Caspases: A treatment target for neurodegenerative disease?

Nature Medicine

Volumn 3, Issue 9, 1997, Pages 954-955

  Holtzman, David M ^a   Deshmukh, Mohanish ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; NERVE GROWTH FACTOR; PROTEINASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL MODEL; APOPTOSIS; CELL DEATH; DEGENERATIVE DISEASE; ENZYME ACTIVITY; MOTOR NEURON DISEASE; MOUSE; NERVE CELL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEINASE INHIBITION; SHORT SURVEY;

APOPTOSIS; ENDOPEPTIDASES; HUMANS; NECROSIS; NERVE DEGENERATION; NERVOUS SYSTEM DISEASES; PROTEASE INHIBITORS;

ANIMALIA;

EID: 0030756576     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0997-954     Document Type: Short Survey

References (14)

1. Oppenheim, R.W. Cell death during the development of the nervous system. Annu. Rev. Neurosci. 14, 453-501 (1991).
2. Kerr, J.F.R., Wyllie, A.H. & Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257 (1972).
3. Schwartz, L.M. & Milligan, C.E. Cold thoughts of death: the role of ICE proteases in neuronal death. Trends Neursci. 19, 555-562 (1996).
4. Hara, H. et al. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. USA 94, 2007-2012 (1997).
5. Johnson, E.M., Deckwerth, T.L. & Deshmukh, M. Neuronal death in developmental models: Possible implications in neuropathology. Brain Pathol. 6, 397-409 (1996).
6. Friedlander, R.M., Brown, R.H., Gagliardini, V., Wang, J. & Yuan, J. Inhibition of ICE slows ALS in mice. Nature 388, 31 (1997).
7. Kim, T.-W., Pettingell, W.H., Jung, Y.-K., Kovacs, D.M. & Tanzi, R.E. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373-376 (1997).
8. Ellis, R.E. & Horvitz, H.R. Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817-829 (1986).
9. Milligan, C.E. et al. Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron 15, 385-393 (1995).
10. Kuida, K. et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368-372 (1996).
11. Deshmukh, M. & Johnson, E.M. Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons. Mol. Pharmacol. 51, 897-906 (1997).
12. Werth, J.L., Cocabo, J., Deshmukh, M., Johnson, E.M. & Rothman, S.M. Physiological properties of SCG neurons prevented from undergoing programmed cell death. Soc. Neurosci. Abstr. (in the press).
13. Kostic, V., Jackson-Lewis, V., de Bilbao, F., Dubois-Dauphin, M. & Przedborski, S. Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 277, 559-562 (1997).
14. Sagot, Y. et al. Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of neurodegenerative disease. J. Neurosci. 15, 7727-7733 (1995).