Autoimmune encephalomyelitis ameliorated by AMPA antagonists

Nature Medicine

Volumn 6, Issue 1, 2000, Pages 62-66

  Smith, Terence ^a   Groom, Anthony ^a   Zhu, Bin ^a   Tukski, Lechoslaw ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR ANTAGONIST; MYELIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MECHANISM; MULTIPLE SCLEROSIS; MUSCLE WEAKNESS; NERVE CELL DEGENERATION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; WHITE MATTER;

ANIMALS; BRAIN STEM; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EXCITATORY AMINO ACID ANTAGONISTS; GUINEA PIGS; MOTOR NEURONS; MULTIPLE SCLEROSIS; MUSCLE TONUS; MYELIN BASIC PROTEINS; NEURONS; PHOSPHONIC ACIDS; QUINOXALINES; RATS; RATS, INBRED LEW; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECURRENCE; SPINAL CORD; T-LYMPHOCYTES;

ANIMALIA; PRIMATES; RODENTIA;

EID: 0033963231     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/71548     Document Type: Article

References (25)

1. Charcot, M. Histologie de la sclerose en plaques. Gaz. Hosp. 141, 554-555 (1868).
2. McFarlin, D.E. & McFarland, H. F. Multiple sclerosis. N. Engl. J. Med. 307, 1183-1188 (1982).
3. Rudick, R.A., Cohen, J.A., Weinstock-Guttman, B., Kinkel, R.P. & Ransohoff, R.M. Management of multiple sclerosis. N. Engl. J. Med. 337, 1604-1611 (1997).
4. Ffrench-Constant, C. Pathogenesis of multiple sclerosis. Lancet 343, 271-275 (1994).
5. Prineas, J.W. & McDonald, W.I. in Greenfield's Neuropathology (eds Graham, D. I. & Lantos, P.L.) 813-896 (Arnold, London, 1997).
6. Wekerle, H., Kojima, K., Lannes-Vieira, J., Lassmann, H. & Linington, C. Animal models. Ann. Neurol. 36, S47-S53 (1994).
7. Martin, R. & McFarland, H.F. in Multiple Sclerosis: Clinical and Pathological Basis (eds. Raine, C. S., McFarland, H.F. & Tourtellotte, W.W.) 221-242 (Chapman & Hall, London, 1997).
8. Brosnan, C.F. & Raine, C.S. Mechanisms of immune injury in multiple sclerosis. Brain Pathol. 6, 243-257 (1996).
9. Ikonomidou, C. Qin Qin, Y., Labruyere, J. & Olney, J.W. Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 55, 211-224 (1996).
10. Feldmeyer, D. et al. Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nature Neurosci. 2, 57-64 (1999).
11. Nakamura, R., Kamakura, K. & Kwak, S. Toxicity of AMPA, an excitatory amino acid, to rat spinal cord neurons under intrathecal administration. Rinsho Shinkeigaku 34, 679-684 (1994).
12. Sheardown, M.J., Nielsen, E.O., Hansen, A.J., Jacobsen, P. & Honore, T. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247, 571-574 (1990).
13. Turski, L. et al. ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma. Proc. Natl Acad. Sci. USA 95, 10960-10965 (1998).
14. Tarnawa, I. & Vizi, E.S. 2,3-Benzodiazepine AMPA antagonists. Restor. Neurol. Neurosci. 13, 41-57, (1998).
15. Humble, J.G., Jayne, W.H.W. & Pulvertaft, R.J.V. Biological interaction between lymphocytes and other cells. Br. J. Haemat. 2, 283-288 (1956).
16. Mikhailovskaya, E.V. Emperipolesis. Cytol. Genet. 31, 81-88 (1997).
17. Stover, J.F. et al. Neurotransmitters in cerebrospinal fluid reflect pathological activity. Eur. J. Clin. Invest. 27, 1038-1043 (1997).
18. Hardin-Pouzet, H. et al. Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis. Glia 20, 79-85 (1997).
19. McDonald, J.W., Althomsons, S.P., Hyrc, K.L., Choi, D.W. & Goldberg, M.P. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nature Med. 4, 291-297 (1998).
20. Matute, C. Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve. Proc. Nail Acad. Sci. USA 95, 10229-10234 (1998).
21. Dunkley, P.R. & Carnegie, P.R. Amino acid sequence of the smaller basic protein from rat brain myelin. Biochem. J. 141, 243-255 (1974).
22. Carnegie, P.R., Dunkley, P.R., Kemp, B.E. & Murray, A.W. Phosphorylation of selected serine and threonine residues in myelin basic protein by endogenous and exogenous protein kinases. Nature 249, 147-150 (1974).
23. Cruz-Orive, L.M. & Weibel, E.R. Recent stereological methods for cell biology: a brief survey. Am. J. Physiol. 258, L148-L156 (1990).
24. Ikonomidou, C. et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283, 70-74 (1999).
25. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic Press, San Diego, California, 1997).