Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease

Journal of Neurochemistry

Volumn 79, Issue 6, 2001, Pages 1246-1249

  Bogdanov, Misha B ^a   Andreassen, Ole A ^b   Dedeoglu, Alpaslan ^c,d   Ferrante, Robert J ^c,d   Beal, M Flint ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

8 hydroxy 2 deoxyguanosine; Free radicals; Huntington's disease; Microdialysis; Oxidative damage; Transgenic

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; CORPUS STRIATUM; DNA DAMAGE; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE CELL DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; TRANSGENIC MOUSE; URINE;

ANIMALS; BIOLOGICAL MARKERS; BRAIN; CEREBRAL CORTEX; CORPUS STRIATUM; DEOXYGUANOSINE; DNA; DNA DAMAGE; FEMALE; HUMANS; HUNTINGTON DISEASE; MALE; MICE; MICE, TRANSGENIC; MICRODIALYSIS; MITOCHONDRIA; MODELS, ANIMAL; NERVE DEGENERATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS;

ANIMALIA; MUS MUSCULUS;

EID: 0035668684     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00689.x     Document Type: Article

References (21)

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2. A carbon column-based liquid chromatography electrochemical approach to routine 8-hydroxy-2′-deoxyguanosine measurements in urine and other biologic matrices: A oneyear evaluation of methods
3. Increased oxidative damage to DNA in ALS patients
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5. Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and γ-glutamyl transpeptidase in post-mortem brain from Huntington's disease and agonal cases
6. Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene
7. 8-Hydroxy-2-deoxyguanosine, an abundant form of oxidative DNA damge causes G-T and A-C substitutions
8. Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions
9. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
10. Oxidative DNA damage induced by simultaneous generation of nitric oxide and superoxide
11. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1
12. The roles of free radicals in amyotrophic lateral sclerosis: Reactive oxygen species and elevated oxidation of protein, DNa, and membrane phospholipids
13. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
14. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
15. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease
16. Striatal oxidative damage parallels the expression of a neurological phenotype in mice transgenic for the mutation of Huntington's disease
17. Oxidative damage to mitochondrial DNA in Huntington's disease parietal cortex
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19. A marker of oxyradical-mediated DNA damage (8-hydroxy-2′deoxyguanosine) is increased in nigro-striatum of Parkinson's disease brain
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