The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death

Neuropharmacology

Volumn 42, Issue 6, 2002, Pages 741-751

  Moroni, Flavio ^a   Attucci, Sabina ^a   Cozzi, Andrea ^a   Meli, Elena ^a   Picca, Roberta ^a   Scheideler, Mark A ^b   Pellicciari, Roberto ^c   Noe, Christian ^d   Sarichelou, Iran ^c   Pellegrini Giampietro, Domenico E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b GSK   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

3 MATIDA; Cerebral ischemia; Metabotropic glutamate receptors; mGlu1; Middle cerebral artery occlusion; Neuronal death; Neuroprotection; Oxygen glucose deprivation

Indexed keywords

3 METHYLAMINOTHIOPHENE DICARBOXYLIC ACID; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUCOSE; IONOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN ISCHEMIA; CELL CULTURE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; GENETIC TRANSFECTION; HAMSTER; HIPPOCAMPUS; IC 50; KIDNEY CELL; MEMBRANE DEPOLARIZATION; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER;

ANIMALS; BRAIN ISCHEMIA; CELL DEATH; CELL HYPOXIA; CELLS, CULTURED; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; THIOPHENES;

EID: 0036094960     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00033-3     Document Type: Article

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