Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Science

Volumn 303, Issue 5660, 2004, Pages 1010-1014

  Chipuk, Jerry E ^a   Kuwana, Tomomi ^a   Bouchier Hayes, Lisa ^a   Droin, Nathalie M ^a   Newmeyer, Donald D ^a   Schuler, Martin ^b   Green, Douglas R ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULAR BIOLOGY; PROTEINS; TUMORS;

CYTOSOLS; TUMOR SUPPRESSORS;

BIOLOGICAL MEMBRANES;

PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53;

MEDICINE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL FUNCTION; CONCENTRATION RESPONSE; CYTOSOL; KINETICS; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CARRIER PROTEINS; CELL LINE, TRANSFORMED; CELL NUCLEUS; CELLS, CULTURED; CYTOCHROMES C; CYTOSOL; GENE EXPRESSION REGULATION; GENES, P53; HELA CELLS; HUMANS; INTRACELLULAR MEMBRANES; LIPOSOMES; MICE; MITOCHONDRIA; MUTATION; PERMEABILITY; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT FUSION PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS; WHEAT GERM AGGLUTININS;

EID: 0842278331     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1092734     Document Type: Article

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