Cytokine effects on glutamate uptake by human astrocytes

NeuroImmunoModulation

Volumn 7, Issue 3, 2000, Pages 153-159

  Hu, Shuxian ^a,b   Sheng, Wen S ^a   Ehrlich, Laura C ^a   Peterson, Phillip K ^a   Chao, Chun C ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Astrocytes; Cytokines; Glutamate uptake; Interferon; Interleukin 1; Nitric oxide

Indexed keywords

CYTOKINE; GLUTAMIC ACID; INTERFERON; INTERLEUKIN 1; NITRIC OXIDE;

AMINO ACID TRANSPORT; ARTICLE; ASTROCYTE; BRAIN INJURY; CALCIUM CELL LEVEL; CELL PROTECTION; CYTOKINE RELEASE; DRUG EFFECT; HUMAN; HUMAN CELL; MEDIATOR RELEASE; MICROGLIA; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR AFFINITY; RECEPTOR BLOCKING;

EID: 0034033077     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000026433     Document Type: Article

References (35)

1. Coyle JT, Bird SJ, Evance RH, Gulley RL, Nadler JV, Nicklas WJ, Olney JW: Excitatory amino acid neurotoxins: Selectivity, specificity, and metabolism of action. Neurosci Res Prog Bull 1981;19:330-427.
2. Rothman SM, Olney JW: Glutamate and the pathophysiology of hypoxic/ischemic brain damage. Ann Neurol 1986;19:1105-1111.
3. Olney JW, Sharpe LG: Brain lesions in an infant rhesus monkey treated with monosodium glutamate. Science 1969;164:719-721.
4. Takahashi M, Billups B, Rossi D, Sarantis M, Hamann M, Attwell D: The role of glutamate transporters in glutamate homeostasis in the brain. J Exp Biol 1997;200:401-409.
5. Sugiyama K, Brunori A, Mayer ML: Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus. Neuroscience 1989;32:779-791.
6. Rosenberg PA, Aizenman E: Hundred-fold increase in neuronal vulnerability to glutamate toxicity in astrocyte-poor cultures of rat cerebral cortex. Neurosci Lett 1989;103:162-168.
7. Benveniste EN: Role of macrophage/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med 1997;75:165-173.
8. Peterson PK, Gekker G, Hu S, Chao CC: Microglia: A double-edged sword; in Peterson PK, Remington JS (ed): In Defense of the brain: Current Concepts in the Immunopathogenesis and Clinical Aspects of CNS Infections. Malden, Blackwell, 1997, pp 31-55.
9. Hickey WF: Leukocyte migration into the central nervous system; in Peterson PK, Remington JS (eds): In Defense of the Brain: Current Concepts in the Immunopathogenesis and Clinical Aspects of CNS Infections. Malden, Blackwell, 1997, pp 11-30.
10. Robinson MB, Dowd LA: Heterogeneity and functional properties of subtypes of sodium-dependent glutamate transporters in the mammalian central nervous system. Adv Pharmacol 1997;37:69-115.
11. Malandro MS, Kilberg MS: Molecular biology of mammalian amino acid transporters. Annu Rev Biochem 1996;65:305-336.
12. Chaudhry FA, Lehre KP, van Lookeren Campagne M, Ottersen OP, Danbolt NC, Storm-Mathisen J: Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron 1995;15: 711-720.
13. Aschner M, LoPachin RM Jr: Astrocytes: Targets and mediators of chemical-induced CNS injury. J Toxicol Environ Health 1993;38:329-342.
14. Lee SC, Dickson DW, Liu W, Brosnan CF: Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-gamma. J Neuroimmunol 1993;46:19-24.
15. Chao CC, Hu S, Sheng WS, Bu D-F, Bukrinsky MI, Peterson PK: Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism. Glia 1996;16:276-284.
16. Chao CC, Hu S: Tumor necrosis factor-α potentiates glutamate neurotoxicity in human fetal brain cell cultures. Dev Neurosci 1994;16: 172-179.
17. Berl S, Lajtha A, Waelsch H: Amino acid and protein metabolism. J Neurochem 1961;8: 186-197.
18. Hertz L: Functional interactions between neurons and astrocytes. I. Turnover and metabolism of putative amino acid neurotransmitters; in Kerkut GA, Phillis JW (eds): Progress in Neurobiology. Oxford, Pergamon Press, 1979, vol 13, pp 277-323.
19. Martinez-Hernandez A, Bell KP, Norenberg MD: Glutamine synthetase: Glial localization in brain. Science 1977;195:1356-1358.
20. Sonnewald U, Westergaard N, Schousboe A: Glutamate transporter and metabolism in astrocytes. Glia 1997;21:56-63.
21. Chao CC, Hu S, Tsang M, Weatherbee J, Molitor TW, Anderson WR, Peterson PK: Effects of transforming growth factor-β on murine astrocyte glutamine synthetase activity: Implications in neuronal injury. J Clin Invest 1992;90: 1786-1793.
22. Rothstein J, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kunel RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF: Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 1997;16: 675-686.
23. Tanaka K, Watase K, Manabe T, Watanabe M, Takahashi K, Iwama H, Nishikawa T, Ichihara N, Kikuchi T, Okuyama S, Kawashima N, Hori S, Takimoto M, Wada K: Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 1997; 276:1699-1702.
24. 2+ and induces a depolarization in cultured astroglial cells. Brain 1996;119:2021-2027.
25. Fine SM, Angel RA, Perry SW, Epstein LG, Rothstein JD, Dcwhurst S, Gelbard HA: Tumor necrosis factor a inhibits glutamate uptake by primary human astrocytes. J Biol Chem 1996;271:15303-15306.
26. Piani D, Frei K, Pfister H-W, Fontana A: Glutamate uptake by astrocytes is inhibited by reactive oxygen intermediates but not by other macrophage-derived molecules including cytokines, leukotrines or platelet-activating factor. J Neuroimmunol 1993;48:99-104.
27. Chao CC, Hu S, Ehrlich L, Peterson PK: Interleukin-1 and tumor necrosis factor-α synergistically mediate neurotoxicity: Involvement of nitric oxide and of N-methyl-D-aspartate receptors. Brain Behav Immun 1995;9:355-365.
28. Ye Z-C, Sontheimer H: Cytokine modulation of glial glutamate uptake: A possible involvement of nitric oxide. NeuroReport 1996;7: 2181-2185.
29. Liu J, Zhao M-L, Brosnan CF, Lee SC: Expression of type II nitric oxide synthase in primary human astrocytes and microglia: Role of IL-1β and IL-1 receptor antagonist. J Immunol 1996; 157:3569-3576.
30. Trotti D, Rossi D, Gjesdal O, Levy LM, Racagni G, Danbolt KC, Volterra A: Peroxynitrite inhibits glutamate transporter subtypes. J Biol Chem 1996;271:5976-5979.
31. Stewart VC, Giovannoni G, Land JM, McDonald WI, Clark JB, Heales SJR: Pretreatment of astrocytes with interferon-α/β impairs interferon-γ induction of nitric oxide synthase. J Neurochem 1997;68:2547-2551.
32. Stewart VC, Land JM, Clark JB, Heales SJR: Pretreatment of astrocytes with interferon-α/β prevents neuronal mitochondrial respiratory-chain damage. J Neurochem 1998;70:432-434.
33. Deguchi M, Inaba K, Muramatsu S: Counteracting effect of interferon-α and β on interferon-γ-induced production of nitric oxide which is suppressive for antibody response. Immunol Lett 1995;45:157-162.
34. Rudick RA, Goodkin DE, Jacobs LD, Cookfair DL, Herndon RM, Richert JR, Salazar AM, Fischer JS, Granger CV, Simon JH, Alam JJ, Simonian NA, Campion MK, Bartoszak DM, Bourdette DN, Braiman J, Brownscheidle CM, Coats ME, Cohan SL, Dougherty DS, Kinkel RP, Mass MK, Munschauer FE, Priore RL, Pullicino PM, Scherokman BJ, Weistock-Guttman B, Whitman RH, and the Multiple Sclerosis Collaborative Research Group (MSCRG): Impact of interferon beta-1a on neurologic disability in relapsing multiple sclerosis. Neurology 1997;49:358-363.
35. Chabot S, Williams G, Yong VW: Microglial production of TNF-α is induced by activated T lymphocytes: Involvement of VLA-4 and inhibition by interfcron β-1b. J Clin Invest 1997; 100:604-612.