A transmembrane form of the prion protein in neurodegenerative disease

Science

Volumn 279, Issue 5352, 1998, Pages 827-834

  Hegde, Ramanujan S ^a   Mastrianni, James A ^b   Scott, Michael R ^b   DeFea, Kathryn A ^a   Tremblay, Patrick ^b   Torchia, Marilyn ^b   DeArmond, Stephen J ^a   Prusiner, Stanley B ^a   Lingappa, Vishwanath R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; MUTANT PROTEIN; PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; GERSTMANN STRAUSSLER SCHEINKER SYNDROME; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS REGULATION; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CRICETINAE; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GERSTMANN-STRAUSSLER-SCHEINKER DISEASE; HUMANS; INTRACELLULAR MEMBRANES; MESOCRICETUS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; NEURODEGENERATIVE DISEASES; PRION DISEASES; PRIONS; PROTEIN CONFORMATION; PRPC PROTEINS; PRPSC PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 0032488777     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.279.5352.827     Document Type: Article

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59. We thank J. Cayetano for help with the histopathology; A. Calayag, O. Nguyen, and R. Köhler for technical assistance; R. Cotter and C. Petromilli for animal care; H. Serban for reagents; G. Telling for advice; and J. Taltzelt, R. Nixon, S. Russel, and J. Lingappa for stimulating discussions. Supported by NIH grant AG02132 and the Medical Scientist Training Program.