Mitochondrial dysfunction in idiopathic Parkinson disease

American Journal of Human Genetics

Volumn 62, Issue 4, 1998, Pages 758-762

  Parker Jr , W Davis ^a   Swerdlow, Russell H ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

BRAIN MITOCHONDRION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HEREDITARY OPTIC ATROPHY; HUMAN; INHERITANCE; PARKINSON DISEASE; PRIORITY JOURNAL; RESPIRATORY CHAIN; REVIEW;

EID: 17344368267     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301812     Document Type: Article

References (44)

1. Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38:357-366
2. Benecke R, Strumper P, Weiss H (1993) Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndromes. Brain 116: 1451-1463
3. Burkhardt C, Kelly JP, Lim YH, Filley CM, Parker WD (1993) Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol 33:512-517
4. Cassarino DS, Fall CP, Swerdlow RH, Smith TS, Halvorsen EM, Miller SW, Parks JK, et al (1997) Elevated reactive oxygen species and antioxidant enzyme activities in animal and cellular models of Parkinson's disease. Biochim Biophys Acta 1362:77-86
5. Damier P, Hirsch EC, Zhang P, Agid Y, Javoy-Agid F (1993) Glutathione peroxidase, glial cells and Parkinson's disease. Neuroscience 52:1-6
6. Edland SD, Silverman JM, Peskind ER, Tsuang D, Wijsman E, Morris JC (1996) Increased risk of dementia in mothers of Alzheimer's disease cases: evidence for maternal inheritance. Neurology 47:254-256
7. Gai WP, Blumbergs PC, Blessing WW (1997) The ultrastructure of Lewy neurites. Mov Disord 12 Suppl 1:5
8. Gu M, Cooper JM, Schapira AHV (1997) Genomic transplantation to determine the molecular basis and pathogenic role of complex I in Parkinson's disease. Mov Disord 12 Suppl 1:2
9. Haas RH, Nasirian F, Nakano K, Ward D, Pay M, Hill R, Shults CW (1995) Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease. Ann Neurol 37:714-722
10. Ikebe S, Tanaka T, Ozawa T (1995) Point mutations of mitochondrial genome in Parkinson's disease. Mol Brain Res 28:281-295
11. Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82:2173-2177
12. Kalra J, Rajput AH, Mantha SV, Prassad K (1992) Serum antioxidant enzyme activity in Parkinson's disease. Mol Cell Biochem 110:165-168
13. Kish SJ, Bergeron C, Rajput A, Dozic S, Mastrogiacono F, Chang L, Wilson JM, et al (1992) Brain cytochrome oxidase in Alzheimer's disease. J Neurochem 59:776-779
14. Kosel S, Lucking CB, Egensperger R, Mehraein P, Graeber MB (1996) Mitochondrial NADH dehydrogenase and CYP2D6 genotypes in Lewy-body parkinsonism. J Neurosci Res 44: 174-183
15. Krige D, Carroll MT, Cooper JM, Marsden CD, Schapira AHV (1992) Platelet mitochondrial function in Parkinson's disease. Ann Neurol 32:782-788
16. Kroemer G, Zamzami N, Susin SA (1997) Mitochondrial control of apoptosis. Immunol Today 18:44-51
17. Lazzarini AM, Myers RH, Zimmerman TR, Mark MH, Golbe LI, Sage JI, Johnson WG, et al (1994) A clinical genetic study of Parkinson's disease: evidence for dominant transmission. Neurology 44:499-506
18. Marsden CD (1987) Parkinson's disease in twins. J Neurol Neurosurg Psychiatry 50:105-106
19. Marttila RJ, Kaprio J, Koskenvuo M, Rinne UK (1988a) Parkinson's disease in a nationwide twin cohort. Neurology 38: 1217-1219
20. Marttila RJ, Lorentz H, Rinne UK (1988b) Oxygen toxicity protecting enzymes in Parkinson's disease: increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus. J Neurol Sci 86:321-331
21. Miller S, Trimmer P, Davis RE, Parker WD (1996) Creation and characterization of mitochondrial DNA-depleted cell lines with "neuronal-like" properties. J Neurochem 67: 1897-1907
22. Mizuno Y, Ohta S, Tanaka M, Takamiya S, Suzuki K, Sato T, Oya H, et al (1989) Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. Biochem Biophys Res Commun 163:1450-1455
23. Morrison PJ, Godwin-Austen RB, Raeburn JA (1996) Familial autosomal dominant dopa responsive Parkinson's disease in three living generations showing extreme anticipation and childhood onset. J Med Genet 33:504-506
24. Mytilineou C, Werner P, Molinari S, Di Rocco A, Cohen G, Yahr MD (1994) Impaired oxidative decarboxylation of pyruvate in fibroblasts from patients with Parkinson's disease. J Neural Transm 8:223-228
25. Parker WD, Boyson SJ, Parks JK (1989a) Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-723
26. Parker WD, Filley CM, Parks JK (1990) Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 40:1302-1303
27. Parker WD, Oley CA, Parks JK (1989b) Deficient NADH: coenzyme Q oxidoreductase in Leber's hereditary optic neuropathy. N Engl J Med 320:1331-1333
28. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, et al (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276:2045-2047
29. Saggu H, Cooksey J, Dexter D, Wells FR, Lees A, Jenner P, Marsden CD (1989) A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra. J Neurochem 53:692-697
30. Schapira AHV, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD (1989) Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1:1269
31. Sheehan JP, Swerdlow RH, Miller SW, Davis RE, Parker WD, Tuttle JB (1997a) Altered calcium homeostasis and reactive oxygen species in cells transformed by mitochondrial DNA from individuals with sporadic Alzheimer's disease. J Neurosci 17:4612-4622
32. Sheehan JP, Swerdlow RH, Parker WD, Miller SW, Davis RE, Tuttle JB (1997b) Altered calcium homeostasis in cells transformed by mitochondria from individuals with Parkinson's disease. J Neurochem 68:1221-1233
33. Shoffner JM, Brown MD, Torroni A, Lott MT, Cabell MF, Mirra SS, Beal MF, et al (1993) Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients. Genomics 17:171-184
34. Shoffner JM, Watts RL, Juncos JL, Torroni A, Wallace DC (1991) Mitochondrial oxidative phosphorylation defects in Parkinson's disease. Ann Neurol 30:332-339
35. Swerdlow RH, Parks JK, Cassarino DS, Maguire DJ, Maguire RS, Bennett JP, Davis RE, et al (1997a) Cybrids in Alzheimer's disease: a cellular model of the disease? Neurology 49:918-925
36. Swerdlow RH, Parks JK, Currie LJ, Wooten GF, Parker WD (1997b) Mitochondrial electron transport function in cybrid cells from members of a Parkinson's disease kindred spanning three generations. Soc Neurosci 23:1907
37. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP, et al (1996) Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-671
38. Tanner CM, Ottman R, Ellenberg JH, Goldman SM, Mayeaux R, Chan P, Langston JW (1997) Parkinson's disease (PD) concordance in elderly male monozygotic (MZ) and dizygotic (DZ) twins. Neurology 48 Suppl 3:A333
39. Vyas I, Heikkila RE, Nicklas WJ (1986) Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine: inhibition of NAD-linked substrate oxidation by its metabolite, 1-methyl-4-pyridinium. J Neurochem 46:1501-1507
40. Ward CD, Duvoisin RC, Ince SE, Nutt JD, Eldridge F, Calne DB (1983) Parkinson's disease in 65 pairs of twins and in a set of quadruplets. Neurology 33:815-824
41. Wooten GF, Currie LJ, Bennett JP, Trugman JM, Harrison MB, Dougherty J (1997a) Maternal inheritance in two large kindreds with Parkinson's disease. Neurology 48 Suppl 3:A333
42. Wooten GF, Currie LJ, Bennett JP, Trugman JM, Harrison MB, Parker WD (1997b) Maternal inheritance in Parkinson's disease. Ann Neurol 41:265-268
43. Yoshino H, Nakagawa-Hattori Y, Kondo T, Mizuno Y (1992) Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease. J Neural Transm 41: 27-34
44. Young WI, Martin WE, Anderson VE (1977) The distribution of ancestral secondary cases in Parkinson's disease. Clin Genet 11:189-192