Endothelial-specific knockdown of interleukin-1 (IL-1) type 1 receptor differentially alters CNS responses to IL-1 depending on its route of administration

Journal of Neuroscience

Volumn 27, Issue 39, 2007, Pages 10476-10486

  Ching, San ^a   Zhang, Hao ^a   Belevych, Natalya ^a   He, Lingli ^a   Lai, Wenmin ^a   Pu, Xin An ^a   Jaeger, Laura B ^b   Chen, Qun ^a   Quan, Ning ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c 4179 Postle Hall ^*  (United States)

Author keywords

Blood brain barrier; Cytokine; Fever; Illness behavior; Locomotor activity; Neuroimmune

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL INFILTRATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; ENDOTHELIUM CELL; FEVER; HYPOTHALAMUS; LEUKOCYTE; LOCOMOTION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THALAMUS MIDLINE NUCLEUS; THALAMUS VENTRAL NUCLEUS;

ANIMALS; CENTRAL NERVOUS SYSTEM; CYCLOOXYGENASE 2; ENDOTHELIAL CELLS; FEVER; GENES, FOS; HYPOTHALAMUS; IMMUNOLOGIC FACTORS; INTERLEUKIN-1; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; NEUROIMMUNOMODULATION; RECEPTORS, INTERLEUKIN-1 TYPE I;

EID: 34848920411     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3357-07.2007     Document Type: Article

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