp. 641-646
-
-
Vendruscolo, M.1
Paci, E.2
Dobson, C.M.3
Karplus, M.4
-
19
-
-
0037215268
-
The topomer search model: A simple, quantitative theory of two-state protein folding kinetics
-
Makarov, D. E. & Plaxco, K. W. The topomer search model: a simple, quantitative theory of two-state protein folding kinetics. Protein Sci. 12, 17-26 (2003).
-
(2003)
Protein Sci.
, vol.12
, pp. 17-26
-
-
Makarov, D.E.1
Plaxco, K.W.2
-
20
-
-
0034604105
-
A surprising simplicity to protein folding
-
Baker, D. A surprising simplicity to protein folding. Nature 405, 39-42 (2000).
-
(2000)
Nature
, vol.405
, pp. 39-42
-
-
Baker, D.1
-
21
-
-
0031055942
-
Kinetic role of early intermediates in protein folding
-
Roder, H. & Colon, W. Kinetic role of early intermediates in protein folding. Curr. Opin. Struct. Biol. 7, 15-28 (1997).
-
(1997)
Curr. Opin. Struct. Biol.
, vol.7
, pp. 15-28
-
-
Roder, H.1
Colon, W.2
-
22
-
-
0037225280
-
Evidence for sequential barriers and obligatory intermediates in apparent two-state protein folding
-
Sanchez, I. E. & Kiefhaber, T. Evidence for sequential barriers and obligatory intermediates in apparent two-state protein folding. J. Mol. Biol. 325, 367-376 (2003).
-
(2003)
J. Mol. Biol.
, vol.325
, pp. 367-376
-
-
Sanchez, I.E.1
Kiefhaber, T.2
-
23
-
-
0141457507
-
The kinetic pathway of folding of barnase
-
Khan, F., Chuang, J. I., Gianni, S. & Fersht, A. R. The kinetic pathway of folding of barnase. J. Mol. Biol. 333, 169-186 (2003).
-
(2003)
J. Mol. Biol.
, vol.333
, pp. 169-186
-
-
Khan, F.1
Chuang, J.I.2
Gianni, S.3
Fersht, A.R.4
-
24
-
-
0345598912
-
Structures and relative free energies of partially folded states of proteins
-
Vendruscolo, M., Paci, E., Karplus, M. & Dobson, C. M. Structures and relative free energies of partially folded states of proteins. Proc. Natl Acad. Sci. USA 100, 14817-14821 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 14817-14821
-
-
Vendruscolo, M.1
Paci, E.2
Karplus, M.3
Dobson, C.M.4
-
25
-
-
0037154268
-
Protein folding mediated by solvation: Water expulsion and formation of the hydrophobic core occur after the structural collapse
-
Cheung, M. S., Garcia, A. E. & Onuchic, J. N. Protein folding mediated by solvation: water expulsion and formation of the hydrophobic core occur after the structural collapse. Proc. Natl Acad. Sci. USA 99, 685-690 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 685-690
-
-
Cheung, M.S.1
Garcia, A.E.2
Onuchic, J.N.3
-
27
-
-
0032489016
-
The Hsp70 and Hsp60 chaperone machines
-
Bukau, B. & Horwich, A. L. The Hsp70 and Hsp60 chaperone machines. Cell 92, 351-366 (1998).
-
(1998)
Cell
, vol.92
, pp. 351-366
-
-
Bukau, B.1
Horwich, A.L.2
-
28
-
-
0037040541
-
Molecular chaperones in the cytosol: From nascent chain to folded protein
-
Hartl, F. U. & Hayer-Hartl, M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295, 1852-1858 (2002).
-
(2002)
Science
, vol.295
, pp. 1852-1858
-
-
Hartl, F.U.1
Hayer-Hartl, M.2
-
29
-
-
0035253217
-
Macromolecular crowding: An important but neglected aspect of the intra cellular environment
-
Ellis, R. J. Macromolecular crowding: an important but neglected aspect of the intracellular environment. Curr. Opin. Struct. Biol. 11, 114-119 (2001).
-
(2001)
Curr. Opin. Struct. Biol.
, vol.11
, pp. 114-119
-
-
Ellis, R.J.1
-
30
-
-
0033952307
-
Enzymes that catalyse the restructuring of proteins
-
Schiene, C. & Fischer, G. Enzymes that catalyse the restructuring of proteins. Curr. Opin. Struct. Biol. 10, 4O-45 (2000).
-
(2000)
Curr. Opin. Struct. Biol.
, vol.10
-
-
Schiene, C.1
Fischer, G.2
-
31
-
-
0029094253
-
Quality control in the secretory pathway
-
Hammon, C. & Helenius, A. Quality control in the secretory pathway. Curr. Opin. Cell. Biol. 7, 523-529 (1995).
-
(1995)
Curr. Opin. Cell. Biol.
, vol.7
, pp. 523-529
-
-
Hammon, C.1
Helenius, A.2
-
32
-
-
0036086064
-
The unfolded protein response in nutrient sensing and differentiation
-
Kaufman, R. J. et al. The unfolded protein response in nutrient sensing and differentiation. Nature Rev. Mol. Cell Biol. 3, 411-421 (2002).
-
(2002)
Nature Rev. Mol. Cell Biol.
, vol.3
, pp. 411-421
-
-
Kaufman, R.J.1
-
34
-
-
0034643336
-
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
-
Schubert, U. et al. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes. Nature 404, 770-774 (2000).
-
(2000)
Nature
, vol.404
, pp. 770-774
-
-
Schubert, U.1
-
35
-
-
0035947372
-
Impairment of the ubiquitin-proteasome system by protein aggregation
-
Bence, N. F., Sampat, R. M. & Kopito, R. R. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292, 1552-1555 (2001).
-
(2001)
Science
, vol.292
, pp. 1552-1555
-
-
Bence, N.F.1
Sampat, R.M.2
Kopito, R.R.3
-
36
-
-
0028856292
-
Defective protein folding as a basis of human disease
-
Thomas, P. J., Qu, B. H. & Pedersen, P. L. Defective protein folding as a basis of human disease. Trends Biochem. Sci. 20, 456-459 (1995).
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 456-459
-
-
Thomas, P.J.1
Qu, B.H.2
Pedersen, P.L.3
-
37
-
-
0035961329
-
The structural basis of protein folding and its links with human disease
-
Dobson, C. M. The structural basis of protein folding and its links with human disease. Phil. Trans. R. Soc. Lond. B356, 133-145 (2001).
-
(2001)
Phil. Trans. R. Soc. Lond. B
, vol.356
, pp. 133-145
-
-
Dobson, C.M.1
-
38
-
-
0036841958
-
Protein aggregation in disease: A role for folding intermediates forming specific multimeric interactions
-
Horwich, A. Protein aggregation in disease: a role for folding intermediates forming specific multimeric interactions. J. Clin. Invest. 110, 1221-1232 (2002).
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1221-1232
-
-
Horwich, A.1
-
39
-
-
0035496607
-
Rescuing the functions of mutant p53
-
Bullock, A. N. & Fersht, A. R. Rescuing the functions of mutant p53. Nature Rev. Cancer 1, 68-76 (2001).
-
(2001)
Nature Rev. Cancer
, vol.1
, pp. 68-76
-
-
Bullock, A.N.1
Fersht, A.R.2
-
41
-
-
0032006678
-
Alternative conformation of amyloidogenic proteins and their multi-step assembly pathways
-
Kelly, J. W. Alternative conformation of amyloidogenic proteins and their multi-step assembly pathways. Curr. Opin. Struct. Biol. 8, 101-106 (1998).
-
(1998)
Curr. Opin. Struct. Biol.
, vol.8
, pp. 101-106
-
-
Kelly, J.W.1
-
42
-
-
0030801746
-
The structure of amyloid fibrils by electron microscopy and X-ray diffraction
-
Sunde, M. & Blake, C. C. F. The structure of amyloid fibrils by electron microscopy and X-ray diffraction. Adv. Protein Chem. 50, 123-159 (1997).
-
(1997)
Adv. Protein Chem.
, vol.50
, pp. 123-159
-
-
Sunde, M.1
Blake, C.C.F.2
-
43
-
-
0033200063
-
Protein misfolding, evolution and disease
-
Dobson, C. M. Protein misfolding, evolution and disease. Trends Biochem. Sci. 24, 329-332 (1999).
-
(1999)
Trends Biochem. Sci.
, vol.24
, pp. 329-332
-
-
Dobson, C.M.1
-
44
-
-
0036845354
-
The behaviour of polyamino acids reveals an inverse side-chain effect in amyloid structure formation
-
Fändrich, M. & Dobson, C. M. The behaviour of polyamino acids reveals an inverse side-chain effect in amyloid structure formation. EMBO J. 21, 5682-5690 (2002).
-
(2002)
EMBO J.
, vol.21
, pp. 5682-5690
-
-
Fändrich, M.1
Dobson, C.M.2
-
45
-
-
0042847751
-
Cryo-electron microscopy of an SH3 amyloid fibril and model of the molecular packing
-
Jiménez, J. L. et al. Cryo-electron microscopy of an SH3 amyloid fibril and model of the molecular packing. EMBO J. 18, 815-821 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 815-821
-
-
Jiménez, J.L.1
-
46
-
-
0037168655
-
A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR
-
Petkova, A. T. et al. A structural model for Alzheimer's β-amyloid fibrils based on experimental constraints from solid state NMR. Proc. Natl Acad. Sci. USA 99, 16742-16747 (2002).
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
-
47
-
-
0042467550
-
Rationalization of mutational effects on protein aggregation rates
-
Chiti, F., Stefani, M., Taddei, N., Ramponi, G. & Dobson, C. M. Rationalization of mutational effects on protein aggregation rates. Nature 424, 805-808 (2003).
-
(2003)
Nature
, vol.424
, pp. 805-808
-
-
Chiti, F.1
Stefani, M.2
Taddei, N.3
Ramponi, G.4
Dobson, C.M.5
-
48
-
-
0037551741
-
Protofibrils, pores, fibrils, and neurode generation: Separating the responsible protein aggregates from the innocent bystanders
-
Caughey, B. & Lansbury, P. T. Jr. Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. Annu. Rev. Neurosci. 26, 267-298 (2003).
-
(2003)
Annu. Rev. Neurosci.
, vol.26
, pp. 267-298
-
-
Caughey, B.1
Lansbury Jr., P.T.2
-
49
-
-
0037422540
-
Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways
-
Bitan, G. et al. Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathways. Proc. Natl Acad. Sci. USA 100, 330-335 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 330-335
-
-
Bitan, G.1
-
50
-
-
0036145439
-
Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: Implications for the study of amyloid formation
-
Nilsson, M. R., Driscoll, M. & Raleigh, D. P. Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: implications for the study of amyloid formation. Protein Sci. 11, 342-349 (2002).
-
(2002)
Protein Sci.
, vol.11
, pp. 342-349
-
-
Nilsson, M.R.1
Driscoll, M.2
Raleigh, D.P.3
-
51
-
-
0030770294
-
Oligomer formation by 3D domain swapping: A model for protein assembly and misassembly
-
Schlunegger, M. P., Bennett, M. J. & Eisenberg, D. Oligomer formation by 3D domain swapping: a model for protein assembly and misassembly. Adv. Protein Chem. 50, 50, 61-122 (1997).
-
(1997)
Adv. Protein Chem.
, vol.50
, Issue.50
, pp. 61-122
-
-
Schlunegger, M.P.1
Bennett, M.J.2
Eisenberg, D.3
-
52
-
-
0037041420
-
Inherent cytotoxicity of aggregates implies a common origin for protein misfolding diseases
-
Bucciantini, M. et al. Inherent cytotoxicity of aggregates implies a common origin for protein misfolding diseases. Nature 416, 507-511 (2002).
-
(2002)
Nature
, vol.416
, pp. 507-511
-
-
Bucciantini, M.1
-
53
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuet, H. A., Hartley, D., Petre, B. M., Walz, T. & Lansbury, P. T. Jr. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature 418, 291 (2002).
-
(2002)
Nature
, vol.418
, pp. 291
-
-
Lashuet, H.A.1
Hartley, D.2
Petre, B.M.3
Walz, T.4
Lansbury Jr., P.T.5
-
54
-
-
0037317334
-
Protein folding and disease: A view from the First Horizon Symposium
-
Dobson, C. M. Protein folding and disease: a view from the First Horizon Symposium. Nature Rev. Drug Discov. 2, 154-160 (2003).
-
(2003)
Nature Rev. Drug Discov.
, vol.2
, pp. 154-160
-
-
Dobson, C.M.1
-
55
-
-
0034727077
-
A yeast prion provides a mechanism for genetic variation and phenotypic diversity
-
True, H. L. & Lindquist, S. L. A yeast prion provides a mechanism for genetic variation and phenotypic diversity. Nature 407, 477-483 (2000).
-
(2000)
Nature
, vol.407
, pp. 477-483
-
-
True, H.L.1
Lindquist, S.L.2
-
56
-
-
0036468673
-
Role of escherichia coli curli operons in directing amyloid fiber formation
-
Chapman, M. R. et al. Role of escherichia coli curli operons in directing amyloid fiber formation. Science 295, 851-855 (2002).
-
(2002)
Science
, vol.295
, pp. 851-855
-
-
Chapman, M.R.1
-
57
-
-
0038612852
-
Amyloid as a natural product
-
Kelly, J. W. & Balch, W. E. Amyloid as a natural product. J. Cell Biol. 161, 461-462 (2003).
-
(2003)
J. Cell Biol.
, vol.161
, pp. 461-462
-
-
Kelly, J.W.1
Balch, W.E.2
-
58
-
-
0034598954
-
Nature disfavours sequences of alternating polar and non-polar amino acids: Implications for amyloidogenesis
-
Broome, B. M. & Hecht, M. H. Nature disfavours sequences of alternating polar and non-polar amino acids: implications for amyloidogenesis. J. Mol. Biol. 296, 961-968 (2000).
-
(2000)
J. Mol. Biol.
, vol.296
, pp. 961-968
-
-
Broome, B.M.1
Hecht, M.H.2
-
59
-
-
0036166319
-
Kinetic partitioning of protein folding and aggregation
-
Chiti, F. et al. Kinetic partitioning of protein folding and aggregation. Nature Struct. Biol. 9, 137-143 (2002).
-
(2002)
Nature Struct. Biol.
, vol.9
, pp. 137-143
-
-
Chiti, F.1
-
60
-
-
0036549108
-
Sick chaperones and ageing: A perspective
-
Macario, A. J. L. & Macario, E. C. Sick chaperones and ageing: a perspective. Ageing Res. Rev. 1, 295-311 (2002).
-
(2002)
Ageing Res. Rev.
, vol.1
, pp. 295-311
-
-
Macario, A.J.L.1
Macario, E.C.2
-
61
-
-
0034255027
-
A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro
-
Ramirez-Alvarado, M., Merkel, J. S. & Regan, L. A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro. Proc. Natl Acad. Sci. USA 97, 8979-8984 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8979-8984
-
-
Ramirez-Alvarado, M.1
Merkel, J.S.2
Regan, L.3
-
62
-
-
0042467574
-
A camelid antibody fragment inhibits amyloid fibril formation by human lysozyme
-
Dumoulin, M. et al. A camelid antibody fragment inhibits amyloid fibril formation by human lysozyme. Nature 424, 783-788 (2003).
-
(2003)
Nature
, vol.424
, pp. 783-788
-
-
Dumoulin, M.1
-
63
-
-
0030822582
-
Prion diseases and the BSE crisis
-
Prusiner S. B. Prion diseases and the BSE crisis. Science 278, 245-251 (1997).
-
(1997)
Science
, vol.278
, pp. 245-251
-
-
Prusiner, S.B.1
-
64
-
-
0037077040
-
Toxic proteins in neurodegenerative disease
-
Taylor, J. P., Hardy, J. & Fischbeck, K. H. Toxic proteins in neurodegenerative disease. Science 296, 1991-1995 (2002).
-
(2002)
Science
, vol.296
, pp. 1991-1995
-
-
Taylor, J.P.1
Hardy, J.2
Fischbeck, K.H.3
-
65
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh, D. M. et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416, 535-539 (2002).
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
-
66
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanisms of pathogenesis
-
Kayed, R. et al. Common structure of soluble amyloid oligomers implies common mechanisms of pathogenesis. Science 300, 486-489 (2003).
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
-
67
-
-
0344944630
-
Protein aggregation and aggregate toxicity: New insights into protein folding, misfolding diseases and biological evolution
-
Stefani, M. & Dobson, C. M. Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution. J. Mol. 81, 678-699 (2003).
-
(2003)
J. Mol.
, vol.81
, pp. 678-699
-
-
Stefani, M.1
Dobson, C.M.2
-
68
-
-
0035139109
-
Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
-
Sherman, M. Y. & Goldberg, A. L. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29, 15-32 (2001).
-
(2001)
Neuron
, vol.29
, pp. 15-32
-
-
Sherman, M.Y.1
Goldberg, A.L.2
-
69
-
-
0034608868
-
Hsp70 and Hsp40 chaperones can can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
-
Muchowski, P. J. et al. Hsp70 and Hsp40 chaperones can can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc. Natl Acad. Sci. USA 97, 7841-7846 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7841-7846
-
-
Muchowski, P.J.1
-
70
-
-
0035576876
-
Chaperone overload is a possible contributor to 'civilization diseases'
-
Cserniely, P. Chaperone overload is a possible contributor to 'civilization diseases'. Trends Genet. 17, 701-704 (2001).
-
(2001)
Trends Genet.
, vol.17
, pp. 701-704
-
-
Cserniely, P.1
-
71
-
-
0037102362
-
Getting out of shape-protein misfolding diseases
-
Dobson, C. M. Getting out of shape-protein misfolding diseases. Nature 418, 729-730 (2002).
-
(2002)
Nature
, vol.418
, pp. 729-730
-
-
Dobson, C.M.1
|