Interleukin-1β: A bridge between inflammation and excitotoxicity?

Journal of Neurochemistry

Volumn 106, Issue 1, 2008, Pages 1-23

  Fogal, Birgit ^a   Hewett, Sandra J ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Excitotoxicity; Glutamate; Interleukin 1 ; Neuroinflammation; Oxidative stress; System xc

Indexed keywords

CHOLINESTERASE INHIBITOR; DIZOCILPINE; GLUTAMIC ACID; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA ANTIBODY; MINOCYCLINE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; CARRIER PROTEIN; NEUROTOXIN;

ACUTE DISEASE; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BRAIN; BRAIN ISCHEMIA; CHRONIC DISEASE; CLINICAL TRIAL; CONTINUOUS INFUSION; DEMENTIA; EXCITOTOXICITY; HIV ASSOCIATED DEMENTIA; HUMAN; HUNTINGTON CHOREA; INFLAMMATION; MULTIPLE SCLEROSIS; NERVE CELL LESION; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FAMILY; REVIEW; SPINAL CORD INJURY; TRAUMATIC BRAIN INJURY; CENTRAL NERVOUS SYSTEM DISEASE; IMMUNOLOGY; MALE; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

CARRIER PROTEINS; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; INTERLEUKIN-1BETA; MALE; NEUROTOXINS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 45249116745     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05315.x     Document Type: Review

References (442)

1. Agrawal S. K., Theriault E. Fehlings M. G. (1998) Role of group I metabotropic glutamate receptors in traumatic spinal cord white matter injury. J. Neurotrauma 15, 929 941.
2. Alexander G. M., Deitch J. S., Seeburger J. L., Del Valle L. Heiman-Patterson T. D. (2000) Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. J. Neurochem. 74, 1666 1673.
3. Allan S. M. Rothwell N. J. (2001) Cytokines and acute neurodegeneration. Nat. Rev. 2, 734 744.
4. Allan S. M., Lawrence C. B. Rothwell N. J. (1998) Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes. Mol. Psychiatry 3, 178 182.
5. Allan S. M., Parker L. C., Collins B., Davies R., Luheshi G. N. Rothwell N. J. (2000) Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proc. Natl Acad. Sci. USA 97, 5580 5585.
6. Allan S. M., Tyrrell P. J. Rothwell N. J. (2005) Interleukin-1 and neuronal injury. Nat. Rev. 5, 629 640.
7. Ances B. M. Ellis R. J. (2007) Dementia and neurocognitive disorders due to HIV-1 infection. Semin. Neurol. 27, 86 92.
8. Andre R., Moggs J. G., Kimber I., Rothwell N. J. Pinteaux E. (2006) Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain. Glia 53, 477 483.
9. Andrei C., Margiocco P., Poggi A., Lotti L. V., Torrisi M. R. Rubartelli A. (2004) Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes. Proc. Natl Acad. Sci. USA 101, 9745 9750.
10. Angel J., Berenbaum F., Le Denmat C., Nevalainen T., Masliah J. Fournier C. (1994) Interleukin-1-induced prostaglandin E2 biosynthesis in human synovial cells involves the activation of cytosolic phospholipase A2 and cyclooxygenase-2. Eur. J. Biochem. 226, 125 131.
11. Aoyama K., Matsumura N., Watabe M. Nakaki T. (2008) Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction. Eur. J. Neurosci. 27, 20 30.
12. Arzberger T., Krampfl K., Leimgruber S. Weindl A. (1997) Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease - an in situ hybridization study. J. Neuropathol. Exp. Neurol. 56, 440 454.
13. Auron P. E., Webb A. C., Rosenwasser L. J., Mucci S. F., Rich A., Wolff S. M. Dinarello C. A. (1984) Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl Acad. Sci. USA 81, 7907 7911.
14. Avital A., Goshen I., Kamsler A., Segal M., Iverfeldt K., Richter-Levin G. Yirmiya R. (2003) Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus 13, 826 834.
15. Bagetta G., Corasaniti M. T., Berliocchi L., Nistico R., Giammarioli A. M., Malorni W., Aloe L. Finazzi-Agro A. (1999) Involvement of interleukin-1beta in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat. Neuroscience 89, 1051 1066.
16. Balcar V. J. Li Y. (1992) Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system. Life Sci. 51, 1467 1478.
17. Balschun D., Randolf A., Pitossi F., Schneider H., Del Rey A. Besedovsky H. O. (2003) Hippocampal interleukin-1 beta gene expression during long-term potentiation decays with age. Ann. NY Acad. Sci. 992, 1 8.
18. Ban E. M., Sarlieve L. L. Haour F. G. (1993) Interleukin-1 binding sites on astrocytes. Neuroscience 52, 725 733.
19. Bannai S. Tateishi N. (1986) Role of membrane transport in metabolism and function of glutathione in mammals. J. Memb. Biol. 89, 1 8.
20. Bannon M. J., Goedert M. Williams B. (1984) The possible relation of glutathione, melanin and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) to Parkinson's disease. Biochem. Pharmacol. 33, 2697 2698.
21. Barbour B., Szatkowski M., Ingledew N. Attwell D. (1989) Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature 342, 918 920.
22. Barger S. W. Basile A. S. (2001) Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function. J. Neurochem. 76, 846 854.
23. Barnham K. J., Masters C. L. Bush A. I. (2004) Neurodegenerative diseases and oxidative stress. Nat. Rev. 3, 205 214.
24. Bartholdi D. Schwab M. E. (1997) Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: an in situ hybridization study. Eur. J. Neurosci. 9, 1422 1438.
25. Basu A., Lazovic J., Krady J. K., Mauger D. T., Rothstein R. P., Smith M. B. Levison S. W. (2005) Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J. Cereb. Blood Flow Metab. 25, 17 29.
26. Bazan J. F., Timans J. C. Kastelein R. A. (1996) A newly defined interleukin-1? Nature 379, 591.
27. Beal M. F. (1992) Role of excitotoxicity in human neurological disease. Curr. Opin. Neurobiol. 2, 657 662.
28. Beal M. F. (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38, 357 366.
29. Beal M. F. (1998) Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis. Ann. Neurol. 44, S110 S114.
30. Beal M. F., Brouillet E., Jenkins B., Henshaw R., Rosen B. Hyman B. T. (1993) Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate. J. Neurochem. 61, 1147 1150.
31. Behl C. Moosmann B. (2002) Oxidative nerve cell death in Alzheimer's disease and stroke: antioxidants as neuroprotective compounds. Biol. Chem. 383, 521 536.
32. Behrens P. F., Franz P., Woodman B., Lindenberg K. S. Landwehrmeyer G. B. (2002) Impaired glutamate transport and glutamate-glutamine cycling: downstream effects of the Huntington mutation. Brain 125, 1908 1922.
33. Bendotti C. Carri M. T. (2004) Lessons from models of SOD1-linked familial ALS. Trends in molecular medicine 10, 393 400.
34. Benveniste H. (1991) The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovasc. Brain Metab. Rev. 3, 213 245.
35. Benveniste E. N., Sparacio S. M., Norris J. G., Grenett H. E. Fuller G. M. (1990) Induction and regulation of interleukin-6 gene expression in rat astrocytes. J. Neuroimmunol. 30, 201 212.
36. Bernardino L., Xapelli S., Silva A. P., Jakobsen B., Poulsen F. R., Oliveira C. R., Vezzani A., Malva J. O. Zimmer J. (2005) Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J. Neurosci. 25, 6734 6744.
37. Betz A. L., Yang G. Y. Davidson B. L. (1995) Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. J. Cereb. Blood Flow Metab. 15, 547 551.
38. Betz A. L., Schielke G. P. Yang G. Y. (1996) Interleukin-1 in cerebral ischemia. Keio J. Med. 45, 230 237 discussion 238.
39. Bianco F., Pravettoni E., Colombo A., Schenk U., Moller T., Matteoli M. Verderio C. (2005) Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J. Immunol. 174, 7268 7277.
40. Blasi F., Riccio M., Brogi A. et al. (1999) Constitutive expression of interleukin-1beta (IL-1beta) in rat oligodendrocytes. Biol. Chem. 380, 259 264.
41. Bliss T. V. Collingridge G. L. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31 39.
42. Bogdanov M. B., Andreassen O. A., Dedeoglu A., Ferrante R. J. Beal M. F. (2001) Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease. J. Neurochem. 79, 1246 1249.
43. Boutin H., LeFeuvre R. A., Horai R., Asano M., Iwakura Y. Rothwell N. J. (2001) Role of IL-1alpha and IL-1beta in ischemic brain damage. J. Neurosci. 21, 5528 5534.
44. Brabers N. A. Nottet H. S. (2006) Role of the pro-inflammatory cytokines TNF-alpha and IL-1beta in HIV-associated dementia. Eur. J. Clin. Invest. 36, 447 458.
45. Breder C. D., Dinarello C. A. Saper C. B. (1988) Interleukin-1 immunoreactive innervation of the human hypothalamus. Science (New York, NY) 240, 321 324.
46. Brough D. Rothwell N. J. (2007) Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death. J. Cell Sci. 120, 772 781.
47. Brown D. R. (1999) Neurons depend on astrocytes in a coculture system for protection from glutamate toxicity. Mol. Cell. Neurosci. 13, 379 389.
48. Browne S. E. Beal M. F. (2006) Oxidative damage in Huntington's disease pathogenesis. Antioxid. Redox Signal. 8, 2061 2073.
49. Butterfield D. A., Howard B. J. LaFontaine M. A. (2001) Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease. Current medicinal chemistry 8, 815 828.
50. Buttini M., Sauter A. Boddeke H. W. (1994) Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat. Brain Res. 23, 126 134.
51. Cacabelos R., Barquero M., Garcia P., Alvarez X. A. Varela de Seijas E. (1991) Cerebrospinal fluid interleukin-1 beta (IL-1 beta) in Alzheimer's disease and neurological disorders. Methods Find. Exp. Clin. Pharmacol. 13, 455 458.
52. Carlson N. G., Wieggel W. A., Chen J., Bacchi A., Rogers S. W. Gahring L. C. (1999) Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J. Immunol. 163, 3963 3968.
53. Carmeliet P., Van Damme J. Denef C. (1989) Interleukin-1 beta inhibits acetylcholine synthesis in the pituitary corticotropic cell line AtT20. Brain Res. 491, 199 203.
54. Castillo J., Davalos A. Noya M. (1999) Aggravation of acute ischemic stroke by hyperthermia is related to an excitotoxic mechanism. Cerebrovasc. Dis. (Basel, Switzerland) 9, 22 27.
55. Cepeda C., Ariano M. A., Calvert C. R., Flores-Hernandez J., Chandler S. H., Leavitt B. R., Hayden M. R. Levine M. S. (2001) NMDA receptor function in mouse models of Huntington disease. J. Neurosci. Res. 66, 525 539.
56. Cerretti D. P., Kozlosky C. J., Mosley B. et al. (1992) Molecular cloning of the interleukin-1 beta converting enzyme. Science (New York, NY) 256, 97 100.
57. Chao M. V., Rajagopal R. Lee F. S. (2006) Neurotrophin signalling in health and disease. Clin. Sci. (Lond) 110, 167 173.
58. Ching S., Zhang H., Belevych N., He L., Lai W., Pu X. A., Jaeger L. B., Chen Q. Quan N. (2007) Endothelial-specific knockdown of interleukin-1 (IL-1) type 1 receptor differentially alters CNS responses to IL-1 depending on its route of administration. J. Neurosci. 27, 10476 10486.
59. Chinta S. J., Kumar M. J., Hsu M., Rajagopalan S., Kaur D., Rane A., Nicholls D. G., Choi J. Andersen J. K. (2007) Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. J. Neurosci. 27, 13997 14006.
60. Choi D. W. (1988) Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11, 465 469.
61. Chopp M., Welch K. M., Tidwell C. D., Knight R. Helpern J. A. (1988) Effect of mild hyperthermia on recovery of metabolic function after global cerebral ischemia in cats. Stroke; J. Cerebral Circ. 19, 1521 1525.
62. Colotta F., Re F., Muzio M., Bertini R., Polentarutti N., Sironi M., Giri J. G., Dower S. K., Sims J. E. Mantovani A. (1993) Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science (New York, NY) 261, 472 475.
63. Conti A., Miscusi M., Cardali S., Germano A., Suzuki H., Cuzzocrea S. Tomasello F. (2007) Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation. Brain Res. Rev. 54, 205 218.
64. Cookson M. R., Menzies F. M., Manning P., Eggett C. J., Figlewicz D. A., McNeil C. J. Shaw P. J. (2002) Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress. Amyotroph Lateral Scler. Motor Neuron Disord. 3, 75 85.
65. Coyle J. T. Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science (New York, NY) 262, 689 695.
66. Cross A. H., Manning P. T., Keeling R. M., Schmidt R. E. Misko T. P. (1998) Peroxynitrite formation within the central nervous system in active multiple sclerosis. J. Neuroimmunol. 88, 45 56.
67. Cuajungco M. P., Goldstein L. E., Nunomura A., Smith M. A., Lim J. T., Atwood C. S., Huang X., Farrag Y. W., Perry G. Bush A. I. (2000) Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc. J. Biol. Chem. 275, 19439 19442.
68. da Cunha A., Jefferson J. A., Jackson R. W. Vitkovic L. (1993) Glial cell-specific mechanisms of TGF-beta 1 induction by IL-1 in cerebral cortex. J. Neuroimmunol. 42, 71 85.
69. Cunningham Jr E. T. De Souza E. B. (1993) Interleukin 1 receptors in the brain and endocrine tissues. Immunol. Today 14, 171 176.
70. Curtis B. M., Widmer M. B., deRoos P. Qwarnstrom E. E. (1990) IL-1 and its receptor are translocated to the nucleus. J. Immunol. 144, 1295 1303.
71. Danbolt N. C. (2001) Glutamate uptake. Prog. Neurobiol. 65, 1 105.
72. Davies C. A., Loddick S. A., Toulmond S., Stroemer R. P., Hunt J. Rothwell N. J. (1999) The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat. J. Cereb. Blood Flow Metab. 19, 87 98.
73. Dayton E. T. Major E. O. (1996) Recombinant human interleukin 1 beta induces production of prostaglandins in primary human fetal astrocytes and immortalized human fetal astrocyte cultures. J. Neuroimmunol. 71, 11 18.
74. Debets R., Timans J. C., Homey B. et al. (2001) Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 167, 1440 1446.
75. Deneke S. M. Fanburg B. L. (1989) Regulation of cellular glutathione. Am. J. Physiol. 257, L163 L173.
76. Dervan A. G., Meshul C. K., Beales M., McBean G. J., Moore C., Totterdell S., Snyder A. K. Meredith G. E. (2004) Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease. Exp. Neurol. 190, 145 156.
77. Desson S. E. Ferguson A. V. (2003) Interleukin 1beta modulates rat subfornical organ neurons as a result of activation of a non-selective cationic conductance. J. Physiol. 550, 113 122.
78. Diab A., Zhu J., Xiao B. G., Mustafa M. Link H. (1997) High IL-6 and low IL-10 in the central nervous system are associated with protracted relapsing EAE in DA rats. J. Neuropathol. Exp. Neurol. 56, 641 650.
79. Diana A., Van Dam A. M., Winblad B. Schultzberg M. (1999) Co-localization of interleukin-1 receptor type I and interleukin-1 receptor antagonist with vasopressin in magnocellular neurons of the paraventricular and supraoptic nuclei of the rat hypothalamus. Neuroscience 89, 137 147.
80. Diem R., Hobom M., Grotsch P., Kramer B. Bahr M. (2003) Interleukin-1 beta protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo. Mol. Cell. Neurosci. 22, 487 500.
81. Dietrich W. D., Busto R., Globus M. Y. Ginsberg M. D. (1996) Brain damage and temperature: cellular and molecular mechanisms. Adv. Neurol. 71, 177 194.
82. Dinarello C. A. (1994) The interleukin-1 family: 10 years of discovery. FASEB J. 8, 1314 1325.
83. Dinarello C. A. (1996) Biologic basis for interleukin-1 in disease. Blood 87, 2095 2147.
84. Dinarello C. A. (1998) Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int. Rev. Immunol. 16, 457 499.
85. Dinarello C. A. (2002) The IL-1 family and inflammatory diseases. Clin. Exp. Rheumatol. 20, S1 S13.
86. Dinarello C. A. Thompson R. C. (1991) Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro. Immunol. Today 12, 404 410.
87. Dinarello C. A. Wolff S. M. (1993) The role of interleukin-1 in disease. N. Engl. J. Med. 328, 106 113.
88. Domercq M., Sanchez-Gomez M. V., Sherwin C., Etxebarria E., Fern R. Matute C. (2007) System xc- and glutamate transporter inhibition mediates microglial toxicity to oligodendrocytes. J. Immunol. 178, 6549 6556.
89. Drejer J., Benveniste H., Diemer N. H. Schousboe A. (1985) Cellular origin of ischemia-induced glutamate release from brain tissue in vivo and in vitro. J. Neurochem. 45, 145 151.
90. Dringen R. (2000) Glutathione metabolism and oxidative stress in neurodegeneration. Eur. J. Biochem. 267, 4903.
91. Dripps D. J., Brandhuber B. J., Thompson R. C. Eisenberg S. P. (1991) Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J. Biol. Chem. 266, 10331 10336.
92. Dugan L. L., Sensi S. L., Canzoniero L. M., Handran S. D., Rothman S. M., Lin T. S., Goldberg M. P. Choi D. W. (1995) Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J. Neurosci. 15, 6377 6388.
93. Dun Y., Mysona B., Van Ells T., Amarnath L., Ola M. S., Ganapathy V. Smith S. B. (2006) Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress. Cell Tissue Res. 324, 189 202.
94. Dunn E., Sims J. E., Nicklin M. J. O'Neill L. A. (2001) Annotating genes with potential roles in the immune system: six new members of the IL-1 family. Trends Immunol. 22, 533 536.
95. Dunnett S. B. Rosser A. E. (2004) Cell therapy in Huntington's disease. NeuroRx 1, 394 405.
96. Emerit J., Edeas M. Bricaire F. (2004) Neurodegenerative diseases and oxidative stress. Biomed. Pharmacother. Biomed. Pharmacother. 58, 39 46.
97. Emsley H. C., Smith C. J., Georgiou R. F., Vail A., Hopkins S. J., Rothwell N. J. Tyrrell P. J. (2005) A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. J. Neurol. Neurosurg. Psychiatry 76, 1366 1372.
98. Endres S., Cannon J. G., Ghorbani R., Dempsey R. A., Sisson S. D., Lonnemann G., Van der Meer J. W., Wolff S. M. Dinarello C. A. (1989) In vitro production of IL 1 beta, IL 1 alpha, TNF and IL2 in healthy subjects: distribution, effect of cyclooxygenase inhibition and evidence of independent gene regulation. Eur. J. Immunol. 19, 2327 2333.
99. Faden A. I. (1993) Experimental neurobiology of central nervous system trauma. Crit. Rev. Neurobiol. 7, 175 186.
100. Faden A. I. Salzman S. (1992) Pharmacological strategies in CNS trauma. Trends Pharmacol. Sci. 13, 29 35.
101. Faden A. I., O'Leary D. M., Fan L., Bao W., Mullins P. G. Movsesyan V. A. (2001) Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improvesoOutcome after brain trauma. Exp. Neurol. 167, 435 444.
102. Fan M. M. Y. Raymond L. A. (2007) N-Methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease. Prog. Neurobiol. 81, 272 293.
103. Fan L., Young P. R., Barone F. C., Feuerstein G. Z., Smith D. H. McIntosh T. K. (1995) Experimental brain injury induces expression of interleukin-1 beta mRNA in the rat brain. Brain Res. 30, 125 130.
104. Fang J., Wang Y. Krueger J. M. (1998) Effects of interleukin-1 beta on sleep are mediated by the type I receptor. Am. J. Physiol. 274, R655 R660.
105. Farrar W. L., Kilian P. L., Ruff M. R., Hill J. M. Pert C. B. (1987) Visualization and characterization of interleukin 1 receptors in brain. J. Immunol. 139, 459 463.
106. Felderhoff-Mueser U., Schmidt O. I., Oberholzer A., Buhrer C. Stahel P. F. (2005) IL-18: a key player in neuroinflammation and neurodegeneration? Trends Neurosci. 28, 487 493.
107. Ferraguti F., Pietra C., Valerio E., Corti C., Chiamulera C. Conquet F. (1997) Evidence against a permissive role of the metabotropic glutamate receptor 1 in acute excitotoxicity. Neuroscience 79, 1 5.
108. Ferrari D., Chiozzi P., Falzoni S., Dal Susino M., Melchiorri L., Baricordi O. R. Di Virgilio F. (1997) Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 159, 1451 1458.
109. Ferrari C. C., Pott Godoy M. C., Tarelli R., Chertoff M., Depino A. M. Pitossi F. J. (2006) Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiol. Dis. 24, 183 193.
110. Fink S. L., Ho D. Y. Sapolsky R. M. (1996) Energy and glutamate dependency of 3-Nitropropionic acid neurotoxicity in culture. Exp. Neurol. 138, 298 304.
111. Fogal B., Li J., Lobner D., McCullough L. D. Hewett S. J. (2007) System x(c)- activity and astrocytes are necessary for interleukin-1 beta-mediated hypoxic neuronal injury. J. Neurosci. 27, 10094 10105.
112. Fonnum F. (1984) Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42, 1 11.
113. Fox J. H., Barber D. S., Singh B. et al. (2004) Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation. J. Neurochem. 91, 413 422.
114. Fray A. E., Ince P. G., Banner S. J., Milton I. D., Usher P. A., Cookson M. R. Shaw P. J. (1998) The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study. Eur. J. Neuroscience 10, 2481 2489.
115. French R. A., VanHoy R. W., Chizzonite R., Zachary J. F., Dantzer R., Parnet P., Bluthe R. M. Kelley K. W. (1999) Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice. J. Neuroimmunol. 93, 194 202.
116. Friedlander R. M., Brown R. H., Gagliardini V., Wang J. Yuan J. (1997a) Inhibition of ICE slows ALS in mice. Nature 388, 31.
117. Friedlander R. M., Gagliardini V., Hara H., Fink K. B., Li W., MacDonald G., Fishman M. C., Greenberg A. H., Moskowitz M. A. Yuan J. (1997b) Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med. 185, 933 940.
118. Friedman W. J. (2001) Cytokines regulate expression of the type 1 interleukin-1 receptor in rat hippocampal neurons and glia. Exp. Neurol. 168, 23 31.
119. Garcia J. H., Liu K. F. Relton J. K. (1995) Interleukin-1 receptor antagonist decreases the number of necrotic neurons in rats with middle cerebral artery occlusion. Am. J. Pathol. 147, 1477 1486.
120. Gayle M. A., Sims J. E., Dower S. K. Slack J. L. (1994) Monoclonal antibody 1994-01 (also known as ALVA 42) reported to recognize type II IL-1 receptor is specific for HLA-DR alpha and beta chains. Cytokine 6, 83 86.
121. Giacobini E. (2003) Cholinesterases: new roles in brain function and in Alzheimer's disease. Neurochem. Res. 28, 515 522.
122. Ginsberg M. D. Busto R. (1998) Combating hyperthermia in acute stroke: a significant clinical concern. Stroke; J. Cerebral Circ. 29, 529 534.
123. Giri J. G., Lomedico P. T. Mizel S. B. (1985) Studies on the synthesis and secretion of interleukin 1. I. A 33,000 molecular weight precursor for interleukin 1. J. Immunol. 134, 343 349.
124. Giulian D., Baker T. J., Shih L. C. Lachman L. B. (1986) Interleukin 1 of the central nervous system is produced by ameboid microglia. J. Exp. Med. 164, 594 604.
125. Glaccum M. B., Stocking K. L., Charrier K., Smith J. L., Willis C. R., Maliszewski C., Livingston D. J., Peschon J. J. Morrissey P. J. (1997) Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J. Immunol. 159, 3364 3371.
126. Goldgaber D., Harris H. W., Hla T., Maciag T., Donnelly R. J., Jacobsen J. S., Vitek M. P. Gajdusek D. C. (1989) Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc. Natl Acad. Sci. USA 86, 7606 7610.
127. Gonsette R. E. (2008) Review: oxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis? Multiple sclerosis (Houndmills, Basingstoke, England) 14, 22 34.
128. Good P. F., Werner P., Hsu A., Olanow C. W. Perl D. P. (1996) Evidence of neuronal oxidative damage in Alzheimer's disease. Am. J. Pathol. 149, 21 28.
129. Gracie J. A., Robertson S. E. McInnes I. B. (2003) Interleukin-18. J. Leukoc. Biol. 73, 213 224.
130. Gray P. W., Glaister D., Chen E., Goeddel D. V. Pennica D. (1986) Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. J. Immunol. 137, 3644 3648.
131. Grenfell S., Smithers N., Miller K. Solari R. (1989) Receptor-mediated endocytosis and nuclear transport of human interleukin 1 alpha. Biochem. J. 264, 813 822.
132. Griffin W. S., Stanley L. C., Ling C., White L., MacLeod V., Perrot L. J., White III C. L. Araoz C. (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl Acad. Sci. USA 86, 7611 7615.
133. Griffin W. S., Liu L., Li Y., Mrak R. E. Barger S. W. (2006) Interleukin-1 mediates Alzheimer and Lewy body pathologies. J. Neuroinflamm. 3, 5.
134. Griffiths R. J., Stam E. J., Downs J. T. Otterness I. G. (1995) ATP induces the release of IL-1 from LPS-primed cells in vivo. J. Immunol. 154, 2821 2828.
135. Grimaldi L. M., Casadei V. M., Ferri C. et al. (2000) Association of early-onset Alzheimer's disease with an interleukin-1alpha gene polymorphism. Ann. Neurol. 47, 361 365.
136. Gurney M. E., Pu H., Chiu A. Y. et al. (1994) Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation. Science (New York, NY) 264, 1772 1775.
137. Gusev E. Skvortsova V. I. (2003) Dynamics of pro-inflammatory and regulatory cytokines and C-reactive protein concentration in CSF of patients with acute ischemic stroke, in Brain Ischemia (Gusev E., ed pp. 125 135. Kluwer Academic/Plenum Publishers, New York.
138. Hall E. D., Andrus P. K. Yonkers P. A. (1993) Brain hydroxyl radical generation in acute experimental head injury. J. Neurochem. 60, 588 594.
139. Hamann M., Rossi D. J., Marie H. Attwell D. (2002) Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia. Eur. J. Neurosci. 15, 308 314.
140. Hammond E. A., Smart D., Toulmond S., Suman-Chauhan N., Hughes J. Hall M. D. (1999) The interleukin-1 type I receptor is expressed in human hypothalamus. Brain 122, 1697 1707.
141. Hao J. X., Watson B. D., Xu X. J., Wiesenfeld-Hallin Z., Seiger A. Sundstrom E. (1992) Protective effect of the NMDA antagonist MK-801 on photochemically induced spinal lesions in the rat. Exp. Neurol. 118, 143 152.
142. Hara H., Fink K., Endres M., Friedlander R. M., Gagliardini V., Yuan J. Moskowitz M. A. (1997) Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. J. Cereb. Blood Flow Metab. 17, 370 375.
143. Hartung H. P., Schafer B., Heininger K. Toyka K. V. (1989) Recombinant interleukin-1 beta stimulates eicosanoid production in rat primary culture astrocytes. Brain Res. 489, 113 119.
144. Hazell A. S. (2007) Excitotoxic mechanisms in stroke: an update of concepts and treatment strategies. Neurochem. Int. 50, 941 953.
145. Heath P. R. Shaw P. J. (2002) Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve 26, 438 458.
146. Hermans G., Stinissen P., Hauben L., Van den Berg-Loonen E., Raus J. Zhang J. (1997) Cytokine profile of myelin basic protein-reactive T cells in multiple sclerosis and healthy individuals. Ann. Neurol. 42, 18 27.
147. Herx L. M., Rivest S. Yong V. W. (2000) Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor. J. Immunol. 165, 2232 2239.
148. Hetier E., Ayala J., Denefle P., Bousseau A., Rouget P., Mallat M. Prochiantz A. (1988) Brain macrophages synthesize interleukin-1 and interleukin-1 mRNAs in vitro. J. Neurosci. Res. 21, 391 397.
149. Hewett S. J., Corbett J. A., McDaniel M. L. Choi D. W. (1993) Interferon-gamma and interleukin-1 beta induce nitric oxide formation from primary mouse astrocytes. Neurosci. Lett. 164, 229 232.
150. Hewett S. J., Muir J. K., Lobner D., Symons A. Choi D. W. (1996) Potentiation of oxygen-glucose deprivation-induced neuronal death after induction of iNOS. Stroke; J. Cerebral Circ. 27, 1586 1591.
151. Hogquist K. A., Unanue E. R. Chaplin D. D. (1991) Release of IL-1 from mononuclear phagocytes. J. Immunol. 147, 2181 2186.
152. Holmer H. K., Keyghobadi M., Moore C. Meshul C. K. (2005) l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience 136, 333 341.
153. Holmin S. Hojeberg B. (2004) In situ detection of intracerebral cytokine expression after human brain contusion. Neurosci. Lett. 369, 108 114.
154. Horai R., Asano M., Sudo K., Kanuka H., Suzuki M., Nishihara M., Takahashi M. Iwakura Y. (1998) Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J. Exp. Med. 187, 1463 1475.
155. Hu S., Sheng W. S., Ehrlich L. C., Peterson P. K. Chao C. C. (2000) Cytokine effects on glutamate uptake by human astrocytes. Neuroimmunomodulation 7, 153 159.
156. Huitinga I., van der Cammen M., Salm L., Erkut Z., van Dam A., Tilders F. Swaab D. (2000) IL-1beta immunoreactive neurons in the human hypothalamus: reduced numbers in multiple sclerosis. J. Neuroimmunol. 107, 8 20.
157. Ilyin S. E., Gayle D., Flynn M. C. Plata-Salaman C. R. (1998) Interleukin-1beta system (ligand, receptor type I, receptor accessory protein and receptor antagonist), TNF-alpha, TGF-beta1 and neuropeptide Y mRNAs in specific brain regions during bacterial LPS-induced anorexia. Brain Res. Bull. 45, 507 515.
158. Jabaudon D., Shimamoto K., Yasuda-Kamatani Y., Scanziani M., Gahwiler B. H. Gerber U. (1999) Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin. Proc. Natl Acad. Sci. USA 96, 8733 8738.
159. Jabaudon D., Scanziani M., Gahwiler B. H. Gerber U. (2000) Acute decrease in net glutamate uptake during energy deprivation. Proc. Natl Acad. Sci. USA 97, 5610 5615.
160. Jander S., Schroeter M. Stoll G. (2000) Role of NMDA receptor signaling in the regulation of inflammatory gene expression after focal brain ischemia. J. Neuroimmunol. 109, 181 187.
161. Jander S., Schroeter M., Peters O., Witte O. W. Stoll G. (2001) Cortical spreading depression induces proinflammatory cytokine gene expression in the rat brain. J. Cereb. Blood Flow Metab. 21, 218 225.
162. Jenner P. Olanow C. W. (2006) The pathogenesis of cell death in Parkinson's disease. Neurology 66, S24 S36.
163. Johannessen J. N., Chiueh C. C., Burns R. S. Markey S. P. (1985) Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects. Life Sci. 36, 219 224.
164. Jones N. C., Prior M. J., Burden-Teh E., Marsden C. A., Morris P. G. Murphy S. (2005) Antagonism of the interleukin-1 receptor following traumatic brain injury in the mouse reduces the number of nitric oxide synthase-2-positive cells and improves anatomical and functional outcomes. Eur. J. Neurosci. 22, 72 78.
165. Juric D. M. Carman-Krzan M. (2001) Interleukin-1 beta, but not IL-1 alpha, mediates nerve growth factor secretion from rat astrocytes via type I IL-1 receptor. Int. J. Dev. Neurosci. 19, 675 683.
166. Kamm K., Vanderkolk W., Lawrence C., Jonker M. Davis A. T. (2006) The effect of traumatic brain injury upon the concentration and expression of interleukin-1beta and interleukin-10 in the rat. J. Trauma 60, 152 157.
167. Kapsimalis F., Richardson G., Opp M. R. Kryger M. (2005) Cytokines and normal sleep. Curr. Opin. Pulmonary Med. 11, 481 484.
168. Kasahara T., Mukaida N., Yamashita K., Yagisawa H., Akahoshi T. Matsushima K. (1991) IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. Immunology 74, 60 67.
169. Katabami T., Shimizu M., Okano K. et al. (1992) Intracellular signal transduction for interleukin-1 beta-induced endothelin production in human umbilical vein endothelial cells. Biochem. Biophys. Res. Commun. 188, 565 570.
170. Katayama Y., Becker D. P., Tamura T. Hovda D. A. (1990) Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J. Neurosurg. 73, 889 900.
171. Katayama Y., Kawamata T., Tamura T., Hovda D. A., Becker D. P. Tsubokawa T. (1991) Calcium-dependent glutamate release concomitant with massive potassium flux during cerebral ischemia in vivo. Brain Res. 558, 136 140.
172. Kaul M., Garden G. A. Lipton S. A. (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410, 988 994.
173. Kawaguchi Y., Nishimagi E., Tochimoto A., Kawamoto M., Katsumata Y., Soejima M., Kanno T., Kamatani N. Hara M. (2006) Intracellular IL-1{alpha}-binding proteins contribute to biological functions of endogenous IL-1{alpha} in systemic sclerosis fibroblasts. Proc. Natl Acad. Sci. 103, 14501 14506.
174. Kim G. W., Copin J. C., Kawase M., Chen S. F., Sato S., Gobbel G. T. Chan P. H. (2000) Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid. J. Cereb. Blood Flow Metab. 20, 119 129.
175. Kimelberg H. K., Goderie S. K., Higman S., Pang S. Waniewski R. A. (1990) Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J. Neurosci. 10, 1583 1591.
176. Kimelberg H. K., Nestor N. B. Feustel P. J. (2004) Inhibition of release of taurine and excitatory amino acids in ischemia and neuroprotection. Neurochem. Res. 29, 267 274.
177. Kinoshita K., Chatzipanteli K., Vitarbo E., Truettner J. S., Alonso O. F. Dietrich W. D. (2002) Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: importance of injury severity and brain temperature. Neurosurgery 51, 195 203.
178. Klevenyi P., Andreassen O., Ferrante R. J., Schleicher Jr J. R., Friedlander R. M. Beal M. F. (1999) Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport 10, 635 638.
179. Knerlich F., Schilling L., Gorlach C., Wahl M., Ehrenreich H. Siren A. L. (1999) Temporal profile of expression and cellular localization of inducible nitric oxide synthase, interleukin-1beta and interleukin converting enzyme after cryogenic lesion of the rat parietal cortex. Brain Res. 68, 73 87.
180. Konsman J. P., Vigues S., Mackerlova L., Bristow A. Blomqvist A. (2004) Rat brain vascular distribution of interleukin-1 type-1 receptor immunoreactivity: relationship to patterns of inducible cyclooxygenase expression by peripheral inflammatory stimuli. J. Comp. Neurol. 472, 113 129.
181. Krueger J. M., Fang J., Taishi P., Chen Z., Kushikata T. Gardi J. (1998) Sleep. A physiologic role for IL-1 beta and TNF-alpha. Ann. NY Acad. Sci. 856, 148 159.
182. Krueger J. M., Obal F. J., Fang J., Kubota T. Taishi P. (2001) The role of cytokines in physiological sleep regulation. Ann. NY Acad. Sci. 933, 211 221.
183. Lafage M., Maroc N., Dubreuil P., de Waal Malefijt R., Pebusque M. J., Carcassonne Y. Mannoni P. (1989) The human interleukin-1 alpha gene is located on the long arm of chromosome 2 at band q13. Blood 73, 104 107.
184. Lafon-Cazal M., Pietri S., Culcasi M. Bockaert J. (1993a) NMDA-dependent superoxide production and neurotoxicity. Nature 364, 535 537.
185. Lafon-Cazal M., Culcasi M., Gaven F., Pietri S. Bockaert J. (1993b) Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells. Neuropharmacology 32, 1259 1266.
186. Laliberte R. E., Perregaux D. G., Hoth L. R., Rosner P. J., Jordan C. K., Peese K. M., Eggler J. F., Dombroski M. A., Geoghegan K. F. Gabel C. A. (2003) Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing. J. Biol. Chem. 278, 16567 16578.
187. Lawrence C. B., Allan S. M. Rothwell N. J. (1998) Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat. Eur. J. Neurosci. 10, 1188 1195.
188. Lazovic J., Basu A., Lin H. W., Rothstein R. P., Krady J. K., Smith M. B. Levison S. W. (2005) Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection. Stroke; J. Cerebral Circ. 36, 2226 2231.
189. Le Feuvre R., Brough D. Rothwell N. (2002a) Extracellular ATP and P2X7 receptors in neurodegeneration. Eur. J. Pharmacol. 447, 261 269.
190. Le Feuvre R. A., Brough D., Iwakura Y., Takeda K. Rothwell N. J. (2002b) Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production. J. Biol. Chem. 277, 3210 3218.
191. Lechan R. M., Toni R., Clark B. D., Cannon J. G., Shaw A. R., Dinarello C. A. Reichlin S. (1990) Immunoreactive interleukin-1 beta localization in the rat forebrain. Brain Res. 514, 135 140.
192. Lee S. C., Dickson D. W., Liu W. Brosnan C. F. (1993) Induction of nitric oxide synthase activity in human astrocytes by interleukin-1 beta and interferon-gamma. J. Neuroimmunol. 46, 19 24.
193. Lee H. G., Casadesus G., Zhu X., Takeda A., Perry G. Smith M. A. (2004) Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Ann. NY Acad. Sci. 1019, 1 4.
194. Lennard A., Gorman P., Carrier M., Griffiths S., Scotney H., Sheer D. Solari R. (1992) Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene. Cytokine 4, 83 89.
195. Li X. Qin J. (2005) Modulation of Toll-interleukin 1 receptor mediated signaling. Journal of molecular medicine (Berlin, Germany) 83, 258 266.
196. Li Y., Liu L., Kang J., Sheng J. G., Barger S. W., Mrak R. E. Griffin W. S. (2000) Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. J. Neurosci. 20, 149 155.
197. Li Y. J., Scott W. K., Zhang L. et al. (2006) Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases. Neurobiol. Aging 27, 1087 1093.
198. Licastro F., Veglia F., Chiappelli M., Grimaldi L. M. Masliah E. (2004) A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease. Neurobiol. Aging 25, 1017 1022.
199. Lieberman A. P., Pitha P. M., Shin H. S. Shin M. L. (1989) Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl Acad. Sci. USA 86, 6348 6352.
200. Lin L. L., Lin A. Y. Knopf J. L. (1992) Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid. Proc. Natl Acad. Sci. USA 89, 6147 6151.
201. Lipton S. A. (1992) Memantine prevents HIV coat protein-induced neuronal injury in vitro. Neurology 42, 1403 1405.
202. Lipton S. A. Rosenberg P. A. (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330, 613 622.
203. Liu T., McDonnell P. C., Young P. R., White R. F., Siren A. L., Hallenbeck J. M., Barone F. C. Feurestein G. Z. (1993) Interleukin-1 beta mRNA expression in ischemic rat cortex. Stroke; J. Cerebral Circ. 24, 1746 1750.
204. Liu C., Chalmers D., Maki R. De Souza E. B. (1996) Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies. J. Neuroimmunol. 66, 41 48.
205. Liu D., Xu G. Y., Pan E. McAdoo D. J. (1999a) Neurotoxicity of glutamate at the concentration released upon spinal cord injury. Neuroscience 93, 1383 1389.
206. Liu X. H., Kwon D., Schielke G. P., Yang G. Y., Silverstein F. S. Barks J. D. (1999b) Mice deficient in interleukin-1 converting enzyme are resistant to neonatal hypoxic-ischemic brain damage. J. Cereb. Blood Flow Metab. 19, 1099 1108.
207. Liu J. S., Zhao M. L., Brosnan C. F. Lee S. C. (2001) Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am. J. Pathol. 158, 2057 2066.
208. Liu X. Y., Li C. Y., Bu H. et al. (2007) The Neuroprotective Potential of Phase II Enzyme Inducer on Motor Neuron Survival in Traumatic Spinal Cord Injury In vitro. Cell. Mol. Neurobiol. [Epub ahead of print]. doi :.
209. Loddick S. A. Rothwell N. J. (1996) Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J. Cereb. Blood Flow Metab. 16, 932 940.
210. Loddick S. A., MacKenzie A. Rothwell N. J. (1996) An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat. Neuroreport 7, 1465 1468.
211. Loddick S. A., Wong M. L., Bongiorno P. B., Gold P. W., Licinio J. Rothwell N. J. (1997) Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem. Biophys. Res. Commun. 234, 211 215.
212. Loddick S. A., Liu C., Takao T., Hashimoto K. De Souza E. B. (1998) Interleukin-1 receptors: cloning studies and role in central nervous system disorders. Brain Res. Brain Res. Rev. 26, 306 319.
213. Lomedico P. T., Gubler U., Hellmann C. P., Dukovich M., Giri J. G., Pan Y. C., Collier K., Semionow R., Chua A. O. Mizel S. B. (1984) Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312, 458 462.
214. Longuemare M. C. Swanson R. A. (1995) Excitatory amino acid release from astrocytes during energy failure by reversal of sodium-dependent uptake. J. Neurosci. Res. 40, 379 386.
215. Lonnemann G., Endres S., Van der Meer J. W., Cannon J. G., Koch K. M. Dinarello C. A. (1989) Differences in the synthesis and kinetics of release of interleukin 1 alpha, interleukin 1 beta and tumor necrosis factor from human mononuclear cells. Eur. J. Immunol. 19, 1531 1536.
216. Lotharius J., Dugan L. L. O'Malley K. L. (1999) Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J. Neurosci. 19, 1284 1293.
217. Lovenberg T. W., Crowe P. D., Liu C., Chalmers D. T., Liu X. J., Liaw C., Clevenger W., Oltersdorf T., De Souza E. B. Maki R. A. (1996) Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). J. Neuroimmunol. 70, 113 122.
218. Lowe J. S. Leigh N. (2002) Disorders of Movement and System Neurodegenerations, in Greenfield's neuropathology, 7th Edition, Vol. 2 (Graham D. I. Lantos P. L. eds), pp 325 430. Arnold (Hodder Headline Group), London, England.
219. Lu K. T., Wang Y. W., Yang J. T., Yang Y. L. Chen H. I. (2005) Effect of interleukin-1 on traumatic brain injury-induced damage to hippocampal neurons. J. Neurotrauma 22, 885 895.
220. Luheshi G., Hopkins S. J., Lefeuvre R. A., Dascombe M. J., Ghiara P. Rothwell N. J. (1993) Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat. Am. J. Pathol. 265, E585 E591.
221. Lynch M. A. Voss K. L. (1990) Arachidonic acid increases inositol phospholipid metabolism and glutamate release in synaptosomes prepared from hippocampal tissue. J. Neurochem. 55, 215 221.
222. Lyras L., Cairns N. J., Jenner A., Jenner P. Halliwell B. (1997) An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J. Neurochem. 68, 2061 2069.
223. Ma G., Chen S., Wang X., Ba M., Yang H. Lu G. (2005) Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells. J. Neurosci. Res. 80, 683 692.
224. MacKenzie A., Wilson H. L., Kiss-Toth E., Dower S. K., North R. A. Surprenant A. (2001) Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15, 825 835.
225. Maher J. Hachinski V. (1993) Hypothermia as a potential treatment for cerebral ischemia. Cerebrovasc. Brain Metab. Rev. 5, 277 300.
226. Maier J. A., Voulalas P., Roeder D. Maciag T. (1990) Extension of the life-span of human endothelial cells by an interleukin-1 alpha antisense oligomer. Science (New York, NY) 249, 1570 1574.
227. Maimone D., Annunziata P., Simone I. L., Livrea P. Guazzi G. C. (1993) Interleukin-6 levels in the cerebrospinal fluid and serum of patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J. Neuroimmunol. 47, 55 61.
228. March C. J., Mosley B., Larsen A. et al. (1985) Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature 315, 641 647.
229. Marin P., Quignard J. F., Lafon-Cazal M. Bockaert J. (1993) Non-classical glutamate receptors, blocked by both NMDA and non-NMDA antagonists, stimulate nitric oxide production in neurons. Neuropharmacology 32, 29 36.
230. Marini H., Altavilla D., Bellomo M. et al. (2004) Modulation of IL-1 beta gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury. Exp. Neurol. 188, 178 186.
231. Martin M. U. Falk W. (1997) The interleukin-1 receptor complex and interleukin-1 signal transduction. Eur. Cytokine Netw. 8, 5 17.
232. Martin M. U. Wesche H. (2002) Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim. Biophys. Acta 1592, 265 280.
233. Martin D., Chinookoswong N. Miller G. (1994) The interleukin-1 receptor antagonist (rhIL-1ra) protects against cerebral infarction in a rat model of hypoxia-ischemia. Exp. Neurol. 130, 362 367.
234. Masaki T. (1989) The discovery, the present state, and the future prospects of endothelin. J. Cardiovasc. Pharmacol. 13 (Suppl 5 S1 S4.
235. Mattila K. M., Rinne J. O., Lehtimaki T., Roytta M., Ahonen J. P. Hurme M. (2002) Association of an interleukin 1B gene polymorphism (-511) with Parkinson's disease in Finnish patients. J. Med. Genet. 39, 400 402.
236. Mattson M. P., Cheng B., Davis D., Bryant K., Lieberburg I. Rydel R. E. (1992) beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12, 376 389.
237. Matute C., Alberdi E., Domercq M., Sanchez-Gomez M. V., Perez-Samartin A., Rodriguez-Antiguedad A. Perez-Cerda F. (2007) Excitotoxic damage to white matter. J. Anat. 210, 693 702.
238. McCann S. M., Licinio J., Wong M. L., Yu W. H., Karanth S. Rettorri V. (1998) The nitric oxide hypothesis of aging. Exp. Gerontol. 33, 813 826.
239. McFarland H. F. Martin R. (2007) Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 8, 913 919.
240. McGeer E. G. McGeer P. L. (2005) Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis. BioDrugs 19, 31 37.
241. McIntosh T. K. (1994) Neurochemical sequelae of traumatic brain injury: therapeutic implications. Cerebrovasc. Brain Metab. Rev. 6, 109 162.
242. McIntosh T. K., Vink R., Soares H., Hayes R. Simon R. (1989) Effects of the N-methyl-D-aspartate receptor blocker MK-801 on neurologic function after experimental brain injury. J. Neurotrauma 6, 247 259.
243. Mecocci P., MacGarvey U. Beal M. F. (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 36, 747 751.
244. Meister A. Anderson M. E. (1983) Glutathione. Annu. Rev. Biochem. 52, 711 760.
245. Meldrum B. Garthwaite J. (1990) Excitatory amino acid neurotoxicity and neurodegenerative disease. Trends Pharmacol. Sci. 11, 379 387.
246. Miguel-Hidalgo J. J., Alvarez X. A., Cacabelos R. Quack G. (2002) Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40). Brain Res. 958, 210 221.
247. Miller B., Sarantis M., Traynelis S. F. Attwell D. (1992) Potentiation of NMDA receptor currents by arachidonic acid. Nature 355, 722 725.
248. Min K. J., Jou I. Joe E. (2003) Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species. Biochem. Biophys. Res. Commun. 312, 969 974.
249. Minami M., Kuraishi Y., Yabuuchi K., Yamazaki A. Satoh M. (1992) Induction of interleukin-1 beta mRNA in rat brain after transient forebrain ischemia. J. Neurochem. 58, 390 392.
250. Mirtella A., Tringali G., Guerriero G., Ghiara P., Parente L., Preziosi P. Navarra P. (1995) Evidence that the interleukin-1 beta-induced prostaglandin E2 release from rat hypothalamus is mediated by type I and type II interleukin-1 receptors. J. Neuroimmunol. 61, 171 177.
251. Mizushima H., Zhou C. J., Dohi K. et al. (2002) Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1. J. Comp. Neurol. 448, 203 216.
252. Modi W. S., Masuda A., Yamada M., Oppenheim J. J., Matsushima K. O'Brien S. J. (1988) Chromosomal localization of the human interleukin 1 alpha (IL-1 alpha) gene. Genomics 2, 310 314.
253. Mogi M., Harada M., Kondo T., Riederer P., Inagaki H., Minami M. Nagatsu T. (1994) Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180, 147 150.
254. Moldofsky H., Lue F. A., Eisen J., Keystone E. Gorczynski R. M. (1986) The relationship of interleukin-1 and immune functions to sleep in humans. Psychosom. Med. 48, 309 318.
255. Molenaar G. J., Berkenbosch F., van Dam A. M. Lugard C. M. (1993) Distribution of interleukin 1 beta immunoreactivity within the porcine hypothalamus. Brain Res. 608, 169 174.
256. Montine T. J., Beal M. F., Robertson D., Cudkowicz M. E., Biaggioni I., O'Donnell H., Zackert W. E., Roberts L. J. Morrow J. D. (1999) Cerebrospinal fluid F2-isoprostanes are elevated in Huntington's disease. Neurology 52, 1104 1105.
257. Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H., Burnashev N., Sakmann B. Seeburg P. H. (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (New York, NY) 256, 1217 1221.
258. Morganti-Kossman M. C., Lenzlinger P. M., Hans V., Stahel P., Csuka E., Ammann E., Stocker R., Trentz O. Kossmann T. (1997) Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol. Psychiatry 2, 133 136.
259. Moroni F., Attucci S., Cozzi A., Meli E., Picca R., Scheideler M. A., Pellicciari R., Noe C., Sarichelou I. Pellegrini-Giampietro D. E. (2002) The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death. Neuropharmacology 42, 741 751.
260. Mrak R. E. Griffin W. S. (2000) Interleukin-1 and the immunogenetics of Alzheimer disease. J. Neuropathol. Exp. Neurol. 59, 471 476.
261. Mukhin A., Fan L. Faden A. I. (1996) Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. J. Neurosci. 16, 6012 6020.
262. Mulcahy N. J., Ross J., Rothwell N. J. Loddick S. A. (2003) Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat. Br. J. Pharmacol. 140, 471 476.
263. Murphy S., Simmons M. L., Agullo L., Garcia A., Feinstein D. L., Galea E., Reis D. J., Minc-Golomb D. Schwartz J. P. (1993) Synthesis of nitric oxide in CNS glial cells. Trends Neurosci. 16, 323 328.
264. Murray C. A., Clements M. P. Lynch M. A. (1999) Interleukin-1 induces lipid peroxidation and membrane changes in rat hippocampus: An age-related study. Gerontology 45, 136 142.
265. Nakao N. Brundin P. (1998) Neurodegeneration and glutamate induced oxidative stress. Prog. Brain Res. 116, 245 263.
266. Nesic O., Xu G. Y., McAdoo D., High K. W., Hulsebosch C. Perez-Pol R. (2001) IL-1 receptor antagonist prevents apoptosis and caspase-3 activation after spinal cord injury. J. Neurotrauma 18, 947 956.
267. Nicholls D. Attwell D. (1990) The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 11, 462 468.
268. Nicklas W. J., Vyas I. Heikkila R. E. (1985) Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36, 2503 2508.
269. Nicklin M. J., Barton J. L., Nguyen M., FitzGerald M. G., Duff G. W. Kornman K. (2002) A sequence-based map of the nine genes of the human interleukin-1 cluster. Genomics 79, 718 725.
270. Nicoll J. A., Mrak R. E., Graham D. I. et al. (2000) Association of interleukin-1 gene polymorphisms with Alzheimer's disease. Ann. Neurol. 47, 365 368.
271. Nieto-Sampedro M. Berman M. A. (1987) Interleukin-1-like activity in rat brain: sources, targets, and effect of injury. J. Neurosci. Res. 17, 214 219.
272. Nishimura M., Kuno S., Kaji R., Yasuno K. Kawakami H. (2005) Glutathione-S-transferase-1 and interleukin-1beta gene polymorphisms in Japanese patients with Parkinson's disease. Mov. Disord. 20, 901 902.
273. Norris J. G., Tang L. P., Sparacio S. M. Benveniste E. N. (1994) Signal transduction pathways mediating astrocyte IL-6 induction by IL-1 beta and tumor necrosis factor-alpha. J. Immunol. 152, 841 850.
274. Nottet H. S. Gendelman H. E. (1995) Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitive/motor complex. Immunol. Today 16, 441 448.
275. Nunomura A., Perry G., Aliev G. et al. (2001) Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60, 759 767.
276. O'Banion M. K., Miller J. C., Chang J. W., Kaplan M. D. Coleman P. D. (1996) Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures. J. Neurochem. 66, 2532 2540.
277. Obal Jr F. Krueger J. M. (2003) Biochemical regulation of non-rapid-eye-movement sleep. Front. Biosci. 8, d520 d550.
278. Ohtaki H., Funahashi H., Dohi K. et al. (2003) Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1. Neurosci. Res. 45, 313 324.
279. Ohtsuki T., Ruetzler C. A., Tasaki K. Hallenbeck J. M. (1996) Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons. J. Cereb. Blood Flow Metab. 16, 1137 1142.
280. Okamura H., Tsutsi H., Komatsu T. et al. (1995) Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378, 88 91.
281. Oleszak E. L., Zaczynska E., Bhattacharjee M., Butunoi C., Legido A. Katsetos C. D. (1998) Inducible nitric oxide synthase and nitrotyrosine are found in monocytes/macrophages and/or astrocytes in acute, but not in chronic, multiple sclerosis. Clin. Diagn. Lab. Immunol. 5, 438 445.
282. Ona V. O., Li M., Vonsattel J. P. et al. (1999) Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 399, 263 267.
283. Opp M. R. Krueger J. M. (1991) Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever. Am. J. Physiol. 260, R453 R457.
284. Opp M. R. Krueger J. M. (1994a) Anti-interleukin-1 beta reduces sleep and sleep rebound after sleep deprivation in rats. Am. J. Physiol. 266, R688 R695.
285. Opp M. R. Krueger J. M. (1994b) Interleukin-1 is involved in responses to sleep deprivation in the rabbit. Brain Res. 639, 57 65.
286. Orencole S. F. Dinarello C. A. (1989) Characterization of a subclone (D10S) of the D10.G4.1 helper T-cell line which proliferates to attomolar concentrations of interleukin-1 in the absence of mitogens. Cytokine 1, 14 22.
287. Owen A. D., Schapira A. H., Jenner P. Marsden C. D. (1996) Oxidative stress and Parkinson's disease. Ann. NY Acad. Sci. 786, 217 223.
288. Panter S. S. Faden A. I. (1992) Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury. Neurosci. Lett. 136, 165 168.
289. Panter S. S., Yum S. W. Faden A. I. (1990) Alteration in extracellular amino acids after traumatic spinal cord injury. Ann. Neurol. 27, 96 99.
290. Parker Jr W. D. Swerdlow R. H. (1998) Mitochondrial dysfunction in idiopathic Parkinson disease. Am. J. Hum. Genet. 62, 758 762.
291. Parnet P., Garka K. E., Bonnert T. P., Dower S. K. Sims J. E. (1996) IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J. Biol. Chem. 271, 3967 3970.
292. Pasinelli P., Borchelt D. R., Houseweart M. K., Cleveland D. W. Brown Jr R. H. (1998) Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proc. Natl Acad. Sci. USA 95, 15763 15768.
293. Patterson D., Jones C., Hart I., Bleskan J., Berger R., Geyer D., Eisenberg S. P., Smith Jr M. F. Arend W. P. (1993) The human interleukin-1 receptor antagonist (IL1RN) gene is located in the chromosome 2q14 region. Genomics 15, 173 176.
294. Pearson V. L., Rothwell N. J. Toulmond S. (1999) Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death. Glia 25, 311 323.
295. Perez-Severiano F., Rios C. Segovia J. (2000) Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease. Brain Res. 862, 234 237.
296. Perez-Severiano F., Santamaria A., Pedraza-Chaverri J., Medina-Campos O. N., Rios C. Segovia J. (2004) Increased formation of reactive oxygen species, but no changes in glutathione peroxidase activity, in striata of mice transgenic for the Huntington's disease mutation. Neurochem. Res. 29, 729 733.
297. Perry T. L. Yong V. W. (1986) Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci. Lett. 67, 269 274.
298. Phillis J. W., Ren J. O'Regan M. H. (2000) Transporter reversal as a mechanism of glutamate release from the ischemic rat cerebral cortex: studies with DL-threo-beta-benzyloxyaspartate. Brain Res. 868, 105 112.
299. Piani D. Fontana A. (1994) Involvement of the cystine transport system xc- in the macrophage-induced glutamate-dependent cytotoxicity to neurons. J. Immunol. 152, 3578 3585.
300. Pinteaux E., Parker L. C., Rothwell N. J. Luheshi G. N. (2002) Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells. J. Neurochem. 83, 754 763.
301. Pioro E. P., Majors A. W., Mitsumoto H., Nelson D. R. Ng T. C. (1999) 1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla. Neurology 53, 71 79.
302. Pitt D., Werner P. Raine C. S. (2000) Glutamate excitotoxicity in a model of multiple sclerosis. Nat. Med. 6, 67 70.
303. Polidori M. C., Mecocci P., Browne S. E., Senin U. Beal M. F. (1999) Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex. Neurosci. Lett. 272, 53 56.
304. Pratico D., Reiss P., Tang L. X., Sung S., Rokach J. McIntosh T. K. (2002) Local and systemic increase in lipid peroxidation after moderate experimental traumatic brain injury. J. Neurochem. 80, 894 898.
305. Pringle A. K., Niyadurupola N., Johns P., Anthony D. C. Iannotti F. (2001) Interleukin-1beta exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischaemia and excitotoxicity in rat organotypic hippocampal slice cultures. Neurosci. Lett. 305, 29 32.
306. Qin S., Colin C., Hinners I., Gervais A., Cheret C. Mallat M. (2006) System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. J. Neurosci. 26, 3345 3356.
307. Regan R. F. Choi D. W. (1991) Glutamate neurotoxicity in spinal cord cell culture. Neuroscience 43, 585 591.
308. Reisberg B., Doody R., Stoffler A., Schmitt F., Ferris S. Mobius H. J. (2003) Memantine in moderate-to-severe Alzheimer's disease. N. Engl. J. Med. 348, 1333 1341.
309. Reisberg B., Doody R., Stoffler A., Schmitt F., Ferris S. Mobius H. J. (2006) A 24-week open-label extension study of memantine in moderate to severe Alzheimer disease. Arch. Neurol. 63, 49 54.
310. Relton J. K. Rothwell N. J. (1992) Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res. Bull. 29, 243 246.
311. Relton J. K., Martin D., Thompson R. C. Russell D. A. (1996) Peripheral administration of Interleukin-1 Receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat. Exp. Neurol. 138, 206 213.
312. Reynolds I. J. Hastings T. G. (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15, 3318 3327.
313. Ross F. M., Allan S. M., Rothwell N. J. Verkhratsky A. (2003) A dual role for interleukin-1 in LTP in mouse hippocampal slices. J. Neuroimmunol. 144, 61 67.
314. Rothenhausler H. B. (2006) [Clinical features, diagnosis and treatment of HIV-induced neuropsychiatric disorders]. Wiener medizinische Wochenschrift (1946) 156, 644 656.
315. Rothstein J. D., Tsai G., Kuncl R. W., Clawson L., Cornblath D. R., Drachman D. B., Pestronk A., Stauch B. L. Coyle J. T. (1990) Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann. Neurol. 28, 18 25.
316. Rothstein J. D., Martin L. J. Kuncl R. W. (1992) Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N. Engl. J. Med. 326, 1464 1468.
317. Rothstein J. D., Dykes-Hoberg M., Pardo C. A. et al. (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675 686.
318. Rothwell N. J. (1991) Functions and mechanisms of interleukin 1 in the brain. Trends Pharmacol. Sci. 12, 430 436.
319. Rothwell N. J. (1999) Annual review prize lecture cytokines - killers in the brain? J. Physiol. 514, 3 17.
320. Rothwell N. J. Luheshi G. N. (2000) Interleukin 1 in the brain: biology, pathology and therapeutic target. Trends Neurosci. 23, 618 625.
321. Rothwell N. J. Relton J. K. (1993) Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage. Cerebrovasc. Brain Metab. Rev. 5, 178 198.
322. Rothwell N. J. Strijbos P. J. (1995) Cytokines in neurodegeneration and repair. Int. J. Dev. Neurosci. 13, 179 185.
323. Rothwell N., Allan S. Toulmond S. (1997) The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications. J. Clin. Invest. 100, 2648 2652.
324. Rottkamp C. A., Atwood C. S., Joseph J. A., Nunomura A., Perry G. Smith M. A. (2002) The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease. Peptides 23, 1333 1341.
325. Roux-Lombard P. (1998) The interleukin-1 family. Eur. Cytokine Netw. 9, 565 576.
326. Rutledge E. M., Aschner M. Kimelberg H. K. (1998) Pharmacological characterization of swelling-induced D-[3H]aspartate release from primary astrocyte cultures. Am. J. Physiol. 274, C1511 C1520.
327. Sairanen T. R., Lindsberg P. J., Brenner M. Siren A. L. (1997) Global forebrain ischemia results in differential cellular expression of interleukin-1beta (IL-1beta) and its receptor at mRNA and protein level. J. Cereb. Blood Flow Metab. 17, 1107 1120.
328. Sakakura Y., Sato H., Shiiya A., Tamba M., Sagara J., Matsuda M., Okamura N., Makino N. Bannai S. (2007) Expression and function of cystine/glutamate transporter in neutrophils. J. Leukoc. Biol. 81, 974 982.
329. Sasaki S., Komori T. Iwata M. (2000) Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis. Acta Neuropathol. 100, 138 144.
330. Satta M. A., Jacobs R. A., Kaltsas G. A. Grossman A. B. (1998) Endotoxin induces interleukin-1beta and nitric oxide synthase mRNA in rat hypothalamus and pituitary. Neuroendocrinology 67, 109 116.
331. Schalkwijk C. G., Vervoordeldonk M., Pfeilschifter J. van den Bosch H. (1993) Interleukin-1 beta-induced cytosolic phospholipase A2 activity and protein synthesis is blocked by dexamethasone in rat mesangial cells. FEBS Lett. 333, 339 343.
332. Schielke G. P., Yang G. Y., Shivers B. D. Betz A. L. (1998) Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice. J. Cereb. Blood Flow Metab. 18, 180 185.
333. Schmitz J., Owyang A., Oldham E. et al. (2005) IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23, 479 490.
334. Schneider H., Pitossi F., Balschun D., Wagner A., del Rey A. Besedovsky H. O. (1998) A neuromodulatory role of interleukin-1beta in the hippocampus. Proc. Natl Acad. Sci. USA 95, 7778 7783.
335. Schulte T., Schols L., Muller T., Woitalla D., Berger K. Kruger R. (2002) Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease. Neurosci. Lett. 326, 70 72.
336. Seki Y., Feustel P. J., Keller Jr R. W., Tranmer B. I. Kimelberg H. K. (1999) Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker. Stroke; J. Cerebral Circ. 30, 433 440.
337. Serou M. J., DeCoster M. A. Bazan N. G. (1999) Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. J. Neurosci. Res. 58, 593 598.
338. Shaftel S. S., Carlson T. J., Olschowka J. A., Kyrkanides S., Matousek S. B. O'Banion M. K. (2007a) Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J. Neurosci. 27, 9301 9309.
339. Shaftel S. S., Kyrkanides S., Olschowka J. A., Miller J. N., Johnson R. E. O'Banion M. K. (2007b) Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J. Clin. Invest. 117, 1595 1604.
340. Shaw P. J., Chinnery R. M. Ince P. G. (1994) [3H]D-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study. Brain Res. 655, 195 201.
341. Shaw P. J., Forrest V., Ince P. G., Richardson J. P. Wastell H. J. (1995) CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients. Neurodegeneration 4, 209 216.
342. Sheng J. G., Mrak R. E. Griffin W. S. (1995) Microglial interleukin-1 alpha expression in brain regions in Alzheimer's disease: correlation with neuritic plaque distribution. Neuropathol. Appl. Neurobiol. 21, 290 301.
343. Sheng J. G., Mrak R. E. Griffin W. S. (1998a) Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain. Acta Neuropathol. 95, 229 234.
344. Sheng J. G., Griffin W. S., Royston M. C. Mrak R. E. (1998b) Distribution
345. Shibayama M., Kuchiwaki H., Inao S., Yoshida K. Ito M. (1996) Intercellular adhesion molecule-1 expression on glia following brain injury: participation of interleukin-1 beta. J. Neurotrauma 13, 801 808.
346. Shiozaki T., Hayakata T., Tasaki O. et al. (2005) Cerebrospinal fluid concentrations of anti-inflammatory mediators in early-phase severe traumatic brain injury. Shock (Augusta, Ga 23, 406 410.
347. Sian J., Dexter D. T., Lees A. J., Daniel S., Agid Y., Javoy-Agid F., Jenner P. Marsden C. D. (1994) Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann. Neurol. 36, 348 355.
348. Simpson D. M. Tagliati M. (1994) Neurologic manifestations of HIV infection. Ann. Intern. Med. 121, 769 785.
349. Sims J. E. Dower S. K. (1994) Interleukin-1 receptors. Eur. Cytokine Netw. 5, 539 546.
350. Sims J. E., Gayle M. A., Slack J. L. et al. (1993) Interleukin 1 signaling occurs exclusively via the type I receptor. Proc. Natl Acad. Sci. USA 90, 6155 6159.
351. Singer I. I., Scott S., Chin J., Bayne E. K., Limjuco G., Weidner J., Miller D. K., Chapman K. Kostura M. J. (1995) The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J. Exp. Med. 182, 1447 1459.
352. Skifter D. A., Allegrini P. R., Wiessner C. Mir A. K. (2002) Similar time-course of interleukin-1 beta production and extracellular-signal-regulated kinase (ERK) activation in permanent focal brain ischemic injury. Metab. Brain Dis. 17, 131 138.
353. Small D. H. (2004) Do acetylcholinesterase inhibitors boost synaptic scaling in Alzheimer's disease? Trends Neurosci. 27, 245 249.
354. Smith S. L., Andrus P. K., Zhang J. R. Hall E. D. (1994) Direct measurement of hydroxyl radicals, lipid peroxidation, and blood-brain barrier disruption following unilateral cortical impact head injury in the rat. J. Neurotrauma 11, 393 404.
355. Smith M. A., Perry G., Richey P. L., Sayre L. M., Anderson V. E., Beal M. F. Kowall N. (1996) Oxidative damage in Alzheimer's. Nature 382, 120 121.
356. Smith M. A., Nunomura A., Zhu X., Takeda A. Perry G. (2000a) Metabolic, metallic, and mitotic sources of oxidative stress in Alzheimer disease. Antioxid. Redox Signal. 2, 413 420.
357. Smith T., Groom A., Zhu B. Turski L. (2000b) Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nat. Med. 6, 62 66.
358. Smith M. A., Casadesus G., Joseph J. A. Perry G. (2002) Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain. Free Radic. Biol. Med. 33, 1194 1199.
359. Sonsalla P. K., Nicklas W. J. Heikkila R. E. (1989) Role for excitatory amino acids in methamphetamine-induced nigrostriatal dopaminergic toxicity. Science (New York, NY) 243, 398 400.
360. Sonsalla P. K., Riordan D. E. Heikkila R. E. (1991) Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice. J. Pharmacol. Exp. Ther. 256, 506 512.
361. Sonsalla P. K., Albers D. S. Zeevalk G. D. (1998) Role of glutamate in neurodegeneration of dopamine neurons in several animal models of parkinsonism. Amino acids 14, 69 74.
362. Srivastava R., Brouillet E., Beal M. F., Storey E. Hyman B. T. (1993) Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss. Neurobiol. Aging 14, 295 301.
363. Steiner J., Haughey N., Li W., Venkatesan A., Anderson C., Reid R., Malpica T., Pocernich C., Butterfield D. A. Nath A. (2006) Oxidative stress and therapeutic approaches in HIV dementia. Antioxid. Redox Signal. 8, 2089 2100.
364. Steinkasserer A., Spurr N. K., Cox S., Jeggo P. Sim R. B. (1992) The human IL-1 receptor antagonist gene (IL1RN) maps to chromosome 2q14-q21, in the region of the IL-1 alpha and IL-1 beta loci. Genomics 13, 654 657.
365. Stella N., Estelles A., Siciliano J., Tence M., Desagher S., Piomelli D., Glowinski J. Premont J. (1997) Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes. J. Neurosci. 17, 2939 2946.
366. Storey E., Hyman B. T., Jenkins B., Brouillet E., Miller J. M., Rosen B. R. Beal M. F. (1992) 1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism. J. Neurochem. 58, 1975 1978.
367. Stover J. F., Pleines U. E., Morganti-Kossmann M. C., Kossmann T., Lowitzsch K. Kempski O. S. (1997) Neurotransmitters in cerebrospinal fluid reflect pathological activity. Eur. J. Clin. Invest. 27, 1038 1043.
368. Strijbos P. J. Rothwell N. J. (1995) Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor. J. Neurosci. 15, 3468 3474.
369. Stroemer R. P. Rothwell N. J. (1998) Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat. J. Cereb. Blood Flow Metab. 18, 833 839.
370. Sung C. S., Wen Z. H., Chang W. K., Ho S. T., Tsai S. K., Chang Y. C. Wong C. S. (2004) Intrathecal interleukin-1beta administration induces thermal hyperalgesia by activating inducible nitric oxide synthase expression in the rat spinal cord. Brain Res. 1015, 145 153.
371. Szatkowski M. Attwell D. (1994) Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 17, 359 365.
372. Szatkowski M., Barbour B. Attwell D. (1990) Non-vesicular release of glutamate from glial cells by reversed electrogenic glutamate uptake. Nature 348, 443 446.
373. Taishi P., Bredow S., Guha-Thakurta N., Obal Jr F. Krueger J. M. (1997) Diurnal variations of interleukin-1 beta mRNA and beta-actin mRNA in rat brain. J. Neuroimmunol. 75, 69 74.
374. Takahashi J. L., Giuliani F., Power C., Imai Y. Yong V. W. (2003) Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity. Ann. Neurol. 53, 588 595.
375. Takao T., Tracey D. E., Mitchell W. M. De Souza E. B. (1990) Interleukin-1 receptors in mouse brain: characterization and neuronal localization. Endocrinology 127, 3070 3078.
376. Tarkowski E., Rosengren L., Blomstrand C., Jensen C., Ekholm S. Tarkowski A. (1999) Intrathecal expression of proteins regulating apoptosis in acute stroke. Stroke; J. Cerebral Circ. 30, 321 327.
377. Taupin V., Toulmond S., Serrano A., Benavides J. Zavala F. (1993) Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand. J. Neuroimmunol. 42, 177 185.
378. Taylor S. L., Renshaw B. R., Garka K. E., Smith D. E. Sims J. E. (2002) Genomic organization of the interleukin-1 locus. Genomics 79, 726 733.
379. Tehranian R., Andell-Jonsson S., Beni S. M., Yatsiv I., Shohami E., Bartfai T., Lundkvist J. Iverfeldt K. (2002) Improved recovery and delayed cytokine induction after closed head injury in mice with central overexpression of the secreted isoform of the interleukin-1 receptor antagonist. J. Neurotrauma 19, 939 951.
380. Terry Jr A. V. Buccafusco J. J. (2003) The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. J. Pharmacol. Exp. Ther. 306, 821 827.
381. Thornberry N. A., Bull H. G., Calaycay J. R. et al. (1992) A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356, 768 774.
382. Thornton P., Pinteaux E., Gibson R. M., Allan S. M. Rothwell N. J. (2006) Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release. J. Neurochem. 98, 258 266.
383. Tipton K. F. Singer T. P. (1993) Advances in our understanding of the mechanisms of the neurotoxicity of MPTP and related compounds. J. Neurochem. 61, 1191 1206.
384. Toggas S. M., Masliah E. Mucke L. (1996) Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine. Brain Res. 706, 303 307.
385. Tomozawa Y., Inoue T. Satoh M. (1995) Expression of type I interleukin-1 receptor mRNA and its regulation in cultured astrocytes. Neurosci. Lett. 195, 57 60.
386. Tong L., Balazs R., Soiampornkul R., Thangnipon W. Cotman C. W. (2008) Interleukin-1[beta] impairs brain derived neurotrophic factor-induced signal transduction. Neurobiol. Aging [Epub ahead of print]. doi :.
387. Torigoe K., Ushio S., Okura T. et al. (1997) Purification and characterization of the human interleukin-18 receptor. J. Biol. Chem. 272, 25737 25742.
388. Toulmond S. Rothwell N. J. (1995) Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat. Brain Res. 671, 261 266.
389. Touzani O., Boutin H., LeFeuvre R., Parker L., Miller A., Luheshi G. Rothwell N. (2002) Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor. J. Neurosci. 22, 38 43.
390. Towne J. E., Garka K. E., Renshaw B. R., Virca G. D. Sims J. E. (2004) Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 279, 13677 13688.
391. Toyooka K., Watanabe Y., Iritani S. et al. (2003) A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients. Neurosci. Res. 46, 299 307.
392. Troy C. M., Stefanis L., Prochiantz A., Greene L. A. Shelanski M. L. (1996) The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc. Natl Acad. Sci. USA 93, 5635 5640.
393. Tunez I., Montilla P., Del Carmen Munoz M., Feijoo M. Salcedo M. (2004) Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. J. Pineal Res. 37, 252 256.
394. Turski L., Bressler K., Rettig K. J., Loschmann P. A. Wachtel H. (1991) Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists. Nature 349, 414 418.
395. Uehara A., Gottschall P. E., Dahl R. R. Arimura A. (1987) Stimulation of ACTH release by human interleukin-1 beta, but not by interleukin-1 alpha, in conscious, freely-moving rats. Biochem. Biophys. Res. Commun. 146, 1286 1290.
396. Van Damme P., Dewil M., Robberecht W. Van Den Bosch L. (2005) Excitotoxicity and amyotrophic lateral sclerosis. Neuro-degenerative diseases 2, 147 159.
397. Vandenabeele P. Fiers W. (1991) Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain? Immunol. Today 12, 217 219.
398. Vazquez E., Herrero I., Miras-Portugal M. T. Sanchez-Prieto J. (1994) Role of arachidonic acid in the facilitation of glutamate release from rat cerebrocortical synaptosomes independent of metabotropic glutamate receptor responses. Neurosci. Lett. 174, 9 13.
399. Vidwans A. S. Hewett S. J. (2004) Enhanced release of synaptic glutamate underlies the potentiation of oxygen-glucose deprivation-induced neuronal injury after induction of NOS-2. Exp. Neurol. 190, 91 101.
400. Viviani B., Corsini E., Binaglia M., Galli C. L. Marinovich M. (2001) Reactive oxygen species generated by glia are responsible for neuron death induced by human immunodeficiency virus-glycoprotein 120 in vitro. Neuroscience 107, 51 58.
401. Viviani B., Bartesaghi S., Gardoni F. et al. (2003) Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J. Neurosci. 23, 8692 8700.
402. Viviani B., Gardoni F., Bartesaghi S., Corsini E., Facchi A., Galli C. L., Di Luca M. Marinovich M. (2006) Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors. J. Biol. Chem. 281, 30212 30222.
403. Wahl F., Obrenovitch T. P., Hardy A. M., Plotkine M., Boulu R. Symon L. (1994) Extracellular glutamate during focal cerebral ischaemia in rats: time course and calcium dependency. J. Neurochem. 63, 1003 1011.
404. Wahner A. D., Sinsheimer J. S., Bronstein J. M. Ritz B. (2007) Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease. Arch. Neurol. 64, 836 840.
405. Wakabayashi G., Gelfand J. A., Burke J. F., Thompson R. C. Dinarello C. A. (1991) A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J. 5, 338 343.
406. Walker D. G., Kim S. U. McGeer P. L. (1995) Complement and cytokine gene expression in cultured microglial derived from postmortem human brains. J. Neurosci. Res. 40, 478 493.
407. Wallstrom E., Diener P., Ljungdahl A., Khademi M., Nilsson C. G. Olsson T. (1996) Memantine abrogates neurological deficits, but not CNS inflammation, in Lewis rat experimental autoimmune encephalomyelitis. J. Neurol. Sci. 137, 89 96.
408. Wang C. X., Olschowka J. A. Wrathall J. R. (1997a) Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat. Brain Res. 759, 190 196.
409. Wang X., Barone F. C., Aiyar N. V. Feuerstein G. Z. (1997b) Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats. Stroke; J. Cerebral Circ. 28, 155 161.
410. Wang X., Li X., Currie R. W., Willette R. N., Barone F. C. Feuerstein G. Z. (2000) Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1beta mRNA in ischemic brain tolerance. J. Neurosci. Res. 59, 238 246.
411. Wang X. F., Yin L., Hu J. G., Huang L. D., Yu P. P., Jiang X. Y., Xu X. M. Lu P. H. (2006) Expression and localization of p80 interleukin-1 receptor protein in the rat spinal cord. J. Mol. Neurosci. 29, 45 53.
412. Watt J. A. Hobbs N. K. (2000) Interleukin-1beta immunoreactivity in identified neurons of the rat magnocellular neurosecretory system: evidence for activity-dependent release. J. Neurosci. Res. 60, 478 489.
413. Webb A. C., Collins K. L., Auron P. E., Eddy R. L., Nakai H., Byers M. G., Haley L. L., Henry W. M. Shows T. B. (1986) Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2. Lymphokine Res. 5, 77 85.
414. Wellington C. L., Ellerby L. M., Hackam A. S. et al. (1998) Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem. 273, 9158 9167.
415. Werner P., Pitt D. Raine C. S. (2000) Glutamate excitotoxicity - a mechanism for axonal damage and oligodendrocyte death in Multiple Sclerosis? J. Neural Transm. 60, 375 385.
416. Wesche H., Korherr C., Kracht M., Falk W., Resch K. Martin M. U. (1997) The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J. Biol. Chem. 272, 7727 7731.
417. Wong M. L. Licinio J. (1994) Localization of interleukin 1 type I receptor mRNA in rat brain. Neuroimmunomodulation 1, 110 115.
418. Woodroofe M. N., Sarna G. S., Wadhwa M., Hayes G. M., Loughlin A. J., Tinker A. Cuzner M. L. (1991) Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J. Neuroimmunol. 33, 227 236.
419. Wu D. C., Jackson-Lewis V., Vila M., Tieu K., Teismann P., Vadseth C., Choi D. K., Ischiropoulos H. Przedborski S. (2002) Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine mouse model of Parkinson disease. J. Neurosci. 22, 1763 1771.
420. Xu G. Y., Hughes M. G., Zhang L., Cain L. McAdoo D. J. (2005) Administration of glutamate into the spinal cord at extracellular concentrations reached post-injury causes functional impairments. Neurosci. Lett. 384, 271 276.
421. Xue S., Brockman D. E., Slater D. M. Myatt L. (1995) Interleukin-1 beta induces the synthesis and activity of cytosolic phospholipase A2 and the release of prostaglandin E2 in human amnion-derived WISH cells. Prostaglandins 49, 351 369.
422. Yabuuchi K., Minami M., Katsumata S., Yamazaki A. Satoh M. (1994) An in situ hybridization study on interleukin-1 beta mRNA induced by transient forebrain ischemia in the rat brain. Brain Res. 26, 135 142.
423. Yamasaki Y., Matsuura N., Shozuhara H., Onodera H., Itoyama Y. Kogure K. (1995) Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke; J. Cerebral Circ. 26, 676 680.
424. Yanase M., Sakou T. Fukuda T. (1995) Role of N-methyl-D-aspartate receptor in acute spinal cord injury. J. Neurosurg. 83, 884 888.
425. Yang G. Y., Zhao Y. J., Davidson B. L. Betz A. L. (1997) Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury. Brain Res. 751, 181 188.
426. Yang G. Y., Liu X. H., Kadoya C., Zhao Y. J., Mao Y., Davidson B. L. Betz A. L. (1998a) Attenuation of ischemic inflammatory response in mouse brain using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist. J. Cereb. Blood Flow Metab. 18, 840 847.
427. Yang Y., Quitschke W. W. Brewer G. J. (1998b) Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species. Brain Res. 60, 40 49.
428. Yang G. Y., Mao Y., Zhou L. F., Gong C., Ge H. L. Betz A. L. (1999a) Expression of intercellular adhesion molecule 1 (ICAM-1) is reduced in permanent focal cerebral ischemic mouse brain using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist. Brain Res. 65, 143 150.
429. Yang G. Y., Mao Y., Zhou L. F., Ye W., Liu X. H., Gong C. Lorris Betz A. (1999b) Attenuation of temporary focal cerebral ischemic injury in the mouse following transfection with interleukin-1 receptor antagonist. Brain Res. 72, 129 137.
430. Yang L., Blumbergs P. C., Jones N. R., Manavis J., Sarvestani G. T. Ghabriel M. N. (2004) Early expression and cellular localization of proinflammatory cytokines interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in human traumatic spinal cord injury. Spine 29, 966 971.
431. Yang L., Jones N. R., Blumbergs P. C., Van Den Heuvel C., Moore E. J., Manavis J., Sarvestani G. T. Ghabriel M. N. (2005) Severity-dependent expression of pro-inflammatory cytokines in traumatic spinal cord injury in the rat. J Clin Neurosci 12, 276 284.
432. Yao J., Keri J. E., Taffs R. E. Colton C. A. (1992) Characterization of interleukin-1 production by microglia in culture. Brain Res. 591, 88 93.
433. Ye Z. C. Sontheimer H. (1999) Glioma cells release excitotoxic concentrations of glutamate. Cancer Res. 59, 4383 4391.
434. Ye Z. C., Wyeth M. S., Baltan-Tekkok S. Ransom B. R. (2003) Functional hemichannels in astrocytes: a novel mechanism of glutamate release. J. Neurosci. 23, 3588 3596.
435. Young P. R. Sylvester D. (1989) Cloning of rabbit interleukin-1 beta: differential evolution of IL-1 alpha and IL-1 beta proteins. Protein Eng. 2, 545 551.
436. Yu A. C., Chan P. H. Fishman R. A. (1987) Arachidonic acid inhibits uptake of glutamate and glutamine but not of GABA in cultured cerebellar granule cells. J. Neurosci. Res. 17, 424 427.
437. Zetterstrom M., Lundkvist J., Malinowsky D., Eriksson G. Bartfai T. (1998) Interleukin-1-mediated febrile responses in mice and interleukin-1 beta activation of NFkappaB in mouse primary astrocytes, involves the interleukin-1 receptor accessory protein. Eur. Cytokine Netw. 9, 131 138.
438. Zhang Z., Chopp M., Goussev A. Powers C. (1998) Cerebral vessels express interleukin 1beta after focal cerebral ischemia. Brain Res. 784, 210 217.
439. Zhang W., Smith C., Howlett C. Stanimirovic D. (2000) Inflammatory activation of human brain endothelial cells by hypoxic astrocytes in vitro is mediated by IL-1beta. J. Cereb. Blood Flow Metab. 20, 967 978.
440. Zhao M. L., Kim M. O., Morgello S. Lee S. C. (2001) Expression of inducible nitric oxide synthase, interleukin-1 and caspase-1 in HIV-1 encephalitis. J. Neuroimmunol. 115, 182 191.
441. Zhu T., Yao Z., Yuan H. N., Lu B. G. Yang S. Y. (2004) Changes of interleukin-1 beta, tumor necrosis factor alpha and interleukin-6 in brain and plasma after brain injury in rats. Chin. J. Traumatol. = Zhonghua chuang shang za zhi/Chin. Med. Assoc. 7, 32 35.
442. Zhu X., Su B., Wang X., Smith M. A. Perry G. (2007) Causes of oxidative stress in Alzheimer disease. Cell Mol. Life Sci. 64, 2202 2210.