Interleukin 1β modulates rat subfornical organ neurons as a result of activation of a non-selective cationic conductance

Journal of Physiology

Volumn 550, Issue 1, 2003, Pages 113-122

  Desson, Sheana E ^a   Ferguson, Alastair Victor ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CATION; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; PYROGEN; DELAYED RECTIFIER POTASSIUM CHANNEL; INTERLEUKIN 1; ION CHANNEL; POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; BATH; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEVER; FREQUENCY DISCRIMINATION; HYPERPOLARIZATION; IMMUNOREGULATION; ION CONDUCTANCE; ION CURRENT; MALE; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROIMMUNOLOGY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; SPIKE WAVE; SUBFORNICAL ORGAN; VOLTAGE CLAMP; ANIMAL TISSUE; BRAIN NERVE CELL; POTASSIUM CONDUCTANCE; STIMULUS RESPONSE; VOLTAGE CLAMP TECHNIQUE; WHOLE CELL PATCH CLAMP; ACTION POTENTIAL; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOLOGY; DRUG EFFECT; ELECTRIC CONDUCTIVITY; IMPEDANCE; METABOLISM; NERVE CELL; PATCH CLAMP; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ACTION POTENTIALS; ANIMALS; CATIONS; ELECTRIC CONDUCTIVITY; ELECTRIC IMPEDANCE; INTERLEUKIN-1; ION CHANNELS; MALE; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; SUBFORNICAL ORGAN;

EID: 0038300730     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.041210     Document Type: Article

References (32)

1. Anderson JW, Smith PM & Ferguson AV (2001). Subfornical organ neurons projecting to paraventricular nucleus: whole-cell properties. Brain Res 921, 78-85.
2. Blatteis CM, Bealer SL, Hunter WS, Llanos-Q J, Ahokas RA & Mashburn TA Jr (1983). Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs. Brain Res Bull 11, 519-526.
3. Boulant JA (2000). Role of the preoptic-anterior hypothalamus in thermoregulation and fever. Clin Infect Dis 31, suppl. 5, S157-S161.
4. Busbridge NJ, Dascombe MJ, Tilders FJH, van Oers JWAM, Linton EA & Rothwell NJ (1989). Central activation of thermogenesis and fever by interleukin- 1β and interleukin-1α involves different mechanisms. Biochem Biophys Res Commun 162, 591-596.
5. Cartmell T, Luheshi GN & Rothwell NJ (1999). Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat. J Physiol 518, 585-594.
6. Coceani F, Lees J & Dinarello CA (1988). Occurrence of interleukin-1 in cerebrospinal fluid of the conscious cat. Brain Res 446, 245-250.
7. Dellmann HD & Simpson JB (1979). The subfornical organ. Int Rev Cytol 58, 333-421.
8. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E & Karin M (1997). A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388, 548-554.
9. Dinarello CA (1994). The interleukin-1 family: 10 years of discovery. FASEB J 8, 1314-1325.
10. Dripps DJ, Brandhuber BJ, Thompson RC & Eisenberg SP (1991). Interleukin-1 (IL-1). receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J Biol Chem 266, 10331-10336.
11. Ebong SJ, Call DR, Bolgos G, Newcomb DE, Granger JI, O'Reilly M & Remick DG (1999). Immunopathologic responses to non-lethal sepsis. Shock 12, 118-126.
12. Eisenberg SP, Evans RJ, Arend WP, Verderber E, Brewer MT, Hannum CH & Thompson RC (1990). Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 343, 341-346.
13. Elmquist JK, Scammell TE & Saper CB (1997). Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosci 20, 565-570.
14. Evans RJ, Bray J, Childs JD, Vigers GP, Brandhuber BJ, Skalicky JJ, Thompson RC & Eisenberg SP (1995). Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta. J Biol Chem 270, 11477-11483.
15. Ferguson AV, Bicknell RJ, Carew MA & Mason WT (1997). Dissociated adult rat subfornical organ neurons maintain membrane properties and angiotensin responsiveness for up to 6 days. Neuroendocrinology 66, 409-415.
16. Hannum CH, Wilcox CJ, Arend WP, Joslin FG, Dripps DJ, Heimdal PL, Armes LG, Sommer A, Eisenberg SP & Thompson RC (1990). Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor. Nature 343, 336-340.
17. Horai R, Asano M, Sudo K, Kanuka H, Suzuki M, Nishihara M, Takahashi M & Iwakura Y (1998). Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 187, 1463-1475.
18. Kluger MJ (1991). Fever-role of pyrogens and cryogens. Physiol Rev 71, 93-127.
19. Laflamme N, Lacroix S & Rivest S (1999). An essential role of interleukin-1beta in mediating NF-kappaB activity and COX-2 transcription in cells of the blood-brain barrier in response to a systemic and localized inflammation but not during endotoxemia. J Neurosci 19, 10923-10930.
20. Lind RW, Van Hoesen GW & Johnson AK (1982). An HRP study of the connections of the subfornical organ of the rat. J Comp Neurol 210, 265-277.
21. Ma XC, Chen LT, Oliver J, Horvath E & Phelps CP (2000). Cytokine and adrenal axis responses to endotoxin. Brain Res 861, 135-142.
22. Matsunaga W, Osawa S, Miyata S & Kiyohara T (2001). Astrocytic Fos expression in the rat posterior pituitary following LPS administration. Brain Res 898, 215-223.
23. Miselis RR (1981). The efferent projections of the subfornical organ of the rat: a circumventricular organ within a neural network subserving water balance. Brain Res 230, 1-23.
24. Oliet SHR & Bourque CW (1993). Steady-state osmotic modulation of cationic conductance in neurons of rat supraoptic nucleus. Am J Physiol 265, R1475-1479.
25. Rothwell NJ (1991). Functions and mechanisms of interleukin 1 in the brain. Trends Pharmacol Sci 12, 430-436.
26. Stitt JT (1990). Passage of immunomodulators across the blood-brain barrier. Yale J Biol Med 63, 121-131.
27. Takahashi Y, Smith PM, Ferguson AV & Pittman QJ (1997). Circumventricular organs and fever. Am J Physiol 273, R1690-1695.
28. 2+ channel current through a pertussis toxin-sensitive G protein in rat pheochromocytoma-derived PC 12 cells. J Clin Invest 98, 14-17.
29. Tilders FJH, Derijk RH, Vandam AM, Vincent VAM, Schotanus K & Persoons JHA (1994). Activation of the hypothalamus-pituitary-adrenal axis by bacterial-endotoxins- routes and intermediate. Psychoneuroendocrinology 19, 209-232.
30. Vallieres L, Lacroix S & Rivest S (1997). Influence of interleukin-6 on neural activity and transcription of the gene encoding corticotrophin-releasing factor in the rat brain: an effect depending upon the route of administration. Eur J Neurosci 9, 1461-1472.
31. Washburn DLS, Beedle AM & Ferguson AV (1999a). Inhibition of subfornical organ neuronal potassium channels by vasopressin. Neuroscience 93, 349-359.
32. Washburn DLS, Smith PM & Ferguson AV (1999b). Control of neuronal excitability by an ion sensing receptor. Eur J Neurosci 11, 1947-1954.