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Volumn 20, Issue 8, 2006, Pages

Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)

Author keywords

APP homo oligomerization; C31; YENPTY region

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; CASPASE; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; MEMBRANE PROTEIN; PEPTIDE FRAGMENT;

EID: 33845661843     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.05-5032fje     Document Type: Article
Times cited : (121)

References (43)
  • 1
    • 0032211830 scopus 로고    scopus 로고
    • The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
    • Selkoe, D. J. (1998) The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8, 447-453
    • (1998) Trends Cell Biol. , vol.8 , pp. 447-453
    • Selkoe, D.J.1
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J., and Selkoe, D. J. (2002) Medicine - the amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 3
    • 0036173420 scopus 로고    scopus 로고
    • ADDLs & protofibrils - The missing links?
    • Klein, W. L. (2002) ADDLs & protofibrils - the missing links? Neurobiol. Aging 23, 231-235
    • (2002) Neurobiol. Aging , vol.23 , pp. 231-235
    • Klein, W.L.1
  • 4
    • 2542455537 scopus 로고    scopus 로고
    • Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease
    • Klein, W. L., Stine, W. B., Jr., and Teplow, D. B. (2004) Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol. Aging 25, 569-580
    • (2004) Neurobiol. Aging , vol.25 , pp. 569-580
    • Klein, W.L.1    Stine Jr., W.B.2    Teplow, D.B.3
  • 7
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe, D. J. (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 8
    • 0027198831 scopus 로고
    • Molecular-cloning of the cDNA for a human amyloid precursor protein homolog - Evidence for a multigene family
    • Sprecher, C. A., Grant, F. J., Grimm, G., Ohara, P. J., Norris, F., Norris, K., and Foster, D. C. (1993) Molecular-cloning of the cDNA for a human amyloid precursor protein homolog - evidence for a multigene family. Biochemistry 32, 4481-4486
    • (1993) Biochemistry , vol.32 , pp. 4481-4486
    • Sprecher, C.A.1    Grant, F.J.2    Grimm, G.3    Ohara, P.J.4    Norris, F.5    Norris, K.6    Foster, D.C.7
  • 9
  • 10
    • 0026442891 scopus 로고
    • Identification of a mouse-brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid-beta-protein precursor
    • Wasco, W., Bupp, K., Magendantz, M., Gusella, J. F., Tanzi, R. E., and Solomon, F. (1992) identification of a mouse-brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid-beta-protein precursor. Proc. Natl. Acad. Sci. USA 89, 10758-10762
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10758-10762
    • Wasco, W.1    Bupp, K.2    Magendantz, M.3    Gusella, J.F.4    Tanzi, R.E.5    Solomon, F.6
  • 11
    • 0030779677 scopus 로고    scopus 로고
    • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
    • Mattson, M. P. (1997) Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 77, 1081-1132
    • (1997) Physiol. Rev. , vol.77 , pp. 1081-1132
    • Mattson, M.P.1
  • 13
    • 0033605252 scopus 로고    scopus 로고
    • Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases
    • Weidemann, A., Paliga, K., Durrwang, U., Reinhard, F. B. M., Schuckert, O., Evin, G., and Masters, C. L. (1999) Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases. J. Biol. Chem. 274, 5823-5829
    • (1999) J. Biol. Chem. , vol.274 , pp. 5823-5829
    • Weidemann, A.1    Paliga, K.2    Durrwang, U.3    Reinhard, F.B.M.4    Schuckert, O.5    Evin, G.6    Masters, C.L.7
  • 14
    • 0033617402 scopus 로고    scopus 로고
    • Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic a beta peptide formation
    • Gervais, F. G., Xu, D. G., Robertson, G. S., Vaillancourt, J. P., Zhu, Y. X., Huang, J. Q., LeBlanc, A., Smith, D., Rigby, M., Shearman, M. S., et al. (1999) Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 97, 395-406
    • (1999) Cell , vol.97 , pp. 395-406
    • Gervais, F.G.1    Xu, D.G.2    Robertson, G.S.3    Vaillancourt, J.P.4    Zhu, Y.X.5    Huang, J.Q.6    Leblanc, A.7    Smith, D.8    Rigby, M.9    Shearman, M.S.10
  • 15
    • 0033597884 scopus 로고    scopus 로고
    • Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and-8
    • Pellegrini, L., Passer, B. J., Tabaton, M., Ganjei, J. K., and D'Adamio, L. (1999) Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and-8. J. Biol. Chem. 274, 21011-21016
    • (1999) J. Biol. Chem. , vol.274 , pp. 21011-21016
    • Pellegrini, L.1    Passer, B.J.2    Tabaton, M.3    Ganjei, J.K.4    D'Adamio, L.5
  • 16
    • 0347479366 scopus 로고    scopus 로고
    • Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease
    • Zhao, M., Su, J., Head, E., and Cotman, C. W. (2003) Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiol. Dis. 14, 391-403
    • (2003) Neurobiol. Dis. , vol.14 , pp. 391-403
    • Zhao, M.1    Su, J.2    Head, E.3    Cotman, C.W.4
  • 18
    • 0031711595 scopus 로고    scopus 로고
    • Pathologic conformations of prion proteins
    • Cohen, F. E., and Prusiner, S. B. (1998) Pathologic conformations of prion proteins. Annu. Rev. Biochem. 67, 793-819
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 793-819
    • Cohen, F.E.1    Prusiner, S.B.2
  • 19
    • 0027212769 scopus 로고
    • Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
    • Sisodia, S. S., Koo, E. H., Hoffman, P. N., Perry, G., and Price, D. L. (1993) Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci. 13, 3136-3142
    • (1993) J. Neurosci. , vol.13 , pp. 3136-3142
    • Sisodia, S.S.1    Koo, E.H.2    Hoffman, P.N.3    Perry, G.4    Price, D.L.5
  • 21
    • 0031031006 scopus 로고    scopus 로고
    • Trafficking of cell-surface beta-amyloid precursor protein: Evidence that a sorting intermediate participates in synaptic vesicle recycling
    • Marquez-Sterling, N. R., Lo, A. C. Y., Sisodia, S. S., and Koo, E. H. (1997) Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. J. Neurosci. 17, 140-151
    • (1997) J. Neurosci. , vol.17 , pp. 140-151
    • Marquez-Sterling, N.R.1    Lo, A.C.Y.2    Sisodia, S.S.3    Koo, E.H.4
  • 22
    • 0035827702 scopus 로고    scopus 로고
    • Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide
    • Maltese, W. A., Wilson, S., Tan, Y., Suomensaari, S., Sinha, S., Barbour, R., and McConlogue, L. (2001) Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide. J. Biol. Chem. 276, 20267-20279
    • (2001) J. Biol. Chem. , vol.276 , pp. 20267-20279
    • Maltese, W.A.1    Wilson, S.2    Tan, Y.3    Suomensaari, S.4    Sinha, S.5    Barbour, R.6    McConlogue, L.7
  • 27
    • 0345602771 scopus 로고    scopus 로고
    • Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes
    • Lu, D. C., Shaked, G. M., Masliah, E., Bredesen, D. E., and Koo, E. H. (2003) Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann. Neurol. 54, 781-789
    • (2003) Ann. Neurol. , vol.54 , pp. 781-789
    • Lu, D.C.1    Shaked, G.M.2    Masliah, E.3    Bredesen, D.E.4    Koo, E.H.5
  • 28
    • 2442592973 scopus 로고    scopus 로고
    • The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages - Modulation of APLP-1 processing by N-glycosylation
    • Eggert, S., Paliga, K., Soba, P., Evin, G., Masters, C. L., Weidemann, A., and Beyreuther, K. (2004) The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages - modulation of APLP-1 processing by N-glycosylation. J. Biol. Chem. 279, 18146-18156
    • (2004) J. Biol. Chem. , vol.279 , pp. 18146-18156
    • Eggert, S.1    Paliga, K.2    Soba, P.3    Evin, G.4    Masters, C.L.5    Weidemann, A.6    Beyreuther, K.7
  • 29
    • 0031437769 scopus 로고    scopus 로고
    • Human amyloid precursor-like protein 1 - CDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid
    • Paliga, K., Peraus, G., Kreger, S., Durrwang, U., Hesse, L., Multhaup, G., Masters, C. L., Beyreuther, K., and Weidemann, A. (1997) Human amyloid precursor-like protein 1 - cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid. Eur. J. Biochem. 250, 354-363
    • (1997) Eur. J. Biochem. , vol.250 , pp. 354-363
    • Paliga, K.1    Peraus, G.2    Kreger, S.3    Durrwang, U.4    Hesse, L.5    Multhaup, G.6    Masters, C.L.7    Beyreuther, K.8    Weidemann, A.9
  • 30
    • 0028059841 scopus 로고
    • Expression of a ubiquitous, cross-reactive homolog of the mouse beta-amyloid precursor protein (App)
    • Slunt, H. H., Thinakaran, G., Vonkoch, C., Lo, A. C. Y., Tanzi, R. E., and Sisodia, S. S. (1994) Expression of a ubiquitous, cross-reactive homolog of the mouse beta-amyloid precursor protein (App). J. Biol. Chem. 269, 2637-2644
    • (1994) J. Biol. Chem. , vol.269 , pp. 2637-2644
    • Slunt, H.H.1    Thinakaran, G.2    Vonkoch, C.3    Lo, A.C.Y.4    Tanzi, R.E.5    Sisodia, S.S.6
  • 31
    • 0037114010 scopus 로고    scopus 로고
    • Processing of beta-amyloid precursor-like protein-1 and-2 by gamma-secretase regulates transcription
    • Scheinfeld, M. H., Ghersi, E., Laky, K., Fowlkes, B. J., and D'Adamio, L. (2002) Processing of beta-amyloid precursor-like protein-1 and-2 by gamma-secretase regulates transcription. J. Biol. Chem. 277, 44195-44201
    • (2002) J. Biol. Chem. , vol.277 , pp. 44195-44201
    • Scheinfeld, M.H.1    Ghersi, E.2    Laky, K.3    Fowlkes, B.J.4    D'Adamio, L.5
  • 32
    • 0035800847 scopus 로고    scopus 로고
    • The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases
    • Soriano, S., Lu, D. C., Chandra, S., Pietrzik, C. U., and Koo, E. H. (2001) The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. J. Biol. Chem. 276, 29045-29050
    • (2001) J. Biol. Chem. , vol.276 , pp. 29045-29050
    • Soriano, S.1    Lu, D.C.2    Chandra, S.3    Pietrzik, C.U.4    Koo, E.H.5
  • 33
    • 0030868903 scopus 로고    scopus 로고
    • Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
    • Kim, T. W., Pettingell, W. H., Jung, Y. K., Kovacs, D. M., and Tanzi, R. E. (1997) Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376
    • (1997) Science , vol.277 , pp. 373-376
    • Kim, T.W.1    Pettingell, W.H.2    Jung, Y.K.3    Kovacs, D.M.4    Tanzi, R.E.5
  • 34
    • 0142179222 scopus 로고    scopus 로고
    • Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity
    • Lu, D. C., Soriano, S., Bredesen, D. E., and Koo, E. H. (2003) Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J. Neurochem. 87, 733-741
    • (2003) J. Neurochem. , vol.87 , pp. 733-741
    • Lu, D.C.1    Soriano, S.2    Bredesen, D.E.3    Koo, E.H.4
  • 35
    • 3242682709 scopus 로고    scopus 로고
    • Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein
    • Heredia, L., Lin, R., Vigo, F. S., Kedikian, G., Busciglio, J., and Lorenzo, A. (2004) Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid beta precursor protein. Neurobiol. Dis. 16, 617-629
    • (2004) Neurobiol. Dis. , vol.16 , pp. 617-629
    • Heredia, L.1    Lin, R.2    Vigo, F.S.3    Kedikian, G.4    Busciglio, J.5    Lorenzo, A.6
  • 36
    • 0034737720 scopus 로고    scopus 로고
    • Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells
    • Melchor, J. P., and Van Nostrand, W. E. (2000) Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells. J. Biol. Chem. 275, 9782-9791
    • (2000) J. Biol. Chem. , vol.275 , pp. 9782-9791
    • Melchor, J.P.1    Van Nostrand, W.E.2
  • 37
    • 4143105782 scopus 로고    scopus 로고
    • The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain
    • Wang, Y. C., and Ha, Y. (2004) The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol. Cell 15, 343-353
    • (2004) Mol. Cell , vol.15 , pp. 343-353
    • Wang, Y.C.1    Ha, Y.2
  • 38
    • 0034846164 scopus 로고    scopus 로고
    • The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells
    • Dumanchin-Njock, C., da Costa, C. A., Mercken, L., Pradier, L., and Checler, F. (2001) The caspase-derived C-terminal fragment of beta APP induces caspase-independent toxicity and triggers selective increase of A beta 42 in mammalian cells. J. Neurochem. 78, 1153-1161
    • (2001) J. Neurochem. , vol.78 , pp. 1153-1161
    • Dumanchin-Njock, C.1    Da Costa, C.A.2    Mercken, L.3    Pradier, L.4    Checler, F.5
  • 39
    • 0037047434 scopus 로고    scopus 로고
    • The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells
    • Kinoshita, A., Whelan, C. M., Berezovska, O., and Hyman, B. T. (2002) The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J. Biol. Chem. 277, 28530-28536
    • (2002) J. Biol. Chem. , vol.277 , pp. 28530-28536
    • Kinoshita, A.1    Whelan, C.M.2    Berezovska, O.3    Hyman, B.T.4
  • 40
    • 33845324145 scopus 로고    scopus 로고
    • C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3 beta expression
    • Epub 2003 Aug 15
    • Kim, H. S., Kim, E. M., Lee, J. P., Park, C. H., Kim, S., Seo, J. H., Chang, K. A., Yu, E., Jeong, S. J., Chong, Y. H., and Suh, Y. H. (2003) C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3 beta expression. FASEB J. 17, 1951-1953. Epub 2003 Aug 15
    • (2003) FASEB J. , vol.17 , pp. 1951-1953
    • Kim, H.S.1    Kim, E.M.2    Lee, J.P.3    Park, C.H.4    Kim, S.5    Seo, J.H.6    Chang, K.A.7    Yu, E.8    Jeong, S.J.9    Chong, Y.H.10    Suh, Y.H.11
  • 41
    • 0034774969 scopus 로고    scopus 로고
    • Presenilin dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
    • Sastre, M., Steiner, H., Fuchs, K., Capell, A., Multhaup, G., Condron, M. M., Teplow, D. B., and Haass, C. (2001) Presenilin dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2, 835-841
    • (2001) EMBO Rep. , vol.2 , pp. 835-841
    • Sastre, M.1    Steiner, H.2    Fuchs, K.3    Capell, A.4    Multhaup, G.5    Condron, M.M.6    Teplow, D.B.7    Haass, C.8
  • 42
    • 0036934466 scopus 로고    scopus 로고
    • Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain
    • Su, J. H., Kesslak, J. P., Head, E., and Cotman, C. W. (2002) Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathol. 104, 1-6
    • (2002) Acta Neuropathol. , vol.104 , pp. 1-6
    • Su, J.H.1    Kesslak, J.P.2    Head, E.3    Cotman, C.W.4
  • 43
    • 31044433933 scopus 로고    scopus 로고
    • Anti-A beta(42)- and anti-A beta(40)-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model
    • Levites, Y., Das, P., Price, R. W., Rochette, M. J., Kostura, L. A., McGowan, E. M., Murphy, M. P., and Golde, T. E. (2006) Anti-A beta(42)- and anti-A beta(40)-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J. Clin. Invest. 116, 193-201
    • (2006) J. Clin. Invest. , vol.116 , pp. 193-201
    • Levites, Y.1    Das, P.2    Price, R.W.3    Rochette, M.J.4    Kostura, L.A.5    McGowan, E.M.6    Murphy, M.P.7    Golde, T.E.8


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