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Volumn 89, Issue 4, 1999, Pages 1051-1066

Involvement of interleukin-1β in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat

Author keywords

Apoptosis; HIV 1 gp120 coat protein; IL 1 ; NGF; Nitric oxide

Indexed keywords

GLYCOPROTEIN GP 120; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; LEUPEPTIN; NERVE GROWTH FACTOR; NITRIC OXIDE; BOVINE SERUM ALBUMIN; CITRULLINE; IL1RN PROTEIN, HUMAN; INTERLEUKIN 1; RECOMBINANT PROTEIN; SIALOGLYCOPROTEIN;

EID: 0032587645     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00363-7     Document Type: Article
Times cited : (74)

References (57)
  • 1
    • 0030052843 scopus 로고    scopus 로고
    • Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat
    • Bagetta G., Corasaniti M.T., Aloe L., Berliocchi L., Costa N., Finazzi-Agrò A., Nisticò G. Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat. Proc. natn. Acad. Sci. U.S.A. 93:1996;928-933.
    • (1996) Proc. Natn. Acad. Sci. U.S.A. , vol.93 , pp. 928-933
    • Bagetta, G.1    Corasaniti, M.T.2    Aloe, L.3    Berliocchi, L.4    Costa, N.5    Finazzi-Agrò, A.6    Nisticò, G.7
  • 3
    • 0030940459 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 reduces the expression of neuronal nitric oxide synthase in the hippocampus but not in the cerebral cortex and medial septal nucleus of rat
    • Bagetta G., Corasaniti M.T., Costa N., Berliocchi L., Finazzi-Agrò A., Nisticò G. The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 reduces the expression of neuronal nitric oxide synthase in the hippocampus but not in the cerebral cortex and medial septal nucleus of rat. Neurosci. Lett. 224:1997;75-78.
    • (1997) Neurosci. Lett. , vol.224 , pp. 75-78
    • Bagetta, G.1    Corasaniti, M.T.2    Costa, N.3    Berliocchi, L.4    Finazzi-Agrò, A.5    Nisticò, G.6
  • 5
    • 0342503780 scopus 로고
    • CGP37849, a competitive NMDA receptor antagonist prevents the behavioural and neurodegenerative effects of tetanus toxin in rat hippocampus
    • Bagetta G., Nisticò G., Bowery N.G. CGP37849, a competitive NMDA receptor antagonist prevents the behavioural and neurodegenerative effects of tetanus toxin in rat hippocampus. Molec. Neuropharmac. 1:1991;45-51.
    • (1991) Molec. Neuropharmac. , vol.1 , pp. 45-51
    • Bagetta, G.1    Nisticò, G.2    Bowery, N.G.3
  • 6
    • 0029559859 scopus 로고
    • Systemic administration of lithium and tacrine but not kainic acid augments citrulline content in the brain of rat
    • Bagetta G., Rodinò P., Paoletti A.M., Arabia A., Massoud R., Nisticò G. Systemic administration of lithium and tacrine but not kainic acid augments citrulline content in the brain of rat. Eur. J. Pharmac. 294:1995;341-344.
    • (1995) Eur. J. Pharmac. , vol.294 , pp. 341-344
    • Bagetta, G.1    Rodinò, P.2    Paoletti, A.M.3    Arabia, A.4    Massoud, R.5    Nisticò, G.6
  • 8
    • 0029035825 scopus 로고
    • Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain
    • Betz A.L., Yang G.-Y., Davdson B.L. Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. J. cerebr. Blood Flow Metab. 15:1995;547-551.
    • (1995) J. Cerebr. Blood Flow Metab. , vol.15 , pp. 547-551
    • Betz, A.L.1    Yang, G.-Y.2    Davdson, B.L.3
  • 10
    • 0029153913 scopus 로고
    • Apoptosis and necrosis: Two distinct events induced respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
    • Bonfoco E., Krainc D., Ankarcrona M., Nicotera P.L., Lipton S.A. Apoptosis and necrosis: two distinct events induced respectively by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. natn. Acad. Sci. U.S.A. 92:1995;7162-7166.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 7162-7166
    • Bonfoco, E.1    Krainc, D.2    Ankarcrona, M.3    Nicotera, P.L.4    Lipton, S.A.5
  • 11
    • 0026334402 scopus 로고
    • NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglicemic damage by stabilizing calcium homeostasis
    • Cheng B., Mattson M.P. NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglicemic damage by stabilizing calcium homeostasis. Neuron. 7:1991;1031-1041.
    • (1991) Neuron , vol.7 , pp. 1031-1041
    • Cheng, B.1    Mattson, M.P.2
  • 12
    • 0027443553 scopus 로고
    • Trophic responses of forebrain cholinergic neurons: A discussion
    • Cuello A.C. Trophic responses of forebrain cholinergic neurons: a discussion. Prog. Brain Res. 98:1993;265-277.
    • (1993) Prog. Brain Res. , vol.98 , pp. 265-277
    • Cuello, A.C.1
  • 13
    • 0031037180 scopus 로고    scopus 로고
    • Suppression of apoptosis by nitric oxide via inhibition of interleukin 1 of IL-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases
    • Dimmeler S., Haendeler J., Nehls M., Zeiher A.M. Suppression of apoptosis by nitric oxide via inhibition of interleukin 1 of IL-1β-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J. exp. Med. 185:1997;601-607.
    • (1997) J. Exp. Med. , vol.185 , pp. 601-607
    • Dimmeler, S.1    Haendeler, J.2    Nehls, M.3    Zeiher, A.M.4
  • 15
    • 0025742947 scopus 로고
    • Interleukin-1 receptor antagonist binds to the 80kDa interleukin-1 receptor, but does not initiate interleukin-1 signal transduction
    • Dripps D.J., Brandhuber B.C., Thompson R.C., Eisenberg S.P. Interleukin-1 receptor antagonist binds to the 80kDa interleukin-1 receptor, but does not initiate interleukin-1 signal transduction. J. biol. Chem. 266:1991;10331-10336.
    • (1991) J. Biol. Chem. , vol.266 , pp. 10331-10336
    • Dripps, D.J.1    Brandhuber, B.C.2    Thompson, R.C.3    Eisenberg, S.P.4
  • 16
    • 0027325328 scopus 로고
    • Human immunodeficiency virus type 1 infection of the nervous system: Pathogenetic mechanisms
    • Epstein L.G., Gendelman H.E. Human immunodeficiency virus type 1 infection of the nervous system: pathogenetic mechanisms. Ann. Neurol. 33:1993;429-436.
    • (1993) Ann. Neurol. , vol.33 , pp. 429-436
    • Epstein, L.G.1    Gendelman, H.E.2
  • 18
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 19
    • 0026440742 scopus 로고
    • Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease
    • Genis P., Jett M., Bernton E.W., Boyle T., Gelbard H.A., Dzenko K., Keane R.W., Resnick L., Mizrachi Y., Volsky D.J., Epstein L.G., Gendelman H.E. Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J. exp. Med. 176:1992;1703-1718.
    • (1992) J. Exp. Med. , vol.176 , pp. 1703-1718
    • Genis, P.1    Jett, M.2    Bernton, E.W.3    Boyle, T.4    Gelbard, H.A.5    Dzenko, K.6    Keane, R.W.7    Resnick, L.8    Mizrachi, Y.9    Volsky, D.J.10    Epstein, L.G.11    Gendelman, H.E.12
  • 20
    • 0027407936 scopus 로고
    • The envelope glycoprotein of human immunodeficiency virus type one stimulates release of neurotoxins from monocytes
    • Giulian D., Wendt E., Vaca K., Noonan C.A. The envelope glycoprotein of human immunodeficiency virus type one stimulates release of neurotoxins from monocytes. Proc. natn. Acad. Sci. U.S.A. 90:1993;2769-2773.
    • (1993) Proc. Natn. Acad. Sci. U.S.A. , vol.90 , pp. 2769-2773
    • Giulian, D.1    Wendt, E.2    Vaca, K.3    Noonan, C.A.4
  • 22
    • 0003057773 scopus 로고
    • Learning impairment following intracerebral administration of the HIV envelope protein gp120 or VIP antagonist
    • Glowa J.R., Panlilio L.V., Brenneman D.E., Gozes I., Fridkin M., Hill J.M. Learning impairment following intracerebral administration of the HIV envelope protein gp120 or VIP antagonist. Brain Res. 603:1992;222-233.
    • (1992) Brain Res. , vol.603 , pp. 222-233
    • Glowa, J.R.1    Panlilio, L.V.2    Brenneman, D.E.3    Gozes, I.4    Fridkin, M.5    Hill, J.M.6
  • 24
    • 0029840954 scopus 로고    scopus 로고
    • Intracerebral NMDA injection stimulates production of interleukin-1b in perinatal rat brain
    • Hagan P., Poole S., Bristow A.F., Tilders F., Silverstein F.S. Intracerebral NMDA injection stimulates production of interleukin-1b in perinatal rat brain. J. Neurochem. 67:1996;2215-2218.
    • (1996) J. Neurochem. , vol.67 , pp. 2215-2218
    • Hagan, P.1    Poole, S.2    Bristow, A.F.3    Tilders, F.4    Silverstein, F.S.5
  • 25
    • 0027447509 scopus 로고
    • HIV envelope protein-induced neuronal damage and retardation of behavioural development in rat neonates
    • Hill J.M., Mervis R.F., Avidor R., Moody T.W., Brenneman D.E. HIV envelope protein-induced neuronal damage and retardation of behavioural development in rat neonates. Brain Res. 603:1993;222-233.
    • (1993) Brain Res. , vol.603 , pp. 222-233
    • Hill, J.M.1    Mervis, R.F.2    Avidor, R.3    Moody, T.W.4    Brenneman, D.E.5
  • 27
    • 0028349156 scopus 로고
    • Nitric oxide synthases in mammals
    • Knowles R.G., Moncada S. Nitric oxide synthases in mammals. Biochem. J. 298:1994;249-258.
    • (1994) Biochem. J. , vol.298 , pp. 249-258
    • Knowles, R.G.1    Moncada, S.2
  • 29
    • 0029154564 scopus 로고
    • Expression of nerve growth factor and p75 low affinity receptor after transient forebrain ischemia in gerbil hippocampal CA1 neurons
    • Lee T.-H., Abe K., Kogure K., Itoyama Y. Expression of nerve growth factor and p75 low affinity receptor after transient forebrain ischemia in gerbil hippocampal CA1 neurons. J. Neurosci. Res. 41:1995;684-695.
    • (1995) J. Neurosci. Res. , vol.41 , pp. 684-695
    • Lee, T.-H.1    Abe, K.2    Kogure, K.3    Itoyama, Y.4
  • 30
    • 0023471275 scopus 로고
    • Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve
    • Lindholm D., Heumann R., Metyer M., Thoenen H. Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature. 330:1987;658-659.
    • (1987) Nature , vol.330 , pp. 658-659
    • Lindholm, D.1    Heumann, R.2    Metyer, M.3    Thoenen, H.4
  • 31
    • 0028909868 scopus 로고
    • Dementia associated with the acquired immunodeficiency syndrome
    • Lipton S.A., Gendelman H.E. Dementia associated with the acquired immunodeficiency syndrome. New Engl. J. Med. 332:1995;934-940.
    • (1995) New Engl. J. Med. , vol.332 , pp. 934-940
    • Lipton, S.A.1    Gendelman, H.E.2
  • 32
  • 34
    • 0025823901 scopus 로고
    • HIV, macrophages, glial cells, and cytokines in AIDS nervous system disease
    • Merrill J.E., Chen I.S. HIV, macrophages, glial cells, and cytokines in AIDS nervous system disease. Fedn Am. Socs exp. Biol. J. 5:1991;2391-2397.
    • (1991) Fedn Am. Socs Exp. Biol. J. , vol.5 , pp. 2391-2397
    • Merrill, J.E.1    Chen, I.S.2
  • 35
    • 0026554880 scopus 로고
    • Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1
    • Merrill J.E., Koyanagi Y., Zack J., Thomas L., Martin F., Chen I.S. Induction of interleukin-1 and tumor necrosis factor alpha in brain cultures by human immunodeficiency virus type 1. J. Virol. 66:1992;2217-2225.
    • (1992) J. Virol. , vol.66 , pp. 2217-2225
    • Merrill, J.E.1    Koyanagi, Y.2    Zack, J.3    Thomas, L.4    Martin, F.5    Chen, I.S.6
  • 36
    • 0027161216 scopus 로고
    • Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide
    • Merrill J.E., Ignarro L.J., Sherman M.P., Melinek J., Lane T.E. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J. Immunol. 151:1993;2132-2141.
    • (1993) J. Immunol. , vol.151 , pp. 2132-2141
    • Merrill, J.E.1    Ignarro, L.J.2    Sherman, M.P.3    Melinek, J.4    Lane, T.E.5
  • 38
    • 0029155889 scopus 로고
    • Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines
    • Mucke L., Masliah E., Campbell I.L. Transgenic models to assess the neuropathogenic potential of HIV-1 proteins and cytokines. Curr. Top. Microbiol. Immunol. 202:1995;187-205.
    • (1995) Curr. Top. Microbiol. Immunol. , vol.202 , pp. 187-205
    • Mucke, L.1    Masliah, E.2    Campbell, I.L.3
  • 39
    • 0026520111 scopus 로고
    • NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats
    • Nisticò G., Ciriolo M.R., Fiskin K., Iannone M., De Martino A., Rotilio G. NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats. Free Rad. Biol. Med. 12:1992;177-181.
    • (1992) Free Rad. Biol. Med. , vol.12 , pp. 177-181
    • Nisticò, G.1    Ciriolo, M.R.2    Fiskin, K.3    Iannone, M.4    De Martino, A.5    Rotilio, G.6
  • 41
    • 0026440742 scopus 로고
    • Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: Implications for the neuropathogenesis of HIV disease
    • Penis P., Jett M., Bernton E.W., Boyle T., Gelbard H.A., Dzenko K., Keane R.W., Resnick L., Mizrachi Y., Volsky D.J., Epstein L.G., Gendelman H.E. Cytokines and arachidonic acid metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J. exp. Med. 176:1992;1703-1718.
    • (1992) J. Exp. Med. , vol.176 , pp. 1703-1718
    • Penis, P.1    Jett, M.2    Bernton, E.W.3    Boyle, T.4    Gelbard, H.A.5    Dzenko, K.6    Keane, R.W.7    Resnick, L.8    Mizrachi, Y.9    Volsky, D.J.10    Epstein, L.G.11    Gendelman, H.E.12
  • 42
    • 0025259796 scopus 로고
    • Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system. I
    • Pioro E.P., Cuello A.C. Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system. I. Neuroscience. 34:1990;57-87.
    • (1990) Neuroscience , vol.34 , pp. 57-87
    • Pioro, E.P.1    Cuello, A.C.2
  • 44
    • 0026656192 scopus 로고
    • Interleukin-1 receptor antagonist inhibits ischemic and excitotoxic neuronal damage in the rat
    • Relton J.K., Rothwell N.J. Interleukin-1 receptor antagonist inhibits ischemic and excitotoxic neuronal damage in the rat. Brain Res. Bull. 29:1992;243-246.
    • (1992) Brain Res. Bull. , vol.29 , pp. 243-246
    • Relton, J.K.1    Rothwell, N.J.2
  • 45
    • 44949266148 scopus 로고
    • Immunopathogenetic mechanisms of HIV infection: Cytokine induction of HIV expression
    • Rosenberg Z.F., Fauci A.S. Immunopathogenetic mechanisms of HIV infection: cytokine induction of HIV expression. Immunol. Today. 11:1990;176-180.
    • (1990) Immunol. Today , vol.11 , pp. 176-180
    • Rosenberg, Z.F.1    Fauci, A.S.2
  • 47
    • 0344935064 scopus 로고
    • Evidence for the expression of functional low affinity and trkA NGF receptors in cultured hippocampal neurones
    • Smith-Swintosky V.L., Mattson M.P. Evidence for the expression of functional low affinity and trkA NGF receptors in cultured hippocampal neurones. Soc. Neurosci. Abstr. 18:1992;951.
    • (1992) Soc. Neurosci. Abstr. , vol.18 , pp. 951
    • Smith-Swintosky, V.L.1    Mattson, M.P.2
  • 48
    • 0026794489 scopus 로고
    • Human immunodeficiency virus and the central nervous system
    • Spencer D.C., Price R.W. Human immunodeficiency virus and the central nervous system. A. Rev. Microbiol. 46:1992;655-693.
    • (1992) A. Rev. Microbiol. , vol.46 , pp. 655-693
    • Spencer, D.C.1    Price, R.W.2
  • 49
    • 0025073281 scopus 로고
    • Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: Comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo
    • Spranger M., Lindholm D., Bandtlow C., Heumann R., Gnahn H., Naher-Noè M., Thoenen H. Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo. Eur. J. Neurosci. 2:1990;69-76.
    • (1990) Eur. J. Neurosci. , vol.2 , pp. 69-76
    • Spranger, M.1    Lindholm, D.2    Bandtlow, C.3    Heumann, R.4    Gnahn, H.5    Naher-Noè, M.6    Thoenen, H.7
  • 50
    • 0027256011 scopus 로고
    • High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of basal forebrain and striatum in the rat brain
    • Steininger T.L., Wainer B.H., Klein R., Barbacid M., Palfrey H.C. High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of basal forebrain and striatum in the rat brain. Brain Res. 612:1993;330-335.
    • (1993) Brain Res. , vol.612 , pp. 330-335
    • Steininger, T.L.1    Wainer, B.H.2    Klein, R.3    Barbacid, M.4    Palfrey, H.C.5
  • 51
    • 0029047891 scopus 로고
    • Interleukin-1beta attenuates excitatory amino acid induced neurodegeneration in vitro: Involvement of nerve growth factor
    • Strijbos P.J., Rothwell N.J. Interleukin-1beta attenuates excitatory amino acid induced neurodegeneration in vitro: involvement of nerve growth factor. J. Neurosci. 15:1995;3468-3474.
    • (1995) J. Neurosci. , vol.15 , pp. 3468-3474
    • Strijbos, P.J.1    Rothwell, N.J.2
  • 52
    • 0028009187 scopus 로고
    • Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice
    • Toggas S.M., Masliah E., Rockenstein E.M., Rall G.F., Abraham C.R., Mucke L. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 367:1994;188-193.
    • (1994) Nature , vol.367 , pp. 188-193
    • Toggas, S.M.1    Masliah, E.2    Rockenstein, E.M.3    Rall, G.F.4    Abraham, C.R.5    Mucke, L.6
  • 53
    • 0029890689 scopus 로고    scopus 로고
    • The contrasting roles of ICE family and interleukin-1β in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation
    • Troy C.M., Stefanis L., Prochiantz A., Greene L.A., Shelansky M. The contrasting roles of ICE family and interleukin-1β in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc. natn. Acad. Sci. U.S.A. 93:1996;5635-5640.
    • (1996) Proc. Natn. Acad. Sci. U.S.A. , vol.93 , pp. 5635-5640
    • Troy, C.M.1    Stefanis, L.2    Prochiantz, A.3    Greene, L.A.4    Shelansky, M.5
  • 54
    • 0026726031 scopus 로고
    • Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: A pathway for the induction of non-specific symptoms of sickness?
    • Van Dam A.M., Broune M., Louisse S., Berkenbosch F. Appearance of interleukin-1 in macrophages and in ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness? Brain Res. 588:1992;291-296.
    • (1992) Brain Res. , vol.588 , pp. 291-296
    • Van Dam, A.M.1    Broune, M.2    Louisse, S.3    Berkenbosch, F.4
  • 57
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • Yuan J., Shaham S., Ledoux S., Ellis H.M., Horvitz H.R. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell. 75:1993;641-652.
    • (1993) Cell , vol.75 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5


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