메뉴 건너뛰기




Volumn 10, Issue 8, 2004, Pages 393-400

Lessons from models of SOD1-linked familial ALS

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR ANTAGONIST; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2 INHIBITOR; CYCLOSPORIN A; MINOCYCLINE; MUTANT PROTEIN; TETRACYCLINE DERIVATIVE;

EID: 4043075622     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2004.06.009     Document Type: Review
Times cited : (179)

References (75)
  • 1
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • D.R. Rosen Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1
  • 2
    • 0037111503 scopus 로고    scopus 로고
    • Do oxidatively modified proteins cause ALS?
    • J.S. Valentine Do oxidatively modified proteins cause ALS? Free Radic. Biol. Med. 33 2002 1314 1320
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 1314-1320
    • Valentine, J.S.1
  • 3
    • 0037013224 scopus 로고    scopus 로고
    • Familial ALS-associated mutations decrease the thermal stability of distinctly metallated species of human copper-zinc superoxide dismutase
    • J.A. Rodriguez Familial ALS-associated mutations decrease the thermal stability of distinctly metallated species of human copper-zinc superoxide dismutase J. Biol. Chem. 277 2002 15932 15937
    • (2002) J. Biol. Chem. , vol.277 , pp. 15932-15937
    • Rodriguez, J.A.1
  • 4
    • 0347155578 scopus 로고    scopus 로고
    • Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis
    • R. Rakhit Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis J. Biol. Chem. 277 2002 47551 47556
    • (2002) J. Biol. Chem. , vol.277 , pp. 47551-47556
    • Rakhit, R.1
  • 5
    • 0037795635 scopus 로고    scopus 로고
    • Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro
    • P.B. Stathopulos Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro Proc. Natl. Acad. Sci. U. S. A. 100 2003 7021 7026
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 7021-7026
    • Stathopulos, P.B.1
  • 6
    • 0038442784 scopus 로고    scopus 로고
    • Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS
    • J.S. Elam Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS Nat. Struct. Biol. 10 2003 461 467
    • (2003) Nat. Struct. Biol. , vol.10 , pp. 461-467
    • Elam, J.S.1
  • 7
    • 0036212119 scopus 로고    scopus 로고
    • Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading
    • J.R. Subramaniam Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading Nat. Neurosci. 5 2002 301 307
    • (2002) Nat. Neurosci. , vol.5 , pp. 301-307
    • Subramaniam, J.R.1
  • 8
    • 0242524455 scopus 로고    scopus 로고
    • Copper-binding-site-null SOD1 causes ALS in transgenic mice:aggregates of non-native SOD1 delineate a common feature
    • J. Wang Copper-binding-site-null SOD1 causes ALS in transgenic mice:aggregates of non-native SOD1 delineate a common feature Hum. Mol. Genet. 12 2003 2753 2764
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2753-2764
    • Wang, J.1
  • 9
    • 1942437507 scopus 로고    scopus 로고
    • Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone
    • M.C. Carroll Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone Proc. Natl. Acad. Sci. U. S. A. 101 2004 5964 5969
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 5964-5969
    • Carroll, M.C.1
  • 10
    • 0037013264 scopus 로고    scopus 로고
    • Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis
    • L.J. Hayward Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis J. Biol. Chem. 277 2002 15923 15931
    • (2002) J. Biol. Chem. , vol.277 , pp. 15923-15931
    • Hayward, L.J.1
  • 11
    • 0002770493 scopus 로고    scopus 로고
    • Superoxide dismutase and the death of motoneurons in ALS
    • J.S. Beckman Superoxide dismutase and the death of motoneurons in ALS Trends Neurosci. 24 2001 S15 S20
    • (2001) Trends Neurosci. , vol.24
    • Beckman, J.S.1
  • 12
    • 0030851761 scopus 로고    scopus 로고
    • Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
    • M.F. Beal Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis Ann. Neurol. 42 1997 644 654
    • (1997) Ann. Neurol. , vol.42 , pp. 644-654
    • Beal, M.F.1
  • 13
    • 0030806228 scopus 로고    scopus 로고
    • Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant
    • L.I. Bruijn Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant Proc. Natl. Acad. Sci. U. S. A. 94 1997 7606 7611
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 7606-7611
    • Bruijn, L.I.1
  • 14
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    • M.E. Gurney Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation Science 264 1994 1772 1775
    • (1994) Science , vol.264 , pp. 1772-1775
    • Gurney, M.E.1
  • 15
    • 0035575761 scopus 로고    scopus 로고
    • Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease
    • M. Nagai Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease J. Neurosci. 21 2001 9246 9254
    • (2001) J. Neurosci. , vol.21 , pp. 9246-9254
    • Nagai, M.1
  • 17
    • 0030887622 scopus 로고    scopus 로고
    • Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • V. Kostic Midbrain dopaminergic neuronal degeneration in a transgenic mouse model of familial amyotrophic lateral sclerosis Ann. Neurol. 41 1997 497 504
    • (1997) Ann. Neurol. , vol.41 , pp. 497-504
    • Kostic, V.1
  • 18
    • 0035070937 scopus 로고    scopus 로고
    • Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation
    • N. Shibata Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation Neuropathology 21 2001 82 92
    • (2001) Neuropathology , vol.21 , pp. 82-92
    • Shibata, N.1
  • 19
    • 0035886428 scopus 로고    scopus 로고
    • Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histiochemical reactivity
    • C. Bendotti Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histiochemical reactivity J. Neurol. Sci. 191 2001 25 33
    • (2001) J. Neurol. Sci. , vol.191 , pp. 25-33
    • Bendotti, C.1
  • 20
    • 0036830072 scopus 로고    scopus 로고
    • Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis
    • C. Jung Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis J. Neurochem. 83 2002 535 545
    • (2002) J. Neurochem. , vol.83 , pp. 535-545
    • Jung, C.1
  • 21
    • 0031559896 scopus 로고    scopus 로고
    • 2+ concentration in transfected neuroblastoma SH-SY5Y cells
    • 2+ concentration in transfected neuroblastoma SH-SY5Y cells FEBS Lett. 414 1997 365 368
    • (1997) FEBS Lett. , vol.414 , pp. 365-368
    • Carrì, M.T.1
  • 22
    • 0033934734 scopus 로고    scopus 로고
    • Mitochondria and the pathogenesis of ALS
    • M.F. Beal Mitochondria and the pathogenesis of ALS Brain 123 2000 1291 1292
    • (2000) Brain , vol.123 , pp. 1291-1292
    • Beal, M.F.1
  • 23
    • 0030026832 scopus 로고    scopus 로고
    • Ultrastructural evidence for altered calcium in motor nerve terminals in amyotropic lateral sclerosis
    • L. Siklos Ultrastructural evidence for altered calcium in motor nerve terminals in amyotropic lateral sclerosis Ann. Neurol. 39 1996 203 216
    • (1996) Ann. Neurol. , vol.39 , pp. 203-216
    • Siklos, L.1
  • 24
    • 0033914937 scopus 로고    scopus 로고
    • Calcineurin activity is regulated both by redox compounds and by mutant FALS-SOD1
    • A. Ferri Calcineurin activity is regulated both by redox compounds and by mutant FALS-SOD1 J. Neurochem. 75 2000 606 613
    • (2000) J. Neurochem. , vol.75 , pp. 606-613
    • Ferri, A.1
  • 25
    • 0034681320 scopus 로고    scopus 로고
    • Cu,Zn superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells
    • M.R. Ciriolo Cu,Zn superoxide dismutase-dependent apoptosis induced by nitric oxide in neuronal cells J. Biol. Chem. 275 2000 5065 5072
    • (2000) J. Biol. Chem. , vol.275 , pp. 5065-5072
    • Ciriolo, M.R.1
  • 26
    • 0032764587 scopus 로고    scopus 로고
    • The roles of free radicals in amyotrophic lateral sclerosis: Reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids
    • D. Liu The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids FASEB J. 13 1999 2318 2328
    • (1999) FASEB J. , vol.13 , pp. 2318-2328
    • Liu, D.1
  • 27
    • 0037119407 scopus 로고    scopus 로고
    • Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice
    • M. Mattiazzi Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice J. Biol. Chem. 277 2002 29626 29633
    • (2002) J. Biol. Chem. , vol.277 , pp. 29626-29633
    • Mattiazzi, M.1
  • 28
    • 0037417220 scopus 로고    scopus 로고
    • Apoptosis and caspases in neurodegenerative diseases
    • M. Friedlander Apoptosis and caspases in neurodegenerative diseases N. Engl. J. Med. 348 2003 1365 1375
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1365-1375
    • Friedlander, M.1
  • 29
    • 0032863462 scopus 로고    scopus 로고
    • Lack of apoptosis in mice with ALS
    • A. Migheli Lack of apoptosis in mice with ALS Nat. Med. 5 1999 966 967
    • (1999) Nat. Med. , vol.5 , pp. 966-967
    • Migheli, A.1
  • 30
    • 0030831352 scopus 로고    scopus 로고
    • Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: Molecular mechanisms of neuronal death and protection
    • G.D. Ghadge Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection J. Neurosci. 17 1997 8756 8766
    • (1997) J. Neurosci. , vol.17 , pp. 8756-8766
    • Ghadge, G.D.1
  • 31
    • 0034610328 scopus 로고    scopus 로고
    • Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis
    • P. Pasinelli Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U. S. A. 97 2000 13901 13906
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 13901-13906
    • Pasinelli, P.1
  • 32
    • 0037240427 scopus 로고    scopus 로고
    • Programmed cell death in amyotrophic lateral sclerosis
    • C. Guégan, and S. Przedborski Programmed cell death in amyotrophic lateral sclerosis J. Clin. Invest. 111 2003 153 161
    • (2003) J. Clin. Invest. , vol.111 , pp. 153-161
    • Guégan, C.1    Przedborski, S.2
  • 33
    • 0034647003 scopus 로고    scopus 로고
    • Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model
    • M. Li Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model Science 288 2000 335 339
    • (2000) Science , vol.288 , pp. 335-339
    • Li, M.1
  • 34
    • 10744223086 scopus 로고    scopus 로고
    • The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model
    • H. Inoue The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model EMBO J. 22 2003 6665 6674
    • (2003) EMBO J. , vol.22 , pp. 6665-6674
    • Inoue, H.1
  • 36
    • 0033749379 scopus 로고    scopus 로고
    • Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis
    • J.A. Johnston Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis Proc. Natl. Acad. Sci. U. S. A. 97 2000 12571 12576
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 12571-12576
    • Johnston, J.A.1
  • 37
    • 0035936804 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis. Unfolding the toxicity of the misfolded
    • J-P. Julien Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded Cell 104 2001 581 591
    • (2001) Cell , vol.104 , pp. 581-591
    • Julien, J.-P.1
  • 38
    • 0034209203 scopus 로고    scopus 로고
    • New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: Inclusions containing SOD1 in neurons and astrocytes
    • S. Kato New consensus research on neuropathological aspects of familial amyotrophic lateral sclerosis with superoxide dismutase 1 (SOD1) gene mutations: inclusions containing SOD1 in neurons and astrocytes Amyotroph. Lateral Scler. Other Motor Neuron Disord. 1 2000 163 184
    • (2000) Amyotroph. Lateral Scler. Other Motor Neuron Disord. , vol.1 , pp. 163-184
    • Kato, S.1
  • 39
    • 0038383029 scopus 로고    scopus 로고
    • Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression
    • M. Tortarolo Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression Mol. Cell. Neurosci. 23 2003 180 192
    • (2003) Mol. Cell. Neurosci. , vol.23 , pp. 180-192
    • Tortarolo, M.1
  • 40
    • 0842288215 scopus 로고    scopus 로고
    • Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice
    • C. Bendotti Activated p38MAPK is a novel component of the intracellular inclusions found in human amyotrophic lateral sclerosis and mutant SOD1 transgenic mice J. Neuropathol. Exp. Neurol. 63 2004 113 119
    • (2004) J. Neuropathol. Exp. Neurol. , vol.63 , pp. 113-119
    • Bendotti, C.1
  • 41
    • 0037458659 scopus 로고    scopus 로고
    • Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways
    • S. Allen Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways J. Biol. Chem. 278 2003 6371 6383
    • (2003) J. Biol. Chem. , vol.278 , pp. 6371-6383
    • Allen, S.1
  • 42
    • 0036892683 scopus 로고    scopus 로고
    • Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in FALS
    • M. Urushitani Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in FALS J. Neurochem. 83 2002 1030 1042
    • (2002) J. Neurochem. , vol.83 , pp. 1030-1042
    • Urushitani, M.1
  • 43
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • J.D. Rothstein Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis N. Engl. J. Med. 326 1992 1464 1468
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1
  • 44
    • 0033366461 scopus 로고    scopus 로고
    • SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
    • D. Trotti SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nat. Neurosci. 2 1999 427 433
    • (1999) Nat. Neurosci. , vol.2 , pp. 427-433
    • Trotti, D.1
  • 45
    • 0035189072 scopus 로고    scopus 로고
    • Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels
    • C. Bendotti Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels J. Neurochem. 79 2001 737 746
    • (2001) J. Neurochem. , vol.79 , pp. 737-746
    • Bendotti, C.1
  • 46
    • 0037022339 scopus 로고    scopus 로고
    • Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
    • D.S. Howland Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) Proc. Natl. Acad. Sci. U. S. A. 99 2002 1604 1609
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 1604-1609
    • Howland, D.S.1
  • 47
    • 0141618315 scopus 로고    scopus 로고
    • Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
    • H. Guo Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice Hum. Mol. Genet. 12 2003 2519 2532
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2519-2532
    • Guo, H.1
  • 48
    • 0037110681 scopus 로고    scopus 로고
    • Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder
    • T. Mennini Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder J. Neurosci. Res. 70 2002 553 560
    • (2002) J. Neurosci. Res. , vol.70 , pp. 553-560
    • Mennini, T.1
  • 49
    • 0344223536 scopus 로고    scopus 로고
    • Differential expression of group I metabotropic glutamate receptors in rat spinal cord somatic and autonomic motoneurons: Possible implications for the pathogenesis of amyotrophic lateral sclerosis
    • J.M. Anneser Differential expression of group I metabotropic glutamate receptors in rat spinal cord somatic and autonomic motoneurons: possible implications for the pathogenesis of amyotrophic lateral sclerosis Neurobiol. Dis. 6 1999 140 147
    • (1999) Neurobiol. Dis. , vol.6 , pp. 140-147
    • Anneser, J.M.1
  • 50
    • 0030015076 scopus 로고    scopus 로고
    • Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
    • S.G. Carriedo Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro J. Neurosci. 16 1996 4069 4079
    • (1996) J. Neurosci. , vol.16 , pp. 4069-4079
    • Carriedo, S.G.1
  • 51
    • 1542378930 scopus 로고    scopus 로고
    • Glutamate receptors: RNA editing and death of motor neurons
    • Y. Kawahara Glutamate receptors: RNA editing and death of motor neurons Nature 427 2004 801
    • (2004) Nature , vol.427 , pp. 801
    • Kawahara, Y.1
  • 52
    • 0037986558 scopus 로고    scopus 로고
    • The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
    • P. Van Damme The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis Neurosci. Lett. 343 2003 81 84
    • (2003) Neurosci. Lett. , vol.343 , pp. 81-84
    • Van Damme, P.1
  • 53
    • 0037068836 scopus 로고    scopus 로고
    • Motoneuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations
    • C. Raoul Motoneuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations Neuron 35 2002 1067 1083
    • (2002) Neuron , vol.35 , pp. 1067-1083
    • Raoul, C.1
  • 54
    • 0036062628 scopus 로고    scopus 로고
    • Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    • K. Hensley Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis J. Neurochem. 82 2002 365 374
    • (2002) J. Neurochem. , vol.82 , pp. 365-374
    • Hensley, K.1
  • 55
    • 1242336763 scopus 로고    scopus 로고
    • Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis
    • M.D. Nguyen Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis J. Neurosci. 24 2004 1340 1349
    • (2004) J. Neurosci. , vol.24 , pp. 1340-1349
    • Nguyen, M.D.1
  • 56
    • 0033957706 scopus 로고    scopus 로고
    • Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation
    • C.I. Cha Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation Brain Res. 853 2000 156 161
    • (2000) Brain Res. , vol.853 , pp. 156-161
    • Cha, C.I.1
  • 57
    • 0031469483 scopus 로고    scopus 로고
    • C-Jun, JNK/SAPK kinases and transcription factor NF-κB are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis
    • A. Migheli c-Jun, JNK/SAPK kinases and transcription factor NF-κB are selectively activated in astrocytes, but not motor neurons, in amyotrophic lateral sclerosis J. Neuropathol. Exp. Neurol. 56 1997 1314 1322
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 1314-1322
    • Migheli, A.1
  • 58
    • 0036892743 scopus 로고    scopus 로고
    • Oxidative modulation of nuclear factor-κB in human cells expressing mutant fALS-typical superoxide dismutases
    • A. Casciati Oxidative modulation of nuclear factor-κB in human cells expressing mutant fALS-typical superoxide dismutases J. Neurochem. 83 2002 1019 1029
    • (2002) J. Neurochem. , vol.83 , pp. 1019-1029
    • Casciati, A.1
  • 59
    • 0035132167 scopus 로고    scopus 로고
    • Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis
    • G. Almer Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis Ann. Neurol. 49 2001 176 185
    • (2001) Ann. Neurol. , vol.49 , pp. 176-185
    • Almer, G.1
  • 60
    • 0036895241 scopus 로고    scopus 로고
    • Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
    • D.B. Drachman Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS Ann. Neurol. 52 2002 771 778
    • (2002) Ann. Neurol. , vol.52 , pp. 771-778
    • Drachman, D.B.1
  • 61
    • 0037161253 scopus 로고    scopus 로고
    • Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients
    • G. Almer Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients Neurology 58 2002 1277 1279
    • (2002) Neurology , vol.58 , pp. 1277-1279
    • Almer, G.1
  • 62
    • 0035873076 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
    • A. Pramatarova Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment J. Neurosci. 21 2001 3369 3374
    • (2001) J. Neurosci. , vol.21 , pp. 3369-3374
    • Pramatarova, A.1
  • 63
    • 0037096354 scopus 로고    scopus 로고
    • Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease
    • M.M. Lino Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease J. Neurosci. 22 2002 4825 4832
    • (2002) J. Neurosci. , vol.22 , pp. 4825-4832
    • Lino, M.M.1
  • 64
    • 0034651102 scopus 로고    scopus 로고
    • Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
    • Y.H. Gong Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration J. Neurosci. 20 2000 660 665
    • (2000) J. Neurosci. , vol.20 , pp. 660-665
    • Gong, Y.H.1
  • 65
    • 4043124885 scopus 로고    scopus 로고
    • Cell death in amyotrophic lateral sclerosis: Interplay between neuronal and glial cells
    • Doi: 10.1096/fj.03-1199fje
    • Ferri, A. et al. (2004) Cell death in amyotrophic lateral sclerosis: interplay between neuronal and glial cells. FASEB J. Doi: 10.1096/fj.03-1199fje (http://www.fasebj.org/)
    • (2004) FASEB J.
    • Ferri, A.1
  • 66
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • S. Zhu Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice Nature 417 2002 74 78
    • (2002) Nature , vol.417 , pp. 74-78
    • Zhu, S.1
  • 67
    • 0141642203 scopus 로고    scopus 로고
    • Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
    • A.M. Clement Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice Science 302 2003 113 117
    • (2003) Science , vol.302 , pp. 113-117
    • Clement, A.M.1
  • 68
    • 0345269737 scopus 로고    scopus 로고
    • Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons
    • S.D. Rao Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons J. Neurosci. 23 2003 2627 2633
    • (2003) J. Neurosci. , vol.23 , pp. 2627-2633
    • Rao, S.D.1
  • 69
    • 10744229158 scopus 로고    scopus 로고
    • Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue
    • J.S. Henkel Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue Ann. Neurol. 55 2004 221 235
    • (2004) Ann. Neurol. , vol.55 , pp. 221-235
    • Henkel, J.S.1
  • 70
    • 0942287666 scopus 로고    scopus 로고
    • Additive neuroprotective effects of creatine and cycloxygenase inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
    • P. Klivnyi Additive neuroprotective effects of creatine and cycloxygenase inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurochem. 88 2004 576 582
    • (2004) J. Neurochem. , vol.88 , pp. 576-582
    • Klivnyi, P.1
  • 71
    • 0242379146 scopus 로고    scopus 로고
    • Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis
    • H. Ding Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis Aging Cell 2 2003 209 217
    • (2003) Aging Cell , vol.2 , pp. 209-217
    • Ding, H.1
  • 72
    • 1542267797 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells
    • M.M. Maxwell RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells Proc. Natl. Acad. Sci. U. S. A. 101 2004 3178 3183
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 3178-3183
    • Maxwell, M.M.1
  • 73
    • 0037459081 scopus 로고    scopus 로고
    • Mitochondria: Releasing power for life and unleashing the machineries of death
    • D.D. Newmeyer, and S. Ferguson-Miller Mitochondria: releasing power for life and unleashing the machineries of death Cell 112 2003 481 490
    • (2003) Cell , vol.112 , pp. 481-490
    • Newmeyer, D.D.1    Ferguson-Miller, S.2
  • 74
    • 0030756459 scopus 로고    scopus 로고
    • Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • V. Kostic Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis Science 277 1997 559 562
    • (1997) Science , vol.277 , pp. 559-562
    • Kostic, V.1
  • 75
    • 1042289650 scopus 로고    scopus 로고
    • An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine a treatment
    • I.G. Kirkinezos An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment J. Neurochem. 88 2004 821 826
    • (2004) J. Neurochem. , vol.88 , pp. 821-826
    • Kirkinezos, I.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.