Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

Neurobiology of Disease

Volumn 21, Issue 2, 2006, Pages 381-391

  Tanaka, Yuji ^a,d   Igarashi, Shuichi ^a,e   Nakamura, Masayuki ^a,e   Gafni, Juliette ^b   Torcassi, Cameron ^b   Schilling, Gabrielle ^a,f   Crippen, Danielle ^b   Wood, Jonathan D ^a,g   Sawa, Akira ^a   Jenkins, Nancy A ^c   Copeland, Neal G ^c   Borchelt, David R ^a,h   Ross, Christopher A ^a   Ellerby, Lisa M ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d OKAYAMA UNIVERSITY   (Japan)

^e NIIGATA UNIVERSITY   (Japan)

^f FRITZ LIPMANN INSTITUTE   (Germany)

^g UNIVERSITY OF SHEFFIELD   (United Kingdom)

^h UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; CASPASE; HUNTINGTIN; MUTANT PROTEIN; TETRACYCLINE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CONTROLLED STUDY; GENE EXPRESSION; HUNTINGTON CHOREA; MOUSE; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; TRANSGENICS; TREMOR; VOLUNTARY MOVEMENT; WEIGHT REDUCTION;

ANIMALS; BLOTTING, WESTERN; BRAIN; CELL NUCLEUS; DISEASE MODELS, ANIMAL; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; INTRANUCLEAR INCLUSION BODIES; MICE; MICE, TRANSGENIC; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PHENOTYPE; PROMOTER REGIONS (GENETICS);

EID: 30744439549     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2005.07.014     Document Type: Article

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