Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury

Journal of Neuroscience

Volumn 16, Issue 19, 1996, Pages 6012-6020

  Mukhin, Alexey ^a   Fan, Lei ^a   Faden, Alan I ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

antisense oligodeoxynucleotides; brain trauma; metabotropic glutamate receptors; neuronal injury; neuroprotection; phosphoinositide hydrolysis

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL DEATH; EMBRYO; FEMALE; HYDROLYSIS; NERVE INJURY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

EID: 0029832301     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-19-06012.1996     Document Type: Article

References (56)

1. 2+ signal transduction. J Biol Chem 267:13361-13368.
2. Amador E, Dorfman LE, Wacher WEC (1963) Serum lactate dehydrogenase activity: an analytical assessment of current assays. Clin Chem 9:391-399.
3. Berridge MJ, Downes CP, Hanley MR (1982) Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J 206:587-595.
4. 2+ accumulation. Neuropharmacology 32:1351-1358.
5. Brabet I, Mary S, Bockaert J, Pin J-P (1995) Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses. Neuropharmacology 34:895-903.
6. Bruno V, Copani A, Battagli G, Raffaele R, Shinozaki H, Nicoletti F (1994) Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death. Eur J Pharmacol 256:109-112.
7. Buisson A, Choi DW (1995) The inhibitory mGluR agonist, S-4-carboxy-3-hydroxy phenylglycine selectively attenuates NMDA neurotoxicity and oxygen-glucose deprivation-induced neuronal death. Neuropharmacology 34:1081-1087.
8. Buisson A, Yu SP, Choi DW (1996) DCG-IV selectively attenuates rapidly triggered NMDA-induced neurotoxicity in cortical neurons. Eur J Neurol 8:138-143.
9. Chiamulera C, Albertini P, Valerio E, Reggiani A (1992) Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia. Eur J Pharmacol 216:335-336.
10. Delahunty TM (1992) Mild traumatic brain injury enhances muscarinic receptor-linked inositol phosphate production in rat hippocampus. Brain Res 594:307-310.
11. Faden AI, Simon RP (1988) A potential role for excitotoxins in the pathophysiology of spinal cord injuries. Ann Neurol 23:623-626.
12. Faden AI (1993) Experimental neurobiology of central nervous system. Crit Rev Neurobiol 7:175-186.
13. Faden AI, Demediuk P, Panter Vink R (1989) The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244:98-800.
14. Fitzjohn SM, Irving AJ, Palmer MJ, Harvey J, Lodge D, Collingridge GL (1996) Activation of group I mGluRs potentiates NMDA responses in rat. Neurosci Lett 203:211-213.
15. Gong QZ, Delahunty TM, Hamm RJ, Lyeth BG (1995) Metabotropic glutamate antagonist (MCPG) treatment of traumatic brain injury in rats. Brain Res 700:299-302.
16. Hayes RL, Jenkins LW, Lyeth BG, Bulster RL, Robinson SE, Clifton GL (1988) Pretreatment with phencyclidine, an N-methyl-D-aspartate antagonist, attenuates long-term behavioral deficits in the rat produced by traumatic brain injury. J Neurotrauma 5:259-274.
17. Hicks RR, Smith DH, McIntosh TK (1995) Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats. Brain Res 678:151-160.
18. Hollmann M, Heinemann S (1994) Cloned glutamate receptors. Annu Rev Neurosci 17:31-108.
19. Katayama Y, Becker DP, Tamura T, Hovda DA (1990) Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury. J Neurosurg 73:889-900.
20. Kingston AE, Burnett JP, Mayne NG, Lodge D (1995) Pharmacological analysis of 4-carboxyphenyl derivatives: comparison of effects of mGluR1α and mGluR5α subtypes. Neuropharmacology 34:887-894.
21. Koh JY, Choi DW (1987) Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods 20:83-90.
22. Koh JY, Palmer E, Cotman C (1991) Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures. Proc Natl Acad Sci USA 88:9431-9435.
23. Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S (1991) Sequence and expression of a metabotropic glutamate receptor. Nature 349:760-765.
24. McDonald JW, Schoepp DD (1992) The metabotropic excitatory amino acid receptor agonist 1S,3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury. Eur J Pharmacol 215:353-354.
25. McDonald JW, Fix AS, Tizzano JP, Schoepp DD (1993) Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. J Neurosci 13:4445-4455.
26. McIntosh TK (1993) Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: a review. J Neurotrauma 10:215-261.
27. McIntosh TK, Vink R, Noble L, Yamakami S, Fernyak S, Soares H, Faden AI (1989) Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 28:233-244.
28. McIntosh TK, Vink R, Soares H, Hayes R, Simon R (1990) Effect of non-competitive blockade of N-methyl-D-aspartate receptors on the neurochemical sequelae of experimental brain injury. J Neurochem 55:1170-1179.
29. McIntosh TK, Soares HL, Hayes RL, Simon RP (1993) The N-methyl-D-aspartate antagonist MK-801 prevents edema and restores magnesium homeostasis following traumatic brain injury in rats. In: Recent advances in excitatory amino acid research (Leahman J, ed), pp 653-656. New York: Liss.
30. 2+ influx after traumatic injury in rat cortical coculture. Soc Neurosci Abstr 21:764.
31. Nilsson P, Hillered L, Ponten U, Ungerstedt U (1990) Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. J Cereb Blood Flow Metab 10:631.
32. Okiyama K, Smith DH, Gennarelli TA, Simon RP, Leach M, McIntosh TK (1995) The sodium channel blocker and glutamate release inhibitor BW1003C87 and magnesium attenuate regional cerebral edema following experimental brain injury in the rat. J Neurochem 64:802-809.
33. Opitz T, Richter R, Reymann KG (1994) The metabotropic glutamate receptor antagonist (+)-α-methyl-4-carboxyphenylglycine protects hippocampal CA1 neurons of the rat from in vitro hypoxia/hypoglycemia. Neuropharmacol 33:715-717.
34. Palmer AM, Marion DW, Botscheller ML, Swedlow PE, Styren SD, DeKosky ST (1993) Traumatic brain injury-induced excitotoxicity assessed in a controlled cortical impact model. J Neurochem 61:2015-2024.
35. Panter SS, Faden AI (1994) Biochemical changes and secondary injury from stroke and trauma. In: Principles and practice of restorative neurology (Young RR, Delawade PJ, eds), pp 32-52. New York: Butterworth.
36. Pin J-P, Duvoisin R (1995) Review: neurotransmitter receptors I - the metabotrobic glutamate receptors: structure and functions. Neuropharmacology 34:1-26.
37. Pin J-P, Fagni L, Bockaert J (1993) The metabotropic glutamate receptors: targets for new pharmacologically active drugs. Curr Drugs Neurodegenerative Dis 1:111-137.
38. Prasad MR, Dhillon HS, Carbary T, Dempsey RJ, Scheff SW (1994) Enhanced phosphodiestric breakdown of phosphatidylinositol biphosphate after experimental brain injury. J Neurochem 63:773-776.
39. Regan RF, Choi DW (1994) The effect of NMDA, AMPA-kainate, and calcium channel antagonist on traumatic cortical neuronal injury in culture. Brain Res 633:236-242.
40. Reid SNM, Romano C, Hughes T, Daw NW (1995) Immunohistochemical study of two phosphoinositide-linked metabotropic glutamate receptors (mGluR1α and mGluR5) in the cat visual cortex before, during, and after the peak of the critical period for eye-specific connections. J Comp Neurol 355:470-477.
41. Romano C, Sesma MA, McDonald CT, O'Malley K, Van Den Pol AN, Olney JW (1995) Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J Comp Neurol 355:455-469.
42. Sacaan AI, Schoepp DD (1992) Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage. Neurosci Lett 139:77-82.
43. Saugstad JA, Kinzie JM, Mulvihill ER, Segerson TP, Westbrook GL (1994) Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors. Mol Pharmacol 45:367-372.
44. Saugstad JA, Segerson TP, Westbrook GL (1995) L-2-Amino-3-phosphonopropionic acid competitively antagonizes metabotropic glutamate receptors 1 alpha and 5 in Xenopus oocytes. Eur J Pharmacol 289:395-397.
45. Schoepp DD, Conn PJ (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci 14:13-20.
46. Schoepp DD, Goldsworthy J, Johnson BG, Salhoff CR, Baker SR (1994) 3,5-Dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus. J Neurochem 63:769-772.
47. Sharpira Y, Yadid C, Cotev A, Niska A, Shohami E (1990) Protective effect of MK-801 in experimental brain trauma. J Neurotrauma 1:131-139.
48. Siliprandi R, Lipartiti M, Fadda E, Sautter J, Manev H (1992) Activation of the glutamate metabotropic receptor protects retina against N-methyl-D-aspartate toxicity. Eur J Pharmacol 219:173-174.
49. Sladeczek F, Pin J-P, Récasens M, Bockaert J, Weiss S (1985) Glutamate stimulates inositol phosphate formation in striatal neurons. Nature 317:717-719.
50. Smith DH, Okiyama K, Thomas MJ, McIntosh TK (1993) Effects of the excitatory amino acid receptor antagonists kynurenate and indole-2-carboxylic acid on behavioral and neurochemical outcome following experimental brain injury. J Neurosci 13:5383-5392.
51. Sun F-Y, Faden AI (1995a) Pretreatment with antisense oligodeoxynucleotides directed against the NMDA-R1 receptor enhances survival and behavioral recovery following traumatic brain injury in rats. Brain Res 693:163-168.
52. Sun F-Y, Faden AI (1995b) Neuroprotective effects of 619C89, a use-dependent sodium channel blocker, in rat traumatic brain injury. Brain Res 673:133-140.
53. Tecoma ES, Monyer H, Goldberg MP, Choi DW (1989) Traumatic neuronal injury in vitro is attenuated by NMDA antagonists. Neuron 2:1541-1545.
54. Toulmond S, Serrano A, Benavides J, Scatton B (1993) Prevention by eliprodil (SL 82,0715) of traumatic brain damage in the rat: existence of a large (18 hr) therapeutic window. Brain Res 620:32-41.
55. Watkins J, Collingridge G (1994) Review: phenylglycine derivatives as antagonists of metabotropic receptors. Trends Pharmacol Sci 15:333-342.
56. Wrathall JR, Teng YD, Choiniere D, Mundt DJ (1992) Evidence that local non-NMDA receptors contribute to functional deficits in contusive spinal cord injury. Brain Res 586:140-143.