Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain

Annals of the New York Academy of Sciences

Volumn 973, Issue , 2002, Pages 323-333

  Russo, Claudio ^a   Dolcini, Virginia ^a   Salis, Serena ^a   Venezia, Valentina ^a   Violani, Elisabetta ^a   Carlo, Pia ^a   Zambrano, Nicola ^b   Russo, Tommaso ^b   Schettini, Gennaro ^b,c  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c CENTRO DI BIOTECNOLOGIE AVANZATE   (Italy)

Author keywords

Adaptor proteins; Alzheimer's disease; Amyloid precursor protein; Astrocytes; MAPK

Indexed keywords

ADAPTOR PROTEIN; AMYLOID PRECURSOR PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN SHC; THROMBIN;

ALZHEIMER DISEASE; ASTROCYTE; BRAIN BLOOD VESSEL; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; CONTROLLED STUDY; GLIA CELL; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 0036959694     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04660.x     Document Type: Conference Paper

References (40)

1. SELKOE, D.J. 2001. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81: 741-766
2. BRAAK, H. & E. BRAAK. 1997. Diagnostic criteria for neuropathologic assessment of Alzheimer's disease. Neurobiol. Aging 18: S85-S88.
3. TERRY, R.D., R. KATZMAN., K.L. BICK & S.S. SISODIA. 1999. Alzheimer Disease. Lippincott Williams & Wilkins. Philadelphia.
4. GLENNER, G.G. & C.W. WONG. 1984. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120: 885-890.
5. MOUNTJOY, C.Q., M. ROTH, N.J.R. EVANS & H.M. EVANS. 1983. Cortical neuronal counts in normal elderly controls and demented patients. Neurobiol. Aging 4: 1-11.
6. TERRY, R.D., R. DE TERESA & L.A. HANSEN. 1987. Neocortical cell counts in normal human adult aging. Ann. Neurol. 21: 530-539.
7. KANG, J., H.G. LEMAIRE, A. UNTERBECK, et al. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325: 733-736.
8. SIMONS, M., B. DE STROOPER, G. MULTHAUP, et al. 1996. Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. J. Neurosci. 16: 899-908.
9. OSTER-GRANITE, M.L., D.L. MCPHIE, J. GREENAN & R.L. NEVE. 1996. Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein. J. Neurosci. 16: 6732-6741.
10. NEVE, R.L., F.M. BOYCE & D.L. MCPHIE. 1996. Transgenic mice expressing APP-C100 in the brain. Neurobiol. Aging 17: 191-203.
11. MCPHIE, D.L., R.K. LEE, C.B. ECKMAN, et al. 1997. Neuronal expression of beta-amy-loid precursor protein Alzheimer mutations causes intracellular accumulation of a C-terminal fragment containing both the amyloid beta and cytoplasmic domains. J. Biol. Chem. 272: 24743-24746.
12. HAASS, C., E.H. KOO, A. MELLON, et al. 1992. Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 327: 500-503.
13. GOLDE, T.E., S. ESTUS, L.H. YOUNKIN, et al. 1992. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science 255: 728-730.
14. VASSAR, R., B.D. BENNETT, S. BABU-KAN, et al. 1999. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286: 735-741.
15. SINHA, S., J.P. ANDERSON, R. BARBOUR, et al. 1999. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402: 537-540.
16. YAN, R., M.J. BIENKOWSKI, M.E. SHUCK, et al. 1999. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402: 533-537.
17. JARRETT, J.T., E.P. BERGER & P.T. LANSBURY, JR. 1993. The carboxy terminus of the β-amyloid protein is critical for the seeding of amyloid formation: implication for the pathogenesis of Alzheimer's disease. Biochemistry 32: 4693-4697.
18. MARCINKIEWICZ, M. & N.G. SEIDAH. Coordinated expression of α-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J. Neurochem. 75: 2133-2143.
19. FORMAN-KAY, J.D. & T. PAWSON. 1999. Diversity in protein recognition by PTB domains. Curr. Opin. Struct. Biol. 9: 690-695.
20. BORG, J.P., J. OOI, E. LEVY & B. MARGOLIS. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol. 16: 6229-6241.
21. HOWELL, B.W., L.M. LANIER, R. FRANK, et al. 1999. The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Mol. Cell. Biol. 19: 5179-5188.
22. ZAMBRANO, N., J.D. BUXBAUM, G. MINOPOLI, et al. 1997. Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins. J. Biol. Chem. 272: 6399-6405.
23. RUSSO, C., S. SALIS, V. DOLCINI, et al. 2001. Identification of amino-terminally and phosphotyrosine modified carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain. Neurobiol. Disease 8: 173-180.
24. ZAMBRANO, N., P. BRUNI, O. MINOPOLI, et al. 2001. The α-amyloid precursor protein APP is tyrosine phosphorilated in cells expressing a constitutively active form of the Abl protoncogene. J. Biol. Chem. 276: 19787-19792.
25. TIENARI, P.J., B. DE STROOPER, E. IKONEN, et al. 1996. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. EMBO J. 15: 5218-5229.
26. YANG, A.J., M. KNAUER, D.A. BURDICK & C. GLABE. 1995. Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells. J. Biol. Chem. 270: 14786-14792.
27. CATTANEO, E. & P.G. PELICCI. 1998. Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain. Trends Neurosci. 21: 476-481.
28. LI, S.C., K.M. LAI, G.D. GISH, et al. 1996. Characterization of the phosphotyrosine-binding domain of the Drosophila Shcprotein. J. Biol. Chem. 271: 31855-31862.
29. HYMAN, B.T., T.E. ELVHAGE & J. REITER. 1994. Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease. Am. J. Pathol. 144: 565-572.
30. Neuroinflammation Working Group. 2000. Neurobiol. Aging 21: 383-421.
31. DAVIS-SALINAS, J., S.M. SAPORITO-IRWIN, F.M. DONOVAN, et al. 1994. Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor. J. Biol. Chem. 269: 22623-22627.
32. RICKETTS, W.A., J.H. BROWN & J.M. OLEFSKY. 1999. Pertussis toxin-sensitive and -insensitive thrombin stimulation of shcphosphorylation and mitogenesis are mediated through distinct pathways. Mol. Endocrinol. 13: 1988-2001.
33. GINGRICH, M.B. & S.F. TRAYNELIS. 2000. Serine proteases and brain damage - Is there a link? Trends Neurosci. 23: 399-407.
34. BHAT, N.R., P. ZHANG & E. HOGAN. 1995. Thrombin activates mitogen-activated protein kinase in primary astrocyte cultures. J. Cell. Physiol. 165: 417-424.
35. AKIYAMA, H., K. IKEDA, H. KONDO & P.L. MCGEER. 1992. Thrombin accumulation in brains of patients with Alzheimer's disease. Neurosci. Lett. 146: 152-154.
36. COCKS, T.M. & J.D. MOFFATT. 2000. Protease-activated receptors: sentries for inflammation? Trends Pharmacol. Sci. 21: 103-108.
37. TURGEON, V. & L.J. HOUENOU. 1997. The role of thrombin-like (serine) proteases in the development, plasticity and pathology of the nervous system. Brain Res. Brain Res. Rev. 25: 85-95.
38. KUBO, Y., M. SUZUKI, A. KUDO, et al. 2000. Thrombin inhibitor ameliorates secondary damage in rat brain injury: suppression of inflammatory cells and vimentin-positive astrocytes. J. Neurotrauma 17: 163-172.
39. T. OKAMOTO, S. TAKEDA, Y. MURAYAMA, et al. 1995. Ligand-dependent G protein coupling function of amyloid transmembrane precursor. J. Biol. Chem. 270: 4205-4208.
40. NEVE, R.L., D.L. MCPHIE & Y. CHEN. 2000. Alzheimer's disease: a dysfunction of the amyloid precursor protein. Brain Res. 886: 54-66.