Biochemical regulation of non-rapid-eye-movement sleep

Frontiers in Bioscience

Volumn 8, Issue , 2003, Pages

  Obal Jr , Ferenc ^a   Krueger, James M ^b,c  

^a UNIVERSITY OF SZEGED   (Hungary)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c Department of VCAPP ^*  (United States)

Author keywords

Cytokine; EEG; Hormones; Review; Sleep; Sleep Regulation; TNF

Indexed keywords

ADENOSINE; CHOLECYSTOKININ; DELTA SLEEP INDUCING PEPTIDE; GLUTATHIONE DISULFIDE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; INSULIN; INTERLEUKIN 1BETA; MURAMYL PEPTIDE; NITRIC OXIDE; OLEAMIDE; PROSTAGLANDIN D2; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; URIDINE;

CELL ACTIVITY; CHOLINERGIC NERVE CELL; CYTOKINE PRODUCTION; FOREBRAIN; HUMAN; HYPOTHALAMUS; NERVE ENDING; NONHUMAN; NONREM SLEEP; PREOPTIC AREA; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVIEW; SLEEP WAKING CYCLE; ANIMAL; PHYSIOLOGY; REM SLEEP;

ANIMALIA;

ANIMALS; HUMANS; SLEEP, REM;

EID: 1542568539     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: None     Document Type: Review

References (384)

1. Tigerstedt R& P.Bergman: Niere und Kreislauf. Arch Physiol 8, 223-211 (1898)
2. Bayliss WM& E.H.Starling: Mechanisms of pancreatic secretion. J Physiol 28, 325-353 (1902)
3. Inoué S. Biology of sleep substances. Boca Raton, Florida: CRC Press, Inc., 1989:
4. Legendre R& H.Piéron: Recherches sur le besoin de sommeil consécutif á une veille prlongée. Z Allg Physiol 14, 235-262 (1913)
5. Hess WR: Das Schlafsyndrom als Folge dienzephaler Reizung. Helv Physiol Pharmacol Acta 2, 305-344 (1944)
6. Monnier M& L.Hösli: Dialysis of sleep and waking factor in blood of the rabbit. Science 146, 796-798 (1964)
7. Schoenenberger GA, P.F.Maier, H.J.Tobler, K.Wilson & M.Monnier: The delta (EEG) sleep inducing peptide (DSlP) XI. Amino acid analysis, sequence, synthesis and activity of the nonapeptide. Pflügers Arch 376, 119-129 (1978)
8. Graf MV& A.J.Kastin: Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev 8, 83-93 (1984)
9. Graf MV& A.J.Kastin: Delta-sleep-inducing peptide (DSIP): an update. Peptides 7, 1165-1187 (1986)
10. Borbély AA& I.Tobler: Endogenous sleep-promoting substances and sleep regulation. Physiol Rev 69, 605-670 (1989)
11. Schoenenberger GA: Characterization, properties and multivariate functions of delta- sleep-inducing peptide (DSIP). Eur Neurol 23, 321-345 (1984)
12. Sudakov KV, P.E.Umryukhin, E.V.Koplik & K.V.Anokhin: Expression of the c-fos gene during emotional stress in rats: the clocking effect of delta sleep-inducing peptide. Neurosci Behav Physiol 31, 635-640 (2001)
13. Obal F, Jr., V.M.Kovalzon, V.N.Kalikhevich, A.Török, P.Alföldi, G.Sary, M.Hajos & B.Penke: Structure-activity relationship in the effects of delta-sleep-inducing peptide (DSIP) on rat sleep. Pharmacol Biochem Behav 24, 889-894 (1986)
14. Sillard R, P.Schulz-Knappe, P.Vogel, K.W.Bensch, W.G.Forssmann & V.Mutt: A novel 77-residue peptide from porcine brain contains a leucine-zipper motif and is recognized by an antiserum to delta-sleep-inducing peptide. Eur J Biochem 216, 429-436 (1993)
15. Uchizono K, Higashi A, Iriki M, Nagasaki H, Ishikawa M, Komoda Y, Inoué S & Honda K: Sleep-promoting fractions obtained from the brain-stem of sleep-deprived rats. In:Eds: Ito M, Kubota K, Tsukahara N, Yagi K, Intergative control functions of the brain vol.I. Amstredam,New York,Oxford: Elsevier/North-Holland Biomedical Press, 1978:392-396
16. Komoda Y, M.Ishikawa, H.Nagasaki, M.Iriki, K.Honda, S.Inoué, A.Higashi & K.Uchizono: Uridine, a sleep-promoting substance from brainstem of sleep-deprived rats. Biomedical Research 4, 223-227 (1983)
17. Komoda Y, K.Honda & S.Inoué: SPS-B, a physiological sleep regulator from the brainstems of sleep-deprived rats, identified as oxidized glutathione. Chem Pharm Bull 28, 2057-2059 (1990)
18. Inoué S, K.Honda, Y.Komoda, K.Uchizono, R.Ueno & O.Hayaishi: Differential sleep-promoting effects of five sleep substances nocturnally infused in unrestrained rats. PNAS 81, 6240-6244 (1984)
19. Honda K, Y.Komoda, S.Nishida, H.Nagasaki, A.Higashi, K.Uchizono & S.Inoué: Uridine as an active component of sleep-promoting substance: its effects on nocturnal sleep in rats. Neurosci Res 1, 243-252 (1984)
20. Honda K, Y.Komoda & S.Inoué: Oxidized glutathione regulates physiological sleep in unrestrained rats. Brain Res 636, 253-258 (1994)
21. Kimura M, L.Kapas & J.M.Krueger: Oxidized glutathione promotes sleep in rabbits. Brain Res Bull 45, 545-548 (1998)
22. Dobolyi A, T.Sziktra, A.K.Kekesi, Z.Kovacs & G.Juhasz: Uridine is released by depolarization and inhibits unit activity in the rat hippocampus. Neuroreport 10, 3049-3053 (1999)
23. Dobolyi A, A.Reichart, T.Sziktra, G.Nyitrai, A.K.Kekesi & G.Juhasz: Sustained depolarisation induces changes in the extracellular concentrations of purine and pyrimidine nucleosides in the rat thalamus. Neurochem Int 37, 71-79 (2000)
24. Zängerle L, M.Cuénod & K.H.Winterthaler: Screening of thiol compounds: depolarization-induced release of glutathione and cysteine from rat brain slices. J Neurochem 59, 181-189 (1992)
25. Inoué S, K.Honda & Y.Komoda: Sleep as a neuronal detoxification and restitution. Behav Brain Res 69, 91-96 (1995)
26. D'Almeida V, L.L.Lobo, D.C.Hipolide, A.C.De Oliviera, J.N.Nobrega & S.Tufik: Sleep deprivation induces brain region-specific decreases in glutathione levels. Neuroreport 9, 2853-2856 (1998)
27. Miller TB, C.A.Goodrich & J.R.Pappenheimer: Sleep-promoting effects of cerebrospinal fluid from sleep deprived goats. PNAS 58, 513-517 (1967)
28. Fencl V, G.Koski & J.R.Pappenheimer: Factors in cerebrospinal fluid from goats that affect sleep and activity in rats. J Physiol 216, 565-589 (1971)
29. Pappenheimer JR: Induction of sleep by muramyl peptides. J Physiol 336, 1-11 (1983)
30. Pappenheimer JR, G.Koski, V.Fencl, M.L.Karnovsky & J.M.Krueger: Extraction of sleep-promoting Factor S from cerebrospinal fluid and from brains of sleep-deprived animals. J Neurophysiol 38, 1299-1311 (1975)
31. Krueger JM, J.Bacsik & J.Garcia-Arraras: Sleep-promoting material from human urine and its relation to Factor S from brain. Am J Physiol 238, E116-E123 (1980)
32. Krueger JM, J.R.Pappenheimer & M.L.Karnovsky: The composition of sleep-promoting factor isolated from human urine. J Biol Chem 257, 1664-1669 (1982)
33. Rehman A, P.Taishi, J.Fang, J.A.Majde & J.M.Krueger: The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation. Cytokine 13, 8-17 (2001)
34. Krueger JM, M.L.Karnovsky, S.A.Martin, J.R.Pappenheimer, J.Walter & K.Biemann: Peptidoglycan s as promoters of slow-wave sleep. II. Somnogenic and pyrogenic activities of some naturally occurring muramyl peptides; correlations with mass spectrometric structure determination. J Biol Chem 259, 12659-12662 (1984)
35. Krueger JM, J.Walter, C.A.Dinarello, S.M.Wolff & L.Chedid: Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am J Physiol 246, R994-R999 (1984)
36. Shoham S, D.Davenne, A.B.Cady, C.A.Dinarello & J.M.Krueger: Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep. Am J Physiol 253, R142-R149 (1987)
37. Prospéro-Garcia O, M.Morales, G.Arankowsky-Sandoval & R.Drucker-Colin: Vasoactive intestinal polypeptide (VIP) and cerebrospinal fluid (CSF) of sleep-deprived cats restores REMS in insomnia recipients. Brain Res 385, 169-173 (1986)
38. Drucker-Colin R, Prospero-Garcia O, Arankowsky-Sandoval G & Perez-Montfort R: Gastropancreatic peptides and sensory stimuli as REM factors. In:Eds: Inoué S, Schneider-Helmert D, Sleep peptides: basic and clinical approaches. Berlin: Springer, 1988:73-94
39. Krueger JM, F.Obal, Jr., M.Opp, L.Toth, L.Johannsen & A.B.Cady: Somnogenic cytokines and models concerning their effects on sleep. Yale J Biol Med 63, 157-172 (1990)
40. Drucker-Colin R: The function of sleep is to regulate brain excitability in order to satisfy the requirements imposed by waking. Behav Brain Res 69, 117-124 (1995)
41. Garcia-Garcia F& R.Drucker-Colin: Endogenous and exogenous factors on sleep-wake cycle regulation. Prog Brain Res 58, 297-314 (1999)
42. Berne RM, Rall TW, Rubio R. Regulatory function of adenosine. Boston: Martinus Nijhoff, 1983:
43. Winn HR: Adenosine and its receptors: influence on cerebral blood flow. In:Eds: Welch KMA, Caplan LR, Reis DJ, Siesjö BK, Weir B, Primer on Cerebrovascular Diseases. San Diego: Academic Press, 1997:77-79
44. Ticho SR& M.Radulovacki: Role of adenosine in sleep and temperature regulation in the preoptic area of rats. Pharmacol Biochem Behav 40, 33-40 (1991)
45. Benington JH, S.K.Kodali & H.C.Heller: Stimulation of Al adenosine receptors mimics the electroencephalographic effects of sleep deprivation. Brain Res 692, 79-85 (1995)
46. Schwierin B, A.A.Borbély & I.Tobler: Effects of N-6-cyclopentyladenosine and caffein on sleep regulation in the rat. Eur J Pharmacol 300, 163-171 (1996)
47. Hendricks JC, S.M.Finn, K.A.Panckeri, J.Chavkin, J.A.Williams, A.Sehgal & A.I.Pack: Rest in Drosophila is a sleep-like state. Neuron 25, 129-138 (2000)
48. Matuszek MT& I.T.Gagalo: The antipyretic activity of adenosine agonists. Gen Pharmacol 29, 371-374 (1997)
49. Porkka-Heiskanen T, R.E.Strecker, M.Thakkar, A.A.Bjorkum, R.W.Greene & R.W.McCarley: Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness. Science 276, 1265-1268 (1997)
50. Porkka-Heiskanen T, R.E.Stecker & R.W.McCarley: Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study. Neuroscience 99, 507-517 (2000)
51. Strecker RE, S.Morairty, M.M.Thakkar, T.Porkka-Heiskanen, R.Basheer, L.J.Dauphin, D.G.Rainnie, C.M.Portas, R.W.Greene & R.W.McCarley: Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state. Behav Brain Res 115, 183-204 (2000)
52. Kaushal N, B.Johansson, L.Halldner, B.Fredholm & R.W.Greene: Reduced slow wave activity in the adenosine Al receptor knockout mice. Soc for Neurosci Absts 27, 1378 (2001)
53. Portas CM, M.Thakkar, D.G.Rainnie, R.W.Greene & R.W.McCarley: Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat. Neuroscience 79, 225-235 (1997)
54. Brundege JM& L.Fadiga: Role of adenosine as a modulator of synaptic activity in the central nervous system. Adv Pharmacol 39, 353-391 (1997)
55. Satoh S, H.Matsumura, N.Koike, Y.Tokunaga, T.Maeda & O.Hayaishi: Region-dependent difference in the sleep-promoting potency of an adenosine A2A receptor antagonist. Eur J Neurosci 11, 1587-1597 (1999)
56. Scammel TE, D.Y.Gerashchenko, T.Mochizuki, M.T.McCarthy, I.V.Estabrooke, C.B.Sears, Y.Urade & O.Hayaishi: An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience 107, 653-663 (2001)
57. Noor Alam Md, R.Szymusiak, H.Gong, J.King & D.McGinty: Adenosinergic modulation of rat basal forebrain neurons during sleep and waking: neuronal recording with microdialysis. J Physiol 521.3, 679-690 (1999)
58. Perez E, G.Zamboni, R.Amici, L.Fadiga & P.L.Parmeggiani: Ultradian and circadian changes in the cAMP concentration in the preoptic region of the rat. Brain Res 551, 132-135 (1991)
59. Basheer R, T.Porkka-Heiskanen, D.Stenberg & R.W.McCarley: Adenosine and behavioral state control: adenosine increases c-Fos protein and API binding in basal forebrain of rats. Mol Brain Res 73, 1-10 (1999)
60. Basheer R, D.G.Rainnie, T.Porkka-Heiskanen, V.Ramesh & R.W.McCarley: Adenosine, prolonged wakefulness, and A1-activated NF-kB DNA binding in the basal forebrain of the rat. Neuroscience 104, 731-739 (2001)
61. Ray KP& N.Kennard: Interleukin-1 induces a nuclear form of transcription factor NF kappa B in human lung epihelial cells. Agents Actions 38, C61-C63 (1993)
62. Karnovsky ML, P.Reich, J.M.Anchors & B.L.Burrows: Changes in brain glycogen during slow-wave sleep in the rat. J Neurochem 41, 1598-1501 (1983)
63. Benington JH& H.C.Heller: Restoration of brain energy metabolism as the function of sleep. Progress in Neurobiology 45, 347-360 (1995)
64. Petit JM, I.Allaman, J.Baudaut, I.Tobler & A.A.Borbély: Transcriptional regulation of genes related to glycogen metabolism by adenosine: possible involvement in the sleep-wake cycle. J Sleep Res 11(S1), 175 (2002)
65. Kong J, N.Shepel, C.P.Holden, M.Mackiewicz, A.I.Pack & J.D.Geiger: Brain glycogen decreases with increased periods of wakefulness: implications for homeostatic drive to sleep. J Neurosci 22, 5581-5587 (2002)
66. Gip P, G.Hagiwara, N.F.Ruby & H.C.Heller: Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats. Am J Physiol 283, R54-R59 (2002)
67. Franken P, P.Gip, G.Hagiwara & H.C.Heller: Brain glycogen content in inbred mice: effects of strain, sleep loss, and brain structure. Soc for Neurosci Absts 27, 1381 (2001)
68. Magistretti PJ, Pellerin L & Martin J-L: Brain energy metabolism. An integrated cellular perspective. In:Eds: Bloom FE, Kupfer DJ, Psychopharmacology: The Fourth Generation of Progress. New York: Raven Press,Ltd., 1995:657-669
69. Haubrich DR, J.Perez-Cruet & W.D.Reid: Prostaglandin E1 causes sedation and increases 5-hydroxytryptamine turnover in rat brain. Br J Pharmacol 48, 80-87 (1973)
70. Laychock SG, D.Johnson & L.S.Harris: PGD2 effects on rodent behavior and EEG patterns in cats. Pharmacol Biochem Behav 12, 747-754 (1980)
71. Urade Y, O.Hayaishi & H.Matsumura: Molecular mechanism of sleep regulation by prostaglandin D2. J Lipid Mediat Cell Signal 14, 71-82 (1996)
72. Urade Y& O.Hayaishi: Prostaglandin D2 and sleep regulation. Bichem Biophys Acta 1436, 606-615 (1999)
73. Ueno R, Y.Ishikawa, T.Nakayama & O.Hayaishi: Prostaglandin D2 induces sleep when microinjected into the preoptic area conscious rats. Biochem Biophys Res Comm 109, 575-582 (1982)
74. Onoe H, R.Ueno, I.Fujita, H.Nishino, Y.Oomura & O.Hayaishi: Prostaglandin D2, a cerebral sleep-inducing substance in monkeys. PNAS 85, 4082-4086 (1988)
75. Krueger JM, L.Kapas, M.R.Opp & F.Obal, Jr.: Prostaglandins E2 and D2 have little effect on rabbit sleep. Physiol Behav 51, 481-485 (1992)
76. Pinzar E, Y.Kanaoka, T.Inui, N.Eguchi, Y.Urade & O.Hayaishi: Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. PNAS 97, 4903-4907 (2000)
77. Naito K, H.Osama, R.Ueno, O.Hayaishi, K.Honda & S.Inoué: Suppression of sleep by prostaglandin synthesis inhibitors in unrestrained rats. Brain Res 453, 329-336 (1988)
78. Matsumura H, R.Takahata & O.Hayaishi: Inhibition of sleep in rats by inorganic selenium compounds, inhibitors of prostaglandin D synthase. PNAS 88, 9046-9050 (1991)
79. Lee B, J.J.Hirst & D.W.Walker: Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero. J Neurosci 22, 5679-5686 (2002)
80. Pandey HP, A.Ram, H.Matsumura & O.Hayaishi: Concentration of prostaglandin D2 in cerebrospinal fluid exhibits a circadian alteration in conscious rats. Biochem Mol Biol Int 37, 431-437 (1995)
81. Ram A, H.P.Pandey, H.Matsumura, K.Kasahara-Orita, T.Nakajima, R.Takahata, S.Satoh, A.Terao & O.Hayaishi: CSF levels of prostaglandins, especially the level of prostaglandin D2, are correlated with increasing propensity towards sleep in rats. Brain Res 751, 81-89 (1997)
82. Nicolaidis S, K.Gerozissis & M.Orosco: Variations des prostaglandines et des monoamines hypothalamiques et corticales révélatrices de la transition entre états de vigilance: étude en microdialyse chez le rat. Rev Neurol (Paris) 11, 5S26-5S33 (2001)
83. Urade Y, K.Kitahama, H.Ohishi, T.Keneko, N.Mizuno & O.Hayaishi: Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus and oligodendrocytes of the adult rat brain. PNAS 90, 9070-9074 (1993)
84. Blödorn B, M.Mäder, Y.Urade, O.Hayaishi, K.Felgenhauer & W.Bruck: Choroid plexus: the major site of mRNA expression for the beta-trace protein (prostaglandin D synthase) in human brain. Neurosci Lett 209, 117-120 (1996)
85. Mizoguchi A, N.Eguchi, K.Kimura, Y.Kiyohara, W.-M.Qu, Z.-L.Huang, T.Mochizuki, M.Lazarus, T.Kobayashi, T.Kaneko, S.Narumiya, Y.Urade & O.Hayaishi: Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. PNAS 98, 11674-11679 (2001)
86. Hayaishi O: Regulation of sleep by prostaglandin D2 and adenosine. In:Eds: Borbély AA, Hayaishi O, Sejnowski TJ, Altman JS, The regulation of sleep. Strasbourg: HFSP, 2000:97-103
87. Koyama Y& O.Hayaishi: Modulation by prostaglandins of activity of sleep-related neurons in the preoptic/anterior hypothalamic areas in rats. Brain Res Bull 33, 367-372 (1994)
88. Hayaishi O: Molecular mechanisms of sleep-wake regulation: roles of prostaglandins D2 and E2. FASEB J 5, 2575-2581 (1991)
89. Matsumura H, K.Honda, Y.Goh, R.Ueno, T.Sakai, S.Inoue & O.Hayaishi: Awakening effect of prostaglandin E2 in freely moving rats. Brain Res. 481, 242-249. (1989)
90. Gerozissis K, Z.De Saint Hilaire, M.Orosco, C.Rouch & S.Nicolaidis: Changes in hypothalamic prostaglandin E2 may predict the occurrence of sleep or wakefulness as assessed by parallel EEG and microdialysis in the rat. Brain Res 689, 239-244 (1995)
91. Matsumura H, H.Kazuki, W.S.Choi, S.Inoué, T.Sakai & M.Hayaishi: Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats. PNAS 86, 5666-5669 (1989)
92. Kantha SS, H.Matsumura, E.Kubo, K.Kawase, R.Takahata, C.N.Serhan & O.Hayaishi: Effects of prostaglandin D2, lipoxins and leukotriens on sleep and brain temperature of rats. Prostaglandins Leukot Essent Fatty Acids 51, 87-93 (1994)
93. Terao A, H.Matsumura, H.Yoneda & M.Saito: Enhancement of slow-wave sleep by tumor necrosis factor-alpha is mediated by cyclooxygenase-2 in rats. Neuroreport 9, 3791-3796 (1998)
94. Terao A, H.Matsumura & M.Saito: Interleukin-1 induces slow-wave sleep at the prostaglandin D2-sensitive sleep-promoting zone in the rat brain. J Neurosci 18, 6599-6607 (1998)
95. Zeitler P, G.S.Tannenbaum, D.K.Clifton & R.A.Steiner: Ultradian oscillations in somatostatin and growth hormone- releasing hormone mRNAs in the brains of adult male rats. PNAS 88, 8920-8924 (1991)
96. Plotsky PM& W.Vale: Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230, 461-463 (1985)
97. Tannenbaum GS& J.B.Martin: Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 98, 562-570 (1976)
98. Kojima M, H.Hosoda, Y.Date, M.Nakazato, H.Matsuo & K.Kangawa: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656-660 (1999)
99. Mayo KE, P.A.Godfrey, S.T.Suhr, D.J.Kulik & J.O.Rahal: Growth hormone-releasing hormone: synthesis and signaling. Recent Prog Horm Res 50, 35-735 (1995)
100. Obal F, Jr.: Effects of peptides (DSIP, DSIP analogues, VIP, GRF and CCK) on sleep in the rat. Clin Neuropharmacol 9 S4, 459-461 (1986)
101. Riou F, R.Cespuglio & M.Jouvet: Endogenous peptides and sleep in the rat. III. The hypnogenic properties of vasoactive intestinal polypeptide. Neuropeptides 2, 265-277 (1982)
102. Obal F, Jr., G.Sáry, P.Alföldi, G.Rubicsek & F.Obal: Vasoactive intestinal polypeptide promotes sleep without effects on brain temperature in rats at night. Neurosci Lett 64, 236-240 (1986)
103. Kruisbrink J, M.Mirmiran, T.P.Van der Woude & G.J.Boer: Effects of enhanced cerebrospinal fluid levels of vasopressin, vasopressin antagonist or vasoactive intestinal polypeptide on circadian sleep-wake rhythm in the rat. Brain Res 419, 76-86 (1987)
104. Drucker-Colin R, J.Bernal-Pedraza, F.Fernández-Cancino & A.Oksenberg: Is vasoactive intestinal polypeptide (VIP) a sleep factor? Peptides 5, 837-840 (1984)
105. Obal F, Jr., M.Opp, A.B.Cady, L.Johannsen & J.M.Krueger: Prolactin, vasoactive intestinal peptide, and peptide-histidine-methionine elicit selective increases in REMS in rabbit. Brain Res 490, 292-300 (1989)
106. Mirmiran M, J.Kruisbrink, N.P.A.Bos, D.Van der Werf & G.J.Boer: Decrease of rapid-eye-movement sleep in the light by intraventricular application of a VIP-antagonist in the rat. Brain Res 458, 192-194 (1988)
107. Mitsugi N& F.Kimura: Simultaneous determination of blood levels of corticosterone and growth hormone in the male rat: relation to sleep-wakefulness cycle. Neuroendocrinology 41, 125-130 (1985)
108. Ehlers C, T.K.Reed & S.J.Henriksen: Effects of corticotropin- releasing factor and growth hormone-releasing factor on sleep and activity in rats. Neuroendocrinology 42, 467-474 (1986)
109. Nistico G, G.B.DeSarro, G.Bagetta & E.E.Müller: Behavioural and electrocortical spectrum power effects of growth hormone releasing factor in rats. Neuropharmacology 26, 75-78 (1987)
110. Obal F, Jr., P.Alföldi, A.B.Cady, L.Johannsen, G.Sáry & J.M.Krueger: Growth hormone-releasing factor enhances sleep in rats and rabbits. Am J Physiol 255, R310-R316 (1988)
111. Steiger A, J.Guldner, U.Hemmeter, B.Rothe, K.Wiedemann & F.Holsboer: Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology 56, 566-573 (1992)
112. Kerkhofs M, E.Van Cauter, A.Van Onderbergen, A.Gaufriez, M.O.Thorner & G.Copinschi: Sleep-promoting effect of growth hormone-releasing hormone in normal men. Am J Physiol 264, E594-E598 (1993)
113. Marshall L, I.Derad, C.J.Starsburger, H.L.Fehm & J.Born: A determinant factor in the efficacy of GHRH administration in promoting sleep: high peak concentration versus recurrent increasing slopes. Psychoneuroendocrinology 24, 363-370 (1999)
114. Obal F, Jr., R.Floyd, L.Kapas, B.Bodosi & J.M.Krueger: Effects of systemic GHRH on sleep in intact and hypophysectomized rats. Am J Physiol 270, E230-E237 (1996)
115. Obal F, Jr.& J.M.Krueger: The somatotropic axis and sleep. Rev Neurol (Paris) 157, 5S12-5S15 (2001)
116. Perras B, L.Marshall, G.Köhler, J.Born & H.L.Fehm: Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans. Psychoneuroendocrinology 24, 743-757 (1999)
117. Zhang J, F.Obal, Jr., T.Zheng, J.Fang, P.Taishi & J.M.Krueger: Intrapreoptic microinjection of GHRH or its antagonist alters sleep in rats. J Neurosci 19, 2187-2194 (1999)
118. Kern W, R.Halder, S.Al-Reda, E.Späth-Schwalbe, H.L.Fehm & J.Born: Systemic growth hormone does not affect human sleep. J Clin Endocrinol Metab 76, 1428-1432 (1993)
119. Obal F, Jr., L.Payne, L.Kapas, M.Opp & J.M.Krueger: Inhibition of growth hormone-releasing factor suppresses both sleep and growth hormone secretion in the rat. Brain Res 557, 149-153 (1991)
120. Obal F, Jr., L.Payne, M.Opp, P.Alföldi, L.Kapas & J.M.Krueger: Growth hormone-releasing hormone antibodies suppress sleep and prevent enhancement of sleep after sleep deprivation. Am J Physiol 263, R1078-R1085 (1992)
121. Obal F, Jr., J.Fang, P.Taishi, B.Kacsoh, J.Gardi & J.M.Krueger: Deficiency of growth hormone-releasing hormone signaling is associated with sleep alterations in the dwarf rat. J Neurosci 21, 2912-2918 (2001)
122. Alt J, F.Obal, Jr., J.Gardi & J.M.Krueger: Sleep in mutant mice with non-functional GHRH receptor: responses to GHRH, ghrelin, and somatostatin. J Sleep Res 11(S1), 3-4 (2002)
123. Zhang J, F.Obal, Jr., J.Fang, B.J.Collins & J.M.Krueger: Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system. Neurosci Lett 220, 97-100 (1996)
124. Hajdu I, F.Obal, Jr., J.Fang, J.M.Krueger & C.D.Rollo: Sleep of transgenic mice producing excess rat growth hormone. Am J Physiol 282, R70-R76 (2002)
125. Bredow S, P.Taishi, F.Obal, Jr., N.Guha-Thakurta & J.M.Krueger: Hypothalamic growth hormone-releasing hormone mRNA varies across the day in rats. Neuroreport 1, 2501-2505 (1996)
126. Gardi J, F.Obal, Jr., J.Fang, J.Zhang & J.M.Krueger: Diurnal variations and sleep deprivation-induced changes in rat hypothalamic GHRH and somatostatin contents. Am J Physiol 211, R1339-R1344 (1999)
127. Zhang J, Z.Chen, P.Taishi, F.Obal, Jr., J.Fang & J.M.Krueger: Sleep deprivation increases rat hypothalamic growth hormone-releasing hormone mRNA. Am J Physiol 215, R1755-R1761 (1999)
128. Toppila J, L.Alanko, M.Asikainen, I.Tobler, D.Stenberg & T.Porkka-Heiskanen: Sleep deprivation increases somatostatin and growth hormone-releasing hormone messenger RNA in the rat hypothalamus. J Sleep Res 6, 171-178 (1997)
129. Bilezikjian LM, H.Seifert & W.Vale: Desensitization to growth hormone-releasing factor (GRF) is associated with down-regulation of GRF-binding sites. Endocrinology 118, 2045-2052 (1986)
130. Gardi J, P.Taishi, R.Speth, F.Obal, Jr. & J.M.Krueger: Sleep deprivation alters hypothalamic growth hormone-releasing hormone mRNA and binding sites. Neurosci Lett in press, (2002)
131. Kimura F& C.-W.Tsai: Ultradian rhythm of growth hormone secretion and sleep in the adult male rat. J Physiol 353, 305-315 (1984)
132. Sawchenko PE, L.W.Swanson, J.Rivier & W.W.Vale: The distribution of growth-hormone-releasing factor (GRF) immunoreactivity in the central nervous system of the rat:an immunohistochemical study using antisera directed against rat hypothalamic GRF. J Comp Neurol 237, 100-115 (1985)
133. Zaborszky L& G.B.Makara: Intrahypothalamic connections: an electron microscopic study in the rat. Exp Brain Res 34, 201-215 (1979)
134. Saeb-Parsy K, S.Lombardelli, F.Z.Khan, K.McDowall, I.T.H.Au-Yong & R.E.J.Dyball: Neural conections of hypothalamic neuroendocrine nuclei in the rat. J Neuroendocrinol 12, 635-648 (2000)
135. Daikoku S, H.Kawano, M.Noguchi, J.Nakanishi, M.Tokuzen, K.Chihara & I.Nagatsu: GRF neurons in the rat hypothalamus. Brain Res 399, 250-261 (1986)
136. Opp M, F.Obal, Jr., L.Payne & J.M.Krueger: Responsiveness of rats to interleukin-1: effects of monosodium glutamate treatments of neonates. Physiol Behav 48, 451-457 (1990)
137. Obal F, Jr.: The role of growth hormone-releasing hormone in sleep regulation. In:Eds: Borbély AA, Hayaishi O, Sejnowski TJ, Altman JS, The regulation of sleep. Strasbourg: HFSP, 2000:112-121
138. 2+ levels in cultured hypothalamic GABAergic neurons. Brain Res 949, 209-212 (2002)
139. Payne LC, F.Obal, Jr., M.R.Opp & J.M.Krueger: Stimulation and inhibition of growth hormone secretion by interleukin-1 beta: the involvement of growth hormone-releasing hormone. Neuroendocrinology 56, 118-123 (1992)
140. Obal F, Jr., J.Fang, L.C.Payne & J.M.Krueger: Growth hormone-releasing hormone mediates the sleep-promoting activity of interleukin-1 in rats. Neuroendocrinology 61, 559-565 (1995)
141. Taishi P, A.De, L.Teodecki, F.Obal, Jr. & J.M.Krueger: Interleukin-1 beta induces expression of GHRH receptor mRNA in neurones. J Sleep Res 11(S1), 221-222 (2002)
142. Alam N, D.McGinty, L.Imeri, M.Opp & R.Szymusiak: Effects of interleukin-1 beta on sleep- and wake-related preoptic anterior hypothalamic neurons in unrestrained rats. Sleep 24, A59 (2001)
143. Lanneau C, S.Peineau, F.Petit & J.Epelbaum: Somatostatin modulation of excitatory synaptic transmission between periventricular and arcuate hypothalamic nuclei in vitro. J Neurophysiol 84, 1464-1474 (2000)
144. Liposits Z, I.Merchenthaler, W.K.Paull & B.Flerko: Synaptic communication between somatostatinergic axons and growth hormone-releasing factor (GRF) synthesizing neurons in the arcuate nucleus of the rat. Histochemistry 89, 247-252 (1988)
145. Bertherat J, M.-T.Bluet-Pajot & J.Epelbaum: Neuroendocrine regulation of growth hormone. Eur J Endocrinology 132, 12-24 (1995)
146. Schindler M, P.P.A.Humphrey & P.C.R.Emson: Somatostatin receptors in the central nervous system. Prog Neurobiol 50, 9-47 (1996)
147. Reisine T: Somatostatin receptors. Am J Physiol 269, G813-G820 (1995)
148. Havlicek V, M.Rezek & H.Friesen: Somatostatin and thyrotropin releasing hormone: central effects on sleep and motor system. Pharmacol Biochem Behav 4, 455-459 (1976)
149. Rezek M, V.Havlicek, K.R.Hughes & H.Friesen: Cortical administration of somatostatin (SRIF): effect on sleep and motor behavior. Pharmacol Biochem Behav 5, 73-77 (1976)
150. Beranek L, F.Obal, Jr., P.Taishi, B.Bodosi, F.Laczi & J.M.Krueger: Changes in rat sleep after single and repeated injections of the long lasting somatostatin analog octreotide. Am J Physiol 271, R1484-R1491 (1997)
151. Beranek L, I.Hajdu, J.Gardi, P.Taishi, F.Obal, Jr. & J.M.Krueger: Central administration of the somatostatin analog octreotide induces captopril-insensitive sleep responses. Am J Physiol 277, R1297-R1304 (1999)
152. Frieboes R-M, H.Murck, T.Schier, F.Holsboer & A.Steiger: Somatostatin impairs sleep in elderly human subjects. Neuropsychopharmacology 16, 339-345 (1997)
153. Steiger A, M.Ziegenbein, H.E.Kuenzel, K.Held, H.Murck & I.A.Antonijevic: Effects of the long lasting somatostatin analogue octreotide on sleep EEG in young men. J Sleep Res 9 S1, 182 (2000)
154. Hajdu I, F.Obal, Jr., J.Gardi, F.Laczi & J.M.Krueger: Octreotide-induced drinking, vasopressin and pressure responses: role of central angiotensin and acetylcholine. Am J Physiol 279, R271-R277 (2000)
155. Gardi J, E.Szentirmai, I.Hajdu, F.Obal, Jr. & J.M.Krueger: The somatostatin analog, octreotide, causes accumulation of growth hormone-releasing hormone and depletion of angiotensin in the rat hypothalamus. Neurosci Lett 315, 37-40 (2001)
156. Hajdu I, E.Szentirmai, F.Obal, Jr. & J.M.Krueger: Brain areas mediatig drinking and inhibition of sleep to the somatostatin agonist, octreotide. J Sleep Res 11(S1), 93 (2002)
157. Danguir J: Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats. Brain Res 367, 26-30 (1986)
158. Danguir J& Z.De Saint-Hilaire Kafi: Reversal of desipramine-induced suppression of paradoxical sleep by a long-acting somatostatin analogue (octreotide) in rats. Neurosci Lett 98, 154-158 (1989)
159. Danguir J& Z.De Saint-Hilaire-Kafi: Somatostatin antiserum blocks carbachol-induced increase of paradoxical sleep in the rat. Brain Res Bull 20, 9-12 (1988)
160. Toppila J, P.Niittymaki, T.Porkka-Heiskanen & D.Stenberg: Intracerebroventricular and locus coeruleus microinjections of somatostatin antagonist decrease REMS in rats. Pharmacol Biochem Behav 66, 721-727 (2000)
161. Drucker-Colin RR, C.W.Spanis, J.Hunyadi, J.F.Sassin & J.L.McGaugh: Growth hormone effects on sleep and wakefulness in the rat. Neuroendocrinology 18, 1-8 (1975)
162. Mendelson WB, S.Slater, P.Gold & J.C.Gillin: The effect of growth hormone administration on human sleep: a dose response study. Biol Psychiatry 15, 613-618 (1980)
163. Spiegel K, R.Leproult, E.F.Colecchia, M.L'Hermite-Baleriaux, Z.Nie, G.Copinschi & E.Van Cauter: Adaptation of the 24-h growth hormone profile to a state of sleep debt. Am J Physiol 279, R874-R883 (2000)
164. Aström C: Interaction between sleep and growth hormone. Acta Neurol Scand 92, 281-296 (1997)
165. Obal F, Jr., B.Bodosi, A.Szilagyi, B.Kacsoh & J.M.Krueger: Antiserum to growth hormone decreases sleep in the rat. Neuroendocrinology 66, 9-16 (1997)
166. Obal F, Jr., L.Kapas, J.Gardi, P.Taishi, B.Bodosi & J.M.Krueger: Insulin-like growth factor-1 (IGF-1)-induced inhibition of growth hormone secretion is associated with sleep suppression. Brain Res 818, 267-274 (1999)
167. Obal F, Jr., L.Kapas, B.Bodosi & J.M.Krueger: Changes in sleep in response to intracerebral injection of insulin-like growth factor-1 (IGF-1) in the rat. Sleep Research Online 1, 87-91 (1998)
168. Uehara A, T.Okumura, S.Kitamori, Y.Takasugi & M.Namiki: A cytokine that has potent antisecretory and anti-ulcer actions via the central nervous system. Biochem Biophys Res Comm 173, 585-590 (1990)
169. Vitkovic L, J.Bockaert & C.Jacque: "Inflammatory" cytokines: neuromodulators in normal brain? J Neurochem 74, 457-471 (2000)
170. Merrill JE: Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological. Dev Neurosci 14, 1-10 (1992)
171. Majde JA, Krueger JM: Neuroimmunology of sleep. In:Eds: D'haenen H, De Boer JA, Westenberg H, Willner P, Textbook of Biological Psychiatry. London: John Willey & Sons, Ltd., 2002:
172. Dinarello CA: The biological properties of interleukin-1. Eur Cytokine Netw 5, 517-532 (1994)
173. Auron PE, G.J.Quigley, C.J.Rosenwasser & L.Gehrke: Multiple amino acid substitutions suggest a structural basis for the separation of biological activity and receptor binding in a mutant interleukin-1 beta protein. Biochemistry 31, 6632-6638 (1992)
174. Cunningham ET& E.B.DeSouza: Interleukin-1 receptors in the brain and
175. Liu C, Y.Bai, D.Ganea & R.Hart: Species-specific activity of rat recombinant IL-1 beta. J Interferon Cytokine Res 15, 985-992 (1995)
176. Ericsson A, C.Liu, R.P.Hart & P.E.Sawchenko: Type I interleukin-1 receptor in the rat brain: distribution, regulation, and relationships to sites of IL-1-induced cellular activation. J Comp Neurol 361, 681-698 (1995)
177. Takeuchi O& A.Shizuo: Toll-like receptors; their physiological role and signal transduction system. Int Immunopharmacol 1, 625-635 (2001)
178. Sporri B, M.Bickel, D.Dobbelaere, J.Machado & D.Lottaz: Soluble interleukin-1 receptor - reverse signaling in innate immunoregulation. Cytokine Growth Factor Rev 12, 27-32 (2001)
179. Sims JE: IL-1 and IL-18 receptors and their extended family. Curr Opinion Immunol 14, 117-122 (2002)
180. Colotta F, S.K.Dower, J.E.Sims & A.Mantovani: The type II 'decoy' receptor: a novel regulatory pathway for interleukin-1. Immunol Today 15, 562-566 (1994)
181. Greenfelder SA, P.Nunes, L.Knee, M.Labon, R.A.Chizzonite & G.Ju: Molecular cloning and characterization of a second subunit of the interleukin-1 receptor complex. J Biol Chem 270, 13757-13765 (1995)
182. Liu C, D.Chalmers, R.Maki & E.B.DeSouza: Rat homolog of mouse interleukin-1 receptor acessory protein: cloning, localization and modulation studies. J Neuroimmunol 66, 41-48 (1996)
183. Liu C, R.P.Hart, X.J.Kiu, W.Celevenger, R.A.Maki & E.B.DeSouza: Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem 271, 20965-20972 (1996)
184. Taishi P, S.Bredow, N.Guha-Thakurta, F.Obal, Jr. & J.M.Krueger: Diurnal variations of interleukin-1 beta mRNA and beta-actin mRNA in rat brain. J Neuroimmunol 75, 69-74 (1997)
185. Breder CD, C.A.Dinarello & C.B.Saper: Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240, 321-324 (1988)
186. Opp MR& L.Imeri: Rat strains that differ in corticotropin-releasing hormone production exhibit different sleep-wake responses to interleukin 1. Neuroendocrinology 73, 272-284 (2001)
187. Chang FC& M.R.Opp: IL-1 is a mediator of increases in slow-wave sleep induced by CRH receptor blockade. Am J Physiol 279, R793-R802 (2000)
188. Krueger JM, F.Obal, Jr., J.Fang, T.Kubota & P.Taishi: The role of cytokines in physiological sleep regulation. Ann N Y Acad Sci 933, 211-221 (2001)
189. Takahashi S, L.Kapas, J.Fang & J.M.Krueger: Somnogenic relationships between tumor necrosis factor and interleukin- 1. Am J Physiol 276, R1132-R1140 (1999)
190. Opp MR& J.M.Krueger: Interleukin-1 is involved in responses to sleep deprivation in the rabbit. Brain Res 639, 57-65 (1994)
191. Susic V& S.Totic: 'Recovery' function of sleep: effects of purified human interleukin-1 on the sleep and febrile response of cats. Metab Brain Dis 4, 73-80 (1989)
192. Friedman EM, S.Boinski & C.L.Coe: Interleukin-J induces sleep-like behavior and alters call structure in juvenile rhesus macaques. Am J Primatol 35, 145-153 (1995)
193. Fang J, Y.Wang & J.M.Krueger: The effects of interleukin-1 beta on sleep are mediated by the type I receptor. Am J Physiol 274, R655-R660 (1998)
194. Tobler I, A.A.Borbély, M.Schwyzer & A.Fontana: Interleukin-1 derived from astrocytes enhances slow wave activity in sleep EEG of the rat. Eur J Pharmacol 104, 191-192 (1984)
195. Dinarello CA: Interleukin-1 and interleukin-1 antagonism. Blood 77, 1627-1652 (1991)
196. Opp MR, F.Obal, Jr. & J.M.Krueger: Interleukin 1 alters rat sleep: temporal and dose-related effects. Am J Physiol 260, R52-R58 (1991)
197. Hansen MK& J.M.Krueger: Subdiaphragmatic vagotomy blocks the sleep and fever-promoting effects of interleukin-1 beta. Am J Physiol 273, R1246-R1253 (1997)
198. Opp MR& J.M.Krueger: Anti-interleukin-1 beta reduces sleep and sleep rebound after sleep deprivation in rats. Am J Physiol 266, R688-R695 (1994)
199. Takahashi S, L.Kapas, J.Fang, J.M.Seyer, Y.Wang & J.M.Krueger: An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits. Am J Physiol 271, R101-R108 (1996)
200. Opp MR, E.M.Smith & T.K.Hughes, Jr.: Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. J Neuroimmunol 60, 165-168 (1995)
201. Takahashi S, L.Kapas, M.Hansen, J.Zhang, J.M.Seyer & J.M.Krueger: An interleukin-1 (IL-1) soluble receptor fragment inhibits IL-1 beta-induced sleep and non-rapid-eye-movement-sleep rebound after sleep deprivation in rabbits. Sleep Res 24A, 457 (1995)
202. Imeri L, M.R.Opp & J.M.Krueger: An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-induced sleep and fever. Am J Physiol 265, R907-R913 (1993)
203. Lue FA, F.A.Bail, J.Jephthah-Ocholo, K.Carayanniotis, R.Gorczynski & H.Moldofsky: Sleep and cerebrospinal fluid interleukin-1 like activity in the cat. Int J Neurosci 42, 179-183 (1998)
204. Nguyen KT, T.Deak, S.M.Owens, T.Kohno, M.Fleshner, L.R.Watkins & S.F.Maier: Exposure to acute stress induces brain interleukin-1 beta protein in the rat. J Neurosci 18, 2239-2246 (1998)
205. Mackiewicz M, P.J.Sollars, M.D.Ogilvie & A.I.Pack: Modulation of IL-1beta gene expression in the rat CNS during sleep deprivation. Neuroreport 7, 529-533 (1996)
206. Moldofsky H, F.A.Lue, J.Eisen, E.Keystone & R.M.Gorcznski: The reletionship of interleukin-I and immune functions to sleep in humans. Psychosom Med 48, 309-318 (1986)
207. Hohagen F, J.Timmer, A.Weyerbrock, R.Fritsch-Montero, U.Ganter, S.Krieger, M.Berger & J.Bauer: Cytokine production during sleep and wakefulness and its relationship to cortisol in healthy humans. Neuropsychobiology 28, 9-16 (1993)
208. Uthgenannt D, D.Schoolmann, R.Pietrowsky, H.-L.Fehm & J.Born: Effects of sleep on the production of cytokines in humans. Psychosom Med 57, 97-104 (1995)
209. Hansen MK, P.Taishi, Z.Chen & J.M.Krueger: Vagotomy blocks the induction of interleukin-1 beta mRNA in the brain of rats in response to systemic interleukin-1 beta. J Neurosci 18, 2247-2253 (1998)
210. Hansen M, L.Kapas, J.Fang & J.M.Krueger: Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy. Am J Physiol 274, R168-R174 (1998)
211. Hansen MK, P.Taishi, Z.Chen & J.M.Krueger: Cafeteria-feeding induces interleukin-1 beta mRNA expression in rat liver and brain. Am J Physiol 43, R1734-R1739 (1998)
212. De Sarro G, P.Gareri, V.A.Sinopoli, E.David & D.Rotiroti: Comparative, behavioural and electrocotical effects of tumor necrosis factor-alpha and interleukin-1 microinjected into the locus ceruleus of rat. Life Sci 60, 555-564 (1997)
213. Imeri L, S.Bianchi, M.Mariotti & M.R.Opp: Interleukin-1 microinjected into the dorsal raphe nucleus enhances NREMS in rats. J Sleep Res 11, 107 (2002)
214. Slisli Y& R.De Beaurepaire: Interleukin-1 beta and calcitonin, but not corticotropin-releasing factor, altersleep cycles when microinjected into the rat hypothalamic lateral paraventricular area. Neurosci Lett 265, 29-32 (1999)
215. Shibata M: Hypothalamic neuronal responses to cytokines. Yale J Biol Med 63, 147-156 (1990)
216. McCann SM, M.Kimura, S.Karanth, W.H.Yu & V.Rettori: Role of nitric oxide in the neuroendocrine response to cytokines. Front Horm Res 29, 117-129 (2002)
217. Luk WP, Y.Zhang, T.D.White, F.A.Lue, C.Wu, C.G.Jiang, L.Zhang & H.Moldofsky: Adenosine: a mediator of interleukin-1 beta-induced hippocampal synaptic inhibition. J Neurosci 19, 4238-4244 (1999)
218. Miller LG, W.G.Galpern, M.Lumpkin, S.F.Chesley & C.A.Dinarello: Interleukin-1 augments gamma-aminobutyric acid-A receptor function in brain. Mol Pharmacol 39, 105-108 (1991)
219. Imeri L, M.Mancia & M.R.Opp: Blockade of 5-hydroxytryptamine (serotonin)-2 receptors alters interleukin-1 induced changes in rat sleep. Neuroscience 92, 745-749 (1999)
220. Tringali G, A.Mirtella, C.Mancuso, G.Guerriero, P.Preziosi & P.Navarra: The release of immunoreactive interleukin-1 beta from rat hypothalamic explants is modulated by neurotransmitters and corticotropin- releasing hormone. Pharmacol Res 36, 269-273 (1997)
221. Krueger JM, Churchill L: Cytokines in sleep regulation. In:Eds: Krontol A, Cytokine and Mental Health. Klumer Academic Publishers, 2002: in press
222. Kriegler M, C.Perez, K.DeFay, I.Albert & S.D.Lu: A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein; ramifications for the complex physiology of TNF. Cell 53, 45-56 (1998)
223. Spriggs DR, Deutsch S & Kufe DW: Genomic structure, induction and production of TNF alpha. In:Eds: Aggarwal BB, Vilcek J, Tumor necrosis factor. New York: Marcel Decker, Inc., 1992:3-34
224. Ledgerwood EC, J.S.Pober & J.R.Bradley: Recent advances in the molecular basis of TNF signal transduction. Lab Invest 79, 1041-1050 (1999)
225. Goeddel DV: Signal transduction by tumor necrosis factor. Chest 116 (S1), 69S-73S (1999)
226. Kyriakis JM: Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family. Gene Expr 7, 217-231 (1999)
227. Wallach D, E.E.Varfolomeev, N.L.Malinin, Y.V.Goltsev, A.V.Kovalenko & M.P.Boldin: Tumor necrosis factor receptor and Fas signaling mechanisms. Ann Rev Immunol 17, 331-367 (1999)
228. Inoue J, T.Ishida, N.Tsukamoto, N.Kobayashi, A.Naito, S.Azuma & T.Yamamoto: Tumor necrosis factor receptor-associated factor (TRAF) family: adapter protein that mediate cytokine signaling. Exp Cell Res 254, 14-24 (2000)
229. Wang CY, M.W.Majo, R.G.Korneluk, D.V.Goeddel & Jr.A.S.Baldwin: NF-kB antiapoptosis: induction of TRAF1 and TRAF2 and C-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683 (1998)
230. Puccioni-Sohler M, P.Rieckmann, B.Kitze, P.Lange, M.Albrecht & K.Flegenhauer: A soluble form of tumor necrosis factor receptor in cerebrospinal fluid and serum of HTVLV-1-associated myelopathy and other neurological diseases. Neurology 242, 239-242 (1995)
231. Breder CD, M.Tsujimoto, Y.Terano, D.W.Scott & C.B.Saper: Distribution and characterization of tumor necrosis factor-alpha-like immuno-reactivity in the murine central nervous system. J Comp Neurol 337, 543-567 (1993)
232. Boka G, P.Anglade, D.Wallach, Y.Javoy-Agid & E.C.Hirsch: Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson's disease. Neurosci Lett 172, 151-154 (1994)
233. Cheng B, S.Christakos & M.A.Mattson: Tumor necrosis factors protect neurons against metabolic-exocitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12, 139-153 (1994)
234. Botchkina GI, M.E.Meistrell III, I.L.Botchkina & K.J.Tracey: Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol Med 3, 765-781 (1997)
235. Peschon JJ, D.S.Toorance, K.L.Stocking, M.B.Glaccum, C.Otten, C.R.Willis, K.Charrier, P.J.Morrissey, C.B.Ware & K.M.Mohler: TNF receptor-deficient mice reveal divergent role for p55 and p75 in several models of inflammation. J Immunol 160, 943-952 (1998)
236. Fontaine V, N.Mohand-Said, N.Hanoteau, C.Fuchs, K.Pfizenmaier & U.Eisel: Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 22, RC216 (2002)
237. Yang L, K.Lindholm, Y.Konishi, R.Li & Y.Shen: Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways. J Neurosci 22, 3025-3032 (2002)
238. Schubert P, T.Ogata, C.Marchini, S.Ferroni & K.Rudolphi: Protective mechanisms of adenosine in neurons and glial cells. Ann N Y Acad Sci 825, 1-10 (1997)
239. Carlson NG, A.Bacchi, S.W.Rogers & L.C.Gahring: Nicotine blocks TNF-alpha mediated neuroprotection to NMDA by an alpha-bungarotoxin-sensitive pathway. J Neurobiol 35, 29-36 (1998)
240. Saper CB& C.D.Breder: Endogenous pyrogens in the CNS: role in febrile response. Prog Brain Res 93, 419-428 (1992)
241. Plata-Salaman CR: Central nervous system mechanisms contributing to the cachexia-anorexia syndrome. Nutrition 16, 1009-1012 (2000)
242. Beattie EC, D.Stellwagen, W.Morishita, J.C.Bresnahan, B.K.Ha, M.Von Zastrow, M.S.Beattie & R.C.Malenka: Control of synaptic strength by glial TNF alpha. Science 295, 2282-2285 (2002)
243. Wilkinson MK, M.L.Earle, C.R.Triggle & S.Barnes: Interleukin-1 beta, tumor necrosis factor alpha and LPS enhances calcium channel currents in isolated vascular smooth muscle cells of rat tail artery. FASEB J 10, 785-791 (1996)
244. Furukawa K& M.P.Mattson: The transcription factor NFkB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor alpha in hippocampal neurons. J Neurochem 70, 1876-1886 (1998)
245. Fang J, Y.Wang & J.M.Krueger: Mice lacking the TNF 55 kD receptor fail to sleep more after TNF alpha treatment. J Neurosci 17, 5949-5955 (1997)
246. Nistico G, DeSarro G & Rotiroti D: Behavioral and electrocortical spectrum power changes of interleukins and tumor necrosis factor after microinjection into different areas of the brain. In:Eds: Smirne S, Francesch M, Ferini-Stambi L, Zucconi M, Sleep, hormones, and immunological system. Milan: Mason, 1992:11-22
247. Dickstein JB, H.Moldofsky, F.A.Lue & J.B.Hay: Intracerebroventricular injection of TNF-alpha promotes sleep and is recovered in cervical lymph. Am J Physiol 276, R1018-R1022 (1999)
248. Takahashi S, L.Kapas, J.Fang & J.M.Krueger: An anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits. Brain Res 690, 241-244 (1995)
249. Takahashi S, D.D.Tooley, L.Kapas, J.Fang, J.M.Seyer & J.M.Krueger: Inhibition of tumor necrosis factor in the brain suppresses rabbit sleep. Pflügers Arch 431, 155-160 (1995)
250. Takahashi S, L.Kapas, J.M.Seyer, Y.Wang & J.M.Krueger: Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits. Neuroreport 7, 642-646 (1996)
251. Takahashi S& J.M.Krueger: Inhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits. Am J Physiol 272, R1325-R1329 (1997)
252. Floyd RA& J.M.Krueger: Diurnal variations of TNF alpha in the rat brain. Neuroreport 8, 915-918 (1997)
253. Bredow S, P.Taishi, N.Guha-Thakurta, F.Obal, Jr. & J.M.Krueger: Diurnal variations of tumor necrosis factor-alpha mRNA and alpha-tubulin mRNA in rat brain. J Neuroimmunomodulation 4, 84-90 (1997)
254. Veasey SC, M.Mackiewicz, P.Fenik, M.Ro, M.D.Oglivie & A.L.Pack: IL1 beta knockout mice lack the TNF alpha response to sleep deprivation but have normal sleep and sleep recovery. Soc Neurosci Abst 23, 792 (1997)
255. Taishi P, J.Gardi, Z.Chen, J.Fang & J.M.Krueger: Sleep deprivation increases the expression of TNF alpha mRNA and TNF 55kD receptor mRNA in rat brain. The Physiologist 42, A4 (1999)
256. Darko DF, J.C.Miller, C.Gallen, J.White, J.Koziol, S.J.Brown, R.Hayduk, J.H.Atkinson, J.Assmus, D.T.Munnel, P.Naitotl, A.McCutchen & M.M.Mitler: Sleep electroencephalogram delta-frequency amplitude, night plasma levels of tumor necrosis factor alpha, and human immunodeficiency virus infection. PNAS 92, 12080-12084 (2002)
257. Yamasu K, Y.Shimada, M.Sakaizumi, G.Soma & D.Mizuno: Activation of the systemic production of tumor necrosis factor after exposure to acute stress. Eur Cytokine Netw 3, 391-398 (1992)
258. Shearer WT, J.M.Reuben, J.M.Mullington, N.J.Price, B.N.Lee, E.O.Smith, M.P.Szuba, H.P.Van Dongen & D.F.Dinges: Soluble TNF-alpha receptor 1 and IL-6 plasma levels in human subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol 107, 165-170 (2001)
259. Entzian P, K.Linnemann, M.Schlaak & P.Zabel: Obstructive sleep apnea syndrome and circadian rhythms of hormones and cytokines. Am J Respir Crit Care Med 153, 1080-1086 (1996)
260. Vgontzas AN, D.A.Papanicolaou, E.O.Bixler, A.Kales, K.Tyson & G.P.Chrousos: Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity. J Clin Endocrinol Metab 82, 1313-1316 (1997)
261. Liu H, J.Kiu, S.Xiong, G.Sgen, Z.Zhang & Y.Xu: The change in interleukin-6 and tumor necrosis factor in patients with obstructive sleep apnea syndrome. J Tongji Med Univ 20, 200-202 (2000)
262. Moss RB, A.Mercandetti & A.Vojdani: TNF-alpha and chronic fatigue syndrome. J Clin Immunol 19, 314-316 (1999)
263. Vgontzas AN, M.Zoumakis, D.A.Papanicolaou, E.O.Bixler, P.Prolo, H.M.Lin, A.Vela-Bueno, A.Kales & G.P.Chrousos: Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime. Metabolism 51, 887-892 (2002)
264. Edwards N, D.M.Blyton, G.J.Kesby, I.Wilcox & C.E.Sullivan: Pre-eclampsia is associated with marked alterations in sleep architecture. Sleep 23, 619-625 (2000)
265. Dreisbach AW, T.Hendrickson, D.Beezhold, L.A.Riesenberg & A.H.Sklar: Elevated levels of tumor necrosis factor alpha in postdialysis fatigue. Int J Artif Organs 21, 83-86 (1998)
266. Sklar AH, D.Beezhold, N.Newman, T.Hendrickson & A.W.Dreisbach: Postdialysis fatigue: lack of effect of a biocompatible membrane. Am J Kidney Dis 31, 1007-1010 (1998)
267. Eskander ED, H.A.Harvey, E.Givant & A.Lipton: Phase I study combining tumor necrosis factor with interferon-alpha and interleukin-2. Am J Clin Oncol 20, 511-514 (1997)
268. Franklin CM: Clinical experience with soluble TNF p75 receptor in rheumatoid arthritis. Semin Arthritis Rheum 29, 171-181 (1999)
269. Kubota T, J.Fang, Z.Guan, J.M.Brundege & J.M.Krueger: Vagotomy attenuates tumor necrosis factor-alpha-induced sleep and EEG delta-activity in rats. Am J Physiol 280, R1213-R1220 (2001)
270. Haack M, A.Schuld, T.Kraus & T.Pollmächer: Effects of sleep on endotoxin-induced host responses in healthy men. Psychosom Med 63, 568-578 (2001)
271. Takahashi S, L.Kapas & J.M.Krueger: A tumor necrosis factor (TNF) receptor fragment attenuates TNF-alpha- and muramyl dipeptide-induced sleep and fever in rabbits. J Sleep Res 5, 106-114 (1996)
272. Kubota T, N.Li, Z.Guan, R.A.Bom & J.M.Krueger: Intrapreptic micrinjection of TNF-alpha enhances non-REMS in rats. Brain Res 932, 37-44 (2002)
273. Takahashi S& J.M.Krueger: Nerve growth factor enhances sleep in rabbits. Neurosci Lett 264, 149-152 (1999)
274. Yamuy J, F.R.Morales & M.H.Chase: Induction of rapid eye movement sleep by the microinjection of nerve growth factor into the pontine reticular formation of the cat. Neuroscience 66, 9-13 (1995)
275. Kapas L, F.Obal, Jr., A.A.Book, J.B.Schweitzer, R.G.Wiley & J.M.Krueger: The effects of immunolesions of nerve growth factor-receptive neurons by 192 IgG-saporin on sleep. Brain Res 712, 53-59 (1996)
276. Yamuy J, S.Sampogna & M.H.Chase: Neurotrophin-receptor immunoreactive neurons in mesopontine regions involved in the control of behavioral states. Brain Res 866, 1-14 (2000)
277. Tononi G, M.Pompeiano & C.Cirelli: The locus coeruleus and immediate-early genes in spontaneous and forced wakefulness. Brain Res Bull 35, 589-596 (1994)
278. Brandt J, L.Churchill, Z.Guan, J.Fang, L.Chen & J.M.Krueger: Sleep deprivation but not a whisker trim increases nerve growth factor within barrel cortical neurons. Brain Res 898, 105-112 (2001)
279. Kushikata T, J.Fang & J.M.Krueger: Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits. Am J Physiol 276, R1334-R1338 (1999)
280. Cirelli C& G.Tononi: Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system. J Neurosci 20, 9187-9194 (2000)
281. Taishi P, C.Sanchez, Y.Wang, J.Fang, J.W.Harding & J.M.Krueger: Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity. Am J Physiol 281, R839-R845 (2001)
282. Cirelli C& G.Tononi: Gene expression in the brain across the sleep-waking cycle. Brain Res 885, 303-321 (2000)
283. Kushikata T, T.Kubota, J.Fang & J.M.Krueger: Glial cell line-derived neurotrophic factor promotes sleep in rats and rabbits. Am J Physiol 280, R1001-R1006 (2001)
284. Lerner RA, G.Siuzdak, O.Prospero-Garcia, S.J.Henriksen, D.L.Boger & B.F.Cravatt: Cerebrodiene: a brain lipid isolated from sleep-deprived cats. PNAS 91, 9505-9508 (1994)
285. Cravatt BF, O.Prospero-Garcia, G.Siuzdak, N.B.Gilula, S.J.Henriksen, D.L.Boger & R.A.Lerner: Chemical characterization of a family of brain lipids that induce sleep. Science 268, 1506-1509 (1995)
286. Sugiura T, S.Kondo, T.Kodaka, T.Tonegawa, S.Nakane, A.Yamashita, Y.Ishima & K.Waku: Enzymatic synthesis of oleamide (cis-9, 10-octadecenoamide), an endogenous sleep-inducing lipid, by rat microsomes. Biochem Mol Biol Int 40, 931-938 (1996)
287. Cravatt BF, D.K.Giang, S.P.Mayfield, D.L.Boger, R.A.Lerner & N.B.Gilula: Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 384, 83-87 (1996)
288. Egertová M, B.F.Cravatt & M.R.Elphick: Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide. Neurosci Lett 282, 13-16 (2000)
289. Basile A, L.Hanus & W.B.Mendelson: Characterization of the hypnotic properties of oleamide. Neuroreport 10, 947-951 (1999)
290. Huitron-Resendiz S, L.Gombart, B.F.Cravatt & S.J.Henriksen: Effect of oleamide on sleep and its relationship to blood pressure, body temperature, and locomotor activity in rats. Exp Neurol 172, 235-243 (2001)
291. Dugovic C, W.Van den Broeck & G.Clincke: Effects of cis-9,10-octadecenoamide on sleep-wakefulness states and EEG power spectra in rats. J Sleep Res 5(S1), 54 (1996)
292. Mendelson WB& A.Basile: The hypnotic actions of the fatty acid amide, oleamide. Neuropsychopharmacology 25, S36-S39 (2001)
293. Murillo-Rodriguez E, M.Giordano, R.Cabeza, S.J.Henriksen, M.M.Diaz & O.Prospero-Garcia: Oleamide modulates memory in rats. Neurosci Lett 313, 61-64 (2001)
294. Murillo-Rodriguez E, M.Sanchez-Alvarez, L.Navarro, D.Martinez-Gonzalez, R.Drucker-Colin & O.Prospero-Garcia: Anandamide modulates sleep and memory in rats. Brain Res 812, 270-274 (1998)
295. Guan X, B.F.Cravatt, G.R.Ehring, J.E.Hall, D.L.Boger, R.A.Lerner & N.B.Gilula: The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J Cell Biol 139, 1785-1792 (1997)
296. Nicholson RA, J.Zheng, C.R.Ganellin, B.Verdon & G.Lees: Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. Anesthesiology 94, 120-128 (2001)
297. Laposky AD, G.E.Homanics, A.Basile & W.B.Mendelson: Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. Neuroreport 12, 4143-4147 (2001)
298. Mendelson WB& A.Basile: The hypnotic actions of oleamide are blocked by a cannabinoid receptor antagonist. Neuroreport 10, 3237-3239 (1999)
299. Mechoulam R, E.Fride, L.Hanus, T.Sheskin, T.Bisogno, V.Di Marzo, M.Bayewitch & Z.Vogel: Anandamide may mediate sleep induction. Nature 389, 25-26 (1997)
300. Cheer JF, A.K.Cadogan, A.A.Marsden, K.C.Fone & D.A.Kendall: Modification of 5-HT2 receptor behaviour in the rat by oleamide and the role of cannabinoid receptors. Neuropharmacology 38, 533-541 (1999)
301. Lichtman AH, E.G.Hawkins, G.Groffin & B.F.Cravatt: Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. J Pharmacol Exp Ther 302, 73-79 (2002)
302. Spier AD& L.De Lecea: Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Rev 33, 228-241 (2000)
303. De Lecea L, P.Ruiz-Lozano, P.Danielson, P.Foye, J.Peelle-Kirley, W.Frankel & J.G.Sutcliffe: cDNA cloning, mRNA distribution and chromosomal mapping of mouse and human preprocortistatin. Genomics 42, 499-506 (1997)
304. De Lecea L, J.A.Del Rio, J.R.Criado, S.Alcantra, M.Morales, S.J.Henriksen, E.Soriano & J.G.Sutcliffe: Cortistatin is expressed in a distinct subset of cortical interneurons. J Neurosci 17, 5868-5880 (2002)
305. De Lecea L, J.R.Criado, O.Prospero-Garcia, K.M.Gautvik, P.Schweitzer, P.E.Danielson, S.J.Henriksen & J.G.Sutcliffe: A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature 381, 242-245 (1996)
306. Vasilaki A, C.Lanneau, P.Dournaud, L.De Lecea, R.Gardette & J.Epelbaum: Cortistatin affects glutamate sensitivity in mouse hypothalamic neurons through activation of sst2 somatostatin receptor subtype. Neuroscience 88, 359-364 (1998)
307. Criado JR, H.Li, X.Jiang, M.Spina, S.Huitron-Resendiz, G.Liapakis, M.Calbet, S.Siehler, S.J.Henriksen, G.Koob, D.Hoyer, G.Sutcliffe, M.Goodman & L.De Lecea: Structural and compositional determinants of cortistatin activity. J Neurosci Res 56, 611-619 (1999)
308. Deghenghi R, R.Avallone, A.Torsello, G.Muccioli, E.Ghigo & V.Locatelli: Growth hormone-inhibiting activity of cortistatin in the rat. J Endocrinol Invest 24, RC31-RC33 (2001)
309. Connor M, S.L.Ingram & M.J.Christie: Cortistatin increase of a potassium conductance in rat locus ceruleus in vitro. Br J Pharmacol 122, 1567-1572 (1997)
310. Deghenghi R, M.Papotti, E.Ghigo & G.Muccioli: Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. J Endocrinol Invest 24, RC1-RC3 (2001)
311. Wells AS, N.W.Read, K.Uvnas-Moberg & P.Alster: Influences of fat and carbohydrate on postprandial sleepiness, mood, and hormones. Physiol Behav 61, 679-686 (1997)
312. Danguir J& S.Nicolaidis: Dependence of sleep on nutrients availability. Physiol Behav 22, 735-740 (1979)
313. Shemiyakin A& L.Kapas: L-364,718, a cholecystokinin-A receptor antagonist, suppresses feeding-induced sleep in rat. Am J Physiol 280, R1420-R1426 (2001)
314. Antin J, J.Gibbs, J.Holt, R.C.Young & P.G.Smith: Cholecystokinin elicits the complete behavioral sequence of satiety in rats. J Comp Physiol Psychol 89, 784-790 (1975)
315. Fara JW, E.H.Rubinstein & Sonnenschein R.R.: Visceral and behavioral responses to intraduodenal fat. Science 166, 110-111 (1969)
316. Bernstein IL: Post-prandial EEG synchronization in normal and hypothalamically lesioned rats. Physiol Behav 12, 525-545 (1974)
317. Crawley JN& R.L.Corwin: Biological actions of cholecystokinin. Peptides 731 Serie III, 755-794 (1994)
318. Rojas-Ramirez JA, J.N.Crawley & W.N.Mendelson: Electroencephalographic analysis of the sleep-inducing actions of cholecystokinin. Neuropeptides 3, 129-138 (1982)
319. Mansbach RS& D.N.Lorenz: Cholecystokinin (CCK -8) elicits prandial sleep in rats. Physiol Behav 30, 179-183 (1983)
320. Kapas L, F.Obal, Jr., P.Alföldi, G.Rubicsek, B.Penke & F.Obal: Effects of nocturnal intraperitoneal administration of cholecystokinin in rats: simultaneous increase in sleep, increase in EEG slow-wave activity, reduction of motor activity, suppression of eating, and decrease in brain temperature. Brain Res 438, 155-164 (1988)
321. Kapas L, F.Obal, Jr., M.Opp, L.Johannsen & J.M.Krueger: Intraperitoneal injection of cholecystokinin elicits sleep in rabbits. Physiol Behav 50, 1241-1244 (1991)
322. De Saint-Hilaire-Kafi Z, H.Depoortere & S.Nicolaidis: Does cholecystokinin induce physiological satiety and sleep? Brain Res 488, 304-310 (1989)
323. Obal F, Jr., L.Kapas & J.M.Krueger: Albumin enhances sleep in the young rat. Physiol Behav 64, 261-266 (1998)
324. Kapas L, F.Obal, Jr., B.Penke & F.Obal: Cholecystokinin-octapeptide- induced hypothermia in rats: dose-effect and structure-effect relationships, effect of ambient temperature, pharmacological interactions and tolerance. Neuropharmacology 26, 131-137 (1987)
325. Chang H-Y& L.Kapas: Selective activation of CCK-B receptors does not induce sleep and does not affect EEG slow-wave activity and brain temperature in rats. Physiol Behav 62, 175-179 (1997)
326. De Saint Hilaire Z, B.P.Roques & S.Nicolaidis: Effect of a highly selective central CCK-B receptor agonist: BC- 264 on rat sleep. Pharmacol Biochem Behav 38, 545-548 (1991)
327. Dourish CT, A.C.Ruckert, F.D.Tattersall & S.D.Iversen: Evidence that decreased feeding induced by systemic injection of cholecystokinin is mediated by CCK-A receptors. Eur J Pharmacol 173, 233-234 (1989)
328. Wells AS, N.W.Read, M.Fried, J.Borovicka & M.D'Amato: Effects of a specific CCK-A antagonist, loxiglumide, on postprandial mood and sleepiness. J Psychopharmacology 11, 241-246 (1997)
329. Lin CW& T.R.Miller: Both CCK-A and CCK-B/gastrin receptors are present on rabbit vagus nerve. Am J Physiol 263, R591-R595 (1992)
330. South E& R.C.Ritter: Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety. Peptides 9, 601-612 (1988)
331. Bucinskaite V, M.Kurosawa, K.Miyasaka, A.Funakoshi & T.Lundeberg: Interleukin-1beta sensitizes the response of the gastric vagal afferent to cholecystokinin in rat. Neurosci Lett 229, 33-36 (1997)
332. Kurosawa M, K.Uvnas-Moberg, K.Miyasaka & T.Lundeberg: Interleukin-1 increases activity of the gastric vagal afferent nerve partly via stimulation of type A CCK receptor in anesthetized rats. J Auton Nerv Syst 62, 72-78 (1997)
333. Sei M, H.Sei & K.Shima: Spontaneous activity, sleep, and body temperature in rats lacking the CCK-A receptor. Physiol Behav 68, 25-29 (1999)
334. Revel L, L.Mennuni, P.Garofalo & F.Makovec: CR 2945: a novel CCKB receptor antagonist with anxiolytic-like activity. Behav Pharmacol 9, 183-194 (1998)
335. Crespi F: Cholecystokinin-B (CCK-B) receptor antagonists improve "aged" sleep: a new class of sleep modulators? Methods Find Exp Clin Pharmacol 21, 31-38 (1999)
336. Sangiah S, D.F.Caldwell, M.J.Villeneuve & J.J.Clancy: Sleep: sequential reduction of paradoxical (REM) and elevation of slow-wave (NREM) sleep by a non-convulsive dose of insulin in rats. Life Sci 31, 763-769 (1982)
337. Danguir J& S.Nicolaidis: Chronic intracerebroventricular infusion of insulin causes selective increase of slow wave sleep in rats. Brain Res 306, 97-103 (1984)
338. Danguir J: Sleep deficits in diabetic rats: restoration following chronic intravenous or intracerebroventricular infusions of insulin. Brain Res Bull 12(6), 641-645 (1984)
339. Kapas L, L.Payne, F.Obal, Jr., M.Opp, L.Johannsen & J.M.Krueger: Sleep in diabetic rats: effects of interleukin 1. Am J Physiol 260, R995-R999 (1991)
340. Valatx J-L, P.Douhet & D.Bucchini: Human insulin gene insertion in mice. Effects on the sleep-wake cycle? J Sleep Res 8(S1), 65-68 (1999)
341. Roth C, H.-P.Landolt, P.Achermann, A.Teuscher & A.A.Borbély: Human versus porcine insulin in patients with insulin-dependent diabetes mellitus: differences in sleep and the sleep EEG during near-normoglycemia. Sleep 21, 92-100 (1998)
342. Zoccoli G, D.A.Grant, J.Wild & A.M.Walker: Nitric oxide inhibition abolishes sleep-wake differences in cerebral circulation. Am J Physiol 280, H2598-H2606 (2001)
343. Ayers NA, L.Kapas & J.M.Krueger: Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain. Brain Res 707, 127-130 (1996)
344. Burlet S& R.Cespuglio: Voltametric detection of nitric oxide (NO) in the rat brain: its variations throughout the sleep-wake cycle. Neurosci Lett 226, 131-135 (1997)
345. Kapas L, J.Fang & J.M.Krueger: Inhibition of nitric oxide synthesis inhibits rat sleep. Brain Res 664, 189-196 (1994)
346. Kapas L, M.Shibata, M.Kimura & J.M.Krueger: Inhibition of nitric oxide synthesis suppresses sleep in rabbits. Am J Physiol 266, R151-R157 (1994)
347. Monti JM, H.Jantos & D.Monti: Increase of waking and reduction of NREM and REMS after nitric oxide synthase inhibition: prevention with GABAA or adenosine A1 receptor antagonist. Behav Brain Res 123, 23-35 (2001)
348. Dzoljic MR, R.De Vries & R.Van Leeuwen: Sleep and nitric oxide: effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase. Brain Res 718, 145-150 (1996)
349. Dzoljic MR& R.De Vries: Nitric oxide synthase inhibition reduces wakefulness. Neuropharmacology 33, 1505-1509 (1994)
350. Burlet.S., L.Leger & R.Cespuglio: Nitric oxide and sleep in the rat: a puzzling relationship. Neuroscience 92, 627-639 (1999)
351. Ribeiro AC, J.G.Gilligan & L.Kapas: Systemic injection of a nitric oxide synthase inhibitor suppresses sleep responses to sleep deprivation in rats. Am J Physiol 278, R1048-R1056 (2000)
352. Dzoljic E, R.Van Leeuwen, R.De Vries & M.R.Dzoljic: Vigilance and EEG power in rats: effects of potent inhibitors of the neuronal nitric oxide synthase. Naunyn Schmiedebergs Arch Pharmacol 356, 56-61 (1997)
353. Kapas L& J.M.Krueger: Nitric oxide donors SIN-1 and SNAP promote nonrapid-eye-movement sleep in rats. Brain Res Bull 41, 293-298 (1996)
354. Ayers NA, L.Kapas & J.M.Krueger: The inhibitory effects of N omega-nitro-L-arginine methyl ester on nitric oxide synthase activity vary among brain regions in vivo but not in vitro. Neurochem Res 22, 81-86 (1997)
355. Leonard TO& R.Lydic: Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate. J Neurosci 17, 774-785 (1997)
356. Datta S, E.H.Patterson & D.F.Siwek: Endogenous and exogenous nitric oxide in the pedunculopontine tegmentum induces sleep. Synapse 27, 69-78 (1997)
357. Hars B: Endogenous nitric oxide in the rat pons promotes sleep. Brain Res 816, 209-219 (1999)
358. Chen L, J.A.Majde & J.M.Krueger: Spontaneous sleep in neuronal and inducible nitric oxide synthase knockout mice. Sleep 25, A170-A171 (2002)
359. Kodama T& Y.Honda: Acetylcholine and glutamate release during sleep-wakefulness in the pedunculopontine tegmental nucleus and norepinephrine changes regulated by nitric oxide. Psychiatry Clin Neurosci 53, 109-111 (1999)
360. Vazquez J, R.Lydic & H.A.Baghdoyan: The nitric oxide synthase inhibitor NG-nitro-L-arginine increases basal forebrain acetylcholine release during sleep and wakefulness. J Neurosci 22, 5597-5605 (2002)
361. Rosenberg PA, Y.Li, M.Le & Y.Zhang: Nitric oxide-stimulated increase in extracellular adenosine accumulation in rat forebrain neurons in culture is associated with ATP hydrolysis and inhibition of adenosine kinase activity. J Neurosci 20, 6294-6301 (2000)
362. Obal F, Jr., M.Opp, A.B.Cady, L.Johannsen, A.E.Postlethwaite, H.M.Poppleton, J.M.Seyer & J.M.Krueger: Interleukin-1alpha and an interleukin-1beta fragment are somnogenic. Am J Physiol 259, R439-R446 (1990)
363. Opp MR, A.E.Postlethwaite, J.M.Seyer & J.M.Krueger: Interleukin 1 receptor antagonist blocks somnogenic and pyrogenic responses to an interleukin 1 fragment. PNAS 89, 3726-3730 (1992)
364. De Sarro GP, Y.Masuda, C.Ascioti, M.G.Audino & G.Nistico: Behavioral and ECoG spectrum changes by intracerebral infusion of interferons and interleukin 2 in rats are antagonized by naloxone. Neuropharmacology 29, 167-179 (1990)
365. Kubota T, R.A.Brown, J.Fang & J.M.Krueger: Interleukin-15 and interleukin-2 enhance non-REMS in rabbits. Am J Physiol 281, R1004-R1012 (2001)
366. Kushikata T, J.Fang, Y.Wang & J.M.Krueger: Interleukin-4 inhibits spontaneous sleep in rabbits. Am J Physiol 275, R1185-R1191 (1998)
367. Opp M, F.Obal, Jr., A.B.Cady, L.Johannsen & J.M.Krueger: Interleukin-6 is pyrogenic but not somnogenic. Physiol Behav 45, 1069-1072 (1989)
368. Späth-Schwalbe E, K.Hansen, F.Schmidt, H.Schrezenmeier, L.Marshall, K.Burger, H.L.Fehm & J.Born: Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men. J Clin Endocrinol Metab 83, 1573-1579 (1998)
369. Kushikata T, J.Fang & J.M.Krueger: Interleukin-10 inhibits spontaneous sleep in rabbits. J Interferon Cytokine Res 19, 1025-1030 (1999)
370. Kubota T, J.Fang, T.Kushikata & J.M.Krueger: Interleukin-13 and transforming growth factor-beta1 inhibit spontaneous sleep in rabbits. Am J Physiol 279, R786-R792 (2000)
371. Kubota T, J.Fang, R.A.Brown & J.M.Krueger: Interleukin-18 promotes sleep in rabbits and rats. Am J Physiol 281, R828-R838 (2001)
372. Kushikata T, J.Fang, Z.Chen, Y.Wang & J.M.Krueger: Epidermal growth factor enhances spontaneous sleep in rabbits. Am J Physiol 275, R509-R514 (1998)
373. De Saint Hilaire Z& S.Nicolaidis: Enhancement of slow wave sleep parallel to the satieting effect of acidic fibroblast growth factor in rats. Brain Res Bull 29, 525-528 (1992)
374. Knefati M, C.Somogyi, L.Kapas, T.Bourcier & J.M.Krueger: Acidic fibroblast growth factor (FGF) but not basic FGF induces sleep and fever in rabbits. Am J Physiol 269, R87-R91 (1995)
375. Galan JM, B.Cuevas, N.Dujovny, G.Gimenez-Gallego & P.Cuevas: Sleep promoting effects of intravenously administered acidic fibroblast growth factor. Neurol Res 18, 567-569 (1996)
376. Birmanns B, D.Saphier & O.Abramsky: Alpha-interferon modifies cortical EEG activity: dose-dependence and antagonism by naloxone. J Neurol Sci 100, 22-26 (1990)
377. Krueger JM, C.A.Dinarello, S.Shoham, D.Davenne, J.Walter & S.Kubillus: Interferon alpha-2 enhances slow-wave sleep in rabbits. Int J Immunopharmacol 9, 23-30 (1987)
378. Kimura M, J.A.Majde, L.A.Toth, M.R.Opp & J.M.Krueger: Somnogenic effects of rabbit and recombinant human interferons in rabbits. Am J Physiol 267, R53-R61 (1994)
379. Toth LA: Strain differences in the somnogenic effects of interferon inducers in mice. J Interferon Cytokine Res 16, 1065-1072 (1996)
380. Späth-Schwalbe E, T.Lange, B.Perras, H.L.Fehm & J.Born: Interferon-alpha acutely impairs sleep in healthy humans. Cytokine 12, 518-521 (2000)
381. Kubota T, J.A.Majde, R.A.Brown & J.M.Krueger: Tumor necrosis factor receptor fragment attenuates interferon-gamma- induced non-REMS in rabbits. J Neuroimmunol 119, 192-198 (2001)
382. Kapas L& J.M.Krueger: Tumor necrosis factor-beta induces sleep, fever, and anorexia. Am J Physiol 263, R703-R707 (1992)
383. Kimura M, T.Kodama, M.C.Aguila, S.-Q.Zhang & S.Inoué: Granulocyte-macrophage colony-stimulating factor modulates rapid eye movement (REM) sleep and non-REMS in rats. J Neurosci 20, 5544-5551 (2000)
384. Schuld A, J.Mullington, D.Hermann, D.Hinze-Selch, T.Fenzel, F.Holsboer & T.Pollmacher: Effects of granulocyte colony-stimulating factor on night sleep in humans. Am J Physiol 276, R1149-R1155 (1999)