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Volumn 19, Issue 1, 2005, Pages 31-37

Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCARNITINE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; AMPA RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ASCORBIC ACID; CELECOXIB; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2 INHIBITOR; CYCLOSPORIN A; GABAPENTIN; GINKGO BILOBA EXTRACT; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; LEUKEMIA INHIBITORY FACTOR; MINOCYCLINE; NEUROTROPHIC FACTOR; NIMESULIDE; PORPHYRIN; RILUZOLE; ROFECOXIB; RPR 119990; SELEGILINE; TACROLIMUS; TOPIRAMATE; TRIENTINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN;

EID: 15944377898     PISSN: 11738804     EISSN: None     Source Type: Journal    
DOI: 10.2165/00063030-200519010-00004     Document Type: Review
Times cited : (78)

References (94)
  • 4
    • 0041903805 scopus 로고    scopus 로고
    • VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
    • Lambrechts D, Storkebaum E, Morimoto M, et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 2003; 34: 383-94
    • (2003) Nat Genet , vol.34 , pp. 383-394
    • Lambrechts, D.1    Storkebaum, E.2    Morimoto, M.3
  • 5
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001; 28: 131-8
    • (2001) Nat Genet , vol.28 , pp. 131-138
    • Oosthuyse, B.1    Moons, L.2    Storkebaum, E.3
  • 7
    • 0017370884 scopus 로고
    • A glutamatergic corticostriatal path?
    • McGeer PL, McGeer EG, Scherer U, et al. A glutamatergic corticostriatal path? Brain Res 1977; 128: 369-73
    • (1977) Brain Res , vol.128 , pp. 369-373
    • McGeer, P.L.1    McGeer, E.G.2    Scherer, U.3
  • 8
    • 0037507019 scopus 로고    scopus 로고
    • Molecular and cellular mechanism of glutamate receptors in relation to amyotrophic lateral sclerosis
    • Oct
    • Iwasaki Y, Ikeda K, Kinoshita M. Molecular and cellular mechanism of glutamate receptors in relation to amyotrophic lateral sclerosis. Curr Drug Targets CNS Neurol Disord 2002 Oct; 1 (5): 511-8
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , Issue.5 , pp. 511-518
    • Iwasaki, Y.1    Ikeda, K.2    Kinoshita, M.3
  • 10
    • 0037393176 scopus 로고    scopus 로고
    • An outcome study of riluzole in amyotrophic lateral sclerosis: A population-based study in Ireland, 1996-2000
    • Traynor BJ, Alexander M, Corr B, et al. An outcome study of riluzole in amyotrophic lateral sclerosis: a population-based study in Ireland. 1996-2000. J Neurol 2003; 250: 473-9
    • (2003) J Neurol , vol.250 , pp. 473-479
    • Traynor, B.J.1    Alexander, M.2    Corr, B.3
  • 12
    • 0036257090 scopus 로고    scopus 로고
    • A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis
    • Bensimon G, Lacomblez L, Delumeau JC, et al. A study of riluzole in the treatment of advanced stage or elderly patients with amyotrophic lateral sclerosis. J Neurol 2002; 249: 609-15
    • (2002) J Neurol , vol.249 , pp. 609-615
    • Bensimon, G.1    Lacomblez, L.2    Delumeau, J.C.3
  • 13
    • 0038723463 scopus 로고    scopus 로고
    • A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: Effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters
    • Ryberg H, Askmark H, Persson LI. A double-blind randomized clinical trial in amyotrophic lateral sclerosis using lamotrigine: effects on CSF glutamate, aspartate, branched-chain amino acid levels and clinical parameters. Acta Neurol Scand 2003; 108: 1-8
    • (2003) Acta Neurol Scand , vol.108 , pp. 1-8
    • Ryberg, H.1    Askmark, H.2    Persson, L.I.3
  • 14
    • 0035836649 scopus 로고    scopus 로고
    • Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis
    • Miller RG, Moore II DH, Gelinas DF, et al. Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology 2001; 56: 843-8
    • (2001) Neurology , vol.56 , pp. 843-848
    • Miller, R.G.1    Moore II, D.H.2    Gelinas, D.F.3
  • 15
    • 0345700290 scopus 로고    scopus 로고
    • Gabapentin therapy for amyotrophic lateral sclerosis: Lack of improvement in neuronal integrity shown by MR spectroscopy
    • Kalra S, Cashman NR, Caramanos Z, et al. Gabapentin therapy for amyotrophic lateral sclerosis: lack of improvement in neuronal integrity shown by MR spectroscopy. Am J Neuroradiol 2003; 24: 476-80
    • (2003) Am J Neuroradiol , vol.24 , pp. 476-480
    • Kalra, S.1    Cashman, N.R.2    Caramanos, Z.3
  • 16
    • 10744222650 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis
    • Cudkowicz ME, Shefner JM, Schoenfeld DA, et al. A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis. Neurology 2003; 61: 456-64
    • (2003) Neurology , vol.61 , pp. 456-464
    • Cudkowicz, M.E.1    Shefner, J.M.2    Schoenfeld, D.A.3
  • 17
    • 0037507201 scopus 로고    scopus 로고
    • Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice
    • Snow RJ, Turnbull J, da Silva S, et al. Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice. Neuroscience 2003; 119: 661-7
    • (2003) Neuroscience , vol.119 , pp. 661-667
    • Snow, R.J.1    Turnbull, J.2    Da Silva, S.3
  • 18
    • 0037468293 scopus 로고    scopus 로고
    • Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice
    • Maragakis NJ, Jackson M, Ganel R, et al. Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice. Neurosci Lett 2003; 338: 107-10
    • (2003) Neurosci Lett , vol.338 , pp. 107-110
    • Maragakis, N.J.1    Jackson, M.2    Ganel, R.3
  • 19
    • 0034802145 scopus 로고    scopus 로고
    • RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: Synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis
    • Canton T, Bohme GA, Boireau A, et al. RPR 119990, a novel alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis. J Pharmacol Exp Ther 2001; 299: 314-22
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 314-322
    • Canton, T.1    Bohme, G.A.2    Boireau, A.3
  • 20
    • 0034601439 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis
    • Andreassen OA, Dedeoglu A. Klivenyi P, et al. N-acetyl-L-cysteine improves survival and preserves motor performance in an animal model of familial amyotrophic lateral sclerosis. Neuroreport 2000; 11: 2491-3
    • (2000) Neuroreport , vol.11 , pp. 2491-2493
    • Andreassen, O.A.1    Dedeoglu, A.2    Klivenyi, P.3
  • 21
    • 0037380924 scopus 로고    scopus 로고
    • Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis
    • Wu AS, Kiaei M, Aguirre N, et al. Iron porphyrin treatment extends survival in a transgenic animal model of amyotrophic lateral sclerosis. J Neurochem 2003; 85: 142-50
    • (2003) J Neurochem , vol.85 , pp. 142-150
    • Wu, A.S.1    Kiaei, M.2    Aguirre, N.3
  • 22
    • 0037332066 scopus 로고    scopus 로고
    • The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice
    • Nagano S, Fujii Y, Yamamoto T, et al. The efficacy of trientine or ascorbate alone compared to that of the combined treatment with these two agents in familial amyotrophic lateral sclerosis model mice. Exp Neurol 2003; 179: 176-80
    • (2003) Exp Neurol , vol.179 , pp. 176-180
    • Nagano, S.1    Fujii, Y.2    Yamamoto, T.3
  • 23
    • 0034803549 scopus 로고    scopus 로고
    • Therapeutic efficacy of EGb761 (Gingko biloba extract) in a transgenic mouse model of amyotrophic lateral sclerosis
    • Ferrante RJ, Klein AM, Dedeoglu A, et al. Therapeutic efficacy of EGb761 (Gingko biloba extract) in a transgenic mouse model of amyotrophic lateral sclerosis. J Mol Neurosci 2001; 17: 89-96
    • (2001) J Mol Neurosci , vol.17 , pp. 89-96
    • Ferrante, R.J.1    Klein, A.M.2    Dedeoglu, A.3
  • 24
    • 0034327293 scopus 로고    scopus 로고
    • Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice
    • Jiang F, DeSilva S, Turnbull J. Beneficial effect of ginseng root in SOD-1 (G93A) transgenic mice. J Neurol Sci 2000; 180: 52-4
    • (2000) J Neurol Sci , vol.180 , pp. 52-54
    • Jiang, F.1    DeSilva, S.2    Turnbull, J.3
  • 25
    • 0033673060 scopus 로고    scopus 로고
    • Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics
    • Poduslo JF, Whelan SL, Curran GL. et al. Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics. Ann Neurol 2000; 48: 943-7
    • (2000) Ann Neurol , vol.48 , pp. 943-947
    • Poduslo, J.F.1    Whelan, S.L.2    Curran, G.L.3
  • 26
    • 0142241350 scopus 로고    scopus 로고
    • Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice
    • Turner BJ, Cheah IK, Macfarlane KJ, et al. Antisense peptide nucleic acid-mediated knockdown of the p75 neurotrophin receptor delays motor neuron disease in mutant SOD1 transgenic mice. J Neurochem 2003; 87: 752-63
    • (2003) J Neurochem , vol.87 , pp. 752-763
    • Turner, B.J.1    Cheah, I.K.2    Macfarlane, K.J.3
  • 27
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar BK, Llado J, Sherkat N, et al. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003; 301: 839-42
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3
  • 28
    • 0037373162 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis
    • Manabe Y, Nagano I, Gazi MS, et al. Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Neurol Res 2003; 25: 195-200
    • (2003) Neurol Res , vol.25 , pp. 195-200
    • Manabe, Y.1    Nagano, I.2    Gazi, M.S.3
  • 29
    • 0036022401 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis
    • Manabe Y, Nagano I, Gazi MS, et al. Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Apoptosis 2002; 7: 329-34
    • (2002) Apoptosis , vol.7 , pp. 329-334
    • Manabe, Y.1    Nagano, I.2    Gazi, M.S.3
  • 30
    • 0037104725 scopus 로고    scopus 로고
    • Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis
    • Wang LJ, Lu YY, Muramatsu S, et al. Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis. J Neurosci 2002; 22: 6920-8
    • (2002) J Neurosci , vol.22 , pp. 6920-6928
    • Wang, L.J.1    Lu, Y.Y.2    Muramatsu, S.3
  • 31
    • 0036292375 scopus 로고    scopus 로고
    • Increased survival and function of SOD1 mice after glial cell-derived neurotrophic factor gene therapy
    • Acsadi G, Anguelov RA, Yang H, et al. Increased survival and function of SOD1 mice after glial cell-derived neurotrophic factor gene therapy. Hum Gene Ther 2002; 13: 1047-59
    • (2002) Hum Gene Ther , vol.13 , pp. 1047-1059
    • Acsadi, G.1    Anguelov, R.A.2    Yang, H.3
  • 32
    • 2642526164 scopus 로고    scopus 로고
    • VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
    • Azzouz M, Ralph GS, Storkebaum E, et al. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 2004; 429: 413-7
    • (2004) Nature , vol.429 , pp. 413-417
    • Azzouz, M.1    Ralph, G.S.2    Storkebaum, E.3
  • 33
    • 0041835830 scopus 로고    scopus 로고
    • The effect of leukaemia inhibitory factor on SOD1 G93A murine amyotrophic lateral sclerosis
    • Feeney SJ, Austin L, Bennett TM, et al. The effect of leukaemia inhibitory factor on SOD1 G93A murine amyotrophic lateral sclerosis. Cytokine 2003; 23: 108-18
    • (2003) Cytokine , vol.23 , pp. 108-118
    • Feeney, S.J.1    Austin, L.2    Bennett, T.M.3
  • 34
    • 0035856861 scopus 로고    scopus 로고
    • Leukemia inhibitory factor by systemic administration rescues spinal motor neurons in the SOD1 G93A murine model of familial amyotrophic lateral sclerosis
    • Azari MF, Galle A, Lopes EC, et al. Leukemia inhibitory factor by systemic administration rescues spinal motor neurons in the SOD1 G93A murine model of familial amyotrophic lateral sclerosis. Brain Res 2001; 922: 144-7
    • (2001) Brain Res , vol.922 , pp. 144-147
    • Azari, M.F.1    Galle, A.2    Lopes, E.C.3
  • 35
    • 0035444173 scopus 로고    scopus 로고
    • Protective effects of cardiotrophin-1 adenoviral gene transfer on neuromuscular degeneration in transgenic ALS mice
    • Bordet T, Lesbordes JC, Rouhani S, et al. Protective effects of cardiotrophin-1 adenoviral gene transfer on neuromuscular degeneration in transgenic ALS mice. Hum Mol Gen 2001; 10: 1925-33
    • (2001) Hum Mol Gen , vol.10 , pp. 1925-1933
    • Bordet, T.1    Lesbordes, J.C.2    Rouhani, S.3
  • 36
    • 0942287666 scopus 로고    scopus 로고
    • Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
    • Klivenyi P, Kiaei M, Gardian G, et al. Additive neuroprotective effects of creatine and cyclooxygenase 2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurochem 2004; 88: 576-82
    • (2004) J Neurochem , vol.88 , pp. 576-582
    • Klivenyi, P.1    Kiaei, M.2    Gardian, G.3
  • 37
    • 0043095290 scopus 로고    scopus 로고
    • Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: Effects of creatine treatment
    • Derave W, Van Den Bosch L, Lemmens G, et al. Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment. Neurobiol Dis 2003; 13: 264-72
    • (2003) Neurobiol Dis , vol.13 , pp. 264-272
    • Derave, W.1    Van Den Bosch, L.2    Lemmens, G.3
  • 38
    • 0037379650 scopus 로고    scopus 로고
    • A randomized sequential trial of creatine in amyotrophic lateral sclerosis
    • Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003; 53: 437-45
    • (2003) Ann Neurol , vol.53 , pp. 437-445
    • Groeneveld, G.J.1    Veldink, J.H.2    Van Der Tweel, I.3
  • 39
    • 0037389393 scopus 로고    scopus 로고
    • A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis
    • Pompl PN, Ho L, Bianchi M, et al. A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. FASEB J 2003; 17: 725-7
    • (2003) FASEB J , vol.17 , pp. 725-727
    • Pompl, P.N.1    Ho, L.2    Bianchi, M.3
  • 40
    • 0036895241 scopus 로고    scopus 로고
    • Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
    • Drachman DB, Frank K, Dykes-Hoberg M, et al. Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Ann Neurol 2002; 52: 771-8
    • (2002) Ann Neurol , vol.52 , pp. 771-778
    • Drachman, D.B.1    Frank, K.2    Dykes-Hoberg, M.3
  • 41
    • 0036406903 scopus 로고    scopus 로고
    • Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
    • Kriz J, Nguyen MD, Julien JP. Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2002: 10: 268-78
    • (2002) Neurobiol Dis , vol.10 , pp. 268-278
    • Kriz, J.1    Nguyen, M.D.2    Julien, J.P.3
  • 42
    • 0037067009 scopus 로고    scopus 로고
    • Minocycline delays disease onset and mortality in a transgenic model of ALS
    • Van Den Bosch L, Tilkin P. Lemmens G, et al. Minocycline delays disease onset and mortality in a transgenic model of ALS. Neuroreport 2002; 13: 1067-70
    • (2002) Neuroreport , vol.13 , pp. 1067-1070
    • Van Den Bosch, L.1    Tilkin, P.2    Lemmens, G.3
  • 43
    • 0037310563 scopus 로고    scopus 로고
    • Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS
    • Zhang W, Narayanan M, Friedlander RM. Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS. Ann Neurol 2003; 53: 267-70
    • (2003) Ann Neurol , vol.53 , pp. 267-270
    • Zhang, W.1    Narayanan, M.2    Friedlander, R.M.3
  • 44
    • 0035964232 scopus 로고    scopus 로고
    • Immunosuppressant FK506 does not exert beneficial effects in symptomatic G93 A Superoxide dismutase-1 transgenic mice
    • Anneser JM, Gmerek A, Gerkrath J, et al. Immunosuppressant FK506 does not exert beneficial effects in symptomatic G93 A Superoxide dismutase-1 transgenic mice. Neuroreport 2001; 12: 2663-5
    • (2001) Neuroreport , vol.12 , pp. 2663-2665
    • Anneser, J.M.1    Gmerek, A.2    Gerkrath, J.3
  • 45
    • 1942486792 scopus 로고    scopus 로고
    • Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice
    • Kieran D, Kalmar B, Dick JR, et al. Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice. Nat Med 2004; 10: 402-5
    • (2004) Nat Med , vol.10 , pp. 402-405
    • Kieran, D.1    Kalmar, B.2    Dick, J.R.3
  • 46
    • 1042289650 scopus 로고    scopus 로고
    • An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment
    • Kirkinezos IG, Hernandez D. Bradley WG, et al. An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment. J Neurochem 2004; 88: 821-6
    • (2004) J Neurochem , vol.88 , pp. 821-826
    • Kirkinezos, I.G.1    Hernandez, D.2    Bradley, W.G.3
  • 47
    • 3042511616 scopus 로고    scopus 로고
    • Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis
    • Karlsson J, Fong KS, Hansson MJ, et al. Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis. J Neurosurg 2004; 101: 128-37
    • (2004) J Neurosurg , vol.101 , pp. 128-137
    • Karlsson, J.1    Fong, K.S.2    Hansson, M.J.3
  • 48
    • 0141837939 scopus 로고    scopus 로고
    • The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis
    • Turner BJ, Lopes EC, Cheema SS. The serotonin precursor 5-hydroxytryptophan delays neuromuscular disease in murine familial amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2003; 4: 171-6
    • (2003) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.4 , pp. 171-176
    • Turner, B.J.1    Lopes, E.C.2    Cheema, S.S.3
  • 49
    • 0242267611 scopus 로고    scopus 로고
    • Opposing effects of low and high-dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice
    • Turner BJ, Rembach A, Spark R, et al. Opposing effects of low and high-dose clozapine on survival of transgenic amyotrophic lateral sclerosis mice. J Neurosci Res 2003; 74: 605-13
    • (2003) J Neurosci Res , vol.74 , pp. 605-613
    • Turner, B.J.1    Rembach, A.2    Spark, R.3
  • 50
    • 2442484678 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Delayed disease progression in mice by treatment with a cannabinoid
    • Raman C, McAllister SD, Rizvi G, et al. Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid. Amyotroph Lateral Scler Other Motor Neuron Disord 2004; 5: 33-9
    • (2004) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.5 , pp. 33-39
    • Raman, C.1    McAllister, S.D.2    Rizvi, G.3
  • 51
    • 0035996539 scopus 로고    scopus 로고
    • Spinal cord mGlu 1a receptors: Possible target for amyotrophic lateral sclerosis therapy
    • Valerio A, Ferrario M, Paterlini M, et al. Spinal cord mGlu 1a receptors: possible target for amyotrophic lateral sclerosis therapy. Pharmacol Biochem Behav 2002; 73: 447-54
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 447-454
    • Valerio, A.1    Ferrario, M.2    Paterlini, M.3
  • 52
    • 0037507015 scopus 로고    scopus 로고
    • Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis
    • Di Matteo V, Esposito E. Biochemical and therapeutic effects of antioxidants in the treatment of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. Curr Drug Targets CNS Neurol Disord 2003; 2: 95-107
    • (2003) Curr Drug Targets CNS Neurol Disord , vol.2 , pp. 95-107
    • Di Matteo, V.1    Esposito, E.2
  • 53
    • 0035880007 scopus 로고    scopus 로고
    • Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins
    • Butterfield DA, Kanski J. Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins. Mech Ageing Dev 2001; 122: 945-62
    • (2001) Mech Ageing Dev , vol.122 , pp. 945-962
    • Butterfield, D.A.1    Kanski, J.2
  • 54
    • 0035516124 scopus 로고    scopus 로고
    • From Charcot to Lou Gehrig: Deciphering selective motor neuron death in ALS
    • Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2001; 2: 806-19
    • (2001) Nat Rev Neurosci , vol.2 , pp. 806-819
    • Cleveland, D.W.1    Rothstein, J.D.2
  • 56
    • 0030851761 scopus 로고    scopus 로고
    • Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
    • Beal MF, Ferrante RJ, Browne SE, et al. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis. Ann Neurol 1997; 42: 646-54
    • (1997) Ann Neurol , vol.42 , pp. 646-654
    • Beal, M.F.1    Ferrante, R.J.2    Browne, S.E.3
  • 57
    • 0030813067 scopus 로고    scopus 로고
    • Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis
    • Ferrante RJ, Browne SE, Shinobu LA, et al. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 1997; 69: 2064-74
    • (1997) J Neurochem , vol.69 , pp. 2064-2074
    • Ferrante, R.J.1    Browne, S.E.2    Shinobu, L.A.3
  • 58
    • 0034793858 scopus 로고    scopus 로고
    • Glial cells of the spinal cord and subcortical white matter upregulate nitric oxide synthase in sporadic amyotrophic lateral sclerosis
    • Anneser JMH, Cookson MR, Ince PG, et al. Glial cells of the spinal cord and subcortical white matter upregulate nitric oxide synthase in sporadic amyotrophic lateral sclerosis. Exp Neurol 2001; 171: 418-21
    • (2001) Exp Neurol , vol.171 , pp. 418-421
    • Anneser, J.M.H.1    Cookson, M.R.2    Ince, P.G.3
  • 59
    • 0345693269 scopus 로고    scopus 로고
    • Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis
    • Pedersen WA, Fu W, Keller JN, et al. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis. Ann Neurol 1998; 44: 8819-24
    • (1998) Ann Neurol , vol.44 , pp. 8819-8824
    • Pedersen, W.A.1    Fu, W.2    Keller, J.N.3
  • 60
    • 0032716333 scopus 로고    scopus 로고
    • A receptor for advanced glycosylation endproducts (AGEs) is colocalized with neurofilament-bound AGEs and SOD1 in motoneurons of ALS: Immunohistochemical study
    • Chous SM, Han CY, Wang HS, et al. A receptor for advanced glycosylation endproducts (AGEs) is colocalized with neurofilament-bound AGEs and SOD1 in motoneurons of ALS: immunohistochemical study. J Neurol Sci 1999; 169: 87-92
    • (1999) J Neurol Sci , vol.169 , pp. 87-92
    • Chous, S.M.1    Han, C.Y.2    Wang, H.S.3
  • 61
    • 0035955478 scopus 로고    scopus 로고
    • Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients
    • Shibata N, Nagai R, Uchida K, et al. Morphological evidence for lipid peroxidation and protein glycoxidation in spinal cords from sporadic amyotrophic lateral sclerosis patients. Brain Res 2001; 917: 97-104
    • (2001) Brain Res , vol.917 , pp. 97-104
    • Shibata, N.1    Nagai, R.2    Uchida, K.3
  • 62
    • 0037293061 scopus 로고    scopus 로고
    • Drug therapy for amyotrophic lateral sclerosis: Where are we now?
    • Carter GT, Krivickas LS, Weydt P, et al. Drug therapy for amyotrophic lateral sclerosis: where are we now? IDrugs 2003; 6: 147-53
    • (2003) IDrugs , vol.6 , pp. 147-153
    • Carter, G.T.1    Krivickas, L.S.2    Weydt, P.3
  • 63
    • 0035233675 scopus 로고    scopus 로고
    • The effect of selegiline and vitamin E in the treatment of ALS: An open randomized clinical trials
    • Kwiecinski H, Janik P, Jamrozik Z, et al. The effect of selegiline and vitamin E in the treatment of ALS: an open randomized clinical trials [in Polish]. Neurol Neurochir Pol 2001; 35 (1 Suppl.): 101-6
    • (2001) Neurol Neurochir Pol , vol.35 , Issue.1 SUPPL. , pp. 101-106
    • Kwiecinski, H.1    Janik, P.2    Jamrozik, Z.3
  • 64
    • 0035007860 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis (ALS)
    • Desnuelle C, Dib M, Garrel C, et al. A double-blind, placebo-controlled randomized clinical trial of alpha-tocopherol (vitamin E) in the treatment of amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler Other Motor Neuron Disord 2001; 2: 9-18
    • (2001) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.2 , pp. 9-18
    • Desnuelle, C.1    Dib, M.2    Garrel, C.3
  • 65
    • 0029040463 scopus 로고
    • Randomized double-blind controlled trial of acetylcysteine in amyotrophic lateral sclerosis
    • Louwerse ES, Weverling GJ, Bossuyt PM, et al. Randomized double-blind controlled trial of acetylcysteine in amyotrophic lateral sclerosis. Arch Neurol 1995; 52: 559-64
    • (1995) Arch Neurol , vol.52 , pp. 559-564
    • Louwerse, E.S.1    Weverling, G.J.2    Bossuyt, P.M.3
  • 66
    • 0029787291 scopus 로고    scopus 로고
    • Survival in patients with amyotrophic lateral sclerosis treated with an array of antioxidants
    • Vyth A, Timmer JG, Bossuyt PM, et al. Survival in patients with amyotrophic lateral sclerosis treated with an array of antioxidants. J Neurol Sci 1996; 139 Suppl.: 99-103
    • (1996) J Neurol Sci , vol.139 , Issue.SUPPL. , pp. 99-103
    • Vyth, A.1    Timmer, J.G.2    Bossuyt, P.M.3
  • 67
  • 68
    • 0037451069 scopus 로고    scopus 로고
    • VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death
    • Li B, Xu W, Luo C, et al. VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. Brain Res Mol Brain Res 2003; 111 (1-2): 155-64
    • (2003) Brain Res Mol Brain Res , vol.111 , Issue.1-2 , pp. 155-164
    • Li, B.1    Xu, W.2    Luo, C.3
  • 69
    • 0038147334 scopus 로고    scopus 로고
    • A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: Feasibility and results
    • Kalra S, Genge A, Arnold DL. A prospective, randomized, placebo-controlled evaluation of corticoneuronal response to intrathecal BDNF therapy in ALS using magnetic resonance spectroscopy: feasibility and results. Amyotroph Lateral Scler Other Motor Neuron Disord 2003; 4: 22-6
    • (2003) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.4 , pp. 22-26
    • Kalra, S.1    Genge, A.2    Arnold, D.L.3
  • 70
    • 0034208461 scopus 로고    scopus 로고
    • A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered fay intrathecal infusion to patients with amyotrophic lateral sclerosis
    • Ochs G, Penn RD, York M, et al. A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered fay intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 2000; 1: 201-6
    • (2000) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.1 , pp. 201-206
    • Ochs, G.1    Penn, R.D.2    York, M.3
  • 71
    • 0036046465 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease
    • CD002064
    • Mitchell JD, Wokke JH, Borasio GD. Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev 2002; (3): CD002064
    • (2002) Cochrane Database Syst Rev , Issue.3
    • Mitchell, J.D.1    Wokke, J.H.2    Borasio, G.D.3
  • 72
    • 0242521526 scopus 로고    scopus 로고
    • Xaliproden: SR 57746, SR 57746A, xaliproden hydrochloride, xaliprodene
    • Xaliproden: SR 57746, SR 57746A, xaliproden hydrochloride, xaliprodene. Drugs R D 2003; 4: 386-8
    • (2003) Drugs R D , vol.4 , pp. 386-388
  • 73
    • 3843136368 scopus 로고    scopus 로고
    • Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: Results of two phase III trials
    • Meininger V, Bensimon G, Bradley WR, et al. Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials. Amyotroph Lateral Scler Other Motor Neuron Disord 2004; 5: 107-17
    • (2004) Amyotroph Lateral Scler Other Motor Neuron Disord , vol.5 , pp. 107-117
    • Meininger, V.1    Bensimon, G.2    Bradley, W.R.3
  • 75
    • 0036787810 scopus 로고    scopus 로고
    • Inflammatory processes in amyotrophic lateral sclerosis
    • McGeer PL, McGeer EG. Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve 2002; 26: 459-70
    • (2002) Muscle Nerve , vol.26 , pp. 459-470
    • McGeer, P.L.1    McGeer, E.G.2
  • 76
    • 0035833937 scopus 로고    scopus 로고
    • Immune reactivity in a mouse model of familial ALS correlates with disease progression
    • Alexianu ME, Kozovska M, Appel SH. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 2001; 57: 1282-9
    • (2001) Neurology , vol.57 , pp. 1282-1289
    • Alexianu, M.E.1    Kozovska, M.2    Appel, S.H.3
  • 77
    • 0035949799 scopus 로고    scopus 로고
    • Marked increase in cyclooxygenase-2 in ALS spinal cord
    • Yasojima K, Tourtellotte WW, McGeer EG, et al. Marked increase in cyclooxygenase-2 in ALS spinal cord. Neurology 2001; 57: 952-6
    • (2001) Neurology , vol.57 , pp. 952-956
    • Yasojima, K.1    Tourtellotte, W.W.2    McGeer, E.G.3
  • 78
    • 0029811105 scopus 로고    scopus 로고
    • Specific domains of β-amyloid from Alzheimer plaque elicit neuron killing in human microglia
    • Giulian D, Haverkamp LI, Yu JH, et al. Specific domains of β-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J Neurosci 1996; 16: 6021-37
    • (1996) J Neurosci , vol.16 , pp. 6021-6037
    • Giulian, D.1    Haverkamp, L.I.2    Yu, J.H.3
  • 79
    • 0025609978 scopus 로고
    • Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1
    • Giulian D, Vaca K, Noonan CA. Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 1990; 250: 1593-6
    • (1990) Science , vol.250 , pp. 1593-1596
    • Giulian, D.1    Vaca, K.2    Noonan, C.A.3
  • 80
    • 0027967219 scopus 로고
    • Rat brain microglia and peritoneal macrophages show similar responses to respiratory burst stimulants
    • Klegeris A, McGeer PL. Rat brain microglia and peritoneal macrophages show similar responses to respiratory burst stimulants. J Neuroimmunol 1994; 53: 83-90
    • (1994) J Neuroimmunol , vol.53 , pp. 83-90
    • Klegeris, A.1    McGeer, P.L.2
  • 81
    • 0023642584 scopus 로고
    • Production of superoxide anions by a CNS macrophage, the microglia
    • Colton CA, Gilbert DI. Production of superoxide anions by a CNS macrophage, the microglia. FEBS Lett 1987; 223: 284-8
    • (1987) FEBS Lett , vol.223 , pp. 284-288
    • Colton, C.A.1    Gilbert, D.I.2
  • 82
    • 0030774899 scopus 로고    scopus 로고
    • Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells
    • Klegeris A, Walker DG, McGeer PL. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells. J Neuroimmunol 1997; 78: 152-61
    • (1997) J Neuroimmunol , vol.78 , pp. 152-161
    • Klegeris, A.1    Walker, D.G.2    McGeer, P.L.3
  • 83
    • 0344838679 scopus 로고    scopus 로고
    • Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis
    • Weydt P, Weiss MD, Moller T, et al. Neuro-inflammation as a therapeutic target in amyotrophic lateral sclerosis. Curr Opin Investig Drugs 2002; 3 (12): 1720-4
    • (2002) Curr Opin Investig Drugs , vol.3 , Issue.12 , pp. 1720-1724
    • Weydt, P.1    Weiss, M.D.2    Moller, T.3
  • 85
    • 0035132167 scopus 로고    scopus 로고
    • Increased expression of the proinflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis
    • Almer G, Guegan C, Teismann P, et al. Increased expression of the proinflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Ann Neurol 2001; 49: 176-85
    • (2001) Ann Neurol , vol.49 , pp. 176-185
    • Almer, G.1    Guegan, C.2    Teismann, P.3
  • 86
    • 0033762974 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis
    • Drachman DB, Rothstein ID. Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis. Ann Neurol 2000; 48: 792-5
    • (2000) Ann Neurol , vol.48 , pp. 792-795
    • Drachman, D.B.1    Rothstein, I.D.2
  • 87
    • 0344609220 scopus 로고    scopus 로고
    • Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis
    • Barneoud P, Curet O. Beneficial effects of lysine acetylsalicylate, a soluble salt of aspirin, on motor performance in a transgenic model of amyotrophic lateral sclerosis. Exp Neurol 1999; 155: 243-51
    • (1999) Exp Neurol , vol.155 , pp. 243-251
    • Barneoud, P.1    Curet, O.2
  • 88
    • 0035970036 scopus 로고    scopus 로고
    • Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate neurotoxicity in cyclooxygenase-2-deficient mice
    • Ladecola C, Niwa K, Nogawa S, et al. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate neurotoxicity in cyclooxygenase-2- deficient mice. Proc Natl Acad Sci U S A 2001; 98: 1294-9
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1294-1299
    • Ladecola, C.1    Niwa, K.2    Nogawa, S.3
  • 89
    • 2342430778 scopus 로고    scopus 로고
    • Survey of cannabis use in patients with amyotrophic lateral sclerosis
    • Amtmann D, Weydt P, Johnson KL, et al. Survey of cannabis use in patients with amyotrophic lateral sclerosis. Am J Hosp Palliat Care 2004; 21: 95-104
    • (2004) Am J Hosp Palliat Care , vol.21 , pp. 95-104
    • Amtmann, D.1    Weydt, P.2    Johnson, K.L.3
  • 90
    • 0035404366 scopus 로고    scopus 로고
    • Marijuana in the management of amyotrophic lateral sclerosis
    • Carter GT, Rosen BS. Marijuana in the management of amyotrophic lateral sclerosis. Am J Hosp Palliat Care 2001; 18: 264-70
    • (2001) Am J Hosp Palliat Care , vol.18 , pp. 264-270
    • Carter, G.T.1    Rosen, B.S.2
  • 91
    • 0038678773 scopus 로고    scopus 로고
    • Reduction of human monocytic cell neurotoxicity and cytokine excretion by ligands of the cannabinoid-type CB2 receptor
    • Klegeris A, Bissonnette CJ, McGeer PL. Reduction of human monocytic cell neurotoxicity and cytokine excretion by ligands of the cannabinoid-type CB2 receptor. Br J Pharmacol 2003; 139: 775-86
    • (2003) Br J Pharmacol , vol.139 , pp. 775-786
    • Klegeris, A.1    Bissonnette, C.J.2    McGeer, P.L.3
  • 92
    • 0036786208 scopus 로고    scopus 로고
    • Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): High tolerability of daily oral melatonin administration in ALS patients
    • Jacob S, Poeggeler B, Weishaupt JH, et al. Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients. J Pineal Res 2002; 33: 186-7
    • (2002) J Pineal Res , vol.33 , pp. 186-187
    • Jacob, S.1    Poeggeler, B.2    Weishaupt, J.H.3
  • 93
    • 44949111449 scopus 로고    scopus 로고
    • Amino acids for amyotrophic lateral sclerosis/motor neuron disease
    • CD003457
    • Parton M, Mitsumoto H, Leigh PN. Amino acids for amyotrophic lateral sclerosis/motor neuron disease. Cochrane Database Syst Rev 2003; (4): CD003457
    • (2003) Cochrane Database Syst Rev , Issue.4
    • Parton, M.1    Mitsumoto, H.2    Leigh, P.N.3
  • 94
    • 0037381851 scopus 로고    scopus 로고
    • Efficient three-drug cocktail for disease induced by mutant superoxide dismutase
    • Kriz J, Gowing G, Julien JP. Efficient three-drug cocktail for disease induced by mutant superoxide dismutase. Ann Neurol 2003; 53: 429-36
    • (2003) Ann Neurol , vol.53 , pp. 429-436
    • Kriz, J.1    Gowing, G.2    Julien, J.P.3


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