Alzheimer's disease and post-operative cognitive dysfunction

Experimental Gerontology

Volumn 41, Issue 4, 2006, Pages 346-359

  Xie, Zhongcong ^a   Tanzi, Rudolph E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Amyloid Precursor Protein (APP); Amyloid protein (A ); Alzheimer's disease; Anesthesia; Apoptosis; Postoperative cognitive dysfunction

Indexed keywords

ADAPTOR PROTEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANESTHETIC AGENT; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; BETA SECRETASE; CASPASE; GAMMA SECRETASE; NICASTRIN; PRESENILIN 1; TAU PROTEIN;

ALZHEIMER DISEASE; ANESTHESIA; APOPTOSIS; COGNITION; COGNITIVE DEFECT; DEMENTIA; ENZYME ACTIVATION; GENETIC PREDISPOSITION; HUMAN; HYPOCAPNIA; HYPOXIA; MEDICAL LITERATURE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PERIOPERATIVE PERIOD; POSTOPERATIVE COGNITIVE DYSFUNCTION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; REVIEW; SENILE PLAQUE; SURGICAL TECHNIQUE; SYNAPSE;

AGE OF ONSET; AGED; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANESTHESIA; ANOXIA; APOPTOSIS; COGNITION DISORDERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERCAPNIA; POSTOPERATIVE COMPLICATIONS;

EID: 33646472576     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2006.01.014     Document Type: Review

References (213)

1. Abe K., Tanzi R.E., and Kogure K. Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci. Lett. 125 (1991) 172-174
2. Alzheimer A. Uber eine eigenartige Erkrankung der Hirnrinde. Allg. Zeitschr. Psychiatr. Psychiatr-Gerichtl. Med. 109 (1907) 146-148
3. Arriagada P.V., Growdon J.H., Hedley-Whyte E.T., and Hyman B.T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42 (1992) 631-639
4. Bancher C., Braak H., Fischer P., and Jellinger K.A. Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neurosci. Lett. 162 (1993) 179-182
5. Barnes N.Y., Li L., Yoshikawa K., Schwartz L.M., Oppenheim R.W., and Milligan C.E. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J. Neurosci. 18 (1998) 5869-5880
6. Bennett D.A., Schneider J.A., Wilson R.S., Bienias J.L., and Arnold S.E. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch. Neurol. 61 (2004) 378-384
7. Bertram L., Blacker D., Mullin K., Keeney D., Jones J., Basu S., Yhu S., McInnis M.G., Go R.C., Vekrellis K., et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 290 (2000) 2302-2303
8. Bertram L., Hiltunen M., Parkinson M., Ingelsson M., Lange C., Ramasamy K., Mullin K., Menon R., Sampson A.J., Hsiao M.Y., et al. Family-based association between Alzheimer's disease and variants in UBQLN1. N. Engl. J. Med. 352 (2005) 884-894
9. Biederer T., Cao X., Sudhof T.C., and Liu X. Regulation of APP-dependent transcription complexes by mint/X11s: differential functions of mint isoforms. J. Neurosci. 22 (2002) 7340-7351
10. Blacker D., Bertram L., Saunders A.J., Moscarillo T.J., Albert M.S., Wiener H., Perry R.T., Collins J.S., Harrell L.E., Go R.C., et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Hum. Mol. Genet. 12 (2003) 23-32
11. Bohnen N., Warner M.A., Kokmen E., and Kurland L.T. Early and midlife exposure to anesthesia and age of onset of Alzheimer's disease. Int. J. Neurosci. 77 (1994) 181-185
12. Bohnen N.I., Warner M.A., Kokmen E., Beard C.M., and Kurland L.T. Alzheimer's disease and cumulative exposure to anesthesia: a case-control study. J. Am. Geriatr. Soc. 42 (1994) 198-201
13. Borg J.P., Ooi J., Levy E., and Margolis B. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell Biol. 16 (1996) 6229-6241
14. Breteler M.M. Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol. Aging 21 (2000) 153-160
15. Campagna J.A., Miller K.W., and Forman S.A. Mechanisms of actions of inhaled anesthetics. N. Engl. J. Med. 348 (2003) 2110-2124
16. Cao X., and Sudhof T.C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase tip60. Science 293 (2001) 115-120
17. Chan S.L., Culmsee C., Haughey N., Klapper W., and Mattson M.P. Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol. Dis. 11 (2002) 2-19
18. Chen G.J., Xu J., Lahousse S.A., Caggiano N.L., and de la Monte S.M. Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. J. Alzheimers Dis. 5 (2003) 209-228
19. Cleary J.P., Walsh D.M., Hofmeister J.J., Shankar G.M., Kuskowski M.A., Selkoe D.J., and Ashe K.H. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat. Neurosci. 8 (2005) 79-84
20. Culley D.J., Baxter M.G., Yukhananov R., and Crosby G. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology 100 (2004) 309-314
21. Daval J.L., Pourie G., Grojean S., Lievre V., Strazielle C., Blaise S., and Vert P. Neonatal hypoxia triggers transient apoptosis followed by neurogenesis in the rat CA1 hippocampus. Pediatr. Res. 55 (2004) 561-567
22. Daw E.W., Heath S.C., and Wijsman E.M. Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees. Am. J. Hum. Genet. 64 (1999) 839-851
23. de Klaver M.J., Manning L., Palmer L.A., and Rich G.F. Isoflurane pretreatment inhibits cytokine-induced cell death in cultured rat smooth muscle cells and human endothelial cells. Anesthesiology 97 (2002) 24-32
24. De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 38 (2003) 9-12
25. De Strooper B., Beullens M., Contreras B., Levesque L., Craessaerts K., Cordell B., Moechars D., Bollen M., Fraser P., George-Hyslop P.S., and Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. J. Biol. Chem. 272 (1997) 3590-3598
26. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398 (1999) 518-522
27. Doan A., Thinakaran G., Borchelt D.R., Slunt H.H., Ratovitsky T., Podlisny M., Selkoe D.J., Seeger M., Gandy S.E., Price D.L., and Sisodia S.S. Protein topology of presenilin 1. Neuron 17 (1996) 1023-1030
28. Dodds C., and Allison J. Postoperative cognitive deficit in the elderly surgical patient. Br. J. Anaesth. 81 (1998) 449-462
29. Duilio A., Faraonio R., Minopoli G., Zambrano N., and Russo T. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Biochem. J. 330 Pt 1 (1998) 513-519
30. Eckenhoff R.G., Johansson J.S., Wei H., Carnini A., Kang B., Wei W., Pidikiti R., Keller J.M., and Eckenhoff M.F. Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology 101 (2004) 703-709
31. Edbauer D., Winkler E., Regula J.T., Pesold B., Steiner H., and Haass C. Reconstitution of gamma-secretase activity. Nat. Cell Biol. 5 (2003) 486-488
32. Egashira N., Iwasaki K., Ishibashi M., Hatip-Al-Khatib I., Wolozin B., Mishima K., Irie K., and Fujiwara M. Hypoxia enhances beta-amyloid-induced apoptosis in rat cultured hippocampal neurons. Jpn. J. Pharmacol. 90 (2002) 321-327
33. Esch F.S., Keim P.S., Beattie E.C., Blacher R.W., Culwell A.R., Oltersdorf T., McClure D., and Ward P.J. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 248 (1990) 1122-1124
34. Esiri M.M., Nagy Z., Smith M.Z., Barnetson L., and Smith A.D. Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer's disease. Lancet 354 (1999) 919-920
35. Esler W.P., Kimberly W.T., Ostaszewski B.L., Ye W., Diehl T.S., Selkoe D.J., and Wolfe M.S. Activity-dependent isolation of the presenilin-gamma-secretase complex reveals nicastrin and a gamma substrate. Proc. Natl Acad. Sci. USA 99 (2002) 2720-2725
36. Farris W., Mansourian S., Chang Y., Lindsley L., Eckman E.A., Frosch M.P., Eckman C.B., Tanzi R.E., Selkoe D.J., and Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl Acad. Sci. USA 100 (2003) 4162-4167
37. Farris W., Mansourian S., Leissring M.A., Eckman E.A., Bertram L., Eckman C.B., Tanzi R.E., and Selkoe D.J. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am. J. Pathol. 164 (2004) 1425-1434
38. Fiore F., Zambrano N., Minopoli G., Donini V., Duilio A., and Russo T. The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J. Biol. Chem. 270 (1995) 30853-30856
39. Fraering P.C., LaVoie M.J., Ye W., Ostaszewski B.L., Kimberly W.T., Selkoe D.J., and Wolfe M.S. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry 43 (2004) 323-333
40. Francis R., McGrath G., Zhang J., Ruddy D.A., Sym M., Apfeld J., Nicoll M., Maxwell M., Hai B., Ellis M.C., et al. Aph-1 and Pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev. Cell 3 (2002) 85-97
41. Franks N.P., and Lieb W.R. Which molecular targets are most relevant to general anaesthesia?. Toxicol. Lett. 100/101 (1998) 1-8
42. Garcia C.K., Wilund K., Arca M., Zuliani G., Fellin R., Maioli M., Calandra S., Bertolini S., Cossu F., Grishin N., et al. Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. Science 292 (2001) 1394-1398
43. Gervais F.G., Xu D., Robertson G.S., Vaillancourt J.P., Zhu Y., Huang J., LeBlanc A., Smith D., Rigby M., Shearman M.S., et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic a beta peptide formation. Cell 97 (1999) 395-406
44. Glenner G.G., and Wong C.W. Alzheimer's disease and down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 122 (1984) 1131-1135
45. Glenner G.G., and Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120 (1984) 885-890
46. Goate A., Chartier-Harlin M.C., Mullan M., Brown J., Crawford F., Fidani L., Giuffra L., Haynes A., Irving N., James L., et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349 (1991) 704-706
47. Goedert M., Wischik C.M., Crowther R.A., Walker J.E., and Klug A. Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau. Proc. Natl Acad. Sci. USA 85 (1988) 4051-4055
48. Goldgaber D., Lerman M.I., McBride O.W., Saffiotti U., and Gajdusek D.C. Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease. Science 235 (1987) 877-880
49. Gomez-Isla T., Hollister R., West H., Mui S., Growdon J.H., Petersen R.C., Parisi J.E., and Hyman B.T. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann. Neurol. 41 (1997) 17-24
50. Gotz J., Chen F., van Dorpe J., and Nitsch R.M. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 293 (2001) 1491-1495
51. Goutte C., Tsunozaki M., Hale V.A., and Priess J.R. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl Acad. Sci. USA 99 (2002) 775-779
52. 2+ and mitogen-activated protein kinases. Anesthesiology 102 (2005) 606-615
53. Green K.N., Boyle J.P., and Peers C. Hypoxia potentiates exocytosis and Ca2+ channels in PC12 cells via increased amyloid beta peptide formation and reactive oxygen species generation. J. Physiol. 541 (2002) 1013-1023
54. 2 changes, and visual evoked potentials in mechanically ventilated, preterm infants. Acta Paediatr. Scand. 76 (1987) 394-400
55. Grundke-Iqbal I., Iqbal K., Tung Y.C., Quinlan M., Wisniewski H.M., and Binder L.I. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl Acad. Sci. USA 83 (1986) 4913-4917
56. Gu Y., Misonou H., Sato T., Dohmae N., Takio K., and Ihara Y. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. J. Biol. Chem. 276 (2001) 35235-35238
57. Gu Y., Chen F., Sanjo N., Kawarai T., Hasegawa H., Duthie M., Li W., Ruan X., Luthra A., Mount H.T., et al. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin nicastrin complexes. J. Biol. Chem. 278 (2003) 7374-7380
58. Guenette S.Y., Chen J., Ferland A., Haass C., Capell A., and Tanzi R.E. hFE65L influences amyloid precursor protein maturation and secretion. J. Neurochem. 73 (1999) 985-993
59. Guillozet A.L., Weintraub S., Mash D.C., and Mesulam M.M. Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch. Neurol. 60 (2003) 729-736
60. Guo Q., Furukawa K., Sopher B.L., Pham D.G., Xie J., Robinson N., Martin G.M., and Mattson M.P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. NeuroReport 8 (1996) 379-383
61. Guo Q., Sebastian L., Sopher B.L., Miller M.W., Ware C.B., Martin G.M., and Mattson M.P. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation. J. Neurochem. 72 (1999) 1019-1029
62. Haass C., and De Strooper B. The presenilins in Alzheimer's disease-proteolysis holds the key. Science 286 (1999) 916-919
63. Hardy J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20 (1997) 154-159
64. Hiesberger T., Trommsdorff M., Howell B.W., Goffinet A., Mumby M.C., Cooper J.A., and Herz J. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 24 (1999) 481-489
65. Ho C.S., Marinescu V., Steinhilb M.L., Gaut J.R., Turner R.S., and Stuenkel E.L. Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism. J. Biol. Chem. 277 (2002) 27021-27028
66. Holtzman D.M., and Deshmukh M. Caspases: a treatment target for neurodegenerative disease?. Nat. Med. 3 (1997) 954-955
67. Homayouni R., Rice D.S., Sheldon M., and Curran T. Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J. Neurosci. 19 (1999) 7507-7515
68. Howell B.W., Gertler F.B., and Cooper J.A. Mouse disabled (mDab1): a src binding protein implicated in neuronal development. EMBO J. 16 (1997) 121-132
69. Hussain I., Powell D., Howlett D.R., Tew D.G., Meek T.D., Chapman C., Gloger I.S., Murphy K.E., Southan C.D., Ryan D.M., et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell Neurosci. 14 (1999) 419-427
70. Inomata H., Nakamura Y., Hayakawa A., Takata H., Suzuki T., Miyazawa K., and Kitamura N. A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J. Biol. Chem. 278 (2003) 22946-22955
71. Jarrett J.T., Berger E.P., and Lansbury Jr. P.T. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 32 (1993) 4693-4697
72. Jellinger K.A. The pathology of ischemic-vascular dementia: an update. J. Neurol. Sci. 203/204 (2002) 153-157
73. Jendroska K., Hoffmann O.M., and Patt S. Amyloid beta peptide and precursor protein (APP) in mild and severe brain ischemia. Ann. NY Acad. Sci. 826 (1997) 401-405
74. Kalaria R.N. The role of cerebral ischemia in Alzheimer's disease. Neurobiol. Aging 21 (2000) 321-330
75. Kalback W., Esh C., Castano E.M., Rahman A., Kokjohn T., Luehrs D.C., Sue L., Cisneros R., Gerber F., Richardson C., et al. Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease. Neurol. Res. 26 (2004) 525-539
76. Kang J., Lemaire H.G., Unterbeck A., Salbaum J.M., Masters C.L., Grzeschik K.H., Multhaup G., Beyreuther K., and Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325 (1987) 733-736
77. Kawaguchi M., Drummond J.C., Cole D.J., Kelly P.J., Spurlock M.P., and Patel P.M. Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. Anesth. Analg. 98 (2004) 798-805 (table of contents)
78. Kim T.W., Pettingell W.H., Jung Y.K., Kovacs D.M., and Tanzi R.E. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277 (1997) 373-376
79. Kim D.Y., Ingano L.A., and Kovacs D.M. Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage. J. Biol. Chem. 277 (2002) 49976-49981
80. Kim S.H., Ikeuchi T., Yu C., and Sisodia S.S. Regulated hyperaccumulation of presenilin-1 and the gamma-secretase complex. Evidence for differential intramembranous processing of transmembrane substrates. J. Biol. Chem. 278 (2003) 33992-34002
81. Kimberly W.T., LaVoie M.J., Ostaszewski B.L., Ye W., Wolfe M.S., and Selkoe D.J. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc. Natl Acad. Sci. USA 100 (2003) 6382-6387
82. Kogure K., and Kato H. Altered gene expression in cerebral ischemia. Stroke 24 (1993) 2121-2127
83. Koistinaho J., Pyykonen I., Keinanen R., and Hokfelt T. Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. NeuroReport 7 (1996) 2727-2731
84. Kokmen E., Whisnant J.P., O'Fallon W.M., Chu C.P., and Beard C.M. Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984). Neurology 46 (1996) 154-159
85. Kosik K.S., Joachim C.L., and Selkoe D.J. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc. Natl Acad. Sci. USA 83 (1986) 4044-4048
86. Kovacs D.M., Mancini R., Henderson J., Na S.J., Schmidt S.D., Kim T.W., and Tanzi R.E. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. J. Neurochem. 73 (1999) 2278-2285
87. Kvolik S., Glavas-Obrovac L., Bares V., and Karner I. Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell lines. Life Sci. 77 (2005) 2369-2383
88. Laffey J.G., and Kavanagh B.P. Hypocapnia. N. Engl. J. Med. 347 (2002) 43-53
89. Lambert M.P., Barlow A.K., Chromy B.A., Edwards C., Freed R., Liosatos M., Morgan T.E., Rozovsky I., Trommer B., Viola K.L., et al. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc. Natl Acad. Sci. USA 95 (1998) 6448-6453
90. Lammich S., Okochi M., Takeda M., Kaether C., Capell A., Zimmer A.K., Edbauer D., Walter J., Steiner H., and Haass C. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J. Biol. Chem. 277 (2002) 44754-44759
91. Larson J., Lynch G., Games D., and Seubert P. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice. Brain Res. 840 (1999) 23-35
92. LaVoie M.J., Fraering P.C., Ostaszewski B.L., Ye W., Kimberly W.T., Wolfe M.S., and Selkoe D.J. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J. Biol. Chem. 278 (2003) 37213-37222
93. Lee V.M., Balin B.J., Otvos Jr. L., and Trojanowski J.Q. A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 251 (1991) 675-678
94. Lee S.F., Shah S., Li H., Yu C., Han W., and Yu G. Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J. Biol. Chem. 277 (2002) 45013-45019
95. Leissring M.A., Farris W., Chang A.Y., Walsh D.M., Wu X., Sun X., Frosch M.P., and Selkoe D.J. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40 (2003) 1087-1093
96. Levy-Lahad E., Wasco W., Poorkaj P., Romano D.M., Oshima J., Pettingell W.H., Yu C.E., Jondro P.D., Schmidt S.D., Wang K., et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 269 (1995) 973-977
97. Lewis J., Dickson D.W., Lin W.L., Chisholm L., Corral A., Jones G., Yen S.H., Sahara N., Skipper L., Yager D., et al. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science 293 (2001) 1487-1491
98. Li X., and Greenwald I. Membrane topology of the C. elegans SEL-12 presenilin. Neuron 17 (1996) 1015-1021
99. Li Y.M., Lai M.T., Xu M., Huang Q., DiMuzio-Mower J., Sardana M.K., Shi X.P., Yin K.C., Shafer J.A., and Gardell S.J. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc. Natl Acad. Sci. USA 97 (2000) 6138-6143
100. Loetscher H., Deuschle U., Brockhaus M., Reinhardt D., Nelboeck P., Mous J., Grunberg J., Haass C., and Jacobsen H. Presenilins are processed by caspase-type proteases. J. Biol. Chem. 272 (1997) 20655-20659
101. Loop T., Dovi-Akue D., Frick M., Roesslein M., Egger L., Humar M., Hoetzel A., Schmidt R., Borner C., Pahl H.L., et al. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology 102 (2005) 1147-1157
102. Luedecking-Zimmer E., DeKosky S.T., Nebes R., and Kamboh M.I. Association of the 3′ UTR transcription factor LBP-1c/CP2/LSF polymorphism with late-onset Alzheimer's disease. Am. J. Med. Genet. B Neuropsychiatr. Genet. 117 (2003) 114-117
103. Lunkes A., Trottier Y., and Mandel J.L. Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases. Essays Biochem. 33 (1998) 149-163
104. Marambaud P., Shioi J., Serban G., Georgakopoulos A., Sarner S., Nagy V., Baki L., Wen P., Efthimiopoulos S., Shao Z., et al. A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J. 21 (2002) 1948-1956
105. Marr R.A., Rockenstein E., Mukherjee A., Kindy M.S., Hersh L.B., Gage F.H., Verma I.M., and Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J. Neurosci. 23 (2003) 1992-1996
106. Masliah E., Mallory M., Alford M., Tanaka S., and Hansen L.A. Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease. J. Neuropathol. Exp. Neurol. 57 (1998) 1041-1052
107. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., and Beyreuther K. Amyloid plaque core protein in Alzheimer disease and down syndrome. Proc. Natl Acad. Sci. USA 82 (1985) 4245-4249
108. Matsuda S., Yasukawa T., Homma Y., Ito Y., Niikura T., Hiraki T., Hirai S., Ohno S., Kita Y., Kawasumi M., et al. C-jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. J. Neurosci. 21 (2001) 6597-6607
109. Matsuoka H., Kurosawa S., Horinouchi T., Kato M., and Hashimoto Y. Inhalation anesthetics induce apoptosis in normal peripheral lymphocytes in vitro. Anesthesiology 95 (2001) 1467-1472
110. Mattson M.P. Contributions of mitochondrial alterations, resulting from bad genes and a hostile environment, to the pathogenesis of Alzheimer's disease. Int. Rev. Neurobiol. 53 (2002) 387-409
111. Mattson M.P., Zhu H., Yu J., and Kindy M.S. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis. J. Neurosci. 20 (2000) 1358-1364
112. May P., Reddy Y.K., and Herz J. Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277 (2002) 18736-18743
113. McLoughlin D.M., and Miller C.C. The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. FEBS Lett. 397 (1996) 197-200
114. Mennerick S., Jevtovic-Todorovic V., Todorovic S.M., Shen W., Olney J.W., and Zorumski C.F. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J. Neurosci. 18 (1998) 9716-9726
115. Miller B.C., Eckman E.A., Sambamurti K., Dobbs N., Chow K.M., Eckman C.B., Hersh L.B., and Thiele D.L. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proc. Natl Acad. Sci. USA 100 (2003) 6221-6226
116. Moller J.T., Cluitmans P., Rasmussen L.S., Houx P., Rasmussen H., Canet J., Rabbitt P., Jolles J., Larsen K., Hanning C.D., et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International study of post-operative cognitive dysfunction. Lancet 351 (1998) 857-861
117. Morais V.A., Crystal A.S., Pijak D.S., Carlin D., Costa J., Lee V.M., and Doms R.W. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex. J. Biol. Chem. 278 (2003) 43284-43291
118. Moroney J.T., Bagiella E., Desmond D.W., Paik M.C., Stern Y., and Tatemichi T.K. Risk factors for incident dementia after stroke. Role of hypoxic and ischemic disorders. Stroke 27 (1996) 1283-1289
119. Muravchick S., and Smith D.S. Parkinsonian symptoms during emergence from general anesthesia. Anesthesiology 82 (1995) 305-307
120. Nagy Z., Esiri M.M., Jobst K.A., Morris J.H., King E.M., McDonald B., Joachim C., Litchfield S., Barnetson L., and Smith A.D. The effects of additional pathology on the cognitive deficit in Alzheimer disease. J. Neuropathol. Exp. Neurol. 56 (1997) 165-170
121. Namura S., Zhu J., Fink K., Endres M., Srinivasan A., Tomaselli K.J., Yuan J., and Moskowitz M.A. Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J. Neurosci. 18 (1998) 3659-3668
122. Narahashi T., Aistrup G.L., Lindstrom J.M., Marszalec W., Nagata K., Wang F., and Yeh J.Z. Ion channel modulation as the basis for general anesthesia. Toxicol. Lett. 100/101 (1998) 185-191
123. Newman M.F., Kirchner J.L., Phillips-Bute B., Gaver V., Grocott H., Jones R.H., Mark D.B., Reves J.G., and Blumenthal J.A. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N. Engl. J. Med. 344 (2001) 395-402
124. Ni C.Y., Murphy M.P., Golde T.E., and Carpenter G. gamma-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294 (2001) 2179-2181
125. Northington F.J., Ferriero D.M., Graham E.M., Traystman R.J., and Martin L.J. Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis. Neurobiol. Dis. 8 (2001) 207-219
126. Noviello C., Vito P., Lopez P., Abdallah M., and D'Adamio L. Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein. J. Biol. Chem. 278 (2003) 31843-31847
127. Nyabi O., Bentahir M., Horre K., Herreman A., Gottardi-Littell N., Van Broeckhoven C., Merchiers P., Spittaels K., Annaert W., and De Strooper B. Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin. J. Biol. Chem. 278 (2003) 43430-43436
128. Ohyu J., Endo A., Itoh M., and Takashima S. Hypocapnia under hypotension induces apoptotic neuronal cell death in the hippocampus of newborn rabbits. Pediatr. Res. 48 (2000) 24-29
129. Panza F., D'Introno A., Colacicco A.M., Capurso C., Basile A.M., Torres F., Capurso A., and Solfrizzi V. LBP-1c/CP2/LSF gene polymorphism and risk of sporadic Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 75 (2004) 166-168
130. Perez-Tur J., Froelich S., Prihar G., Crook R., Baker M., Duff K., Wragg M., Busfield F., Lendon C., Clark R.F., et al. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. NeuroReport 7 (1995) 297-301
131. Poirier J. Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism. Ann. NY Acad. Sci. 924 (2000) 81-90
132. Price D.L., and Sisodia S.S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21 (1998) 479-505
133. Price D.L., Tanzi R.E., Borchelt D.R., and Sisodia S.S. Alzheimer's disease: genetic studies and transgenic models. Annu. Rev. Genet. 32 (1998) 461-493
134. Qiu W.Q., Walsh D.M., Ye Z., Vekrellis K., Zhang J., Podlisny M.B., Rosner M.R., Safavi A., Hersh L.B., and Selkoe D.J. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J. Biol. Chem. 273 (1998) 32730-32738
135. Raina A.K., Hochman A., Ickes H., Zhu X., Ogawa O., Cash A.D., Shimohama S., Perry G., and Smith M.A. Apoptotic promoters and inhibitors in Alzheimer's disease: who wins out?. Prog. Neuropsychopharmacol. Biol. Psychiatry 27 (2003) 251-254
136. Ratovitski T., Slunt H.H., Thinakaran G., Price D.L., Sisodia S.S., and Borchelt D.R. Endoproteolytic processing and stabilization of wild-type and mutant presenilin. J. Biol. Chem. 272 (1997) 24536-24541
137. Robakis N.K., Ramakrishna N., Wolfe G., and Wisniewski H.M. Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides. Proc. Natl Acad. Sci. USA 84 (1987) 4190-4194
138. Rogaev E.I., Sherrington R., Rogaeva E.A., Levesque G., Ikeda M., Liang Y., Chi H., Lin C., Holman K., Tsuda T., et al. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376 (1995) 775-778
139. Roncarati R., Sestan N., Scheinfeld M.H., Berechid B.E., Lopez P.A., Meucci O., McGlade J.C., Rakic P., and D'Adamio L. The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds numb and inhibits Notch signaling. Proc. Natl Acad. Sci. USA 99 (2002) 7102-7107
140. Russo C., Dolcini V., Salis S., Venezia V., Violani E., Carlo P., Zambrano N., Russo T., and Schettini G. Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain. Ann. NY Acad. Sci. 973 (2002) 323-333
141. Sabo S.L., Lanier L.M., Ikin A.F., Khorkova O., Sahasrabudhe S., Greengard P., and Buxbaum J.D. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J. Biol. Chem. 274 (1999) 7952-7957
142. Santacruz K., Lewis J., Spires T., Paulson J., Kotilinek L., Ingelsson M., Guimaraes A., DeTure M., Ramsden M., McGowan E., et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309 (2005) 476-481
143. Sastre M., Steiner H., Fuchs K., Capell A., Multhaup G., Condron M.M., Teplow D.B., and Haass C. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2 (2001) 835-841
144. Scheinfeld M.H., Roncarati R., Vito P., Lopez P.A., Abdallah M., and D'Adamio L. Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP). J. Biol. Chem. 277 (2002) 3767-3775
145. Schellenberg G.D., Bird T.D., Wijsman E.M., Orr H.T., Anderson L., Nemens E., White J.A., Bonnycastle L., Weber J.L., Alonso M.E., et al. Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science 258 (1992) 668-671
146. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 2 (1996) 864-870
147. Schmitz A., Schneider A., Kummer M.P., and Herzog V. Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways. Traffic 5 (2004) 89-101
148. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
149. Selkoe D.J., Podlisny M.B., Joachim C.L., Vickers E.A., Lee G., Fritz L.C., and Oltersdorf T. Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc. Natl Acad. Sci. USA 85 (1988) 7341-7345
150. Sherrington R., Rogaev E.I., Liang Y., Rogaeva E.A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375 (1995) 754-760
151. Shibata M., Yamada S., Kumar S.R., Calero M., Bading J., Frangione B., Holtzman D.M., Miller C.A., Strickland D.K., Ghiso J., and Zlokovic B.V. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106 (2000) 1489-1499
152. Shimohama S., Tanino H., and Fujimoto S. Changes in caspase expression in Alzheimer's disease: comparison with development and aging. Biochem. Biophys. Res. Commun. 256 (1999) 381-384
153. Shirotani K., Edbauer D., Capell A., Schmitz J., Steiner H., and Haass C. Gamma-secretase activity is associated with a conformational change of nicastrin. J. Biol. Chem. 278 (2003) 16474-16477
154. Sinha S., and Lieberburg I. Cellular mechanisms of beta-amyloid production and secretion. Proc. Natl Acad. Sci. USA 96 (1999) 11049-11053
155. Sisodia S.S., and St George-Hyslop P.H. Gamma-secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?. Nat. Rev. Neurosci. 3 (2002) 281-290
156. Sisodia S.S., Koo E.H., Beyreuther K., Unterbeck A., and Price D.L. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 248 (1990) 492-495
157. Snowdon D.A., Greiner L.H., Mortimer J.A., Riley K.P., Greiner P.A., and Markesbery W.R. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 277 (1997) 813-817
158. Snyder E.M., Nong Y., Almeida C.G., Paul S., Moran T., Choi E.Y., Nairn A.C., Salter M.W., Lombroso P.J., Gouras G.K., and Greengard P. Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci. 8 (2005) 1051-1058
159. Song E.S., Juliano M.A., Juliano L., and Hersh L.B. Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development. J. Biol. Chem. 278 (2003) 49789-49794
160. St George-Hyslop P.H. Molecular genetics of Alzheimer's disease. Biol. Psychiatry 47 (2000) 183-199
161. Steiner H., Winkler E., Edbauer D., Prokop S., Basset G., Yamasaki A., Kostka M., and Haass C. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J. Biol. Chem. 277 (2002) 39062-39065
162. Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., and Roses A.D. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl Acad. Sci. USA 90 (1993) 1977-1981
163. Su J.H., Anderson A.J., Cummings B.J., and Cotman C.W. Immunohistochemical evidence for apoptosis in Alzheimer's disease. NeuroReport 5 (1994) 2529-2533
164. Su J.H., Deng G., and Cotman C.W. Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology. J. Neuropathol. Exp. Neurol. 56 (1997) 86-93
165. Takasugi N., Tomita T., Hayashi I., Tsuruoka M., Niimura M., Takahashi Y., Thinakaran G., and Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature 422 (2003) 438-441
166. Tanahashi H., and Tabira T. Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein. Neurosci. Lett. 261 (1999) 143-146
167. Tanzi R.E. A genetic dichotomy model for the inheritance of Alzheimer's disease and common age-related disorders. J. Clin. Invest. 104 (1999) 1175-1179
168. Tanzi R.E. The synaptic Abeta hypothesis of Alzheimer disease. Nat. Neurosci. 8 (2005) 977-979
169. Tanzi R.E. Tangles and neurodegenerative disease-a surprising twist. N. Engl. J. Med. 353 (2005) 1853-1855
170. Tanzi R.E., and Bertram L. New frontiers in Alzheimer's disease genetics. Neuron 32 (2001) 181-184
171. Tanzi R.E., and Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 120 (2005) 545-555
172. Tanzi R.E., Bird E.D., Latt S.A., and Neve R.L. The amyloid beta protein gene is not duplicated in brains from patients with Alzheimer's disease. Science 238 (1987) 666-669
173. Tanzi R.E., Gusella J.F., Watkins P.C., Bruns G.A., St George-Hyslop P., Van Keuren M.L., Patterson D., Pagan S., Kurnit D.M., and Neve R.L. Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus. Science 235 (1987) 880-884
174. Tanzi R.E., Moir R.D., and Wagner S.L. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron 43 (2004) 605-608
175. Tarr P.E., Roncarati R., Pelicci G., Pelicci P.G., and D'Adamio L. Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. J. Biol. Chem. 277 (2002) 16798-16804
176. Tatemichi T.K., Paik M., Bagiella E., Desmond D.W., Stern Y., Sano M., Hauser W.A., and Mayeux R. Risk of dementia after stroke in a hospitalized cohort: results of a longitudinal study. Neurology 44 (1994) 1885-1891
177. Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., and Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30 (1991) 572-580
178. Thinakaran G. The role of presenilins in Alzheimer's disease. J. Clin. Invest. 104 (1999) 1321-1327
179. Thinakaran G., Borchelt D.R., Lee M.K., Slunt H.H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron 17 (1996) 181-190
180. Tomimoto H., Wakita H., Akiguchi I., Nakamura S., and Kimura J. Temporal profiles of accumulation of amyloid beta/A4 protein precursor in the gerbil after graded ischemic stress. J. Cereb. Blood Flow Metab. 14 (1994) 565-573
181. Trommsdorff M., Borg J.P., Margolis B., and Herz J. Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J. Biol. Chem. 273 (1998) 33556-33560
182. Tyther R., Fanning N., Halligan M., Wang J., Redmond H.P., and Shorten G. The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosis in vitro. Ir. J. Med. Sci. 170 (2001) 41-44
183. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 (1999) 735-741
184. Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., and Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416 (2002) 535-539
185. Webster N.J., Green K.N., Peers C., and Vaughan P.F. Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia. J. Neurochem. 83 (2002) 1262-1271
186. Wei H., Kang B., Wei W., Liang G., Meng Q.C., Li Y., and Eckenhoff R.G. Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently. Brain Res. 1037 (2005) 139-147
187. Weidemann A., Konig G., Bunke D., Fischer P., Salbaum J.M., Masters C.L., and Beyreuther K. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57 (1989) 115-126
188. Weidemann A., Eggert S., Reinhard F.B., Vogel M., Paliga K., Baier G., Masters C.L., Beyreuther K., and Evin G. A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry 41 (2002) 2825-2835
189. Weingarten M.D., Lockwood A.H., Hwo S.Y., and Kirschner M.W. A protein factor essential for microtubule assembly. Proc. Natl Acad. Sci. USA 72 (1975) 1858-1862
190. Wise-Faberowski L., Raizada M.K., and Sumners C. Oxygen and glucose deprivation-induced neuronal apoptosis is attenuated by halothane and isoflurane. Anesth. Analg. 93 (2001) 1281-1287
191. Wise-Faberowski L., Aono M., Pearlstein R.D., and Warner D.S. Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-d-aspartate excitotoxicity. Anesth. Analg. 99 (2004) 1708-1714 (table of contents)
192. Wolfe M.S. The secretases of Alzheimer's disease. Curr. Top Dev. Biol. 54 (2003) 233-261
193. Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., and Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398 (1999) 513-517
194. Wollman S.B., and Orkin L.R. Postoperative human reaction time and hypocarbia during anaesthesia. Br. J. Anaesth. 40 (1968) 920-926
195. Wolozin B., Alexander P., and Palacino J. Regulation of apoptosis by presenilin 1. Neurobiol. Aging 19 (1998) S23-S27
196. Wong P.C., Zheng H., Chen H., Becher M.W., Sirinathsinghji D.J., Trumbauer M.E., Chen H.Y., Price D.L., Van der Ploeg L.H., and Sisodia S.S. Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature 387 (1997) 288-292
197. Xie Z., Moir R., Romano D.M., Tesco G., Kovacs D., and Tanzi R.E. Hypocapnia induces caspase-3 activation and increases A-beta production. Neurodegenerative Dis. 1 (2004) 29-37
198. Xie Z., Romano D.M., Kovacs D.M., and Tanzi R.E. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J. Biol. Chem. 279 (2004) 34130-34137
199. Xie Z., Romano D.M., and Tanzi R.E. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. J. Mol. Neurosci. 25 (2005) 67-77
200. Xie Z., Romano D.M., and Tanzi R.E. RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. J. Biol. Chem. 280 (2005) 15413-15421
201. Xie, Z., Dong, Y., Maeda, U., Alfille, P., Culley, DJ., Crosby, G., Tanzi, RE., in press. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta-protein levels. Anesthesiology.
202. Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., Pauley A.M., Brashier J.R., Stratman N.C., Mathews W.R., Buhl A.E., et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402 (1999) 533-537
203. Yan S.D., Zhu H., Zhu A., Golabek A., Du H., Roher A., Yu J., Soto C., Schmidt A.M., Stern D., and Kindy M. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat. Med. 6 (2000) 643-651
204. Yang F., Sun X., Beech W., Teter B., Wu S., Sigel J., Vinters H.V., Frautschy S.A., and Cole G.M. Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. Am. J. Pathol. 152 (1998) 379-389
205. Yokota M., Saido T.C., Tani E., Yamaura I., and Minami N. Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia. J. Cereb. Blood Flow Metab. 16 (1996) 1219-1223
206. Yu G., Nishimura M., Arawaka S., Levitan D., Zhang L., Tandon A., Song Y.Q., Rogaeva E., Chen F., Kawarai T., et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 407 (2000) 48-54
207. Yu C., Kim S.H., Ikeuchi T., Xu H., Gasparini L., Wang R., and Sisodia S.S. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma-secretase processing of the APP and Notch1 transmembrane domains. J. Biol. Chem. 276 (2001) 43756-43760
208. Zambrano N., Buxbaum J.D., Minopoli G., Fiore F., De Candia P., De Renzis S., Faraonio R., Sabo S., Cheetham J., Sudol M., and Russo T. Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins. J. Biol. Chem. 272 (1997) 6399-6405
209. Zaugg M., Jamali N.Z., Lucchinetti E., Shafiq S.A., and Siddiqui M.A. Norepinephrine-induced apoptosis is inhibited in adult rat ventricular myocytes exposed to volatile anesthetics. Anesthesiology 93 (2000) 209-218
210. Zhang Z., Hartmann H., Do V.M., Abramowski D., Sturchler-Pierrat C., Staufenbiel M., Sommer B., van de Wetering M., Clevers H., Saftig P., et al. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395 (1998) 698-702
211. Zhao G., Mao G., Tan J., Dong Y., Cui M.Z., Kim S.H., and Xu X. Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. J. Biol. Chem. 279 (2004) 50647-50650
212. Zheng P., Eastman J., Vande Pol S., and Pimplikar S.W. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl Acad. Sci. USA 95 (1998) 14745-14750
213. Zlokovic B.V., Martel C.L., Matsubara E., McComb J.G., Zheng G., McCluskey R.T., Frangione B., and Ghiso J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc. Natl Acad. Sci. USA 93 (1996) 4229-4234