메뉴 건너뛰기




Volumn 73, Issue 2, 2003, Pages 213-224

Interleukin-18

Author keywords

Autoimmunity; Cytokine; Infectious disease; Inflammation; Interleukin 18

Indexed keywords

AMINO ACID; ENDOTOXIN; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 18; LIPOPOLYSACCHARIDE; POLYPEPTIDE;

EID: 0037310025     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0602313     Document Type: Review
Times cited : (646)

References (187)
  • 1
    • 0024490105 scopus 로고
    • Endotoxin-induced serum factor that stimulates gamma interferon production
    • Nakamura, K., Okamura, H., Wada, M., Nagata, K., Tamura, T. (1989) Endotoxin-induced serum factor that stimulates gamma interferon production. Infect. Immun. 57, 590-595.
    • (1989) Infect. Immun. , vol.57 , pp. 590-595
    • Nakamura, K.1    Okamura, H.2    Wada, M.3    Nagata, K.4    Tamura, T.5
  • 3
    • 15844367093 scopus 로고    scopus 로고
    • Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
    • Ushio, S., Namba, M., Okura, T., Hattori, K., Nukada, Y., Akita, K., Tanabee, F., Konishi, K., Micallef, M., Fujii, M., et al. (1996) Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein. J. Immunol. 156, 4274-4279.
    • (1996) J. Immunol. , vol.156 , pp. 4274-4279
    • Ushio, S.1    Namba, M.2    Okura, T.3    Hattori, K.4    Nukada, Y.5    Akita, K.6    Tanabee, F.7    Konishi, K.8    Micallef, M.9    Fujii, M.10
  • 4
    • 0031573558 scopus 로고    scopus 로고
    • Regulation of IL-18 (IFN-gamma-inducing factor) gene expression
    • Tone, M., Thompson, S. A., Tone, Y., Fairchild, P. J., Waldmann, H. (1997) Regulation of IL-18 (IFN-gamma-inducing factor) gene expression. J. Immunol. 159, 6156-6163.
    • (1997) J. Immunol. , vol.159 , pp. 6156-6163
    • Tone, M.1    Thompson, S.A.2    Tone, Y.3    Fairchild, P.J.4    Waldmann, H.5
  • 5
    • 0033514959 scopus 로고    scopus 로고
    • Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells
    • Puren, A. J., Fantuzzi, G., Dinarello, C. A. (1999) Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells. Proc. Natl. Acad. Sci. USA 96, 2256-2261.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2256-2261
    • Puren, A.J.1    Fantuzzi, G.2    Dinarello, C.A.3
  • 6
    • 0033567084 scopus 로고    scopus 로고
    • Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression
    • Kim, Y. M., Kang, H. S., Paik, S. G., Pyun, K. H., Anderson, K. L., Torbett, B. E., Choi, I. (1999) Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression. J. Immunol. 163, 2000-2007.
    • (1999) J. Immunol. , vol.163 , pp. 2000-2007
    • Kim, Y.M.1    Kang, H.S.2    Paik, S.G.3    Pyun, K.H.4    Anderson, K.L.5    Torbett, B.E.6    Choi, I.7
  • 7
    • 0028168646 scopus 로고
    • IFN consensus sequence binding protein (ICSBP) is a conditional repressor of IFN inducible promoters
    • Weisz, A., Kirchhoff, S., Levi, B. Z. (1994) IFN consensus sequence binding protein (ICSBP) is a conditional repressor of IFN inducible promoters. Int. Immunol. 6, 1125-1131.
    • (1994) Int. Immunol. , vol.6 , pp. 1125-1131
    • Weisz, A.1    Kirchhoff, S.2    Levi, B.Z.3
  • 8
    • 0030899516 scopus 로고    scopus 로고
    • Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
    • Sharf, R., Meraro, D., Azriel, A., Thornton, A. M., Ozato, K., Petricoin, E. F., Lamer, A. C., Schaper, F., Hauser, H., Levi, B. Z. (1997) Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA. J. Biol. Chem. 272, 9785-9792.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9785-9792
    • Sharf, R.1    Meraro, D.2    Azriel, A.3    Thornton, A.M.4    Ozato, K.5    Petricoin, E.F.6    Lamer, A.C.7    Schaper, F.8    Hauser, H.9    Levi, B.Z.10
  • 9
    • 0028977911 scopus 로고
    • IFN-gamma and lipopolysaccharide induce DNA binding of transcription factor PU.1 in murine tissue macrophages
    • Shackelford, R., Adams, D. O., Johnson, S. P. (1995) IFN-gamma and lipopolysaccharide induce DNA binding of transcription factor PU.1 in murine tissue macrophages. J. Immunol. 154, 1374-1382.
    • (1995) J. Immunol. , vol.154 , pp. 1374-1382
    • Shackelford, R.1    Adams, D.O.2    Johnson, S.P.3
  • 10
    • 0034665506 scopus 로고    scopus 로고
    • IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages
    • Kim, Y. M., Im, J. Y., Han, S. H., Kang, H. S., Choi, I. (2000) IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages. J. Immunol. 165, 3198-3205.
    • (2000) J. Immunol. , vol.165 , pp. 3198-3205
    • Kim, Y.M.1    Im, J.Y.2    Han, S.H.3    Kang, H.S.4    Choi, I.5
  • 11
    • 0031179507 scopus 로고    scopus 로고
    • Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells
    • Matsui, K., Yoshimoto, T., Tsutsui, H., Hyodo, Y., Hayashi, N., Hiroishi, K., Kawada, N., Okamura, H., Nakanishi, K., Higashino, K. (1997) Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells. J. Immunol. 159, 97-106.
    • (1997) J. Immunol. , vol.159 , pp. 97-106
    • Matsui, K.1    Yoshimoto, T.2    Tsutsui, H.3    Hyodo, Y.4    Hayashi, N.5    Hiroishi, K.6    Kawada, N.7    Okamura, H.8    Nakanishi, K.9    Higashino, K.10
  • 12
    • 0031705349 scopus 로고    scopus 로고
    • Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development
    • Stoll, S., Jonuleit, H., Schmitt, E., Muller, G., Yamauchi, H., Kurimoto, M., Knop, J., Enk, A. H. (1998) Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL-12-dependent Th1 development. Eur. J. Immunol. 28, 3231-3239.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3231-3239
    • Stoll, S.1    Jonuleit, H.2    Schmitt, E.3    Muller, G.4    Yamauchi, H.5    Kurimoto, M.6    Knop, J.7    Enk, A.H.8
  • 13
    • 0031181474 scopus 로고    scopus 로고
    • Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes
    • Stoll, S., Muller, G., Kurimoto, M., Saloga, J., Tanimoto, T., Yamauchi, H., Okamura, H., Knop, J., Enk, A. H. (1997) Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes. J. Immunol. 159, 298-302.
    • (1997) J. Immunol. , vol.159 , pp. 298-302
    • Stoll, S.1    Muller, G.2    Kurimoto, M.3    Saloga, J.4    Tanimoto, T.5    Yamauchi, H.6    Okamura, H.7    Knop, J.8    Enk, A.H.9
  • 14
    • 17544389276 scopus 로고    scopus 로고
    • Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation
    • Udagawa, N., Horwood, N. J., Elliott, J., Mackay, A., Owens, J., Okamura, H., Kurimoto, M., Chambers, T. J., Martin, T. J., Gillespie, M. T. (1997) Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J. Exp. Med. 185, 1005-1012.
    • (1997) J. Exp. Med. , vol.185 , pp. 1005-1012
    • Udagawa, N.1    Horwood, N.J.2    Elliott, J.3    Mackay, A.4    Owens, J.5    Okamura, H.6    Kurimoto, M.7    Chambers, T.J.8    Martin, T.J.9    Gillespie, M.T.10
  • 15
    • 15144344777 scopus 로고    scopus 로고
    • Induction of interferon-gamma inducing factor in the adrenal cortex
    • Conti, B., Jahng, J. W., Tinti, C., Son, J. H., Joh, T. H. (1997) Induction of interferon-gamma inducing factor in the adrenal cortex. J. Biol. Chem. 272, 2035-2037.
    • (1997) J. Biol. Chem. , vol.272 , pp. 2035-2037
    • Conti, B.1    Jahng, J.W.2    Tinti, C.3    Son, J.H.4    Joh, T.H.5
  • 17
    • 0032970384 scopus 로고    scopus 로고
    • Murine microglial cells produce and respond to interleukin-18
    • Prinz, M., Hanisch, U. K. (1999) Murine microglial cells produce and respond to interleukin-18. J. Neurochem. 72, 2215-2218.
    • (1999) J. Neurochem. , vol.72 , pp. 2215-2218
    • Prinz, M.1    Hanisch, U.K.2
  • 22
    • 0032521457 scopus 로고    scopus 로고
    • Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice
    • Fantuzzi, G., Puren, A. J., Harding, M. W., Livingston, D. J., Dinarello C. A. (1998) Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. Blood 91, 2118-2125.
    • (1998) Blood , vol.91 , pp. 2118-2125
    • Fantuzzi, G.1    Puren, A.J.2    Harding, M.W.3    Livingston, D.J.4    Dinarello, C.A.5
  • 24
    • 0033564334 scopus 로고    scopus 로고
    • Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway
    • Pirhonen, J., Sareneva, T., Kurimoto, M., Julkunen, I., Matikainen, S. (1999) Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway. J. Immunol. 162, 7322-7329.
    • (1999) J. Immunol. , vol.162 , pp. 7322-7329
    • Pirhonen, J.1    Sareneva, T.2    Kurimoto, M.3    Julkunen, I.4    Matikainen, S.5
  • 26
    • 0030693371 scopus 로고    scopus 로고
    • Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
    • Akita, K., Ohtsuki, T., Nukada, Y., Tanimoto, T., Namba, M., Okura, T., Takakura-Yamamoto, R., Torigoe, K., Gu, Y., Su, M. S., et al. (1997) Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. J. Biol. Chem. 272, 26595-26603.
    • (1997) J. Biol. Chem. , vol.272 , pp. 26595-26603
    • Akita, K.1    Ohtsuki, T.2    Nukada, Y.3    Tanimoto, T.4    Namba, M.5    Okura, T.6    Takakura-Yamamoto, R.7    Torigoe, K.8    Gu, Y.9    Su, M.S.10
  • 28
    • 0033136775 scopus 로고    scopus 로고
    • Cutting edge: Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
    • Hoshino, K., Tsutsui, H., Kawai, T., Takeda, K., Nakanishi, K., Takeda, Y., Akira, S. (1999) Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J. Immunol. 162, 5041-5044.
    • (1999) J. Immunol. , vol.162 , pp. 5041-5044
    • Hoshino, K.1    Tsutsui, H.2    Kawai, T.3    Takeda, K.4    Nakanishi, K.5    Takeda, Y.6    Akira, S.7
  • 29
    • 0029989325 scopus 로고    scopus 로고
    • IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
    • Parnet, P., Garka, K. E., Bonnert, T. P., Dower, S. K., Sims, J. E. (1996) IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J. Biol. Chem. 271, 3967-3970.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3967-3970
    • Parnet, P.1    Garka, K.E.2    Bonnert, T.P.3    Dower, S.K.4    Sims, J.E.5
  • 30
    • 0032491599 scopus 로고    scopus 로고
    • Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
    • Born, T. L., Thomassen, E., Bird, T. A., Sims, J. E. (1998) Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J. Biol. Chem. 273, 29445-29450.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29445-29450
    • Born, T.L.1    Thomassen, E.2    Bird, T.A.3    Sims, J.E.4
  • 32
    • 0033084021 scopus 로고    scopus 로고
    • IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor
    • Hyodo, Y., Matsui, K., Hayashi, N., Tsutsui, H., Kashiwamura, S., Yamauchi, H., Hiroishi, K., Takeda, K., Tagawa, Y., Iwakura, Y., et al. (1999) IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor. J. Immunol. 162, 1662-1668.
    • (1999) J. Immunol. , vol.162 , pp. 1662-1668
    • Hyodo, Y.1    Matsui, K.2    Hayashi, N.3    Tsutsui, H.4    Kashiwamura, S.5    Yamauchi, H.6    Hiroishi, K.7    Takeda, K.8    Tagawa, Y.9    Iwakura, Y.10
  • 33
    • 0037148510 scopus 로고    scopus 로고
    • Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for atherogenesis
    • Gerdes, N., Sukhova, G. K., Libby, P., Reynolds, R. S., Young, J. L., Schonbeek, U. (2002) Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. J. Exp. Med. 195, 245-257.
    • (2002) J. Exp. Med. , vol.195 , pp. 245-257
    • Gerdes, N.1    Sukhova, G.K.2    Libby, P.3    Reynolds, R.S.4    Young, J.L.5    Schonbeek, U.6
  • 35
    • 0032193770 scopus 로고    scopus 로고
    • IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-gamma production
    • Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kashiwamura, S., Okamura, H., Akira, S., Nakanishi, K. (1998) IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J. Immunol. 161, 3400-3407.
    • (1998) J. Immunol. , vol.161 , pp. 3400-3407
    • Yoshimoto, T.1    Takeda, K.2    Tanaka, T.3    Ohkusu, K.4    Kashiwamura, S.5    Okamura, H.6    Akira, S.7    Nakanishi, K.8
  • 37
    • 0035898446 scopus 로고    scopus 로고
    • Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4
    • Smeltz, R. B., Chen, J., Hu-Li, J., Shevach, E. M. (2001) Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4. J. Exp. Med. 194, 143-153.
    • (2001) J. Exp. Med. , vol.194 , pp. 143-153
    • Smeltz, R.B.1    Chen, J.2    Hu-Li, J.3    Shevach, E.M.4
  • 38
    • 0031423761 scopus 로고    scopus 로고
    • MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
    • Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., Cao, Z. (1997) MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847.
    • (1997) Immunity , vol.7 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3    Li, S.4    Cao, Z.5
  • 39
    • 0033526110 scopus 로고    scopus 로고
    • Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
    • Kanakaraj, P., Ngo, K., Wu, Y., Angulo, A., Ghazal, P., Harris, C. A., Siekierka, J. J., Peterson, P. A., Fung-Leung, W. P. (1999) Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice. J. Exp. Med. 189, 1129-1138.
    • (1999) J. Exp. Med. , vol.189 , pp. 1129-1138
    • Kanakaraj, P.1    Ngo, K.2    Wu, Y.3    Angulo, A.4    Ghazal, P.5    Harris, C.A.6    Siekierka, J.J.7    Peterson, P.A.8    Fung-Leung, W.P.9
  • 41
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira, S., Takeda, K., Kaisho, T. (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2, 675-680.
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 42
    • 0035865249 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta
    • Seki, E., Tsutsui, H., Nakano, H., Tsuji, N., Hoshino, K., Adachi, O., Adachi, K., Futatsugi, S., Kuida, K., Takeuchi, O., et al. (2001) Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta. J. Immunol. 166, 2651-2657.
    • (2001) J. Immunol. , vol.166 , pp. 2651-2657
    • Seki, E.1    Tsutsui, H.2    Nakano, H.3    Tsuji, N.4    Hoshino, K.5    Adachi, O.6    Adachi, K.7    Futatsugi, S.8    Kuida, K.9    Takeuchi, O.10
  • 43
    • 0029761275 scopus 로고    scopus 로고
    • TRAF6 is a signal transducer for interleukin-1
    • Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., Goeddel, D. V. (1996) TRAF6 is a signal transducer for interleukin-1. Nature 383, 443-446.
    • (1996) Nature , vol.383 , pp. 443-446
    • Cao, Z.1    Xiong, J.2    Takeuchi, M.3    Kurama, T.4    Goeddel, D.V.5
  • 45
    • 0030694235 scopus 로고    scopus 로고
    • IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB
    • Robinson, D., Shibuya, K., Mui, A., Zonin, F., Murphy, E., Sana, T., Hartley, S. B., Menon, S., Kastelein, R., Bazan, F., et al. (1997) IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB. Immunity 7, 571-581.
    • (1997) Immunity , vol.7 , pp. 571-581
    • Robinson, D.1    Shibuya, K.2    Mui, A.3    Zonin, F.4    Murphy, E.5    Sana, T.6    Hartley, S.B.7    Menon, S.8    Kastelein, R.9    Bazan, F.10
  • 48
    • 0034254194 scopus 로고    scopus 로고
    • IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21
    • Kalina, U., Kauschat, D., Koyama, N., Nuernberger, H., Ballas, K., Koschmieder, S., Bug, G., Hofmann, W. K., Hoelzer, D., Ottmann, O. G. (2000) IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21. J. Immunol. 165, 1307-1313.
    • (2000) J. Immunol. , vol.165 , pp. 1307-1313
    • Kalina, U.1    Kauschat, D.2    Koyama, N.3    Nuernberger, H.4    Ballas, K.5    Koschmieder, S.6    Bug, G.7    Hofmann, W.K.8    Hoelzer, D.9    Ottmann, O.G.10
  • 49
    • 0035261399 scopus 로고    scopus 로고
    • IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production
    • Yang, J., Zhu, H., Murphy, T. L., Ouyang, W., Murphy, K. M. (2001) IL-18-stimulated GADD45 beta required in cytokine-induced, but not TCR-induced, IFN-gamma production. Nat. Immunol. 2, 157-164.
    • (2001) Nat. Immunol. , vol.2 , pp. 157-164
    • Yang, J.1    Zhu, H.2    Murphy, T.L.3    Ouyang, W.4    Murphy, K.M.5
  • 50
    • 0030934694 scopus 로고    scopus 로고
    • Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
    • Gerwins, P., Blank, J. L., Johnson, G. L. (1997) Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem. 272, 8288-8295.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8288-8295
    • Gerwins, P.1    Blank, J.L.2    Johnson, G.L.3
  • 51
    • 0032514967 scopus 로고    scopus 로고
    • A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
    • Takekawa, M., Saito, H. (1998) A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95, 521-530.
    • (1998) Cell , vol.95 , pp. 521-530
    • Takekawa, M.1    Saito, H.2
  • 53
    • 0032521933 scopus 로고    scopus 로고
    • IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes
    • Barbulescu, K., Becker, C., Schlaak, J. F., Schmitt, E., Meyer zum Buschenfelde, K. H., Neurath, M. F. (1998) IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes. J. Immunol. 160, 3642-3647.
    • (1998) J. Immunol. , vol.160 , pp. 3642-3647
    • Barbulescu, K.1    Becker, C.2    Schlaak, J.F.3    Schmitt, E.4    Meyer zum Buschenfelde, K.H.5    Neurath, M.F.6
  • 54
    • 0036467440 scopus 로고    scopus 로고
    • Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1
    • Nakahira, M., Ahn, H. J., Park, W. R., Gao, P., Tomura, M., Park, C. S., Hamaoka, T., Ohta, T., Kurimoto, M., Fujiwara, H. (2002) Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1. J. Immunol. 168, 1146-1153.
    • (2002) J. Immunol. , vol.168 , pp. 1146-1153
    • Nakahira, M.1    Ahn, H.J.2    Park, W.R.3    Gao, P.4    Tomura, M.5    Park, C.S.6    Hamaoka, T.7    Ohta, T.8    Kurimoto, M.9    Fujiwara, H.10
  • 55
    • 0035813099 scopus 로고    scopus 로고
    • A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways
    • Morel, J. C., Park, C. C., Woods, J. M., Koch, A. E. (2001) A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. J. Biol. Chem. 276, 37069-37075.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37069-37075
    • Morel, J.C.1    Park, C.C.2    Woods, J.M.3    Koch, A.E.4
  • 56
    • 8944226108 scopus 로고    scopus 로고
    • Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production
    • Micallef, M. J., Ohtsuki, T., Kohno, K., Tanabe, F., Ushio, S., Namba, M., Tanimoto, T., Torigoe, K., Fujii, M., Ikeda, M., et al. (1996) Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur. J. Immunol. 26, 1647-1651.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1647-1651
    • Micallef, M.J.1    Ohtsuki, T.2    Kohno, K.3    Tanabe, F.4    Ushio, S.5    Namba, M.6    Tanimoto, T.7    Torigoe, K.8    Fujii, M.9    Ikeda, M.10
  • 57
    • 0032169511 scopus 로고    scopus 로고
    • IL-18 augments perforindependent cytotoxicity of liver NK-T cells
    • Dao, T., Mehal, W. Z., Crispe, I. N. (1998) IL-18 augments perforindependent cytotoxicity of liver NK-T cells. J. Immunol. 161, 2217-2222.
    • (1998) J. Immunol. , vol.161 , pp. 2217-2222
    • Dao, T.1    Mehal, W.Z.2    Crispe, I.N.3
  • 58
    • 0030296747 scopus 로고    scopus 로고
    • Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
    • Dao, T., Ohashi, K., Kayano, T., Kurimoto, M., Okamura, H. (1996) Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells. Cell. Immunol. 173, 230-235.
    • (1996) Cell. Immunol. , vol.173 , pp. 230-235
    • Dao, T.1    Ohashi, K.2    Kayano, T.3    Kurimoto, M.4    Okamura, H.5
  • 59
    • 0030293444 scopus 로고    scopus 로고
    • IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
    • Tsutsui, H., Nakanishi, K., Matsui, K., Higashino, K., Okamura, H., Miyazawa, Y., Kaneda, K. (1996) IFN-gamma-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones. J. Immunol. 157, 3967-3973.
    • (1996) J. Immunol. , vol.157 , pp. 3967-3973
    • Tsutsui, H.1    Nakanishi, K.2    Matsui, K.3    Higashino, K.4    Okamura, H.5    Miyazawa, Y.6    Kaneda, K.7
  • 61
    • 0033136326 scopus 로고    scopus 로고
    • IL-18 is a potent coinducer of IL-13 in NK and T cells: A new potential role for IL-18 in modulating the immune response
    • Hoshino, T., Wiltrout, R. H., Young, H. A. (1999) IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response. J. Immunol. 162, 5070-5077.
    • (1999) J. Immunol. , vol.162 , pp. 5070-5077
    • Hoshino, T.1    Wiltrout, R.H.2    Young, H.A.3
  • 62
    • 0033949150 scopus 로고    scopus 로고
    • In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells
    • Hoshino, T., Yagita, H., Ortaldo, J. R., Wiltrout, R. H., Young, H. A. (2000) In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells. Eur. J. Immunol. 30, 1998-2006.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1998-2006
    • Hoshino, T.1    Yagita, H.2    Ortaldo, J.R.3    Wiltrout, R.H.4    Young, H.A.5
  • 64
    • 0033730039 scopus 로고    scopus 로고
    • IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background
    • Xu, D., Trajkovic, V., Hunter, D., Leung, B. P., Schulz, K., Gracie, J. A., McInnes, I. B., Liew, F. Y. (2000) IL-18 induces the differentiation of Th1 or Th2 cells depending upon cytokine milieu and genetic background. Eur. J. Immunol. 30, 3147-3156.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3147-3156
    • Xu, D.1    Trajkovic, V.2    Hunter, D.3    Leung, B.P.4    Schulz, K.5    Gracie, J.A.6    McInnes, I.B.7    Liew, F.Y.8
  • 66
    • 0032526840 scopus 로고    scopus 로고
    • Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation
    • Munder, M., Mallo, M., Eichmann, K., Modolell, M. (1998) Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J. Exp. Med. 187, 2103-2108.
    • (1998) J. Exp. Med. , vol.187 , pp. 2103-2108
    • Munder, M.1    Mallo, M.2    Eichmann, K.3    Modolell, M.4
  • 67
    • 0033970867 scopus 로고    scopus 로고
    • Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells
    • Fukao, T., Matsuda, S., Koyasu, S. (2000) Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. J. Immunol. 164, 64-71.
    • (2000) J. Immunol. , vol.164 , pp. 64-71
    • Fukao, T.1    Matsuda, S.2    Koyasu, S.3
  • 68
    • 0033788437 scopus 로고    scopus 로고
    • Interleukin-18 induces production of proinflammatory cytokines in mice: No intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta
    • Netea, M. G., Kullberg, B. J., Verschueren, I., Van Der Meer, J. W. (2000) Interleukin-18 induces production of proinflammatory cytokines in mice: no intermediate role for the cytokines of the tumor necrosis factor family and interleukin-1beta. Eur. J. Immunol. 30, 3057-3060.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3057-3060
    • Netea, M.G.1    Kullberg, B.J.2    Verschueren, I.3    Van Der Meer, J.W.4
  • 69
    • 0033556175 scopus 로고    scopus 로고
    • IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
    • Olee, T., Hashimoto, S., Quach, J., Lotz, M. (1999) IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses. J. Immunol. 162, 1096-1100.
    • (1999) J. Immunol. , vol.162 , pp. 1096-1100
    • Olee, T.1    Hashimoto, S.2    Quach, J.3    Lotz, M.4
  • 71
    • 0033842374 scopus 로고    scopus 로고
    • Human keratinocytes constitutively produce but do not process interleukin-18
    • Mee, J. B., Alam, Y., Groves, R. W. (2000) Human keratinocytes constitutively produce but do not process interleukin-18. Br. J. Dermatol. 143, 330-336.
    • (2000) Br. J. Dermatol. , vol.143 , pp. 330-336
    • Mee, J.B.1    Alam, Y.2    Groves, R.W.3
  • 72
    • 0032709099 scopus 로고    scopus 로고
    • Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene
    • Naik, S. M., Cannon, G., Burbach, G. J., Singh, S. R., Swerlick, R. A., Wilcox, J. N., Ansel, J. C., Caughman, S. W. (1999) Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene. J. Invest. Dermatol. 113, 766-772.
    • (1999) J. Invest. Dermatol. , vol.113 , pp. 766-772
    • Naik, S.M.1    Cannon, G.2    Burbach, G.J.3    Singh, S.R.4    Swerlick, R.A.5    Wilcox, J.N.6    Ansel, J.C.7    Caughman, S.W.8
  • 73
    • 0035067261 scopus 로고    scopus 로고
    • Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism
    • Cumberbatch, M., Dearman, R. J., Antonopoulos, C., Groves, R. W., Kimber, I. (2001) Interleukin (IL)-18 induces Langerhans cell migration by a tumour necrosis factor-alpha- and IL-1beta-dependent mechanism. Immunology 102, 323-330.
    • (2001) Immunology , vol.102 , pp. 323-330
    • Cumberbatch, M.1    Dearman, R.J.2    Antonopoulos, C.3    Groves, R.W.4    Kimber, I.5
  • 82
    • 0033613224 scopus 로고    scopus 로고
    • IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins
    • Xiang, Y., Moss, B. (1999) IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins. Proc. Natl. Acad. Sci. USA 96, 11537-11542.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11537-11542
    • Xiang, Y.1    Moss, B.2
  • 84
    • 0027473108 scopus 로고
    • Purification of a factor which provides a costimulatory signal for gamma interferon production
    • Nakamura, K., Okamura, H., Nagata, K., Komatsu, T., Tamura, T. (1993) Purification of a factor which provides a costimulatory signal for gamma interferon production. Infect. Immun. 61, 64-70.
    • (1993) Infect. Immun. , vol.61 , pp. 64-70
    • Nakamura, K.1    Okamura, H.2    Nagata, K.3    Komatsu, T.4    Tamura, T.5
  • 85
    • 0033198145 scopus 로고    scopus 로고
    • Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
    • Wei, X. Q., Leung, B. P., Niedbala, W., Piedrafita, D., Feng, G. J., Sweet, M., Dobbie, L., Smith, A. J., Liew, F. Y. (1999) Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. J. Immunol. 163, 2821-2828.
    • (1999) J. Immunol. , vol.163 , pp. 2821-2828
    • Wei, X.Q.1    Leung, B.P.2    Niedbala, W.3    Piedrafita, D.4    Feng, G.J.5    Sweet, M.6    Dobbie, L.7    Smith, A.J.8    Liew, F.Y.9
  • 87
    • 0034662234 scopus 로고    scopus 로고
    • IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells
    • Kawakami, K., Koguchi, Y., Qureshi, M. H., Miyazato, A., Yara, S., Kinjo, Y., Iwakura, Y., Takeda, K., Akira, S., Kurimoto, M., et al. (2000) IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-gamma production by NK cells. J. Immunol. 165, 941-947.
    • (2000) J. Immunol. , vol.165 , pp. 941-947
    • Kawakami, K.1    Koguchi, Y.2    Qureshi, M.H.3    Miyazato, A.4    Yara, S.5    Kinjo, Y.6    Iwakura, Y.7    Takeda, K.8    Akira, S.9    Kurimoto, M.10
  • 89
    • 0036570015 scopus 로고    scopus 로고
    • The role of IL-18 in blood-stage immunity against murine malaria Plasmodium yoelii 265 and Plasmodium berghei ANKA
    • Singh, R. P., Kashiwamura Si. S., Rao, P., Okamura, H., Mukherjee, A., Chauhan, V. S. (2002) The role of IL-18 in blood-stage immunity against murine malaria Plasmodium yoelii 265 and Plasmodium berghei ANKA. J. Immunol. 168, 4674-4681.
    • (2002) J. Immunol. , vol.168 , pp. 4674-4681
    • Singh, R.P.1    Kashiwamura, Si.S.2    Rao, P.3    Okamura, H.4    Mukherjee, A.5    Chauhan, V.S.6
  • 90
    • 0032924518 scopus 로고    scopus 로고
    • Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
    • Sugawara, I., Yamada, H., Kaneko, H., Mizuno, S., Takeda, K., Akira, S. (1999) Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect. Immun. 67, 2585-2589.
    • (1999) Infect. Immun. , vol.67 , pp. 2585-2589
    • Sugawara, I.1    Yamada, H.2    Kaneko, H.3    Mizuno, S.4    Takeda, K.5    Akira, S.6
  • 91
    • 0032990966 scopus 로고    scopus 로고
    • IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock
    • Sakao, Y., Takeda, K., Tsutsui, H., Kaisho, T., Nomura, F., Okamura, H., Nakanishi, K., Akira, S. (1999) IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock. Int. Immunol. 11, 471-480.
    • (1999) Int. Immunol. , vol.11 , pp. 471-480
    • Sakao, Y.1    Takeda, K.2    Tsutsui, H.3    Kaisho, T.4    Nomura, F.5    Okamura, H.6    Nakanishi, K.7    Akira, S.8
  • 92
    • 0035173776 scopus 로고    scopus 로고
    • Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18
    • Wei, X., Leung, B. P., Arthur, H. M., McInnes, I. B., Liew, F. Y. (2001) Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18. J. Immunol. 166, 517-521.
    • (2001) J. Immunol. , vol.166 , pp. 517-521
    • Wei, X.1    Leung, B.P.2    Arthur, H.M.3    McInnes, I.B.4    Liew, F.Y.5
  • 94
    • 0036179484 scopus 로고    scopus 로고
    • Essential role of interleukin-12 (IL-12) and IL-18 for gamma interferon production induced by listeriolysin O in mouse spleen cells
    • Nomura, T., Kawamura, I., Tsuchiya, K., Kohda, C., Baba, H., Ito, Y., Kimoto, T., Watanabe, I., Mitsuyama, M. (2002) Essential role of interleukin-12 (IL-12) and IL-18 for gamma interferon production induced by listeriolysin O in mouse spleen cells. Infect. Immun. 70, 1049-1055.
    • (2002) Infect. Immun. , vol.70 , pp. 1049-1055
    • Nomura, T.1    Kawamura, I.2    Tsuchiya, K.3    Kohda, C.4    Baba, H.5    Ito, Y.6    Kimoto, T.7    Watanabe, I.8    Mitsuyama, M.9
  • 95
    • 0034665289 scopus 로고    scopus 로고
    • IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells
    • Shi, F. D., Takeda, K., Akira, S., Sarvetnick, N., Ljunggren, H. G. (2000) IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J. Immunol. 165, 3099-3104.
    • (2000) J. Immunol. , vol.165 , pp. 3099-3104
    • Shi, F.D.1    Takeda, K.2    Akira, S.3    Sarvetnick, N.4    Ljunggren, H.G.5
  • 96
    • 0034033678 scopus 로고    scopus 로고
    • Role of interleukin-18 (IL-18) during lethal shock: Decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice
    • Hochholzer, P., Lipford, G. B., Wagner, H., Pfeffer, K., Heeg, K. (2000) Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect. Immun. 68, 3502-3508.
    • (2000) Infect. Immun. , vol.68 , pp. 3502-3508
    • Hochholzer, P.1    Lipford, G.B.2    Wagner, H.3    Pfeffer, K.4    Heeg, K.5
  • 97
    • 0035817397 scopus 로고    scopus 로고
    • Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13
    • Helmby, H., Takeda, K., Akira, S., Grencis, R. K. (2001) Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13. J. Exp. Med. 194, 355-364.
    • (2001) J. Exp. Med. , vol.194 , pp. 355-364
    • Helmby, H.1    Takeda, K.2    Akira, S.3    Grencis, R.K.4
  • 98
    • 0035881917 scopus 로고    scopus 로고
    • Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection
    • Mori, I., Hossain, M. J., Takeda, K., Okamura, H., Imai, Y., Kohsaka, S., Kimura, Y. (2001) Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection. Virology 287, 163-170.
    • (2001) Virology , vol.287 , pp. 163-170
    • Mori, I.1    Hossain, M.J.2    Takeda, K.3    Okamura, H.4    Imai, Y.5    Kohsaka, S.6    Kimura, Y.7
  • 99
    • 0036644065 scopus 로고    scopus 로고
    • Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: A comparative study with IL-12p40
    • Kinjo, Y., Kawakami, K., Uezu, K., Yara, S., Miyagi, K., Koguchi, Y., Hoshino, T., Okamoto, M., Kawase, Y., Yokota, K., et al. (2002) Contribution of IL-18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL-12p40. J. Immunol. 169, 323-329.
    • (2002) J. Immunol. , vol.169 , pp. 323-329
    • Kinjo, Y.1    Kawakami, K.2    Uezu, K.3    Yara, S.4    Miyagi, K.5    Koguchi, Y.6    Hoshino, T.7    Okamoto, M.8    Kawase, Y.9    Yokota, K.10
  • 100
    • 0031259706 scopus 로고    scopus 로고
    • Decreased expression of cytokines that induce type 1 helper T cell/interferon-gamma responses in genetically susceptible mice infected with Mycobacterium avium
    • Kobayashi, K., Nakata, N., Kai, M., Kasama, T., Hanyuda, Y., Hatano, Y. (1997) Decreased expression of cytokines that induce type 1 helper T cell/interferon-gamma responses in genetically susceptible mice infected with Mycobacterium avium. Clin. Immunol. Immunopathol. 85, 112-116.
    • (1997) Clin. Immunol. Immunopathol. , vol.85 , pp. 112-116
    • Kobayashi, K.1    Nakata, N.2    Kai, M.3    Kasama, T.4    Hanyuda, Y.5    Hatano, Y.6
  • 104
    • 0032913015 scopus 로고    scopus 로고
    • Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium
    • Mastroeni, P., Clare, S., Khan, S., Harrison, J. A., Hormaeche, C. E., Okamura, H., Kurimoto, M., Dougan, G. (1999) Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium. Infect. Immun. 67, 478-483.
    • (1999) Infect. Immun. , vol.67 , pp. 478-483
    • Mastroeni, P.1    Clare, S.2    Khan, S.3    Harrison, J.A.4    Hormaeche, C.E.5    Okamura, H.6    Kurimoto, M.7    Dougan, G.8
  • 105
    • 0031931392 scopus 로고    scopus 로고
    • IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice
    • Bohn, E., Sing, A., Zumbihl, R., Bielfeldt, C., Okamura, H., Kurimoto, M., Heesemann, J., Autenrieth, I. B. (1998) IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J. Immunol. 160, 299-307.
    • (1998) J. Immunol. , vol.160 , pp. 299-307
    • Bohn, E.1    Sing, A.2    Zumbihl, R.3    Bielfeldt, C.4    Okamura, H.5    Kurimoto, M.6    Heesemann, J.7    Autenrieth, I.B.8
  • 106
    • 0034219872 scopus 로고    scopus 로고
    • Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity
    • Lu, H., Yang, X., Takeda, K., Zhang, D., Fan, Y., Luo, M., Shen, C., Wang, S., Akira, S., Brunham, R. C. (2000) Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity. Mol. Med. 6, 604-612.
    • (2000) Mol. Med. , vol.6 , pp. 604-612
    • Lu, H.1    Yang, X.2    Takeda, K.3    Zhang, D.4    Fan, Y.5    Luo, M.6    Shen, C.7    Wang, S.8    Akira, S.9    Brunham, R.C.10
  • 108
    • 0032981470 scopus 로고    scopus 로고
    • Interleukin-18 protects mice against acute herpes simplex virus type 1 infection
    • Fujioka, N., Akazawa, R., Ohashi, K., Fujii, M., Ikeda, M., Kurimoto, M. (1999) Interleukin-18 protects mice against acute herpes simplex virus type 1 infection. J. Virol. 73, 2401-2409.
    • (1999) J. Virol. , vol.73 , pp. 2401-2409
    • Fujioka, N.1    Akazawa, R.2    Ohashi, K.3    Fujii, M.4    Ikeda, M.5    Kurimoto, M.6
  • 110
    • 0035919753 scopus 로고    scopus 로고
    • Down modulation of IL-18 expression by human papillomavirus type 16 E6 oncogene via binding to IL-18
    • Cho, Y. S., Kang, J. W., Cho, M., Cho, C. W., Lee, S., Choe, Y. K., Kim, Y., Choi, I., Park, S. N., Kim, S., et al. (2001) Down modulation of IL-18 expression by human papillomavirus type 16 E6 oncogene via binding to IL-18. FEBS Lett. 501, 139-145.
    • (2001) FEBS Lett. , vol.501 , pp. 139-145
    • Cho, Y.S.1    Kang, J.W.2    Cho, M.3    Cho, C.W.4    Lee, S.5    Choe, Y.K.6    Kim, Y.7    Choi, I.8    Park, S.N.9    Kim, S.10
  • 112
    • 0035450760 scopus 로고    scopus 로고
    • Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells
    • Choi, H. J., Dinarello, C. A., Shapiro, L. (2001) Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells. J. Infect. Dis. 184, 560-568.
    • (2001) J. Infect. Dis. , vol.184 , pp. 560-568
    • Choi, H.J.1    Dinarello, C.A.2    Shapiro, L.3
  • 114
    • 0034880934 scopus 로고    scopus 로고
    • Feline leukemia virus DNA vaccine efficacy is enhanced by coadministration with interleukin-12 (IL-12) and IL-18 expression vectors
    • Hanlon, L., Argyle, D., Bain, D., Nicolson, L., Dunham, S., Golder, M. C., McDonald, M., McGillivray, C., Jarrett, O., Neil, J. C., et al. (2001) Feline leukemia virus DNA vaccine efficacy is enhanced by coadministration with interleukin-12 (IL-12) and IL-18 expression vectors. J. Virol. 75, 8424-8433.
    • (2001) J. Virol. , vol.75 , pp. 8424-8433
    • Hanlon, L.1    Argyle, D.2    Bain, D.3    Nicolson, L.4    Dunham, S.5    Golder, M.C.6    McDonald, M.7    McGillivray, C.8    Jarrett, O.9    Neil, J.C.10
  • 115
    • 0035158948 scopus 로고    scopus 로고
    • Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: Induction of proinflammatory mechanisms
    • Mayne, M., Cheadle, C., Soldan, S. S., Cermelli, C., Yamano, Y., Akhyani, N., Nagel, J. E., Taub, D. D., Becker, K. G., Jacobson, S. (2001) Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms. J. Virol. 75, 11641-11650.
    • (2001) J. Virol. , vol.75 , pp. 11641-11650
    • Mayne, M.1    Cheadle, C.2    Soldan, S.S.3    Cermelli, C.4    Yamano, Y.5    Akhyani, N.6    Nagel, J.E.7    Taub, D.D.8    Becker, K.G.9    Jacobson, S.10
  • 116
    • 0034885457 scopus 로고    scopus 로고
    • Role of interleukin-18 in peripheral blood mononuclear cells infected with human herpes virus type 6
    • Arena, A., Iannello, D., Gazzara, D., Speranza, A., Bonina, L., Mastroeni, P. (2001) Role of interleukin-18 in peripheral blood mononuclear cells infected with human herpes virus type 6. Intervirology 44, 250-254.
    • (2001) Intervirology , vol.44 , pp. 250-254
    • Arena, A.1    Iannello, D.2    Gazzara, D.3    Speranza, A.4    Bonina, L.5    Mastroeni, P.6
  • 117
    • 0036468242 scopus 로고    scopus 로고
    • Interleukin-18 reduces expression of cardiac tumor necrosis factor-alpha and atrial natriuretic peptide in a murine model of viral myocarditis
    • Yoshida, A., Kand, T., Tanaka, T., Yokoyama, T., Kurimoto, M., Tamura, J., Kobayashi, I. (2002) Interleukin-18 reduces expression of cardiac tumor necrosis factor-alpha and atrial natriuretic peptide in a murine model of viral myocarditis. Life Sci. 70, 1225-1234.
    • (2002) Life Sci. , vol.70 , pp. 1225-1234
    • Yoshida, A.1    Kand, T.2    Tanaka, T.3    Yokoyama, T.4    Kurimoto, M.5    Tamura, J.6    Kobayashi, I.7
  • 119
    • 0034849953 scopus 로고    scopus 로고
    • Persistent expression of cytokines in the chronic stage of CVB3-induced myocarditis in NMRI mice
    • Gluck, B., Schmidtke, M., Merkle, I., Stelzner, A., Gemsa, D. (2001) Persistent expression of cytokines in the chronic stage of CVB3-induced myocarditis in NMRI mice. J. Mol. Cell. Cardiol. 33, 1615-1626.
    • (2001) J. Mol. Cell. Cardiol. , vol.33 , pp. 1615-1626
    • Gluck, B.1    Schmidtke, M.2    Merkle, I.3    Stelzner, A.4    Gemsa, D.5
  • 120
    • 0032169916 scopus 로고    scopus 로고
    • The possible role of interleukin (IL)-12 and interferon-gamma-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice
    • Kobayashi, K., Kai, M., Gidoh, M., Nakata, N., Endoh, M., Singh, R. P., Kasama, T., Saito, H. (1998) The possible role of interleukin (IL)-12 and interferon-gamma-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice. Clin. Immunol. Immunopathol. 88, 226-231.
    • (1998) Clin. Immunol. Immunopathol. , vol.88 , pp. 226-231
    • Kobayashi, K.1    Kai, M.2    Gidoh, M.3    Nakata, N.4    Endoh, M.5    Singh, R.P.6    Kasama, T.7    Saito, H.8
  • 121
    • 0033914491 scopus 로고    scopus 로고
    • Depressed interleukin-12 (IL-12), but not IL-18, production in response to a 30- or 32-kilodalton mycobacterial antigen in patients with active pulmonary tuberculosis
    • Song, C. H., Kim, H. J., Park, J. K., Lim, J. H., Kim, U. O., Kim, J. S., Paik, T. H., Kim, K. J., Suhr, J. W., Jo, E. K. (2000) Depressed interleukin-12 (IL-12), but not IL-18, production in response to a 30- or 32-kilodalton mycobacterial antigen in patients with active pulmonary tuberculosis. Infect. Immun. 68, 4477-4484.
    • (2000) Infect. Immun. , vol.68 , pp. 4477-4484
    • Song, C.H.1    Kim, H.J.2    Park, J.K.3    Lim, J.H.4    Kim, U.O.5    Kim, J.S.6    Paik, T.H.7    Kim, K.J.8    Suhr, J.W.9    Jo, E.K.10
  • 122
    • 0034163312 scopus 로고    scopus 로고
    • IL-12-independent Th1-type immune responses to respiratory viral infection: Requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes
    • Xing, Z., Zganiacz, A., Wang, J., Divangahi, M., Nawaz, F. (2000) IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-gamma release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes. J. Immunol. 164, 2575-2584.
    • (2000) J. Immunol. , vol.164 , pp. 2575-2584
    • Xing, Z.1    Zganiacz, A.2    Wang, J.3    Divangahi, M.4    Nawaz, F.5
  • 123
    • 0034327172 scopus 로고    scopus 로고
    • Cutting edge: Selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection
    • Pien, G. C., Satoskar, A. R., Takeda, K., Akira, S., Biron, C. A. (2000) Cutting edge: selective IL-18 requirements for induction of compartmental IFN-gamma responses during viral infection. J. Immunol. 165, 4787-4791.
    • (2000) J. Immunol. , vol.165 , pp. 4787-4791
    • Pien, G.C.1    Satoskar, A.R.2    Takeda, K.3    Akira, S.4    Biron, C.A.5
  • 124
    • 0035008212 scopus 로고    scopus 로고
    • Interleukin-18 expression induced by Epstein-Barr virus-infected cells
    • Yao, L., Setsuda, J., Sgadari, C., Cherney, B., Tosato, G. (2001) Interleukin-18 expression induced by Epstein-Barr virus-infected cells. J. Leukoc. Biol. 69, 779-784.
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 779-784
    • Yao, L.1    Setsuda, J.2    Sgadari, C.3    Cherney, B.4    Tosato, G.5
  • 125
    • 0035019199 scopus 로고    scopus 로고
    • Comparative analysis of host responses related to immunosuppression between measles patients and vaccine recipients with live attenuated measles vaccines
    • Okada, H., Sato, T. A., Katayama, A., Higuchi, K., Shichijo, K., Tsuchiya, T., Takayama, N., Takeuchi, Y., Abe, T., Okabe, N., et al. (2001) Comparative analysis of host responses related to immunosuppression between measles patients and vaccine recipients with live attenuated measles vaccines. Arch. Virol. 146, 859-874.
    • (2001) Arch. Virol. , vol.146 , pp. 859-874
    • Okada, H.1    Sato, T.A.2    Katayama, A.3    Higuchi, K.4    Shichijo, K.5    Tsuchiya, T.6    Takayama, N.7    Takeuchi, Y.8    Abe, T.9    Okabe, N.10
  • 126
    • 0032526917 scopus 로고    scopus 로고
    • Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells
    • Sareneva, T., Matikainen, S., Kurimoto, M., Julkunen, I. (1998) Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells. J. Immunol. 160, 6032-6038.
    • (1998) J. Immunol. , vol.160 , pp. 6032-6038
    • Sareneva, T.1    Matikainen, S.2    Kurimoto, M.3    Julkunen, I.4
  • 129
    • 0036498098 scopus 로고    scopus 로고
    • Proinflammatory response during Ebola virus infection of primate models: Possible involvement of the tumor necrosis factor receptor superfamily
    • Hensley, L. E., Young, H. A., Jahrling, P. B., Geisbert, T. W. (2002) Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily. Immunol. Lett. 80, 169-179.
    • (2002) Immunol. Lett. , vol.80 , pp. 169-179
    • Hensley, L.E.1    Young, H.A.2    Jahrling, P.B.3    Geisbert, T.W.4
  • 130
    • 0033029561 scopus 로고    scopus 로고
    • Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans
    • Qureshi, M. H., Zhang, T., Koguchi, Y., Nakashima, K., Okamura, H., Kurimoto, M., Kawakami, K. (1999) Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans. Eur. J. Immunol. 29, 643-649.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 643-649
    • Qureshi, M.H.1    Zhang, T.2    Koguchi, Y.3    Nakashima, K.4    Okamura, H.5    Kurimoto, M.6    Kawakami, K.7
  • 131
    • 0030885123 scopus 로고    scopus 로고
    • Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells
    • Zhang, T., Kawakami, K., Qureshi, M. H., Okamura, H., Kurimoto, M., Saito, A. (1997) Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. Infect. Immun. 65, 3594-3599.
    • (1997) Infect. Immun. , vol.65 , pp. 3594-3599
    • Zhang, T.1    Kawakami, K.2    Qureshi, M.H.3    Okamura, H.4    Kurimoto, M.5    Saito, A.6
  • 132
    • 0035212598 scopus 로고    scopus 로고
    • IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2
    • Blease, K., Kunkel, S. L., Hogaboam, C. M. (2001) IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2. Inflamm. Res. 50, 552-560.
    • (2001) Inflamm. Res. , vol.50 , pp. 552-560
    • Blease, K.1    Kunkel, S.L.2    Hogaboam, C.M.3
  • 134
    • 0034040798 scopus 로고    scopus 로고
    • Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection
    • Monteforte, G. M., Takeda, K., Rodriguez-Sosa, M., Akira, S., David, J. R., Satoskar, A. R. (2000) Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection. J. Immunol. 164, 5890-5893.
    • (2000) J. Immunol. , vol.164 , pp. 5890-5893
    • Monteforte, G.M.1    Takeda, K.2    Rodriguez-Sosa, M.3    Akira, S.4    David, J.R.5    Satoskar, A.R.6
  • 135
    • 0000326073 scopus 로고    scopus 로고
    • Trypanosoma cruzi induces strong IL-12 and IL-18 gene expression in vivo: Correlation with interferon-gamma (IFN-gamma) production
    • Meyer Zum Buschenfelde, C., Cramer, S., Trumpfheller, C., Fleischer, B., Frosch, S. (1997) Trypanosoma cruzi induces strong IL-12 and IL-18 gene expression in vivo: correlation with interferon-gamma (IFN-gamma) production. Clin. Exp. Immunol. 110, 378-385.
    • (1997) Clin. Exp. Immunol. , vol.110 , pp. 378-385
    • Meyer Zum Buschenfelde, C.1    Cramer, S.2    Trumpfheller, C.3    Fleischer, B.4    Frosch, S.5
  • 136
    • 0035802930 scopus 로고    scopus 로고
    • Early IFN-gamma production is related to the presence of interleukin (IL)-18 and the absence of IL-13 in experimental Trypanosoma cruzi infections
    • Antunez, M. I., Cardoni, R. L. (2001) Early IFN-gamma production is related to the presence of interleukin (IL)-18 and the absence of IL-13 in experimental Trypanosoma cruzi infections. Immunol. Lett. 79, 189-196.
    • (2001) Immunol. Lett. , vol.79 , pp. 189-196
    • Antunez, M.I.1    Cardoni, R.L.2
  • 137
    • 0033491194 scopus 로고    scopus 로고
    • Interleukin-18: A novel cytokine that augments both innate and acquired immunity
    • Okamura, H., Tsutsui, H., Kashiwamura, S., Yoshimoto, T., Nakanishi, K. (1998) Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv. Immunol. 70, 281-312.
    • (1998) Adv. Immunol. , vol.70 , pp. 281-312
    • Okamura, H.1    Tsutsui, H.2    Kashiwamura, S.3    Yoshimoto, T.4    Nakanishi, K.5
  • 138
    • 0034987525 scopus 로고    scopus 로고
    • Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria
    • Torre, D., Giola, M., Speranza, F., Matteelli, A., Basilico, C., Biondi, G. (2001) Serum levels of interleukin-18 in patients with uncomplicated Plasmodium falciparum malaria. Eur. Cytokine Netw. 12, 361-364.
    • (2001) Eur. Cytokine Netw. , vol.12 , pp. 361-364
    • Torre, D.1    Giola, M.2    Speranza, F.3    Matteelli, A.4    Basilico, C.5    Biondi, G.6
  • 139
    • 0031303092 scopus 로고    scopus 로고
    • IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production
    • Kawakami, K., Qureshi, M. H., Zhang, T., Okamura, H., Kurimoto, M., Saito, A. (1997) IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production. J. Immunol. 159, 5528-5534.
    • (1997) J. Immunol. , vol.159 , pp. 5528-5534
    • Kawakami, K.1    Qureshi, M.H.2    Zhang, T.3    Okamura, H.4    Kurimoto, M.5    Saito, A.6
  • 140
    • 0032416437 scopus 로고    scopus 로고
    • Human defenses against Cryptococcus neoformans: An update
    • Brummer, E. (1998) Human defenses against Cryptococcus neoformans: an update. Mycopathologia 143, 121-125.
    • (1998) Mycopathologia , vol.143 , pp. 121-125
    • Brummer, E.1
  • 142
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner, S. L., Locksley, R. M. (1995) The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13, 151-177.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, R.M.2
  • 143
    • 0034445617 scopus 로고    scopus 로고
    • Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii
    • Cai, G., Kastelein, R., Hunter, C. A. (2000) Interleukin-18 (IL-18) enhances innate IL-12-mediated resistance to Toxoplasma gondii. Infect. Immun. 68, 6932-6938.
    • (2000) Infect. Immun. , vol.68 , pp. 6932-6938
    • Cai, G.1    Kastelein, R.2    Hunter, C.A.3
  • 144
    • 0035340506 scopus 로고    scopus 로고
    • A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment
    • Yap, G. S., Ortmann, R., Shevach, E., Sher, A. (2001) A heritable defect in IL-12 signaling in B10.Q/J mice. II. Effect on acute resistance to Toxoplasma gondii and rescue by IL-18 treatment. J. Immunol. 166, 5720-5725.
    • (2001) J. Immunol. , vol.166 , pp. 5720-5725
    • Yap, G.S.1    Ortmann, R.2    Shevach, E.3    Sher, A.4
  • 145
    • 0035887943 scopus 로고    scopus 로고
    • Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines
    • Mordue, D. G., Monroy, F., La Regina, M., Dinarello, C. A., Sibley, L. D. (2001) Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines. J. Immunol. 167, 4574-4584.
    • (2001) J. Immunol. , vol.167 , pp. 4574-4584
    • Mordue, D.G.1    Monroy, F.2    La Regina, M.3    Dinarello, C.A.4    Sibley, L.D.5
  • 146
    • 0032607876 scopus 로고    scopus 로고
    • IL-18: A TH1-inducing, proinflammatory cytokine and new member of the IL-1 family
    • Dinarello, C. A. (1999) IL-18: a TH1-inducing, proinflammatory cytokine and new member of the IL-1 family. J. Allergy Clin. Immunol. 103, 11-24.
    • (1999) J. Allergy Clin. Immunol. , vol.103 , pp. 11-24
    • Dinarello, C.A.1
  • 148
    • 0034909059 scopus 로고    scopus 로고
    • Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells
    • Tanaka, M., Harigai, M., Kawaguchi, Y., Ohta, S., Sugiura, T., Takagi, K., Ohsako-Higami, S., Fukasawa, C., Hara, M., Kamatani, N. (2001) Mature form of interleukin 18 is expressed in rheumatoid arthritis synovial tissue and contributes to interferon-gamma production by synovial T cells. J. Rheumatol. 28, 1779-1787.
    • (2001) J. Rheumatol. , vol.28 , pp. 1779-1787
    • Tanaka, M.1    Harigai, M.2    Kawaguchi, Y.3    Ohta, S.4    Sugiura, T.5    Takagi, K.6    Ohsako-Higami, S.7    Fukasawa, C.8    Hara, M.9    Kamatani, N.10
  • 153
    • 0034769467 scopus 로고    scopus 로고
    • Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation
    • Morel, J. C., Park, C. C., Kumar, P., Koch, A. E. (2001) Interleukin-18 induces rheumatoid arthritis synovial fibroblast CXC chemokine production through NFkappaB activation. Lab. Invest. 81, 1371-1383.
    • (2001) Lab. Invest. , vol.81 , pp. 1371-1383
    • Morel, J.C.1    Park, C.C.2    Kumar, P.3    Koch, A.E.4
  • 155
    • 0034659770 scopus 로고    scopus 로고
    • Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
    • Leung, B. P., McInnes, I. B., Esfandiari, E., Wei, X. Q., Liew, F. Y. (2000) Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis. J. Immunol. 164, 6495-6502.
    • (2000) J. Immunol. , vol.164 , pp. 6495-6502
    • Leung, B.P.1    McInnes, I.B.2    Esfandiari, E.3    Wei, X.Q.4    Liew, F.Y.5
  • 157
    • 0030777296 scopus 로고    scopus 로고
    • Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2
    • Rothe, H., Jenkins, N. A., Copeland, N. G., Kolb, H. (1997) Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J. Clin. Invest. 99, 469-474.
    • (1997) J. Clin. Invest. , vol.99 , pp. 469-474
    • Rothe, H.1    Jenkins, N.A.2    Copeland, N.G.3    Kolb, H.4
  • 158
    • 0038407295 scopus 로고    scopus 로고
    • Cellular and molecular changes accompanying the progression from insulitis to diabetes
    • Andre-Schmutz, I., Hindelang, C., Benoist, C., Mathis, D. (1999) Cellular and molecular changes accompanying the progression from insulitis to diabetes. Eur. J. Immunol. 29, 245-255.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 245-255
    • Andre-Schmutz, I.1    Hindelang, C.2    Benoist, C.3    Mathis, D.4
  • 159
    • 0033178614 scopus 로고    scopus 로고
    • IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis
    • Rothe, H., Hausmann, A., Casteels, K., Okamura, H., Kurimoto, M., Burkart, V., Mathieu, C., Kolb, H. (1999) IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis. J. Immunol. 163, 1230-1236.
    • (1999) J. Immunol. , vol.163 , pp. 1230-1236
    • Rothe, H.1    Hausmann, A.2    Casteels, K.3    Okamura, H.4    Kurimoto, M.5    Burkart, V.6    Mathieu, C.7    Kolb, H.8
  • 160
    • 0035081444 scopus 로고    scopus 로고
    • Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type I diabetes
    • Nicoletti, F., Conget, I., Di Marco, R., Speciale, A. M., Morinigo, R., Bendtzen, K., Gomis, R. (2001) Serum levels of the interferon-gamma-inducing cytokine interleukin-18 are increased in individuals at high risk of developing type I diabetes. Diabetologia 44, 309-311.
    • (2001) Diabetologia , vol.44 , pp. 309-311
    • Nicoletti, F.1    Conget, I.2    Di Marco, R.3    Speciale, A.M.4    Morinigo, R.5    Bendtzen, K.6    Gomis, R.7
  • 161
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • Steinman, L. (1996) Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85, 299-302.
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 162
    • 0032400918 scopus 로고    scopus 로고
    • Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis
    • Wildbaum, G., Youssef, S., Grabie, N., Karin, N. (1998) Neutralizing antibodies to IFN-gamma-inducing factor prevent experimental autoimmune encephalomyelitis. J. Immunol. 161, 6368-6374.
    • (1998) J. Immunol. , vol.161 , pp. 6368-6374
    • Wildbaum, G.1    Youssef, S.2    Grabie, N.3    Karin, N.4
  • 163
    • 0032476702 scopus 로고    scopus 로고
    • Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat
    • Jander, S., Stoll, G. (1998) Differential induction of interleukin-12, interleukin-18, and interleukin-1beta converting enzyme mRNA in experimental autoimmune encephalomyelitis of the Lewis rat. J. Neuroimmunol. 91, 93-99.
    • (1998) J. Neuroimmunol. , vol.91 , pp. 93-99
    • Jander, S.1    Stoll, G.2
  • 164
    • 0033536062 scopus 로고    scopus 로고
    • CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions
    • Balashov, K. E., Rottman, J. B., Weiner, H. L., Hancock, W. W. (1999) CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc. Natl. Acad. Sci. USA 96, 6873-6878.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6873-6878
    • Balashov, K.E.1    Rottman, J.B.2    Weiner, H.L.3    Hancock, W.W.4
  • 168
  • 173
    • 0036103112 scopus 로고    scopus 로고
    • Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: Blocking interleukin 18 attenuates intestinal damage
    • Sivakumar, P. V., Westrich, G. M., Kanaly, S., Garka, K., Born, T. L., Derry, J. M., Viney, J. L. (2002) Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 50, 812-820.
    • (2002) Gut , vol.50 , pp. 812-820
    • Sivakumar, P.V.1    Westrich, G.M.2    Kanaly, S.3    Garka, K.4    Born, T.L.5    Derry, J.M.6    Viney, J.L.7
  • 175
    • 0036135586 scopus 로고    scopus 로고
    • Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
    • Wirtz, S., Becker, C., Blumberg, R., Galle, P. R., Neurath, M. F. (2002) Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J. Immunol. 168, 411-420.
    • (2002) J. Immunol. , vol.168 , pp. 411-420
    • Wirtz, S.1    Becker, C.2    Blumberg, R.3    Galle, P.R.4    Neurath, M.F.5
  • 177
    • 0036246975 scopus 로고    scopus 로고
    • Reduced interleukin-18 levels in BAL specimens from patients with asthma compared to patients with sarcoidosis and healthy control subjects
    • Ho, L. P., Davis, M., Denison, A., Wood, F. T., Greening, A. P. (2002) Reduced interleukin-18 levels in BAL specimens from patients with asthma compared to patients with sarcoidosis and healthy control subjects. Chest 121, 1421-1426.
    • (2002) Chest , vol.121 , pp. 1421-1426
    • Ho, L.P.1    Davis, M.2    Denison, A.3    Wood, F.T.4    Greening, A.P.5
  • 179
    • 0036224842 scopus 로고    scopus 로고
    • Effects of post-inhalation treatment with interleukin-12 on airway hyper-reactivity, eosinophilia interleukin-18 receptor expression in a mouse model of asthma
    • Kuribayashi, K., Kodama, T., Okamura, H., Sugita, M., Matsuyama, T. (2002) Effects of post-inhalation treatment with interleukin-12 on airway hyper-reactivity, eosinophilia interleukin-18 receptor expression in a mouse model of asthma. Clin. Exp. Allergy 32, 641-649.
    • (2002) Clin. Exp. Allergy , vol.32 , pp. 641-649
    • Kuribayashi, K.1    Kodama, T.2    Okamura, H.3    Sugita, M.4    Matsuyama, T.5
  • 180
    • 0035873683 scopus 로고    scopus 로고
    • Il-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity
    • Walter, D. M., Wong, C. P., DeKruyff, R. H., Berry, G. J., Levy, S., Umetsu, D. T. (2001) Il-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity. J. Immunol. 166, 6392-6398.
    • (2001) J. Immunol. , vol.166 , pp. 6392-6398
    • Walter, D.M.1    Wong, C.P.2    DeKruyff, R.H.3    Berry, G.J.4    Levy, S.5    Umetsu, D.T.6
  • 183
    • 0034650652 scopus 로고    scopus 로고
    • Differential roles of IL-18 in allergic airway disease: Induction of eotaxin by resident cell populations exacerbates eosinophil accumulation
    • Campbell, E., Kunkel, S. L., Strieter, R. M., Lukacs, N. W. (2000) Differential roles of IL-18 in allergic airway disease: induction of eotaxin by resident cell populations exacerbates eosinophil accumulation. J. Immunol. 164, 1096-1102.
    • (2000) J. Immunol. , vol.164 , pp. 1096-1102
    • Campbell, E.1    Kunkel, S.L.2    Strieter, R.M.3    Lukacs, N.W.4
  • 186
    • 0033786599 scopus 로고    scopus 로고
    • Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus
    • Wong, C. K., Li, E. K., Ho, C. Y., Lam, C. W. (2000) Elevation of plasma interleukin-18 concentration is correlated with disease activity in systemic lupus erythematosus. Rheumatology 39, 1078-1081.
    • (2000) Rheumatology , vol.39 , pp. 1078-1081
    • Wong, C.K.1    Li, E.K.2    Ho, C.Y.3    Lam, C.W.4
  • 187
    • 0034933401 scopus 로고    scopus 로고
    • Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease
    • Kawaguchi, Y., Terajima, H., Harigai, M., Hara, M., Kamatani, N. (2001) Interleukin-18 as a novel diagnostic marker and indicator of disease severity in adult-onset Still's disease. Arthritis Rheum. 44, 1716-1717.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1716-1717
    • Kawaguchi, Y.1    Terajima, H.2    Harigai, M.3    Hara, M.4    Kamatani, N.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.