Challenging the amyloid cascade hypothesis: Senile plaques and amyloid-β as protective adaptations to Alzheimer disease

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 1-4

  Lee, Hyoung Gon ^a   Casadesus, Gemma ^a   Zhu, Xiongwei ^a   Takeda, Atsushi ^b   Perry, George ^a   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer disease; Amyloid ; Antioxidant; Free radical; Senile plaque

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; HEMOGLOBIN; PRESENILIN 1; PRESENILIN 2;

AGING; ALTITUDE DISEASE; ALZHEIMER DISEASE; CELL DEATH; COGNITIVE DEFECT; CONFERENCE PAPER; DISEASE EXACERBATION; ERYTHROPOIESIS; GENE MUTATION; HUMAN; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; SENILE PLAQUE;

EID: 3242737470     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.001     Document Type: Conference Paper

References (25)

1. HARDY, J. & D.J. SELKOE. 2002. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356.
2. NEVE, R.L. & N.K. ROBAKIS. 1998. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci. 21: 15-19.
3. YAN, S.D., X. CHEN, J. FU, et al. 1996. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 382: 685-691.
4. PRATICÓ, D., U. URYU, S. LEIGHT, et al. 2001. Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J. Neurosci. 21: 4183-4187.
5. NUNOMURA, A., G. PERRY, M.A. PAPPOLLA, et al. 1999. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J. Neurosci. 19: 1959-1964.
6. NUNOMURA, A., G. PERRY, G. ALIEV, et al. 2001. Oxidative damage is the earliest event in Alzheimer disease. J. Neuropathol. Exp. Neurol. 60: 759-767.
7. ROTTKAMP, C.A., C.S. ATWOOD, J.A. JOSEPH, et al. 2002. The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease. Peptides 23: 1333-1341.
8. SMITH, M.A., G. CASADESUS, J.A. JOSEPH, et al. 2002. Amyloid-β and τ serve antioxidant functions in the aging and Alzheimer brain. Free Radic. Biol. Med. 33: 1194-1199.
9. ROTTKAMP, C.A., A.K. RAINA, X. ZHU, et al. 2001. Redox-active iron mediates amyloid-β toxicity. Free Radic. Biol. Med. 30: 447-450.
10. LIM, G.P., T. CHU, F. YANG, et al. 2001. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 21: 8370-8377.
11. VEURINK, G., D. LIU, K. TADDEI, et al. 2003. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radic. Biol. Med. 34: 1070-1077.
12. NUNOMURA, A., G. PERRY, M.A. PAPPOLLA, et al. 2000. Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome. J. Neuropathol. Exp. Neurol. 59: 1011-1017.
13. JOSEPH, J., B. SHUKITT-HALE, N.A. DENISOVA, et al. 2001. Copernicus revisted: amyloid beta in Alzheimer's disease. Neurobiol. Aging 22: 131-146.
14. SMITH, M.A., C.S. ATWOOD, J.A. JOSEPH, et al. 2002. Predicting the failure of the amyloid-β vaccine. The Lancet 359: 1864-1865.
15. GENTLEMAN, S.M., M.J. NASH, C.J. SWEETING, et al. 1993. β-amyloid precursor protein (βAPP) as a marker for axonal injury after head injury. Neurosci. Lett. 160: 139-144.
16. CUAJUNGCO, M.P., L.E. GOLDSTEIN, A. NUNOMURA, et al. 2000. Evidence that the β-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of Aβ by zinc. J. Biol. Chem. 275: 19439-19442.
17. DAVIS, D.G., F.A. SCHMITT, D.R. WEKSTEIN, et al. 1999. Alzheimer neuropathologic alterations in aged cognitively normal subjects. J. Neuropathol. Exp. Neurol. 58: 376-388.
18. ATWOOD, C.S., S.R. ROBINSON & M.A. SMITH. 2002. Amyloid-β: redox-metal chelator and antioxidant. J. Alzheimers Dis. 4: 203-214.
19. SMITH, M.A., R.K. KUTTY, P.L. RICHEY, et al. 1994. Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. Am. J. Pathol. 145: 42-47.
20. MORI, H., J. KONDO & Y. IHARA. 1987. Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 235: 1641-1644.
21. PERRY, G., R. FRIEDMAN, G. SHAW, et al. 1987. Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains. Proc. Natl. Acad. Sci. USA 84: 3033-3036.
22. OBRENOVICH, M.E., J.A. JOSEPH, C.S. ATWOOD, et al. 2002. Amyloid-β: a (life) preserver for the brain. Neurobiol. Aging 23: 1097-1099.
23. PERRY, G., A. NUNOMURA, A.K. RAINA, et al. 2000. Amyloid-β junkies. The Lancet 355: 757.
24. SMITH, M.A., J.A. JOSEPH, C.S. ATWOOD, et al. 2002. Dangers of the amyloid-β vaccine. Acta Neuropathol. 104: 110.
25. SMITH, M.A., C.S. ATWOOD, J.A. JOSEPH, et al. 2002. Ill-fated amyloid-β vaccine. J. Neurosci. Res. 69: 285.